Tag: 200-300

On December 2, 1999, Shirasawa, Eiichi; Konomi, Koji; Ichikawa, Masaki; Suhara, Hiroshi published a patent.Recommanded Product: 29704-38-9 The title of the patent was Preparation of novel 4-propenoylcinnamic acid or 1-propenoyl-4-(phosphonovinyl)benzene derivatives for treatment of glaucoma. And the patent contained the following:

Compounds represented by general formula (I) and salts thereof (wherein R1 is H, lower alkyl or Ph, the Ph being optionally substituted with lower alkyl, hydroxyl, lower alkoxy, halogeno, nitro or phenyl; R2 and R3 are each independently H, halogeno or lower alkyl; R4 and R5 are each independently H, lower alkyl or carboxyl, or a group derived therefrom through esterification; and R6 is carboxyl or phosphono, or a group derived from either through esterification), which decrease intraocular pressure based on the action similar to that of ethacrynic acid and are useful as glaucoma remedies, are prepared Thus, Et 4-carboxycinnamate was refluxed with SOCl2 in the presence of one drop of DMF in CHCl3 for 30 min and concentrated in vacuo to give the acid chloride. A 0.5 M solution of potassium bis(trimethylsilyl)amide in PhMe was added dropwise to a solution of tert-Bu 2,3,4,5,6-pentafluorophenylacetate in THF under dry ice-cooling and after 5 min, treated dropwise with a solution of the acid chloride in THF. In 20 min after completing the addition, the resulting mixture was stirred at room temperature for 20 min to give 4-[(2,3,4,5,6-pentafluorophenyl)acetyl]cinnamic acid which was heated with paraformaldehyde and dimethylamine hydrochloride in dioxane containing one drop of AcOH under stirring overnight to give the title compound (II) in 93% yield. When intracamerally injected in living monkeys, 4-(2-ethylacryloyl)cinnamic effected the greatest mean intraocular pressure reduction (7.0 mmHg) after 6 h vs. 2.0 mmHg for ethacrynic acid. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Recommanded Product: 29704-38-9

The Article related to propenoylcinnamic acid preparation treatment glaucoma, propenoylphosphonovinylbenzene preparation treatment glaucoma, intraocular pressure reduction, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 1992, Takagishi, Sadahito; Katsoulos, Georges; Schlosser, Manfred published an article.Formula: C12H14F3NO2 The title of the article was Fluorine and trifluoromethyl substituted anilines: site selective metalation and electrophilic substitution. And the article contained the following:

When treated with tert-butyllithium in THF at -50°, N-BOC (tert-butoxycarbonyl) protected fluoroanilines and trifluoromethylanilines, e.g., o-, m-, or p-F3CC6H4NHCO2CMe3, undergo metalation at the position adjacent to that carrying the nitrogen. If, however, the nitrogen carries two alkyl or trimethylsilyl groups as substituents and highly polar metalating reagents such as butyllithium activated by N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDTA) or potassium tert-butoxide are employed, the fluoroaniline derivatives are preferentially deprotonated next to the halogen atom. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to lithiation regioselective fluoroaniline, substituent effect lithiation fluoroaniline, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Tao; Hu, Jing; Yong, Li; Zhang, Gang; Zhang, Yi; Chen, Tong; Wang, Gongying published an article in 2019, the title of the article was Qualitative and quantitative analysis of the product and by-products from transesterification between phenol and dimethyl carbonate.Safety of Phenyl Salicylate And the article contains the following content:

Byproducts (Ph salicylate, Ph 4-hydroxybenzoate and xanthone) from transesterification between phenol and di-Me carbonate (DMC) were qual. analyzed by gas chromatog., mass spectrometry and a gas chromatog. method with directed injection for simultaneous quant. anal. of the product (DPC) and byproducts of the transesterification was established. Based on the results of qual. and quant. analyses, the mechanism of the byproducts generation was preliminarily deduced. The sample for quant. anal. was directly diluted in acetone, and related compounds were separated on an HP-5 capillary column and detected by a hydrogen flame ionization detector (FID). The product and byproducts were well separated, the correlation coefficients (r) within the concentration range of 1.0 μg/mL-100 μg/mL were ≥0.9997, the relative standard deviations were between 0.5% and 4.4%, spiked recoveries were between 91.5% and 105.6%, and detection limits were between 0.11 and 0.18 μg/mL. The established method was simple, rapid, accurate, sensitive and highly specific. It was suitable for simultaneous qual. and quant. analyses of the product and byproducts of transesterification between phenol and DMC. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to phenol dimethyl carbonate transesterification, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sarnowski, Matthew P.; Kang, Chang Won; Elbatrawi, Yassin M.; Wojtas, Lukasz; Del Valle, Juan R. published an article in 2017, the title of the article was Peptide N-Amination Supports β-Sheet Conformations.Synthetic Route of 53838-27-0 And the article contains the following content:

The conformational heterogeneity of backbone N-substituted peptides limits their ability to adopt stable secondary structures. Herein, we describe a practical synthesis of backbone aminated peptides that readily adopt β-sheet folds. Data derived from model N-amino peptides suggest that extended conformations are stabilized through cooperative steric, electrostatic, and hydrogen-bonding interactions. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Synthetic Route of 53838-27-0

The Article related to backbone aminated peptide beta sheet conformation, foldamers, peptidomimetics, secondary structures, β-hairpins, β-strands, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Synthetic Route of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Neuroth, Gero; Klapper, Helmut published an article in 2020, the title of the article was The Generation of Growth Dislocations by Inclusions and Growth-Face Damages: An Experimental Study.Quality Control of Phenyl Salicylate And the article contains the following content:

The generation of growth dislocations in crystals by intentionally introduced foreign-particle inclusions and by mech. damaging (scratching) of the growth face is reported. The formation of dislocations is studied by in situ observation of the step pattern on the involved growth face by optical microscopy and-after growth-by X-ray diffraction topog. This is performed on three different growth faces of orthorhombic salol (C13H10O3, melting temperature Tm = 41.5°C) growing from the melt supercooled by 1-2°C. The development of the growth pattern after the closure of the inclusion by overgrowing layers and after the scratching is recorded by videos. Particularly instructive is the inclusion experiment on the fast-growing (100) face: immediately after the closure a big pyramid and fast step source appears, which dominates and sporadically overflows neighbored secondary step sources. In the sequel the big pyramid splits into a row of small hills which gradually diverge. This indicates that the associated dislocations fan out within the (010) plane of the crystal, as is confirmed by X-ray topog. The in situ scratching of the growth face triggers the immediate appearance and fast development of a complex hill structure associated with numerous dislocations. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Quality Control of Phenyl Salicylate

The Article related to growth dislocation inclusion face damage, Crystallography and Liquid Crystals: Crystallization and Recrystallization, Nucleation, Crystal Growth, Epitaxy, Nonepitaxial Film Deposition and other aspects.Quality Control of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhardwaj, Monika; Rasool, Bisma; Mukherjee, Debaraj published an article in 2022, the title of the article was Ni-catalyzed domino transformation of enopyranoses and 2-iodo phenols/anilines to pyrano cis fused dihydro-benzofurans/indoles.Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate And the article contains the following content:

A Ni-catalyzed direct access to various pyrano cis-fused dihydro benzofurans and indoles, e.g. I (R1 = MeCO, PhCO; X = O, R2 = H, Me, t-Bu; X = NH, R2 = H), from unsaturated enopyranoses, e.g. II, and o-iodo phenols/anilines, e.g. III, is developed. The domino synthesis of pyrano C2-C1 and C3-C2 cis-fused heteroarynes was achieved both from glycals and pseudo glycals, in which heteroatoms are linked at C2 and C3 positions, resp., with excellent chemo-selectivity. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to pyrano cis fused dihydro benzofuran indole preparation stereoselective chemoselective, enopyranose iodo phenol aniline nickel catalyst domino heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 17, 2008, Hama, Takuo; Hartwig, John F. published an article.Application of 29704-38-9 The title of the article was Palladium-Catalyzed α-Arylation of Esters with Chloroarenes. And the article contained the following:

Palladium-catalyzed α-arylations of esters with chloroarenes are reported. The reactions of chloroarenes with the sodium enolates of tert-Bu propionate and Me isobutyrate occur in high yields with 0.2-1 mol % of {[P(t-Bu)3]PdBr}2 or the combination of Pd(dba)2 and P(t-Bu)3 as catalyst. The reactions of chloroarenes with the Reformatsky reagent of tert-Bu acetate were most challenging but occurred in high yields for chlorobenzene and electron-poor chloroarenes catalyzed by 1 mol % of Pd(dba)2 and pentaphenylferrocenyl di-tert-butylphosphine (Q-phos). The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Application of 29704-38-9

The Article related to ester enolate chloroarene palladium catalyst alpha arylation, reformatsky reagent butyl acetate chloroarene palladium catalyst alpha arylation, alpha aryl ester preparation and other aspects.Application of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bayer, Andreas; Wijaya, Bernard; Rademacher, Franziska; Moebus, Lena; Preuss, Mark; Singh, Michael; Tohidnezhad, Mersedeh; Kubo, Yusuke; Rodewald, Meno; Behrendt, Peter; Weitkamp, Jan-Tobias; Glaeser, Regine; Harder, Juergen published an article in 2021, the title of the article was Platelet-Released Growth Factors Induce Genes Involved in Extracellular Matrix Formation in Human Fibroblasts.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Platelet concentrate products are increasingly used in many medical disciplines due to their regenerative properties. As they contain a variety of chemokines, cytokines, and growth factors, they are used to support the healing of chronic or complicated wounds. To date, underlying cellular mechanisms have been insufficiently investigated. Therefore, we analyzed the influence of Platelet-Released Growth Factors (PRGF) on human dermal fibroblasts. Whole transcriptome sequencing and gene ontol. (GO) enrichment anal. of PRGF-treated fibroblasts revealed an induction of several genes involved in the formation of the extracellular matrix (ECM). Real-time PCR analyses of PRGF-treated fibroblasts and skin explants confirmed the induction of ECM-related genes, in particular transforming growth factor beta-induced protein (TGFBI), fibronectin 1 (FN1), matrix metalloproteinase-9 (MMP-9), transglutaminase 2 (TGM2), fermitin family member 1 (FERMT1), collagen type I alpha 1 (COL1A1), a disintegrin and metalloproteinase 19 (ADAM19), serpin family E member 1 (SERPINE1) and lysyl oxidase-like 3 (LOXL3). The induction of these genes was time-dependent and in part influenced by the epidermal growth factor receptor (EGFR). Moreover, PRGF induced migration and proliferation of the fibroblasts. Taken together, the observed effects of PRGF on human fibroblasts may contribute to the underlying mechanisms that support the beneficial wound-healing effects of thrombocyte concentrate products. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to transcriptome prgf fibroblast extracellular matrix formation wound healing, extracellular matrix (ecm), fibroblasts, platelet-released growth factors (prgf), wound healing and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Manoj; Reddy, Thurpu Raghavender; Gurawa, Aakanksha; Kashyap, Sudhir published an article in 2020, the title of the article was Copper(II)-catalyzed stereoselective 1,2-addition vs. Ferrier glycosylation of “armed” and “disarmed” glycal donors.Related Products of 2873-29-2 And the article contains the following content:

Selective activation of “armed’ and ”disarmed” glycal donors enabling the stereo-controlled glycosylations by employing Cu(II)-catalyst as the promoter has been realized. The distinctive stereochem. outcome in the process is mainly influenced by the presence of diverse protecting groups on the donor and the solvent system employed. The protocol is compatible with a variety of aglycons including carbohydrates, amino acids, and natural products to access deoxy-glycosides and glycoconjugates with high α-anomeric selectivity. Notably, the synthetic practicality of the method is amply verified for the stereoselective assembling of trisaccharides comprising 2-deoxy components. Mechanistic studies involving deuterated experiments validate the syn-diastereoselective 1,2-addition of acceptors on the double bond of armed donors. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to trisaccharide stereoselective addition copper catalyzed glycoconjugate glycal nucleoside, amino acid glycoside preparation stereoselective glycosylation ferrier glycal alc and other aspects.Related Products of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kusumoto, Sotaro; Kobayashi, Fumiya; Ohtani, Ryo; Zhang, Yingjie; Harrowfield, Jack; Kim, Yang; Hayami, Shinya; Nakamura, Masaaki published an article in 2018, the title of the article was Creating capsules with cubanes.Synthetic Route of 118-55-8 And the article contains the following content:

A sextuply linked capsule incorporating two Ni(II) cubane units is formed when Ni(II) salts are reacted with N-aminoalkyl salicylamidato ligands in a 4:3 ratio in methanol. With a short (propyl) alkyl substituent, addnl. chloride counterions are included in the cavity by occupation of one apex of each of the linked cubanes, while with a longer (pentyl) substituent, perchlorate and tetrafluoroborate anions are included, probably by H-bonding involving hydroxyl groups on the inner apexes of the cubanes, indicating that the cavity can be regarded as suited to binding of hydrophilic units despite the lipophilic character of its links. The dicubane capsules show ferromagnetic behavior typical of Ni(II) cubanes in general, with coupling constants dependent upon the nature of the salt-derived counteranions. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to nickel aminoalkyl salicylamidato capsule cubane complex preparation crystal structure, thermal stability magnetic property nickel aminoalkyl salicylamidato capsule cubane and other aspects.Synthetic Route of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics