Tag: 200-300

Kumar, Sonu; Binder, Wolfgang H. published an article in 2020, the title of the article was Peptide-induced RAFT polymerization via an amyloid-β17-20-based chain transfer agent.Product Details of 2358-84-1 And the article contains the following content:

We here describe the synthesis of a novel peptide/polymer-conjugate, embedding the amyloid-β (Aβ) protein core sequence Leu-Val-Phe-Phe (LVFF, Aβ17-20) via RAFT polymerization Based on a novel chain transfer-agent, the “grafting-from” approach effectively generates the well-defined peptide-polymer conjugates with appreciably high monomer conversion rate, resulting in mech. stiffer peptide-functional cross-linked polymeric hydrogels. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Product Details of 2358-84-1

The Article related to peptide induced raft polymerization amyloid chain transfer agent, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Product Details of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2011, Archana; Gupta, D. C. published an article.Application In Synthesis of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Synthesis and characterization of macroporous acrylonitrile-dimethacrylates copolymer beads. And the article contained the following:

Macroporous acrylonitrile-dimethacrylate copolymer beads were prepared by suspension polymerization of acrylonitrile (AN) and ethylene glycol dimethacrylate (EGDMA), bisphenol A dimethacrylate (BADMA), butanediol dimethacrylate (BDDMA) or neopentyl glycol dimethacrylate (NGDMA) using AIBN as an initiator and starch as a suspending agent in water at 70° under nitrogen. The copolymer beads were characterized using FTIR, TGA and determining apparent d. and swelling degree. The solvent effect on the surface area of AN-EGDMA copolymer was also investigated. The formation of macroporous structure due to incorporation of diluents was confirmed by increased swelling, BET surface area and surface morphol. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Application In Synthesis of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to macroporous acrylonitrile dimethacrylate copolymer bead, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Application In Synthesis of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 1982, Fujisawa, S.; Kadoma, Y.; Masuhara, E. published an article.Product Details of 1985-51-9 The title of the article was Action of drugs, detergents, and monomers on liposomes. And the article contained the following:

The interactions of 16 organic compounds used in dentistry with phospholipid bilayers of multilamellar lecithin-cholesterol liposomes were studied to clarify actions of the compounds in biol. systems. colchicine  [64-86-8], dimethyl-p-toluidine  [99-97-8], And salicylic acid  [69-72-7] had a stabilizing effect on liposomes in wide concentrations, whereas phenol   [108-95-2], m-cresol  [108-39-4], p-chlorophenol  [106-48-9], eugenol  [97-53-0], barbituric acid  [67-52-7], o-ethoxybenzoic acid  [134-11-2], mefenamic acid  [61-68-7], methyl methacrylate  [80-62-6], neopentylglycol dimethacrylate  [1985-51-9], toluensulfonyl-N-ethylamide  [26914-52-3], and triton x-100  [9002-93-1] had a stabilizing effect at low and a labilizing effect at high concentrations chloroform  [67-66-3] Had a stabilizing effect at 0.05 and 0.5 mM and a labilizing action at 0.005 mM. prednisolone  [50-24-8] Had a stabilizing effect at 0.05 mM and caused liposomal disruption at ≥0.5 mM. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Product Details of 1985-51-9

The Article related to dentistry drug liposome interaction, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Product Details of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 3, 2021, Gray, Nathanael S.; Hatcher, John M.; Sreevatsan, Prasanna published a patent.Related Products of 1198284-94-4 The title of the patent was Potent and selective azaindole inhibitors of CDK8 and CDK19 for disease treatment. And the patent contained the following:

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with CDK8 and/or CDK19. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Related Products of 1198284-94-4

The Article related to cdk8 cdk19 inhibitor azaindole, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Related Products of 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 25, 2002, Schaschke, Norbert; Dominik, Andreas; Matschiner, Gabriele; Sommerhoff, Christian P. published an article.SDS of cas: 53838-27-0 The title of the article was Bivalent inhibition of β-Tryptase: distance scan of neighboring subunits by dibasic inhibitors. And the article contained the following:

Based on bifunctional diketopiperazines as templates and m-aminomethyl-phenylalanine as arginine mimetic, we have synthesized a new class of structurally related dibasic tryptase inhibitors with systematically increasing spacer length. These compounds were used to scan the distance between the active sites of two neighboring subunits of the β-tryptase tetramer. The Ki-values obtained are a function of the distance between the terminal amino groups and indicate optimal binding of inhibitors with 29-31 bonds between the amino groups. These exptl. data are in full agreement with predictions derived from a novel modeling program that allows the docking of bivalent ligands. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0

The Article related to bivalent inhibitor tryptase active site stereochem, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.SDS of cas: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stepanova, Mariia; Solomakha, Olga; Ten, Daria; Tennikova, Tatiana; Korzhikova-Vlakh, Evgenia published an article in 2020, the title of the article was Flow-through macroporous polymer monoliths containing artificial catalytic centers mimicking chymotrypsin active site.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Synthetic catalysts that could compete with enzymes in term of the catalytic efficiency but surpass them in stability have a great potential for the practical application. In this work, we have developed a novel kind of organic catalysts based on flow-through macroporous polymer monoliths containing catalytic centers that mimic the catalytic site of natural enzyme chymotrypsin. It is known that chymotrypsin catalytic center consists of L-serine, L-histidine, and L-aspartic acid and has specificity to C-terminal residues of hydrophobic amino acids (L-phenylalanine, L-tyrosine, and L-tryptophan). In this paper, we have prepared the macroporous polymer monoliths bearing grafted polymer layer on their surface. The last one was synthesized via copolymerization of N-methacryloyl-L-serine, N-methacryloyl-L-histidine, and N-methacryloyl-L-aspartic acid. The spatial orientation of amino acids in the polymer layer, generated on the surface of monolithic framework, was achieved by coordinating amino acid-polymerizable derivatives with cobalt (II) ions without substrate-mimicking template and with its use. The conditions for the preparation of mimic materials were optimized to achieve a mech. stable system. Catalytic properties of the developed systems were evaluated towards the hydrolysis of ester bond in a low mol. substrate and compared to the results of using chymotrypsin immobilized on the surface of a similar monolithic framework. The effect of flow rate increase and temperature elevation on the hydrolysis efficiency were evaluated for both mimic monolith and column with immobilized enzyme. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to chymotrypsin active site monolith, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Other and other aspects.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 26, 2000, Kubo, Keiji; Hori, Akira; Kusaka, Masami published a patent.Category: esters-buliding-blocks The title of the patent was Benzimidazole derivatives as neovascularization inhibitors and pharmaceutical compositions containing them. And the patent contained the following:

Neovascularization inhibitors contain the derivatives I [ring A = (un)substituted phenyl; ring B = (un)substituted cyclyl; R4, R6 = (1) H, (ii) C1-6 alkyl which may have substituents selected from mono- or di(C1-6 alkyl)amino, 5-7-membered cyclic amino, CO2H, or C2-7 alkoxycarbonyl, (iii) C2-6 alkenyl, (iv) C3-7 cycloalkyl, (v) C7-13 aralkyl which may have 1-5 substituents selected from halo, C1-6 alkoxy, C1-6 alkyl, mono- or di(C1-6 alkyl)amino, (vi) C2-7 alkoxycarbonyl; R5 = (i) H, (ii) halo, (iii) C1-6 alkyl which may have substituents selected from mono- or di(C1-6 alkyl)amino and halo, (iv) C1-6 alkoxy, (v) C2-7 alkoxycarbonyl, (vi) mono- or di(C1-6 alkyl)amino, (vii) carbamoyl which may be substituted with C1-6 alkyl or C7-13 aralkyl; X = (i) direct bond, (ii) C1-6 alkylene, (iii) C2-6 alkenylene, (iv) C1-6 alkylene-aminocarbonyl, (v) C1-6 alkylene-oxycarbonylamino; Y = CO, SO2, NHCO, C1-6 alkylenecarbonyl, C2-6 alkenylenecarbonyl, C1-6 alkylene] or their pharmaceutically acceptable salts. Also claimed are pharmaceutical compositions containing I or their salts for treatment of neoplasm, inflammatory diseases, diabetic retinopathy, etc. IC50 of 2-(4-methoxyphenyl)-5-[3-methoxy-4-(4-pyridyl)methoxybenzoyl]aminobenzimidazole (preparation given) against recombinant VEGF-induced proliferation of HUVEC was 0.012 μM. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Category: esters-buliding-blocks

The Article related to benzimidazole derivative preparation neovascularization inhibitor, angiogenesis inhibitor benzimidazole derivative preparation, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2020, Shevchenko, N. N.; Pankova, G. A.; Laishevkina, S. G. published an article.Recommanded Product: 2358-84-1 The title of the article was Influence of the Structure of a Surface Layer of Methyl Methacrylate-Based Cationic Particles on Adsorption of Biomolecules. And the article contained the following:

Crosslinked cationic particles 200-600 nm in diameter have been synthesized via emulsifier-free copolymerization of Me methacrylate and 2-aminoethyl methacrylate hydrochloride in the presence of crosslinking agents (N,N’-methylenebisacrylamide, triethylene glycol dimethacrylate, and diethylene glycol dimethacrylate). It has been shown that polymer particles with a maximum concentration of surface functional groups (1.42μmol/m2) and a stable structure of a surface layer are formed only in the presence of ethanol (20 vol %). The synthesized particles efficiently adsorb biol. active substances, and their dispersions are stable against aggregation in buffer solutions at pH 7.0. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: 2358-84-1

The Article related to methyl methacrylate crosslinked cationic particle emulsifier free copolymerization, biomol adsorption, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Recommanded Product: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2021, Mahmood, Malik H.; Himics, Laszlo; Vaczi, Tamas; Rigo, Istvan; Holomb, Roman; Beiler, Barbara; Veres, Miklos published an article.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Raman spectroscopic study of gamma radiation-initiated polymerization of diethylene glycol dimethacrylate in different solvents. And the article contained the following:

In this work, the degree of conversion and polymerization kinetics of diethylene glycol dimethacrylate (DEGDMA) monomer in different solvents upon gamma irradiation with different doses have been studied by Raman spectroscopy and mass difference measurements. D. functional theory calculations were performed on the monomer and the crosslinked structure to obtain the assignment of Raman peaks to specific bonds. The evolution of the bonding configuration of the structure with dose and the composition of the monomer mixture was investigated. The dependence of the polymerization rate on the solvent type was explained by the mechanism of the polymerization affected by the relative solubility of the components of the monomer mixture Raman measurements revealed also that there are not fully crosslinked monomer mols. in the polymer matrix. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to raman spectroscopy gamma radiation diethylene glycol dimethacrylate polymerization solvent, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gonzato, Carlo; Pasetto, Pamela; Bedoui, Fahmi; Mazeran, Pierre-Emmanuel; Haupt, Karsten published an article in 2014, the title of the article was On the effect of using RAFT and FRP for the bulk synthesis of acrylic and methacrylic molecularly imprinted polymers.Related Products of 1985-51-9 And the article contains the following content:

Molecularly imprinted polymers (MIPs) are synthetic polymeric receptors, capable of specifically binding a target mol., just like a biol. antibody. There has been a recent trend to improve the properties of these materials by using modern methods of controlled radical polymerization (CRPs) for their synthesis. Despite the recognized advantages associated with their “living character”, the effect of the “controlled nature” has still to be clearly demonstrated. This is far from obvious as the high amounts of short crosslinkers normally used for their synthesis complicate the formation of homogeneous polymer networks. In order to gain more insights into the potential benefits for the binding properties of MIPs resulting from the use of CRPs, the imprinting of a model target (S-propranolol) has been used to compare reversible addition-fragmentation chain transfer polymerization (RAFT) and free-radical polymerization (FRP) on acrylic and methacrylic matrixes. While most MIPs are based on methacrylates, we used acrylates as a “difficult imprinting matrix” for comparison. In fact, the absence of the Me groups in their polymer back-bone reduces their entanglement, resulting in a more flexible network. This renders the material more difficult to imprint, and at the same time makes it easier to evaluate the effects of RAFT polymerization and FRP on structural parameters and thus binding properties. Moreover, we also progressively reduced the amount of crosslinking in order to explore the effects of RAFT and FRP on a wider range of scaffold rigidities. Although MIPs are normally highly crosslinked, some recent emerging applications require lower degrees of crosslinking. Binding experiments, SEM, BET, DMA, swelling and nanoindentation analyses revealed that RAFT is effective in promoting the synthesis of more homogeneous networks compared to FRP, even at very high crosslinker contents, which results in higher target affinities, especially in the case of acrylates. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Related Products of 1985-51-9

The Article related to polyacrylate polymethacrylate molecularly imprinted polymer raft radical polymerization, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Related Products of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics