Tag: 200-300

Wuensch, E.; Wendlberger, G.; Hallett, A.; Jaeger, E.; Knof, S.; Moroder, L.; Scharf, R.; Schmidt, I.; Thamm, P.; Wilschowitz, L. published an article in 1977, the title of the article was Total synthesis of human big gastrin I and the 32-leucine analog. (Preliminary communication).COA of Formula: C10H19NO4 And the article contains the following content:

Human big gastrin I (I) was prepared by coupling a protected 1-8 fragment to a protected 9-34 fragment (II) and deblocking the resulting protected 1-34 fragment. Protected peptide fragments related to sequences 9-14, 15-30, 21-22, 23-27, and 28-34 were prepared and used in the fragment peptide synthesis of II. The 32-leucine analog of I was also prepared The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).COA of Formula: C10H19NO4

The Article related to big gastrin i synthesis, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.COA of Formula: C10H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cook, Ronald M.; Stevenson, David; Weinstein, Boris published an article in 1974, the title of the article was Amino acids and peptides. XXXVI. Synthesis of decapeptide sequence (A28-A37) of rubredoxin.Computed Properties of 53838-27-0 And the article contains the following content:

The protected rubredoxin A28-A37 fragment Bpoc-Ala-Phe-Glu(OCMe3)-Asp(OCMe3)-Val-Ser (OCMe3)-Glu-(OCMe3)-Asn-Trp-Val-OMe (I) (Bpoc = p-PhC6H4CMe2 O2C) was prepared by a 3 + 3 coupling sequence. Thus, PhCH2O2C-Val-Ser(OCMe3)-Glu(OCMe3)-OH, coupled with Asn-Trp-Val-OMe and removal of the PhCH2O2C group gave Val-Ser(OCMe2)-OMe and removal of the PhCH2O2C group gave Val-Ser(OCMe2)-Glu(OCMe3)-Asn-Trp-Val-OMe which was coupled with Ph-CH2O2C-Asp-(OCMe)3-OH and then with Bpoc-Ala-Phe-Glu-(OCMe3)-OH to give I. The fragment condensations occurred without racemization. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Computed Properties of 53838-27-0

The Article related to rubredoxin decapeptide, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.Computed Properties of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weber, Ulrich; Andre, Michael published an article in 1975, the title of the article was Synthesis of a [Glu5,Ala12,Ala18,Ala21] sheep insulin A chain by fragment condensation on a polymer support.Formula: C10H19NO4 And the article contains the following content:

[Glu5,Ala12,Ala18,-Ala21]sheep insulin-A-chain (I) was prepared in 9% yield by condensation of Boc-Glu(OCMe3)-Ala-Tyr(CH2Ph)-Cys(CHMe2)-N2H3, Boc-Cys(CHMe2)-Ala-Leu-Tyr-Gln-Leu, Boc-Cys(CHMe2)-Ala-Gly-Val, Boc-Cys(CHMe2)-OH, and Boc-Gly-Ile-Val-Glu(OCMe3)-Glu(OCMe3)-OH (Boc = Me3CO2C), which were prepared in 60-98% yields on an alanine polymer. The failure sequence peptides were separated by ion exchange chromatog. on DEAD-Sephadex and by chromatog. on Biogel P 4. Combination of I with natural B-chain gave insulin activities comparable to that obtained with natural A-chain. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Formula: C10H19NO4

The Article related to insulin a analog sheep, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.Formula: C10H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Costes, Jean-Pierre; Duhayon, Carine; Vendier, Laure; Wernsdorfer, Wolfgang published an article in 2022, the title of the article was Structural determinations and magnetic properties of a “chiral at metal” complex and its resulting [Cu-Ln]2 compounds.Formula: C13H10O3 And the article contains the following content:

A chiral trianionic ligand possessing one amide, one imine, two phenol functions and one asym. carbon atom into its diamino chain reacts with CuII ions to yield anionic [LCu]- units that crystallize in a non-centrosym. space group as infinite 1D zig-zag chains in which a transmission of chirality to the CuII ion is effective. The distorted square planar environment of the CuII ion is large enough to induce the presence of a stereogenic CuII center. Further reaction with LnIII ions in presence of ancillary ligands does not preserve such an arrangement but yields a tetranuclear complex made of two [LCu-Ln] units in a head-to-tail position. The tetranuclear [LCu-Ln]2 complexes made with the racemic and chiral LCu units crystallize in different space groups, so that racemization does not occur. The structural determinations confirm that a symmetry center is present in the two structures, except for the Me groups linked to the chiral carbon atoms, which appear as disordered in the (S-S) tetranuclear entity. Such an arrangement implies a conformation change of the diamino chain linked to the CuII ion in one [LCu-Ln] unit of the (S-S) entity, and cancels any chirality contribution of the CuII ions, as in the meso compound Ferromagnetic Cu-Ln interactions, resulting from an alternate distribution of the CuII and LnIII ions, are the only ones to be active. Eventually the micro-Squid studies confirm that the hysteresis loops of the corresponding racemate and chiral tetranuclear [LCu-Dy]2 entities are slightly different. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Formula: C13H10O3

The Article related to crystal structure chiral tetranuclear transition schiff base complex preparation, ferromagnetic exchange magnetic relaxation rare earth schiff base complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Costes, Jean-Pierre; Rodriguez Douton, Maria-Jesus; Shova, Sergiu; Vendier, Laure published an article in 2020, the title of the article was Role of the Main and Auxiliary Ligands in the Nuclearity of Cu-Ln Complexes.Quality Control of Phenyl Salicylate And the article contains the following content:

Trianionic ligands with an inner N2O2, an outer O2O2 or O2O coordination site and an oxygen atom coming from an amide function not involved in these sites yield dinuclear Cu-Ln complexes that self-assemble into tetranuclear species with an alternate arrangement of Cu and Ln ions. This alternate Cu-Gd arrangement impedes Cu-Cu and Gd-Gd interactions that could be antiferromagnetic and favors ferromagnetic Cu-Gd interactions whose strength depends on the nature of the bridge, the phenoxo bridge made of a single oxygen atom or the amidato bridge made of three NCO atoms. Depending on the ligands, the phenoxo bridges can be single (CuOGd) or double (CuO2Gd), while the amidato bridge is always a single (CuNCOGd) bridge. A particular complex involving a trinuclear Cu-Gd-Cu arrangement through two amidato bridges confirms that the Cu-Gd interaction through the amidato bridge is always weaker than the interaction through the phenoxo bridge. It was possible to obtain complexes with an alternate Cu-Gd arrangement involving more than two Cu-Gd entities when two amidato bridges are present. These two amidato bridges may come from a main ligand, as in the case of tetraanionic ligands possessing two amide functions, or from two different ligands involving one amide function that are assembled by a Gd ion through their phenoxo functions. Note that the presence of auxiliary ligands with a good chelating ability for the Gd ion, such as the diketonato ligands, gave tetranuclear species only, regardless of the number of amide functions. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Quality Control of Phenyl Salicylate

The Article related to transition metal lanthanide salicylate amide complex preparation crystal structure, magnetic property transition metal lanthanide salicylate amide complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Quality Control of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Zhang, Yu-Hang; Hoopmann, Michael R.; Castaldi, Peter J.; Simonsen, Kirsten A.; Midha, Mukul K.; Cho, Michael H.; Criner, Gerard J.; Bueno, Raphael; Liu, Jiangyuan; Moritz, Robert L.; Silverman, Edwin K. published an article.Computed Properties of 2358-84-1 The title of the article was Lung proteomic biomarkers associated with chronic obstructive pulmonary disease. And the article contained the following:

Identifying protein biomarkers for chronic obstructive pulmonary disease (COPD) has been challenging. Most previous studies have used individual proteins or preselected protein panels measured in blood samples. Mass spectrometry proteomic studies of lung tissue have been based on small sample sizes. Author used mass spectrometry proteomic approaches to discover protein biomarkers from 150 lung tissue samples representing COPD cases and controls. Top COPD-associated proteins were identified based on multiple linear regression anal. with false discovery rate (FDR) < 0.05. Correlations between pairs of COPD-associated proteins were examined Machine learning models were also evaluated to identify potential combinations of protein biomarkers related to COPD. Author identified 4,407 proteins passing quality controls. Twenty-five proteins were significantly associated with COPD at FDR < 0.05, including interleukin 33, ferritin (light chain and heavy chain), and two proteins related to caveolae (CAV1 and CAVIN1). Multiple previously reported plasma protein biomarkers for COPD were not significantly associated with proteomic anal. of COPD in lung tissue, although RAGE was borderline significant. Eleven pairs of top significant proteins were highly correlated (r > 0.8), including several strongly correlated with RAGE (EHD2 and CAVIN1). Machine learning models using Random Forests with the top 5% of protein biomarkers demonstrated reasonable accuracy (0.707) and area under the curve (0.714) for COPD prediction. Mass spectrometry-based proteomic anal. of lung tissue is a promising approach for the identification of biomarkers for COPD. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Computed Properties of 2358-84-1

The Article related to proteome chronic obstructive pulmonary disease, biomarkers, chronic obstructive pulmonary disease, machine learning, mass spectrometry, proteomics, Mammalian Pathological Biochemistry: Respiratory Diseases and other aspects.Computed Properties of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 28, 2006, Koppel, Gary A. published a patent.COA of Formula: C10H19NO4 The title of the patent was Preparation of β-lactams as vasopressin V1b antagonists.. And the patent contained the following:

Title compounds [I; A = carboxylic acid, ester, amide; B = A, alc, thiol, derivative thereof; R1 = H, alkyl; R2 = H, alkyl, alkoxy, alkylthio, cyano, CHO, alkylcarbonyl, etc.; R3 = (substituted) amino, amido, acylamido, ureido, N-containing heterocyclyl; R4 = alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkylcarbonyl, (substituted) aryl, aralkyl, arylhaloalkyl, aralkoxyalkyl, aralkenyl, aralkynyl, etc.], were prepared Thus, title compound [II; A = (R)-1,2,3,4-tetrahydronaphth-1-ylamino] [preparation using L-glutamic acid γ-tert-Bu ester-α-4-cyclohexylpiperazinylamide, cinnamaldehyde, and (S)-2-(4-phenyloxazolidin-2-on-3-yl)acetyl chloride outlined] showed rat V1b binding affinity with IC50 = 0.05 μM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).COA of Formula: C10H19NO4

The Article related to beta lactam preparation vasopressin v1b antagonist, anxiety depression obsessive compulsive disorder impulsivity treatment azetidinone, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.COA of Formula: C10H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 8, 1981, Meienhofer, Johannes Arnold published a patent.COA of Formula: C10H19NO4 The title of the patent was Peptides and their pharmaceutical preparations. And the patent contained the following:

Peptides H-X-Glu-Asn-OH (I; X = null, Ala, Glu-Ala, Glu-Glu-Ala, Val-Glu-Glu-Ala, Val-Val-Glu-Glu-Ala) were prepared as agents for influencing the regulation, differentiation, and function of thymus lymphocytes. Thus, Z-Ala-OH (Z = PhCH2O2C) was coupled to H-Glu(OCMe3)-Asn-OCMe3 by ClCO2CH2CHMe2 to give 81.7% Z-Ala-Glu(OCMe3)-Asn-OCMe3, which was Z-deblocked by hydrogenolysis over Pd/BaSO4 to give 96.8% H-Ala-Glu(OCMe3)-Asn-OCMe3, which was deblocked by CF3CO2H to give 60.4% H-Ala-Glu-Asn-OH. The effects of I on glucocorticoid resistance of mouse thymus cells were determined and these activities were compared to those of thymosin α1 and thymosin fraction 5. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).COA of Formula: C10H19NO4

The Article related to glutamylasparagine peptide preparation lymphocyte t differentiation, thymus cell glutamylasparagine peptide influence, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.COA of Formula: C10H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Widmer, Fred; Breddam, Klaus; Johansen, Jack T. published an article in 1980, the title of the article was Carboxypeptidase Y catalyzed peptide synthesis using amino acid alkyl esters as amine components.HPLC of Formula: 53838-27-0 And the article contains the following content:

Carboxypeptidase catalyzed peptide coupling reactions of Bz-Ala-OMe with amino acid alkyl esters and the peptide coupling of N-protected dipeptide Me esters with amino acid alkyl esters. The yield of peptide and the extent of oligomerization of the amine components depended on the nature of the amino acid side chains and the nature of the alkyl ester. The Me esters of hydrophobic amino acids oligomerized to various extents with total product yields of 60-90%, whereas the Me esters of hydrophilic amino acids did not oligomerize and gave peptides in 25-50% yields. As the size of the alkyl ester was increased, the degree of oligomerization was drastically decreased. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).HPLC of Formula: 53838-27-0

The Article related to carboxypeptidase catalyst peptide coupling, alkyl ester amino acid peptide carboxypeptidase, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.HPLC of Formula: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 3, 2020, Okten Besli, Nur Sena; Orakdogen, Nermin published an article.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Thermomechanical analysis and pH-triggered elastic response of charge-balanced sulfonated poly(tertiary amine-methacrylate)-based terpolymer cryogels. And the article contained the following:

PH-responsive terpolymer poly(hydroxyethyl methacrylate-2-acrylamido-2-methyl-propanosulfonic acid-diethylaminoethyl methacrylate) cryogels and hydrogels (named as CGs-PHA/Dm and HGs-PHA/Dm) were synthesized in ethanol-water mixture using different monomer feed compositions By the combination of three monomers, an interesting system was designed with tunable pH/temperature responsiveness and elasticity. ATR-FTIR spectra obtained after swelling in pH buffer solution of 2.1 indicated -R2NH+ stretching of DEAEMA moities in terpolymer matrixes. By incorporation of DEAEMA units with ionizable amino groups, terpolymer CGs-PHA/Dm and HGs-PHA/Dm gels exhibited pH-responsive swelling behavior. Inclusion of DEAEMA dramatically altered pH-responsiveness of terpolymers in simulated intestinal fluid at pH 6.6. Dependence of interaction parameter χon terpolymer volume fraction in gel ν2by a linear function and its enthalpic/entropic components with swelling pH were determined At pH < 6.6, dependence of χ parameter on the swelling was evaluated as χ = 1.097 - 2.965ν2, while at basic pH region, pH > 6.6, χ = 0.576 + 0.459ν2. Both pH of swelling medium and the amount of DEAEMA in terpolymer composition affected the compression moduli of terpolymer gels. Flory-Rehner theory extended to correlate the compressive modulus with swelling pH and the dependence of the effective crosslink d. νeon mol% DEAEMA was expressed in both acidic and basic conditions. pH-triggered swelling/shrinking of terpolymer gels were studied as reversible cycles in buffer solutions of pH 2.1 and 9.8. DEAEMA-rich terpolymer gels showed overshooting phenomena due to dynamic conformational changes of diethylaminoethyl units. Terpolymer cryogels exhibited much faster swelling kinetics than that of terpolymer hydrogels in simulated gastric fluid at pH 2.1. The values of diffusion coefficient seemed to be strongly dependent of terpolymer composition The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to thermomech ph triggered elastic charge balanced sulfonated terpolymer, Plastics Manufacture and Processing: Preparation Of Resins and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics