Tag: 200-300

On January 31, 1978, Okubo, H.; Yoshii, F.; Honda, S.; Kaetsu, I. published an article.Application of 1985-51-9 The title of the article was Casting of organic glass by radiation-induced polymerization of glass-forming monomers at low temperatures. IV. Casting and polymer properties of monomeric systems including polyfunctional monomers. And the article contained the following:

The addition of polyfunctional monomers such as tetraethylene glycol diacrylate to internally-plasticized compositions, i.e., 35:35:30 volume% Bu acrylate-Me methacrylate(I)-glycidyl methacrylate, 60:31:8.7:4.7 volume% I-hexanediol monoacrylate-hexanediol diacrylate(II)-hexanediol(III), and 35:30:26.6:17.9:4.7 volume % hydroxyethyl methacrylate-I-hexanediol monomethacrylate-II-III mixtures, improved the glass-forming properties of the composition in radiation-induced casting polymerization and the heat resisistance of the organic glasses. The phys. properties of the best products were tabulated and discussed. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Application of 1985-51-9

The Article related to casting polymerization methacrylate, irradiation polymerization organic glass, Synthetic High Polymers: Processing Of Monomers and Reagents For Their Preparation and other aspects.Application of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 2, 2020, Balijepalli, Anant S.; McNeely, James H.; Hamoud, Aladin; Grinstaff, Mark W. published an article.Quality Control of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Guidelines for β-Lactam Synthesis: Glycal Protecting Groups Dictate Stereoelectronics and [2+2] Cycloaddition Kinetics. And the article contained the following:

The alkene-isocyanate cycloaddition method affords β-lactams from glycals with high regio- and stereoselectivity, but the factors that determine substrate reactivity are poorly understood. Thus, we synthesized a library of 17 electron-rich alkenes (glycals) with varied protecting groups to systematically elucidate the factors that influence their reactivity toward the electron-poor trichloroacetyl isocyanate. The exptl. determined reaction rates exponentially correlate with the computationally determined HOMO-LUMO (HOMO-LUMO) gap and natural bond orbital (NBO) valence energies. The electron-withdrawing ability of the protecting groups, but not bulk, impacts the electron d. of the glycal allyloxocarbenium system when oriented pseudo-axially (i.e., stereoelectronics). In this conformation, ring σC-O* orbitals oriented antiperiplanar to the allyloxocarbenium system decrease glycal reactivity via neg. hyperconjugation as protecting group electron withdrawal increases. Transition-state calculations reveal that protecting group stereoelectronics direct the reaction to proceed via an asynchronous one-step mechanism through a zwitterionic species. The combined exptl. and computational findings, along with exptl. validation on an unknown glycal, provide insight on the reaction mechanism and the role of distant protecting groups in glycal reactivity. Together, these studies will aid in the synthesis of new β-lactam antibiotics, β-lactamase inhibitors, and bicyclic carbohydrate-β-lactam monomers prepared by the alkene-isocyanate method. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Quality Control of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to glycal isocyanate cycloaddition kinetics protecting group effect beta lactam, Physical Organic Chemistry: Ring Formation, Cleavage, Enlargement, and Contraction and other aspects.Quality Control of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 10, 2018, Corvis, Yohann; Espeau, Philippe published an article.Formula: C13H10O3 The title of the article was Interpretation of the global heat of melting in eutectic binary systems. And the article contained the following:

Starting from ten eutectic binary phase diagrams, the heat absorbed to melt completely a binary mixture from its solid state was plotted as a function of the mole fraction of one of the two components of the system. Surprisingly, a linear relationship was found for all the studied systems. The extrapolated total heat values at pure component composition (i.e. x = 0 and x = 1) obtained via the heat capacity exptl. determined for each compound were interpreted as the melting enthalpies of the pure components at the eutectic temperature, for each binary system. A math. model is proposed that takes into account an ideal liquid state and an enthalpy in the liquid state independent of the temperature The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Formula: C13H10O3

The Article related to interpretation global heat melting eutectic binary system, Thermodynamics, Thermochemistry, and Thermal Properties: Thermochemical Properties and other aspects.Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2012, Zhang, Hui Min; Kawabata, Kazuya; Miyauchi, Hideki; Shimo, Tetsuro published an article.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was One-pot synthesis of macrocyclic di- and tetralactones using [2 + 2] photocycloaddition reactions of di-2-pyrones with α,ω-diolefins. And the article contained the following:

Sensitized photocycloaddition reactions of 6,6′-dimethyl-4,4′-[1,4-bis(methylenoxy)phenylene]-di-pyrone (I) with poly(ethyleneglycol)divinyl ethers II [n = 2, 3] or 2,2′-dimethyltrimethylene dimethacrylate (III), together with the reactions of 6,6′-dimethyl-4,4′-polymethylenedioxy-2-pyrones (6a, b) with 4 were described. The reactions of I with II gave crown ether type macrocyclic compounds possessing 19- and 22-membered rings across the C3-C4 and C3′-C4′ double bonds in 1, resp. Similar reactions of I with III and IV [X = (CH2)n, n= 5, 6] with III afforded different types of macrocycles having 19- to 21-membered rings across the C5-C6 and C5′-C6′ double bonds in 2-pyrone ring. The stereochem. features of macrocycles V and VI were determined by X-ray crystal anal. The reaction mechanism was inferred by MO methods. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to macrocyclic dilactone tetralactone preparation mol modeling, photocycloaddition dipyrone diolefin, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Malpani, Sakshi Kabra; Rani, Ashu published an article in 2019, the title of the article was A Greener Route for Synthesis of Fly Ash Supported Heterogeneous Acid Catalyst.Product Details of 118-55-8 And the article contains the following content:

Fly ash, a solid byproduct obtained from coal-fired thermal power plants, is basically a silico-aluminate material having varying minor amounts of other metal oxides. For suitable bulk utilization of this solid waste, a novel kind of solid acid catalyst has been successfully synthesized by employing microwave assisted greener route. For enhancing the efficacy, amorphous silica was extracted from fly ash in a cost-effective manner which was further chem. activated with H2SO4. Various anal. techniques were utilized to study physico-chem. properties of the as-prepared catalyst, while the catalytic activity was tested by a serious of microwave assisted esterification and Friedel-Crafts alkylation reactions under optimized reaction conditions. Higher yield of products attributes to the presence of significant number of Bronsted acidic sites on catalyst, also proved by Pyridine adsorbed FT-IR spectrum of catalyst. The catalyst was recovered and reused up to five reaction cycles with similar competence as in first run which deliberates its stability during the course of reaction. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Product Details of 118-55-8

The Article related to fly ash esterification friedel crafts alkylation structural thermal property, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalytic Reactions and other aspects.Product Details of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 5, 2019, Yebdri, Sihem; Nehar, Oussama; Mahboub, Radia; Roisnel, Thierry; Boukli-Hacene, Leila; Louhibi, Samira published an article.Recommanded Product: Phenyl Salicylate The title of the article was Characterizations of crystalline structure and catalytic activity of zwitterionic imidazole derivatives. And the article contained the following:

The zwitterion ligand L1 has been synthesized and characterized by single-crystal X-ray diffraction, and spectroscopic techniques (1H, 13C NMR, FT-IR, ESI-MS, and UV-Vis). The crystal structure shows that L1 mols. are planar and are connected via intermol. N-H—-O and intramol. N-H—-O interactions. The NMR anal. shows the presence of two mesomeric forms of L1: zwitterion and ketone-imidazolidine. The kinetic study of in situ complexes is followed by UV-vis spectroscopy and revealed a binuclear structure built from square base pyramidal geometry and octahedral one. In situ complexes obtained from L1 with different copper (II) salts are studied for their catecholase activities using 3,5-di-tert-butylcatechol. The obtained 3,5-di-tert-butylquinone was characterized by single-crystal X-ray diffraction,. The results show that the catalytic activity depends on the nature of the metal salt anion. From Michaelis-Menten model, we have evaluated the dissociation constant and the bond constant which are in good agreement with those of literature. The structure-activity relationship show that the high rate of catalytic oxidation depends on the presence of copper ion in the complex. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: Phenyl Salicylate

The Article related to zwitterionic imidazole derivative catalytic activity crystalline structure, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalytic Reactions and other aspects.Recommanded Product: Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 26, 2020, Takemura, Hiroyuki; Morikawa, Akino; Tanaka, Mari; Tatsumi, Akane; Kubota, Yukiko; Kaji, Natsuko; Hasegawa, Ayako; Kumamoto, Fumiko; Obara, Tomoko; Iwanaga, Tetsuo; Sako, Katsuya published an article.SDS of cas: 118-55-8 The title of the article was Syntheses of diaza(hetera)2[1.1.1.1]paracyclophanes by Chapman rearrangement. And the article contained the following:

Diaza(hetera)2[1.1.1.1]paracyclophanes (PCPs) I (X = SO2, CH2; Y = SO2; Q = NH) were prepared by the Chapman rearrangement. This is the first synthesis of highly strained and heteroatom-containing PCPs performed by a rearrangement reaction. The structures of the two precursors, [3.1.3.1]PCPs, e.g., II and [1.1.1.1]PCPs I (X = SO2, CH2, C=O; Y = SO2, C=O; Q = N-C(=O)-o-C6H4-OH), are discussed in detail. In contrast to the small strain of [3.1.3.1]PCPs, e.g., II, [1.1.1.1]PCPs I (Q = N-C(=O)-o-C6H4-OH) release their large strain by bending the aromatic rings and Carom.-X angles. Interestingly, Aromatic-X-Aromatic angles are smaller than those of the corresponding strain-free model compounds The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).SDS of cas: 118-55-8

The Article related to diaza hetera paracyclophane preparation, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.SDS of cas: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pal, Ashutosh published an article in 2021, the title of the article was Synthesis of salicylate and salicylamide alcohols for the preparation of phosphorodiamidates and ifosfamide prodrugs.COA of Formula: C13H10O3 And the article contains the following content:

Different types of salicylate and salicylamide alcs. for the preparation of phosphorodiamidates and ifosfamide prodrugs were reported. In drug discovery and development, prodrugs were well-known for pharmacokinetic effects of pharmacol. nimble products. Almost 10% of drugs permitted, whole world were classified as prodrugs, where the application of a prodrug method during initial stages of development was an emergent fashion. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).COA of Formula: C13H10O3

The Article related to hydroxyalkyl benzodioxinone preparation, aldehyde salicylate alc cyclocondensation, alkyl benzoxazinone preparation, salicylamide aldehyde cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.COA of Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Arias, Consuelo; Saavedra, Nicolas; Leal, Karla; Vasquez, Belgica; Abdalla, Dulcineia S. P.; Salazar, Luis A. published an article in 2020, the title of the article was Histological evaluation and gene expression profiling of autophagy-related genes for cartilage of young and senescent rats.Product Details of 2358-84-1 And the article contains the following content:

Autophagy is a cellular mechanism that protects cells from stress by digesting non-functional cellular components. In the cartilage, chondrocytes depend on autophagy as a principal mechanism to maintain cellular homeostasis. This protective role diminishes prior to the structural damage that normally occurs during aging. Considering that aging is the main risk factor for osteoarthritis, evaluating the expression of genes associated with autophagy in senescent cartilage might allow for the identification of potential therapeutic targets for treatment. Thus, we studied two groups of young and senescent rats. A histol. anal. of cartilage and gene expression quantification for autophagy-related genes were performed. In aged cartilage, morphol. changes were observed, such as an increase in cartilage degeneration as measured by the modified Mankin score, a decrease in the number of chondrocytes and collagen II (Col2a1), and an increase in matrix metalloproteinase 13 (Mmp13). Moreover, 84 genes associated with autophagy were evaluated by a PCR array anal., and 15 of them were found to be significantly decreased with aging. Furthermore, an in silico anal. based on by two different bioinformatics software tools revealed that several processes including cellular homeostasis, autophagosome assembly, and aging-as well as several biol. pathways such as autophagy, insulin-like growth factor 1 (IGF-1) signaling, PI3K (phosphoinositide 3-kinase)/AKT (serine/threonine kinase) signaling, and mammalian target of rapamycin (mTOR) signaling-were enriched. In conclusion, the anal. identified some potential targets for osteoarthritis treatment that would allow for the development of new therapeutic strategies for this chronic disease. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Product Details of 2358-84-1

The Article related to autophagy gene expression histol evaluation cartilage young senescent, aging, autophagy, osteoarthritis, Mammalian Pathological Biochemistry: Musculoskeletal and Connective Tissue Diseases and other aspects.Product Details of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 29, 2015, Lim, Yeon-Hee; Guo, Zhuyan; Ali, Amjad; Edmondson, Scott D.; Liu, Weiguo; Gallo-Etienne, Gioconda V.; Wu, Heping; Gao, Ying-Duo; Stamford, Andrew M.; Yu, Younong; Kevin, Nancy J.; Anand, Rajan; Sha, Deyou; Neelamkavil, Santhosh F.; Hussain, Zahid; Kumar, Puneet; Moningka, Remond; Duffy, Joseph L.; Xu, Jiayi; Jiang, Yu; Sone, Hiroki; Chakrabarti, Anjan published a patent.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of spiropyridooxazinepyrrolidine compounds as factor XIa inhibitors. And the patent contained the following:

The invention provides a compounds of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective factor XIa inhibitors or dual inhibitors of factor XIa and plasma kallikrein. Compounds of formula I wherein Y1 – Y4 are independently CR4 and N; Z is S, SO, SO2 and CO; L is a bond, CONH, NHCO, etc.; M is (un)substituted aryl, heteroaryl, CH2, etc.; R1a is H, halo, CN, etc.; R1b is H, CN, OH, etc.; R2 is H, CN, halo, etc.; each R3 is independently H, halo, CN, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). Example compounds of the invention were tested in an assay to measure effectiveness as inhibitors of human factor XIa and plasma kallikrein. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to spiropyridooxazinepyrrolidine compound preparation factor xia inhibitor kallikrein therapy, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics