Tag: 200-300

On September 28, 2006, Gonzalez, Jesus E.; Wilson, Dean M.; Termin, Andreas P.; Grootenhuis, Peter D. J.; Zhang, Yulian; Petzoldt, Benjamin J.; Fanning, Lev Tyler Dewey; Neubert, Timothy D.; Tung, Roger D.; Martinborough, Esther; Zimmerman, Nicole published a patent.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of quinazolines as modulators of ion channels. And the patent contained the following:

The title compounds [I; NR1R2 = (un)substituted 3-12 membered monocyclic or bicyclic (un)saturated ring having 0-3 heteroatoms selected from N, S or O; ring A = (un)substituted 5-7 membered aryl, 8-10 membered bicyclic aryl having 0-3 heteroatoms selected from N, S or O, etc.; x = 0-4; R3 = QR (wherein Q = a bond, alkylidene wherein up to two non-adjacent methylene units are optionally replaced by S, O, CS, etc.; R = halo, NO2, CN, etc.); with provisos], useful as inhibitors of voltage-gated sodium channels and calcium channels, were prepared Thus, reacting 2-(4-chloro-7-methylquinazolin-2-yl)phenol with 4-aminopiperidine in the presence of Et3N in CH2Cl2 afforded 89% II. Representative compounds I were found to possess desired N-type calcium channel modulation activity and selectivity (no specific data given). Also, representative compounds I were found to possess desired voltage gated sodium channel activity and selectivity (no specific data given). The invention also provides pharmaceutically acceptable compositions comprising the compounds I and methods of using the compositions in the treatment of various disorders. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to quinazoline preparation modulator sodium calcium ion channel analgesic, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 17, 2021, Hess, Stephan N.; Mo, Xiaobin; Wirtz, Conny; Fuerstner, Alois published an article.Formula: C12H16O7 The title of the article was Total Synthesis of Limaol. And the article contained the following:

A nonthermodynamic array of four skipped methylene substituents on the hydrophobic tail renders limaol (I), a C40-polyketide of marine origin, unique in structural terms. This conspicuous segment was assembled by a two-directional approach and finally coupled to the polyether domain by an allyl/alkenyl Stille reaction under neutral conditions. The core region itself was prepared via a 3,3′-dibromo-BINOL-catalyzed asym. propargylation, a gold-catalyzed spirocyclization, and introduction of the southern sector via substrate-controlled allylation as the key steps. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7

The Article related to limaol total synthesis stille asym propargylation spirocyclization, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 9, 2003, Basarab, Gregory; Eyermann, Joseph; Gowravaram, Madhusudhan; Green, Oluyinka; MacPherson, Lawrence; Morningstar, Marshall; Nguyen, Thanh published a patent.HPLC of Formula: 141940-37-6 The title of the patent was Preparation of pyrazolo[3,4-d]pyrimidines for inhibiting H. pylori infections. And the patent contained the following:

Title compounds I [wherein R1 and R2 = independently H, NH2, or (un)substituted (cyclo)alkyl, (cyclo)alkenyl, alkynyl, aryl, alkoxy, or heterocyclyl; R3 = (un)substituted monocyclic or bicyclic ring system comprising 0-3 heteroatoms independently selected from N, O, or S; R4 = (un)substituted alkyl or (di)alkylamino, with exceptions; Y = CH2, CHCH3, SO, or SO2; and pharmaceutically acceptable salts thereof] were prepared For example, 6-hydrazino-1-isobutyl-3-methylpyrimidine-2,4-(1H,3H)-dione (4-step preparation given) was condensed with 1-naphthaldehyde in MeOH to give the hydrazone. Cyclocondensation with N-(4-formylphenyl)acetamide in DMF afforded II. Compounds of the invention exhibited glutamate racemase (MurI) activity with IC50 values of < 400 μM. Thus, I and pharmaceutical compositions containing them are useful in the treatment or prophylaxis of Helicobacter pylori (H. pylori) infection (no data). The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).HPLC of Formula: 141940-37-6

The Article related to pyrazolopyrimidine preparation antibacterial helicobacter pylori, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 8, 2020, Fu, Zhifei; Luo, Miaorong; Zhang, Yang; Cai, Yalei; Zhu, Wu; Li, Jian; Chen, Shuhui published a patent.Safety of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate The title of the patent was Nitrogen-containing spiro derivative as RET inhibitor. And the patent contained the following:

The invention disclosed a kind of nitrogen-containing spiro derivative as RET inhibitor. The claimed compound is shown in structure I (T = CN or N; R1,R2,R3 = H, halo, C1-6 alkyl, etc.; R4 = H, amino, hydroxy, etc.; D1,D2 = (un)substituted -CH2CH2-; D3 = methylene, carbonyl, etc.; D4 = ethylene, propylene, -OCH2CH2-, etc.). The claimed compound is prepared via multiple steps (procedure given). The prepared compound can be used as RET inhibitor for treating RET mediated disease. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Safety of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

The Article related to nitrogen containing spiro derivative preparation ret inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Safety of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2020, Nedaei, Maryam; Abdi, Khosrou; Ghorbanian, Sohrab Ali; Pirooznia, Nazanin published an article.Quality Control of Phenyl Salicylate The title of the article was Ultrasonic-Air-Assisted Solidification of Settled Organic Drop Microextraction Using Terpene-Based Deep Eutectic Solvents for the Effectual Enrichment of Methadone in Biological Samples. And the article contained the following:

Abstract: In this research, three novel ultra-hydrophobic, low-viscosity, non-ionic, and heavier-than-water deep eutectic solvents (DES) based on salol and terpenes are proposed. The prepared DESs were effectively used as extraction solvents in the solidification of settled organic drop (SSOD) microextraction Despite other hydrophobic DESs, these sustainable bio-compatible extraction mediums are compatible with GC. The ultrasonic-air agitation service for the formation of the emulsion was used to enhance the mass transfer of target analytes to extract into the fine DES droplets. Phase separation in this new enrichment method was simply achieved by centrifugation of cloudy solution at 20°C followed by decanting the aqueous solution The effect of the main variables on the extraction efficiency of methadone was investigated. The proposed method because of its distinctive features can be introduced as a simple and effective method for the enrichment of methadone in water and biol. samples. Limits of detection derived after optimizing influential parameters ranged between 0.3 and 1.5μg L-1. The relative standard deviations (RSD) were less than 10% and the enrichment factor values were in the range of 65-314. Recoveries obtained through methadone anal. in real samples were in the acceptable range of 91.5-105.5%. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Quality Control of Phenyl Salicylate

The Article related to salol terpene deep eutectic solvents green analytical chem, microextraction sample methadone, Biochemical Methods: Miscellaneous Separations (Not Covered At Other Subsections) and other aspects.Quality Control of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 1984, Makuuchi, Keizo; Hagiwara, Miyuki published an article.Related Products of 1985-51-9 The title of the article was Radiation vulcanization of natural rubber latex with polyfunctional monomers. And the article contained the following:

Natural rubber latex was irradiated with γ-rays from 60Co source in the presence of polyfunctional monomers to accelerate the vulcanization of rubber mols. Hydrophobic monomers were more effective than hydrophilic monomers in accelerating the vulcanization of natural rubber, presumably due to the high solubility of the former in rubber particles. Of the 26 polyfunctional monomers studied, neopentyl glycol dimethacrylate (I) [1985-51-9] exhibited the highest efficiency in accelerating the vulcanization. Advantages of using I included high colloidal stability of the irradiated latex and high heat resistance of the dried rubber film. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Related Products of 1985-51-9

The Article related to radiation vulcanization natural rubber latex, polyfunctional monomer vulcanization accelerator, neopentyl glycol methacrylate vulcanization accelerator, Synthetic Elastomers and Natural Rubber: Vulcanization, Curing, and Crosslinking and other aspects.Related Products of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 1, 2021, Luo, Zhibo; Wang, Lingli; Fu, Zhifei; Shuai, Bin; Luo, Miaorong; Hu, Guoping; Chen, Jian; Sun, Jikui; Wang, Jiansong; Li, Jian; Chen, Shuhui; Zhang, Yang published an article.Application In Synthesis of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate The title of the article was Discovery and optimization of selective RET inhibitors via scaffold hopping. And the article contained the following:

Aberrant alterations of rearranged during transfection (RET) have been identified as actionable drivers of multiple cancers, including thyroid carcinoma and lung cancer. Currently, several approved multikinase inhibitors such as vandetanib and cabozantinib demonstrate clin. activity in patients with RET-rearranged or RET-mutant cancers. However, the observed response rates are only modest and the ‘off-target’ toxicities resulted from the inhibition of other kinases is also a concern. Herein, we designed and synthesized a series of RET inhibitors based on the structure of selective RET inhibitor BLU-667 and investigated their biol. activities. We identified compound I as a novel potent and selective RET inhibitor with improved drug-like properties. Compound I exhibits a selective inhibitory profile with an inhibitory concentration 50 (IC50) of 1.29 nM for RET and 1.97 (RET V804M) or 0.99 (RET M918T) for mutant RETs. The proliferation of Ba/F3 cells transformed with NSCLC related KIF5B-RET fusion was effectively suppressed by compound I (IC50 = 19 nM). Addnl., compound 9 displayed less ‘off-target’ effects than BLU-667. In mouse xenograft models, compound I repressed tumor growth driven by KIF5B-RET-Ba/F3 cells in a dose-dependent manner. Based on its exceptional kinase selectivity, good potency and high exposure in tumor tissues, compound 9 represents a promising lead for the discovery of RET directed therapeutic agents and the study of RET-driven tumor biol. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Application In Synthesis of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

The Article related to pyrimidine derivative synthesis ret inhibitor antitumor agent, lung cancer, papillary thyroid cancer, ret inhibitor, tyrosine kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Makuuchi, K.; Hagiwara, M. published an article in 1984, the title of the article was Radiation vulcanization of natural rubber latex with polyfunctional monomers – II.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) And the article contains the following content:

Natural rubber latexes were vulcanized by γ-rays with 2 polyfunctional monomers, neopentyl glycol diacrylate (I) [2223-82-7] and neopentyl glycol dimethacrylate (II) [1985-51-9]. In comparison with I, II was more soluble in rubber particles, but it was less effective as an accelerating agent for the vulcanization because of the smaller rate of polymerization On the other hand, the colloidal stability of the latex containing I was low because it was localized on the surface of rubber particles due to its poor solubility in the particles. The solubility of I was improved by adding I with solvents. The maximum tensile strength of the irradiated latex film was 350 kg/cm2 at 3 Mrad. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to natural rubber diacrylate vulcanization accelerator, dimethacrylate vulcanization accelerator natural rubber, Synthetic Elastomers and Natural Rubber: Vulcanization, Curing, and Crosslinking and other aspects.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 18, 2009, Nicolaou, K. C.; Krasovskiy, Arkady; Majumder, Utpal; Trepanier, Vincent E.; Chen, David Y.-K. published an article.Related Products of 141940-37-6 The title of the article was New Synthetic Technologies for the Construction of Heterocycles and Tryptamines. And the article contained the following:

New synthetic methods for the construction of novel heterocycles and tryptamines are described. Thus, N-Boc anilines are sequentially converted to (3-(2-aminophenyl)pyrrolidin-3-ol) derivatives, substituted 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3′-pyrrolidines, and 2-(4,5-dihydro-1H-pyrrol-3-yl)aniline derivatives through a route involving t-BuLi induced ortho-metalation/LaCl3·2LiCl metal exchange, reaction with N-Boc pyrrolidin-3-one, and subsequent decarboxylative fragmentation. Labile intermediates 2-(4,5-dihydro-1H-pyrrol-3-yl)anilines are effectively converted to tryptamines under controlled protic acid conditions. In addition to providing expedient access to the 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3′-pyrrolidines, the method is applicable to the synthesis of the corresponding 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3′-piperidine series of spirocycles and their precursors 3-(2-aminophenyl)piperidin-3-ol derivatives by using N-Boc-protected piperidin-3-one. Applications of the developed synthetic technologies to the synthesis of regioisomeric spirocycles, tryptamines, Corey’s aspidophytine tryptamine, and efavirenz are also described. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to spiroheterocycle tryptamine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 14, 2022, Wang, Hui; Fliedel, Christophe; Manoury, Eric; Poli, Rinaldo published an article.Reference of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Core-crosslinked micelles with a poly-anionic poly(styrene sulfonate)-based outer shell made by RAFT polymerization. And the article contained the following:

Core-crosslinked micelles (CCMs) with a permanently charged anionic shell of sodium poly(styrene sulfonate) (PSS-Na+) chains were developed by a convergent three-step one-pot RAFT polymerization starting with 4-cyano-4-thiothiopropylsulfanyl pentanoic acid (CTPPA, R0-SC(S)SnPr) as chain transfer agent, which includes polymerization-induced self-assembly (PISA) in the second step. The final crosslinking step of the R0-(SS-Na+)x-b-Sty-SC(S)SnPr diblock chains was carried out with diethylene glycol dimethacrylate (DEGDMA), either diluted into styrene (DEGDMA/St = 10:90) or neat. The morphol. of the intermediate micelles and of the final CCM particles was studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM) as a function of the relative degrees of polymerizations for the shell, core, and crosslinking blocks. Conformational instability was observed for the aqueous dispersions of the diblock micelles, especially with the shorter PSt blocks, yielding equilibrium with single chains and large agglomerates. However, crosslinking led to well-defined CCMs with narrow size distributions for the optimized polymer compositions The DLS anal. in a compatibilizing 60:40 THF/H2O solvent mixture demonstrates that the final step of the polymer synthesis has quant. crosslinked all diblock arms. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Reference of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to anionic polystyrene sulfonate crosslinked micelle reversible addition fragmentation polymerization, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Reference of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics