Tag: 200-300

On April 22, 2020, de los Reyes Jimenez, Marta; Lechner, Antonie; Alessandrini, Francesca; Bohnacker, Sina; Schindela, Sonja; Trompette, Aurelien; Haimerl, Pascal; Thomas, Dominique; Henkel, Fiona; Mourao, Andre; Geerlof, Arie; da Costa, Clarissa Prazeres; Chaker, Adam M.; Bruene, Bernhard; Nuesing, Rolf; Jakobsson, Per-Johan; Nockher, Wolfgang A.; Feige, Matthias J.; Haslbeck, Martin; Ohnmacht, Caspar; Marsland, Benjamin J.; Voehringer, David; Harris, Nicola L.; Schmidt-Weber, Carsten B.; Esser-von Bieren, Julia published an article.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. And the article contained the following:

Eicosanoids are key mediators of type-2 inflammation, e.g., in allergy and asthma. Helminth products have been suggested as remedies against inflammatory diseases, but their effects on eicosanoids are unknown. Here, we show that larval products of the helminth Heligmosomoides polygyrus bakeri (HpbE), known to modulate type-2 responses, trigger a broad anti-inflammatory eicosanoid shift by suppressing the 5-lipoxygenase pathway, but inducing the cyclooxygenase (COX) pathway. In human macrophages and granulocytes, the HpbE-driven induction of the COX pathway resulted in the production of anti-inflammatory mediators [e.g., prostaglandin E2 (PGE2) and IL-10] and suppressed chemotaxis. HpbE also abrogated the chemotaxis of granulocytes from patients suffering from aspirin-exacerbated respiratory disease (AERD), a severe type-2 inflammatory condition. Intranasal treatment with HpbE extract attenuated allergic airway inflammation in mice, and intranasal transfer of HpbE-conditioned macrophages led to reduced airway eosinophilia in a COX/PGE2-dependent fashion. The induction of regulatory mediators in macrophages depended on p38 mitogen-activated protein kinase (MAPK), hypoxia-inducible factor-1α (HIF-1α), and Hpb glutamate dehydrogenase (GDH), which we identify as a major immunoregulatory protein in HpbE. Hpb GDH activity was required for anti-inflammatory effects of HpbE in macrophages, and local administration of recombinant Hpb GDH to the airways abrogated allergic airway inflammation in mice. Thus, a metabolic enzyme present in helminth larvae can suppress type-2 inflammation by inducing an anti-inflammatory eicosanoid switch, which has important implications for the therapy of allergy and asthma. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to helminth larval product antiinflammatory eicosanoid inflammation suppression, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 7, 1984, Felix, Arthur Martin; Meienhofer, Johannes Arnold; Trzeciak, Arnold; Gillessen, Dieter; Studer, Rolf published a patent.Quality Control of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Intermediates for thymosin α1 and desacetylthymosin α1. And the patent contained the following:

R-Ser(CMe3)-Asp(OCMe3)-Ala-Ala-Val-Asp(OCMe3)-Thr(CMe3)-Ser(CMe3)-Ser(CMe3)-Glu(OCMe3)-OR1 [I; R = Ac, Me3CO2C (Boc); R1 = H, Ph] were prepared as intermediates for the synthesis of thymosin α1 (II, R2 = Ac) and desacetylthymosin α1 (II, R2 = H). Thus, Ac-Ser(CMe3)-Asp(OCMe3)-Ala-ONSu (III, NSu = succinimido) was coupled with H-Ala-Val-Asp(OCMe3)-Thr(CMe3)-Ser(CMe3)-Ser(CMe3)-Glu(OCMe3)-OPh (IV) to give I (R = Ac, R1 = Ph), which was saponified in the presence of H2O2 to give I (R = Ac, R1 = H) (V). Z-Ile-Thr(CMe3)-Thr(CMe3)-Lys(Boc)-Asp(OCMe3)-Leu-Lys(Boc)-Glu(OCMe3)-Lys(Boc)-Lys(Boc)-Glu(OCMe3)-Val-Val-Glu(OCMe3)-Glu(OCMe3)-Ala-Glu(OCMe3)-Asn-OCMe3 (VI, Z = PhCH2O2C) was Z-deblocked by hydrogenolysis and then coupled with V by DCC/1-hydroxybenzotriazole to give protected thymosin α1, which was deblocked by CF3CO2H to give II (R2 = H). VI was prepared by a series of fragment condensations from H-Glu(OCMe3)-Ala-Glu(OCMe3)-Asn-OCMe3 (VII), Z-Glu(OCMe3)-Val-Val-Glu(OCMe3)-OH (VIII), Z-Glu(OCMe3)-Lys(Boc)-Lys(Boc)-OH (IX), Z-Asp(OCMe3)-Leu-Lys(Boc)-OH (X), and Z-Ile-Thr(CMe3)-Thr(CMe3)-Lys(Boc)-OH (XI). III, IV, and VII-XI were prepared by conventional solution methods. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Quality Control of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to thymosin preparation peptide intermediate, desacetylthymosin preparation peptide intermediate, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Quality Control of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 1, 2018, Yu, Sun-Chol; Ri, Dong-Myong; Kuhn, Hartmut published an article.Name: Phenyl Salicylate The title of the article was Hydrophobicity and glutathione peroxidase-like activity of substituted salicyloyl-5-seleninic acids: Re-investigations on aromatic selenium compounds based on their hydrophobicity. And the article contained the following:

Previously we have shown that some of 5-selenized salicylic acid derivatives exhibit glutathione peroxidase (GPx)-like activities higher than or equal to ebselen [Yu et al., Chem. Eur. J., 2008, 14, 7066; Organic Biomol. Chem., 2010, 8, 828]. For understanding the absence of GPx-like activity of the homolog of 5-seleninic anhydride of salicyloylglycine with a loger side chain, we have further synthesized 19 new derivatives (5-seleninic acids of Me or Ph salicylates, N-salicyloyl ω-carboxyalkylamines or N-salicyloyl alkyl/phenyl amines, and some of their diselenides). Some of the 5-seleninic acids which carry long side chains or cyclohexyl group have exerted no GPx-like activity, irresp. of whether they are derived from ω-carboxyalkylamines or simple alkylamines. Such lacks of GPx-like activity let us quant. relate the GPx-like activities of the congeners of the above 3 series with their hydrophobicity (ClogP), which showed satisfactory correlations in each series. The mol. hydrophobicity was then extensively applied to diverse known aromatic selenium GPx mimics including diaryl diselenides and ebselen derivatives to explain their GPx-like activities in comparably quant. mode, which could be helpful in designing new improved GPx mimic analogs in each series. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Name: Phenyl Salicylate

The Article related to hydrophobicity glutathione peroxidase like activity substituted salicyloylseleninic acid, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Name: Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2002, Saksena, Anil K.; Girijavallabhan, Viyyoor Moopil; Lovey, Raymond G.; Jao, Edwin E.; Bennett, Frank; McCormick, Jinping; Wang, Haiyan; Pike, Russell E.; Bogen, Stephane L.; Liu, Yi-Tsung; Arasappan, Ashok; Parekh, Tejal; Pinto, Patrick A.; Njoroge, F. George; Ganguly, Ashit K.; Brunck, Terence K.; Kemp, Scott Jeffrey; Levy, Odile Esther; Lim-Wilby, Marguerita published a patent.Recommanded Product: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of novel peptides as NS3-serine protease inhibitors of hepatitis C virus. And the patent contained the following:

Novel peptides I [Z = O, NH or substituted imino; X = (un)substituted alkylsulfonyl, heterocyclylsulfonyl, heterocyclylalkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylcarbonyl, heterocyclylcarbonyl, heterocyclylalkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, heterocyclyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkyaminocarbonyl, heterocyclylaminocarbonyl, arylaminocarbonyl, or heteroarylaminocarbonyl; X1 = H, alkyl, arylmethyl; P1a, P1b, P2-P6 = H, (un)substituted alkyl, alkenyl, cycloalkyl, heterocyclyl, cycloalkylalkyl, heterocyclylalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; P1a and P1b may optionally be joined to each other to form a spirocyclic or spiroheterocyclic ring containing 0-6 oxygen, nitrogen, sulfur, or phosphorus atoms; P1′ = H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl] having HCV protease inhibitory activity are disclosed. Thus, peptide II was prepared via peptide coupling in solution and showed Ki = 1-100 nM for inhibition of HCV protease. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Recommanded Product: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to peptide preparation ns3 serine protease inhibitor, hepatitis c virus treatment peptide, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Recommanded Product: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 1993, Schwartz, Brenda L.; Erickson, Bruce W.; Bursey, Maurice M.; Marbury, G. Dean published an article.SDS of cas: 53838-27-0 The title of the article was Dependence of benzyl alcohol loss on C-terminal amino acid in tandem mass spectrometry of N-protected tripeptides. And the article contained the following:

The effect of the basicity and chain length of the C-terminal amino acid on the fragmentation of N-protected tripeptides was investigated with a hybrid tandem instrument. Pos.-ion unimol. decomposition and collisionally activated decomposition studies on the [M + H]+ ions of a series of N-benzyloxycarbonyl (Z)-protected tripeptides Z-Gly-Leu-Xxx-OMe and Z-Gly-Pro-Xxx-OMe (Xxx = Arg, Lys, Orn, Gln Glu) indicate that substitution of Leu with Pro at the second position in the tripeptides facilitates the loss of benzyl alc. (108 u) from the precursor. Addnl., higher gas-phase basicity and longer chain length of the C-terminal side-chain group promote the formation of the [M + H – 108]+ ion. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0

The Article related to protected tripeptide mass spectra, benzyloxycarbonyl tripeptide mass spectra, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.SDS of cas: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 7, 2019, Talik, Agnieszka; Tarnacka, Magdalena; Geppert-Rybczynska, Monika; Minecka, Aldona; Kaminska, Ewa; Kaminski, Kamil; Paluch, Marian published an article.Quality Control of Phenyl Salicylate The title of the article was Impact of the Interfacial Energy and Density Fluctuations on the Shift of the Glass-Transition Temperature of Liquids Confined in Pores. And the article contained the following:

The behavior of the low- and high-mol. weight glass formers confined in nanoporous templates remains an unsolved puzzle despite the intensive long-term studies in this matter. Special effort is taken to understand the enhancement of segmental or structural dynamics and the depression of the glass-transition temperatures, Tgs in materials infiltrated in pores of the nanometric size. In this paper, we have analyzed dielec., calorimetric, and contact angle data collected for various systems to determine which factors are responsible for these effects. It turned out that with increasing interfacial energy, mols. attached to the pore walls (interfacial layer) vitrify at higher temperatures Moreover, the dynamics of core mols. starts to deviate from bulk-like behavior. Therefore, a greater depression of the glass-transition temperature, Tg, of this fraction of mols. is noted. Also, it was found that the sensitivity of structural dynamics to the d. fluctuations, quantified by the pressure coefficient of the glass-transition temperature, dTg/dp, is another useful parameter to predict the shift of the glass-transition temperature of the confined glass formers. The results presented herein emphasize the great importance of surface effects, which play a primary role in a unified description of the impact of the nanometric spatial restriction on the dynamics of confined materials. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Quality Control of Phenyl Salicylate

The Article related to interfacial energy glass transition temperature liquid confined pore, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Quality Control of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 26, 2009, Gellerman, Gary published a patent.SDS of cas: 53838-27-0 The title of the patent was Preparation of diketopiperazines and related heterocyclic scaffolds which are useful for the preparation of combinatorial libraries. And the patent contained the following:

The invention discloses heterocyclic scaffolds I [X, Y, Z are independently CH2 or CO; R1, R2 are (CH2)0-5CO2H or (CH2)0-5-Q1-P1 or (CH2)0-5-Q2-P2, resp.; R3 is (CO)0-1-A-CO2H or (CO)0-1-A-Q3-P3, where Q1, Q2, Q3 are linkers N, NH, O, or S; P1, P2, P3 are protecting groups; A is a linker (CH2)0-5, O(CH2)0-5, NH(CH2)0-5, -N-alkyl-(CH2)0-5, phenylene-(CH2)0-5, cyclopropylene-(CH2)0-5, cyclobutylene-(CH2)0-5, cyclopentylene-(CH2)0-5, cyclohexylene-(CH2)0-5, piperidinylene-(CH2)0-5, pyrrolene-(CH2)0-5; R4 is H or CH2 or CO attached to linker A], which are useful, for example, for the solid-phase organic synthesis of combinatorial libraries. Thus, I (X, Y are CO; Z-A-R3 is CH2CO2H; R1-CH2 is ornithine Alloc-protected side chain; R2-CH2 is lysine Fmoc-protected side chain; R4 is H) was prepared via peptide coupling in solution and heterocyclization (NMM in 2-butanol at reflux for 10 h). The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0

The Article related to peptide piperazinedione preparation scaffold combinatorial library, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.SDS of cas: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 2, 2009, Manoharan, Muthiah; Rajeev, Kallanthottathil G.; Jayaraman, Muthusamy; Narayanannair, Jayaprakash K. published a patent.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of oligonucleotide-folate conjugates. And the patent contained the following:

The invention provides an iRNA agent having at least one monomer with the structure shown in formula I, where A and B are each independently O, imino groups, or S; X, Y are independently H, a protecting group, a phosphate, phosphodiester, activated phosphate or phosphite group, phosphoramidite, a solid support, -P(Z’)(Z”)O-nucleoside, -P(Z’)(Z”O)-oligonucleotide, a lipid, a PEG, a steroid, a polymer, -P(Z’)(Z”)O-L6-Q’-L7-OP(Z”’)(Z””)O-oligonucleotide, a nucleotide, or an oligonucleotide (Y may also be a lipophile); R is folate, a folate analog or mimic or a folate receptor-binding ligand; L6, L7 are independently -(CH2)n-, -CR’R”(CH2)n-, -(CH2)nCR’R”-, -(CH2CH2O)mCH2CH2-, or -(CH2CH2O)mCH2CH2NH-; Q’ is NH, O, S, CH2, CO2, CONH, NHCH(Ra)CO-, -COCH(Ra)NH-, CO, etc.; Ra is H or an amino acid side chain; R’, R” are independently H, Me, OH, SH, NH2, alkyl- or dialkylamino; Z’, Z”, Z”’, and Z”” are independently O or S; n is 1-20; and m is 0-50. The synthesis and biol. properties of oligonucleotide-folate conjugates are described. An example describes the synthesis of folate conjugate monomer II (CPG = controlled pore glass long-chain alkylamine, DMTr = 4,4′-dimethoxytrityl). A figure shows the in vivo targeting of folate-conjugated siRNAs. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to folate oligonucleotide conjugate preparation antitumor, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2020, Yemanyi, Felix; Vranka, Janice; Raghunathan, Vijay Krishna published an article.COA of Formula: C12H18O5 The title of the article was Glucocorticoid-induced cell-derived matrix modulates transforming growth factor β2 signaling in human trabecular meshwork cells. And the article contained the following:

Aberrant remodeling of trabecular meshwork (TM) extracellular matrix (ECM) may induce ocular hypertensive phenotypes in human TM (hTM) cells to cause ocular hypertension, via a yet unknown mechanism. Here, we show that, in the absence of exogenous transforming growth factor-beta2 (TGFβ2), compared with control matrixes (VehMs), glucocorticoid-induced cell-derived matrixes (GIMs) trigger non-Smad TGFβ 2 signaling in hTM cells, correlated with overexpression/activity of structural ECM genes (fibronectin, collagen IV, collagen VI, myocilin), matricellular genes (connective tissue growth factor [CTGF], secreted protein, acidic and rich in cysteine), crosslinking genes/enzymes (lysyl oxidase, lysyl oxidase-like 2-4, tissue transglutaminase-2), and ECM turnover genes/enzymes (matrix metalloproteinases-MMP2,14 and their inhibitors-TIMP2). However, in the presence of exogenous TGFβ2, VehMs and GIMs activate Smad and non-Smad TGFβ2 signaling in hTM cells, associated with overexpression of α-smooth muscle actin (α-SMA), and differential upregulation of aforementioned ECM genes/proteins with new ones emerging (collagen-I, thrombospondin-I, plasminogen activator inhibitor, MMP1, 9, ADAMTS4, TIMP1); with GIM-TGFβ2-induced changes being mostly more pronounced. This suggests dual glaucomatous insults potentiate profibrotic signaling/phenotypes. Lastly, we demonstrate type I TGFβreceptor kinase inhibition abrogates VehM-/GIM- and/or TGFβ2-induced upregulation of α-SMA and CTGF. Collectively, pathol. TM microenvironments are sufficient to elicit adverse cellular responses that may be ameliorated by targeting TGFβ2 pathway. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to tgfbeta gim signaling human trabecular meshwork, Mammalian Hormones: Corticosteroid, Gonadal, and Placental Hormones and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 4, 2019, Wang, Zesheng; Cong, Xin; He, Guangwen; Liu, Chao; Dong, Ke; Wang, Peng; Cui, Qian; Yu, Yanbing published a patent.Category: esters-buliding-blocks The title of the patent was Preparation method of iodophosphine oxide ligand, complex and catalyst system comprising the iodophosphine oxide ligand, and application of the catalyst system. And the patent contained the following:

The invention discloses a preparation method of an iodophosphine oxide ligand, a complex comprising the iodophosphine oxide ligand, a catalyst system comprising the complex, and application of the catalyst system in the preparation of isocaprylic acid by oxidizing isooctyl aldehyde. The iodophosphine oxide ligand has a structural formula I as shown in claim 1, wherein in R1-R10 are independently selected from electron-withdrawing functional group of CF3, F and Br, or electron-donating functional group of CH3, OCH3 and CH(CH3)3; and preferably, R1 = R4, R2 = R3, R6 = R9, R8 = R5, and R7 = R10. The catalyst system adopts the iodophosphine oxide ligand and cesium complex as the catalyst, and a potassium salt as a co-catalyst, and was used for preparing isocaprylic acid by oxidizing isooctyl aldehyde. The inventive preparation method can overcome the defect of poor selectivity in prior art, and has mild process. The ligand has simple preparation, high activity, and low using amount The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to iodo aryl phosphine oxide ligand preparation oxidation catalyst, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics