Tag: 200-300

Gharpure, Santosh J.; Nanda, Santosh K.; Fartade, Dipak J. published an article in 2019, the title of the article was Expeditious diastereoselective synthesis of medium ring heterocycle-fused chromenes via tandem 8/9-endo-dig and 8-exo-dig hydroalkoxylation-formal-[4+2] cycloaddition.Recommanded Product: 2873-29-2 And the article contains the following content:

The first examples of highly diastereoselective tandem 8/9-endo-dig and 8-exo-dig hydroalkoxylation-formal-[4+2] cycloaddition are described for the synthesis of medium ring heterocycle-fused chromenes. TMS-alkynols preferred the exo-dig mode of hydroalkoxylation over the endo-dig mode leading to spiro-cyclic chromenes. The method could be used for the synthesis of linearly-fused ladder-like polyethers. A thia-heterocycle-fused chromene could be transformed into a complex bridged tricyclic ketal by a tandem carbene-insertion-[2,3]-sigmatropic shift. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Recommanded Product: 2873-29-2

The Article related to heterocycle fused chromene preparation diastereoselective, alkynol benzaldehyde hydroalkoxylation cycloaddition cascade, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Recommanded Product: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sato, Takeru; Sasaki, Muneo; Ikeda, Yoshiyuki; Kimoto, Masaki published an article in 2013, the title of the article was Preparation and estimation of super water-repellent film coated by silica and acrylic-silicon containing active methylene group.Formula: C13H20O4 And the article contains the following content:

In acrylic silicone (M-CAS) solution containing active methylene group, silica micro particles were synthesized by addition of tetraethoxysilane. When this composite film coated on a glass substrate, the water contact angle showed 120°. Furthermore, the film which the hexamethyldisilazane as silane coupling agent was added to together, showed the contact angle of 155°. However, as a result of the wear test, the contact angle of the composite film reduced to 60°. When the crosslinking agent was added in reaction solution and was cured by UV irradiation, contact angle of the coating film showed 130°. Even through wear test, the UV-irradiation-curing composite film maintained its contact angle ca.100°. Repeated coating and UV irradiation-curing formed the super water – repellent film, and even through wear test it maintained excellent water – repellency, its contact angle being reduced only to 130°C. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Formula: C13H20O4

The Article related to acrylic silicon active methylene crosslinking silica particle water repellent, Coatings, Inks, and Related Products: Acrylic and Water-Sol (Electrophoretic) Resin Coatings and other aspects.Formula: C13H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 29, 2018, Bellenie, Benjamin Richard; Cheung, Kwai Ming Jack; Davis, Owen Alexander; Hoelder, Swen; Huckvale, Rosemary; Lloyd, Matthew Garth published a patent.Safety of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate The title of the patent was Preparation of 4,6-diamino-quinolin-2(1H)-one derived inhibitors of Bcl6 for treatment of cancer. And the patent contained the following:

The invention relates to compounds of formula I that function as inhibitors of Bcl6 (B-cell lymphoma 6) useful for treatment of disorders involving Bcl6 activity such as proliferative disorders including cancers. Addnl., the invention comprises synthetic processes for the preparation of I and pharmaceutical compositions containing I. Compounds of formula I [wherein X1 = N, CH, C-alkyl, C-halo, etc.; X2 and X3 independently = N, CH, CF, CCl, etc.; R1 = H, CH3, 2-(methoxyethoxy)ethyl, etc.; R2 = 2,3-dichloro-pyridin-4-yl, 2-chloro-4-cyano-pyridin-4-yl, 2-chloro-5-methoxy-pyrimidin-4-yl, etc.; R3 = H, C1-2 alkyl, cyano, etc.; R4 = cyano, C1-4 alkyl, C1-4 haloalkyl, etc.; R5 = H, C1-4 alkyl, cyano, nitro, acetylenyl, Ph, etc.; with provisos] and pharmaceutically acceptable salts or solvates thereof, are claimed and exemplified. Example compound II was prepared from the reaction of 6-amino-1-methyl-4-[(1-methyl-1-pyrimidin-2-ylethyl)amino]quinolin-2-one and 2,4-dichloropyridine-3-carbonitrile under microwave heating for 1 h at 160°C. Pharmacol. activity of I was evaluated using a HTRF assay and Trx-6xHis-Bcl6 derived from the human Bcl6 BRB domain from which II demonstrated a pIC50 value of 7.38 μM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Safety of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

The Article related to quinolinone diamino derivative preparation inhibitor bcl6 inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Safety of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Cheng; Liao, Yilin; Chen, Zhuoyuan; Xiao, Bo; Zhao, Ziyue; Li, Aoyu; Xia, Yu; Wang, Pingxiao; Li, Hui; Xiao, Tao published an article in 2022, the title of the article was Network pharmacology and molecular docking to elucidate the potential mechanism of ligusticum chuanxiong against osteoarthritis.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Osteoarthritis (OA) is a degenerative disease which serious affects patients. Ligusticum chuanxiong (CX) has been shown to have a certain curative effect on osteoarthritis in traditional Chinese medicine therapy. This study is based on network pharmacol. and mol. docking technol. to explore the potential mechanism of CX. Components of CX to treat osteoarthritis were screened in the TCMSP database and targets were predicted by the PharmMapper database, the osteoarthritis targets were collected from the GeneCards database, and intersection genes were found to be the possible targets of CX anti-OA. The STRING database and Cytoscape software were utilized for protein-protein interaction anal. and further screening of core targets. The Metascape database was used for KEGG and GO enrichment analyses. Then, the top 10 pathways were selected to construct “drug-compound-target-pathway-disease” network anal. Finally, mol. docking was used to analyze the binding affinity of seven compounds with core targets and TNF-α. Seven compounds with 253 non-repetitive targets of CX were screened fromthe TCMSP database and 60 potential intersection targets of CX anti-OA were found. PPI network anal. showed that the core targets were ALB, AKT1, IGF1, CASP3, MAPK1, ANXA5, and MAPK14, while GO and KEGG pathway enrichment analyses showed that the relevant biol. processes involved in the treatment of osteoarthritis by CX might include the MAPK cascade and reactive oxygen species metabolic process. The KEGG pathway anal. result was mainly associated with the MAPK signaling pathway and PI3K-AKT signaling pathway. We further docked seven ingredients with MAPK1 and MAPK14 enriched in the MAPK pathway, and TNF-α as the typical inflammatory cytokine. The results also showed good binding affinity, especially FA, which may be the most important component of CX anti-OA. Our research revealed the potential mechanism of CX in the treatment of OA, and our findings can also pave the way for subsequent basic exptl. verification and a new research direction. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to ligusticum chuanxiong pharmacol mol docking osteoarthritis, mapk pathway, ligusticum chuanxiong, molecular docking, network pharmacology, osteoarthritis, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 10, 2022, Eren, Hamit; Bednarz, Roland Jan-Reiner; Alimoradi Jazi, Maryam; Donk, Laura; Gudjonsdottir, Solrun; Bohlaender, Peggy; Eelkema, Rienk; Houtepen, Arjan J. published an article.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Permanent Electrochemical Doping of Quantum Dot Films through Photopolymerization of Electrolyte Ions. And the article contained the following:

Quantum dots (QDs) are considered for devices like light-emitting diodes (LEDs) and photodetectors as a result of their tunable optoelectronic properties. To utilize the full potential of QDs for optoelectronic applications, control over the charge carrier d. is vital. However, controlled electronic doping of these materials has remained a long-standing challenge, thus slowing their integration into optoelectronic devices. Electrochem. doping offers a way to precisely and controllably tune the charge carrier concentration as a function of applied potential and thus the doping levels in QDs. However, the injected charges are typically not stable after disconnecting the external voltage source because of electrochem. side reactions with impurities or with the surfaces of the QDs. Here, we use photopolymerization to covalently bind polymerizable electrolyte ions to polymerizable solvent mols. after electrochem. charge injection. We discuss the importance of using polymerizable dopant ions as compared to nonpolymerizable conventional electrolyte ions such as LiClO4 when used in electrochem. doping. The results show that the stability of charge carriers in QD films can be enhanced by many orders of magnitude, from minutes to several weeks, after photochem. ion fixation. We anticipate that this novel way of stable doping of QDs will pave the way for new opportunities and potential uses in future QD electronic devices. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to permanent electrochem doping quantum dot film photopolymerization electrolyte ion, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Electronic Spectroscopy and other aspects.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

da Silva, Erotides Capistrano; Arrington, Justine; Yau, Peter M.; Smith-Fleming, Kathryn M.; Canisso, Igor Frederico; da Costa Martins, Bianca published an article in 2021, the title of the article was Proteome composition of bovine amniotic membrane and its potential role in corneal healing.Application of 2358-84-1 And the article contains the following content:

To investigate the protein profile of bovine amniotic membranes (bAM) and to determine putative associations between protein composition in bAM and known corneal healing pathways. The bAM were acquired from normal full-term births (n = 10), processed, and stored at -80°C for two days. Subsequently, the frozen membranes were thawed at room temperature and prepared for proteomic exploration using high-resolution liquid chromatog.-mass spectrometry, followed by bioinformatics anal. Recently identified corneal healing pathways were contrasted with protein profiles and pathways present in bAM. Results. The analyses identified 2105 proteins, with an interactive network of 1271 nodes (proteins) and 8757 edges (interactions). The proteins with higher betweenness centrality measurements include microfibril-associated protein 4, HSD3B1, CAPNS1, ATP1B3, CAV1, ANXA2, YARS, and GAPDH. The top four pathways in Kyoto Encyclopedia of Genes and Genomes were ribosome, metabolic pathway, spliceosome, and oxidative phosphorylation. The bAM and cornea shared abundant proteins, genome ontol., and signaling pathways. The high-throughput proteomic profile of the bAM demonstrated that numerous proteins present in the cornea are also present in this fetal membrane. Our findings collectively demonstrate the similarity between bAM and the cornea’s protein composition, supporting our hypothesis that bAM can be used to treat corneal diseases. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application of 2358-84-1

The Article related to bovine amniotic membrane corneal healing proteome, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Application of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 28, 2021, Bukowska, Agnieszka; Bester, Karol; Pytel, Maciej; Bukowski, Wiktor published an article.Application of 2358-84-1 The title of the article was Polymer Beads Decorated with Dendritic Systems as Supports for A3 Coupling Catalysts. And the article contained the following:

The gel type microscopic polymer beads bearing epoxy functionalities were modified using the two-stage procedures in order to decorate their surface with the moieties of the zeroth order PAMAM type dendrimer and different heterocyclic aldehydes (2-pyridinecarboxaldehyde, 2-pyrrolidinecarboxaldehyde, furfural or 2-thiophenecarboxaldehyde). The polymeric supports provided in this manner were then used for the immobilization of copper(II) ions. The resulting materials were characterized using different instrumental techniques (optical microscopy, SEM, FTIR microscopy, DR UV-Vis, ICP-OES, and thermal anal.). They were also used as catalysts in the model A3 coupling reaction of benzaldehyde, morpholine and phenylacetylene. The best catalytic activity was found for the polymeric catalyst bearing 2-pyridinecarboxaldehyde moieties. It turned out to be effective in the A3 coupling reactions included different benzaldehyde, alkyne, and secondary amine derivatives, as well. It could also be recycled several times without a significant decrease in its activity in the model A3 coupling reaction. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application of 2358-84-1

The Article related to polymer bead decorated dendritic system coupling catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Application of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nicolaou, K. C.; Krasovskiy, Arkady; Trepanier, Vincent E.; Chen, David Y.-K. published an article in 2008, the title of the article was An expedient strategy for the synthesis of tryptamines and other heterocycles.Category: esters-buliding-blocks And the article contains the following content:

N-Boc-protected anilines are converted into an array of useful N-heterocycles and tryptamines through an expedient, cascade-based synthetic sequence involving ortho metalation and subsequent coupling with N-Boc-pyrrolidin-3-one. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to tryptamine preparation protected aniline pyrrolidinone, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 1994, Iwao, Masatomo published an article.Computed Properties of 141940-37-6 The title of the article was A new method for the construction of indole nucleus. And the article contained the following:

Directed lithiation of N-tert-butoxycarbonylanilines I (X = H, Y = H, F, MeO; X = Me, CF3, MeO, Cl, F, Y = H) and subsequent reaction with 1-tert-butyldimethylsilyl-1-phenylsulfinylethene gave the conjugate addition products which, without isolation, were cyclized to 1-tert-butoxycarbonyl-2-(phenylthio)indolines II under thermal sila-Pummerer reaction conditions. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Computed Properties of 141940-37-6

The Article related to indole, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 2, 2020, Shen, Xiuqing; Du, Jiayuan; Sun, Jiaxin; Guo, Jia; Hu, Xinhua; Wang, Changchun published an article.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Transparent and UV Blocking Structural Colored Hydrogel for Contact Lenses. And the article contained the following:

Usually, materials with perfect structures possess excellent properties, but it is not always the case. Here, a new approach is reported to construct structural colored hydrogel films with excellent UV blocking performance for contact lenses. The theor. simulation predicts that with perfect periodic structures, the hydrogel films can strongly reflect incident light in a narrow visible wavelength range and thus exhibit extraordinarily brilliant colors. However, such hydrogel films cannot effectively block UV light. By slightly breaking the structural periodicity (quasi-periodic structure), strong diffuse scattering or pseudoabsorption of light can occur for all of the wavelengths shorter than a structural characteristic length, leading to perfect UV blocking. According to the theor. prediction, a structural colored hydrogel film with nearly periodic polystyrene sphere arrays in poly(hydroxyethyl methacrylate) hydrogel matrix is fabricated; this hydrogel film possesses brilliant colors and perfect UV blocking, and the core particle composition and size have been investigated in detail for the optimized properties of contact lenses. Meanwhile, the cell proliferation assay proves the cytocompatibility of the hydrogel for real application. Regarding its unique optical characteristics, the as-prepared structural colored hydrogel shows great promise in the fields of UV-protective equipment, medical device, soft robot, sensor, and so on. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to transparent uv blocking structural colored hydrogel contact lens, uv protection, contact lenses, polymer hydrogel, scattering matrix method, structural colors, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Optical Properties (Linear) and other aspects.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics