Tag: 200-300

Hardy, Craig; Kociok-Kohn, Gabriele; Buchard, Antoine published an article in 2022, the title of the article was UV degradation of poly(lactic acid) materials through copolymerisation with a sugar-derived cyclic xanthate.Computed Properties of 2873-29-2 And the article contains the following content:

The copolymerization of L-Lactide with a cyclic xanthate monomer derived from tri-O-acetyl-D-glucal has been used to incorporate thionocarbonate and thioester linkages into a polyester backbone. The poly(lactide-co-xanthate) copolymers show enhanced UV-degradability compared to PLA, with 40% mass loss within 6 h of UV exposure (365 nm) for only 3% of sulfur-containing linkages. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Computed Properties of 2873-29-2

The Article related to polylactic acid sugar cyclic xanthate copolymerization uv degradation, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Computed Properties of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2018, Hareesh, K.; Sunitha, D. V.; Ramya, P.; Williams, J. F.; Samarin, S.; Dhole, S. D.; Sanjeev, G. published an article.Synthetic Route of 118-55-8 The title of the article was Gamma radiation-assisted diffusion of Au nanoparticles in nanocavities of polycarbonate: nano-structural and surface properties. And the article contained the following:

The in situ gamma ray-assisted diffusion of gold nanoparticles in a polycarbonate film modified the nano-structural and surface properties to enable control of functional use with decreases in the free volume nano-hole size and in the fractional free volume measured using positron annihilation lifetime spectroscopic techniques. Coincidenace Doppler broadened spectra showed the identifiable spreading of the gold broadened region of the intensity ratio relative to the pristine polycarbonate film. These results were further corroborated by XPS and Transmission electron microscopy which showed the diffused gold nanoparticles had an average size of about 8 nm, and also showed the bonding of gold nanoparticles with the oxygen functional groups of polycarbonate film. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to gold nanoparticle polycarbonate film nanostructural surface property, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Other and other aspects.Synthetic Route of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2021, Garcia-Alloza, Monica; Bacskai, Brian J.; Calvo-Rodriguez, Maria published an article.Electric Literature of 2358-84-1 The title of the article was Mitochondria-ER contacts and glucose: the powerhouse of Alzheimer’s disease?. And the article contained the following:

A mechanism involving endoplasmic reticulum-mitochondria contacts noted in diabetes mellitus may explain the neurodegeneration and amyloidogenesis observed in these patients. Urolithin A, a metabolite found in the gut microbiome, is proposed as a therapeutic strategy for the treatment of the diabetes-related dementia. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to alzheimer disease powerhouse mitochondria er contact glucose, Mammalian Pathological Biochemistry: Nervous System and Psychiatric Diseases and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 8, 2011, Nagib, David A.; MacMillan, David W. C. published an article.COA of Formula: C12H14F3NO2 The title of the article was Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. And the article contained the following:

A simple and mild strategy for the direct trifluoromethylation of unactivated arenes and heteroarenes that acts via a radical-mediated mechanism and uses com. photocatalysts. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to arene heteroarene photoredox catalyst trifluoromethylation, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2019, Razak, Norazizah Abdul; Fagge, Ibrahim Isah; Elhefian, Esam Abdulkader; Khan, Mohammad Niyaz published an article.Application In Synthesis of Phenyl Salicylate The title of the article was Kinetics and Mechanism of Flexible Nanoparticles-Catalyzed Piperidinolysis of Anionic Phenyl Salicylate: Flexible Nanoparticles: CTABr/M2X/H2O (M2X = 4-MeOSaNa2, 3,4-MeSaNa2). And the article contained the following:

Apparent pseudo second-order rate constants, kX, for flexible nanoparticles, FNs, (CTABr/M2X/H2O)-catalyzed piperidinolysis of anionic Ph salicylate, PSa-, at a constant [CTABr], 0.1 M piperidine (Pip) and temperature, were calculated from an empirical equation. CTABr = cetyltrimethylammonium bromide and X2- = 4-methoxysalicylate (4-MeOSa2-) and 3-,4-methylsalicylate (3-,4-MeSa2-) with Sa2- representing -O-C6H3CO2-. The values of kX/k0 = μ measure the apparent rate enhancement due to FN catalysis for piperidinolysis of PSa- at a constant [CTABr] and temperature The values of μ decrease with the increase in [CTABr] within the range of 5-15 mM. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Application In Synthesis of Phenyl Salicylate

The Article related to phenyl salicyalate piperidinolysis kinetics, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Application In Synthesis of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2020, Mahmood, Malik H.; Himics, Laszlo; Peter, Laszlo; Baranyai, Peter; Veres, Miklos published an article.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Characterization of luminescent monodisperse microparticles prepared by gamma radiation-initiated polymerization. And the article contained the following:

Fluorescent microparticles have been prepared by gamma radiation-initiated precipitation polymerization of diethylene glycol dimethacrylate monomer with Et propionate solvent and fluorescein isothiocyanate isomer-I (FITC) fluorophore. Different FITC concentrations and irradiation conditions were used, and their effect on the particle properties was studied. The samples were characterized by SEM, Raman and photoluminescence spectroscopies. Our results showed that the size of the microspheres is dependent on the composition of the monomer mixture The uniformity of the microparticles decreases with increasing FITC concentration, relative to the monomer. Changes in the emission spectrum of the FITC were also observed after irradiation The gamma irradiation-initiated polymerization was found to be a promising and simple technique to prepare luminescent spherical microparticles. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to acrylic polymer isothiocyanatofluorescein luminescent monodisperse microparticle gamma radiation property, Plastics Manufacture and Processing: Physical Properties and Testing Methods and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 25, 2011, Brain, Christopher Thomas; Cho, Young Shin; Giraldes, John William; Lagu, Bharat; Levell, Julian; Luzzio, Michael; Perez, Lawrence Blas; Wang, Yaping; Yang, Fan published a patent.Recommanded Product: 1198284-94-4 The title of the patent was Preparation of pyrrolopyrimidine derivatives for use as CDK4/6 inhibitors. And the patent contained the following:

Title compounds I [A = CH or N; L = bond, C(O), or S(O)2; R1 = alkyl, (un)substituted cycloalkyl, PH, piperidinyl, or tetrahydropyranyl; R2 = (un)substituted diazabycycloheptanyl, diazaspirononanyl, diazabicyclooctanyl, etc.; R4 = H, D, CH3, etc.; R8, R9, R10, and R11 independently = H or D], and their pharmaceutically acceptable salts, are prepared and disclosed as cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in CDK4/cyclin D1 enzymic activity assays, e.g., II demonstrated an IC50 value of 0.008 to 0.016 μM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Recommanded Product: 1198284-94-4

The Article related to pyrimidine pyrrolo derivative preparation cdk4 cdk6 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 16, 2004, Gonzales, Jesus E., III; Wilson, Dean Mitchell; Termin, Andreas Peter; Grootenhuis, Peter Diederik Jan; Zhang, Yulian; Petzoldt, Benjamin John; Fanning, Lev Tyler Dewey; Neubert, Timothy Donald; Tung, Roger D.; Martinborough, Esther; Zimmermann, Nicole published a patent.Related Products of 141940-37-6 The title of the patent was Preparation of quinazolines as modulators of ion channels. And the patent contained the following:

The title compounds [I; NR1R2 = (un)substituted 3-12 membered monocyclic or bicyclic (un)saturated ring having 0-3 heteroatoms selected from N, S or O; ring A = (un)substituted 5-7 membered aryl or 8-10 membered bicyclic aryl having 0-3 heteroatoms selected from N, S or O; x = 0-4; R3 = QR (wherein Q = a bond, alkylidene wherein up to two non-adjacent methylene units are optionally replaced by S, O, CS, etc.; R = halo, NO2, CN, etc.)], useful as inhibitors of voltage-gated sodium channels and calcium channels, were prepared Thus, reacting 2-(4-chloro-7-methylquinazolin-2-yl)phenol with 4-aminopiperidine in the presence of Et3N in CH2Cl2 afforded 89% II. Representative compounds I were found to possess desired N-type calcium channel modulation activity and selectivity (no specific data given). Also, representative compounds I were found to possess desired voltage gated sodium channel activity and selectivity (no specific data given). The invention also provides pharmaceutically acceptable compositions comprising the compounds I and methods of using the compositions in the treatment of various disorders. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to quinazoline preparation modulator sodium calcium ion channel, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 20, 2020, Cao, Ping; Zhang, Chao; Bishop, Michael J. published a patent.Computed Properties of 201811-20-3 The title of the patent was Preparation of novel pyridinylpyrimidines as FGFR inhibitors for the treatment of cancer. And the patent contained the following:

The invention provides the title compounds I [each R1-R5 = (independently) H, F, Cl, Br, alkyl, etc.; R6 = (CH2)0-5CH:CH2, (CH2)0-5CCH, NHCO(CH2)0-5CH:CH2, etc.; Linker = (un)substituted alkyl, COalkyl, CO2alkyl, etc.] or optically pure stereoisomers, solvates, or pharmaceutically acceptable salts thereof with broad inhibitory activity against all FGFR isoforms, and inhibitors with selective inhibition against FGFR4. E.g., a multi-step synthesis of II, starting from 4-amino-3-nitro-phenol and tert-Bu 3-iodoazetidine-1-carboxylate, was described. Exemplified compounds I were evaluated for FGFR inhibition (data given). These novel pyridinylpyrimidine-based FGFR inhibitors, or their derivatives, have strong potential to be used to treat cancer. The experimental process involved the reaction of tert-Butyl (4-hydroxy-2-nitrophenyl)carbamate(cas: 201811-20-3).Computed Properties of 201811-20-3

The Article related to pyridinylpyrimidine preparation fgfr4 inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 201811-20-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dowgiallo, Matthew G.; Miller, Brandon C.; Kassu, Mintesinot; Smith, Kenneth P.; Fetigan, Andrew D.; Guo, Jason J.; Kirby, James E.; Manetsch, Roman published an article in 2022, the title of the article was The convergent total synthesis and antibacterial profile of the natural product streptothricin F.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate And the article contains the following content:

A convergent, diversity-enabling total synthesis of the natural product streptothricin F has been achieved. Herein, authors describe the potent antimicrobial activity of streptothricin F and highlight the importance of a total synthesis that allows for the installation of practical divergent steps for medicinal chem. exploits. Key features of synthesis include a Burgess reagent-mediated 1,2-anti-diamine installation, diastereoselective azidation of a lactam enolate, and a mercury(II) chloride-mediated desulfurization-guanidination. The development of this chem. enables the synthesis and structure-activity studies of streptothricin F analogs. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to streptothricin f convergent total synthesis antibacterial, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics