Tag: 200-300

On November 30, 1982, Van der Walle, H. B.; Bensink, T. published an article.Recommanded Product: 1985-51-9 The title of the article was Cross-reaction pattern of 26 acrylic monomers on guinea pig skin. And the article contained the following:

The cross-reaction pattern of acrylic monomers was investigated in 20 groups of animals sensitized to a different acrylic monomer. Animals sensitized to 1 monoacrylate tend to react to other monoacrylates. Reactions to corresponding or other monomethacrylates did not occur. Some reactions to di(meth)acrylates were observed A number of animals sensitized to 1 monomethacrylate reacted to some other monomethacrylates and monoacrylates. Reactions to di(meth)acrylates were observed Animals sensitized to di(meth)acrylates showed hardly any pos. cross-reaction. A universal screening allergen to detect acrylic monomer sensitizations does not exist. The composition of (industrial) products should be made accessible to the occupational dermatologist to prevent the undesirable situation in which a patient suspected of having an acrylic monomer sensitization must be tested with a large series of potent allergens to detect the real origin of the sensitization. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 1985-51-9

The Article related to acrylic monomer skin cross reaction, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Recommanded Product: 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 1984, Bjoerkner, Bert published an article.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was The sensitizing capacity of multifunctional acrylates in the guinea pig. And the article contained the following:

The sensitizing capacity of multifunctional acrylates and their cross-reactivity patterns were investigated with the guinea pig maximization test. 1,4-Butanediol diacrylate  [1070-70-8] and 1,6-hexanediol diacrylate  [13048-33-4] were moderate to strong sensitizers and they probably cross-react with each other. The n-ethylene glycol diacrylates and methacrylates tested were weak and nonsensitizers. Tripropylene glycol diacrylate  [94120-00-0] was a moderate and neopentyl glycol diacrylate  [2223-82-7] a strong sensitizer, whereas neopentyl glycol dimethacrylate  [1985-51-9] was a nonsensitizer. The com. PETA is a mixture of pentaerythritol tri- [3524-68-3] and tetraacrylate [4986-89-4] (PETA 3 and PETA 4, resp.). PETA 3 is a much stronger sensitizer than PETA 4. Simultaneous reactions were seen between PETA 3, PETA 4 and trimethylolpropane triacrylate (TMPTA) [15625-89-5]. The oligotriacrylate  [101661-95-4] is a moderate sensitizer, but no concomitant reactions were seen with PETA 3, PETA 4 or TMPTA. Of multifunctional acrylates tested, the di- and triacrylic compounds, should be regarded as potent sensitizers. The methacrylate multifunctional acrylic compounds were weak or nonsensitizers. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to acrylate sensitization, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Shin Heon; Kwon, Hyung Joon; Park, Saewhan; Kim, Chan Il; Ryu, Haseo; Kim, Sung Soo; Park, Jong Bae; Kwon, Jeong Taik published an article in 2021, the title of the article was Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme.Electric Literature of 2358-84-1 And the article contains the following content:

Radiation therapy is among the most essential treatment methods for glioblastoma multiforme (GBM). Radio-resistance and cancer stem cell properties can cause therapeutic resistance, cancer heterogeneity, and poor prognoses in association with GBM. Furthermore, the GBM subtype transition from proneural to the most malignant mesenchymal subtype after radiation therapy also accounts for high resistance to conventional treatments. Here, we demonstrate that the inhibition of macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) by 4-iodo-6-phenylpyrimidine (4-IPP), a dual inhibitor targeting MIF and DDT, downregulates stemness phenotype, intracellular signaling cascades, mesenchymal trans-differentiation, and induces apoptosis in proneural glioma stem cells (GSCs). In an anal. of The Cancer Genome Atlas, high MIF and DDT expression were associated with poor prognosis. GSC growth was effectively inhibited by 4-IPP in a time- and dose-dependent manner, and 4-IPP combined with radiation therapy led to significantly reduced proliferation compared with radiation therapy alone. The expression of stemness factors, such as Olig2 and SOX2, and the expression of pAKT, indicating PI3K signaling pathway activation, were decreased in association with both 4-IPP monotherapy and combination treatment. The expression of mesenchymal markers, TGM2 and NF-κB, and expression of pERK (indicating MAPK signaling pathway activation) increased in association with radiation therapy alone but not with 4-IPP monotherapy and combination therapy. In addition, the combination of 4-IPP and radiation therapy significantly induced apoptosis compared to the monotherapy of 4-IPP or radiation. In vivo results demonstrated a significant tumor-suppressing effect of 4-IPP when combined with radiation therapy. Collectively, our results showed that the targeted inhibition of MIF and DDT has the potential to strengthen current clin. strategies by enhancing the anticancer effects of radiation therapy. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to macrophage migration inhibitory factor phenylpyrimidine stemness phenotype glioblastoma multiforme, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 15, 2008, Riss, Patrick J.; Kroll, Carsten; Nagel, Verena; Roesch, Frank published an article.Formula: C12H15NO4 The title of the article was NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. And the article contained the following:

This report concerns synthesis, 68Ga-radiolabelling and stability data of 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothio-cyanatophenyl-acetic acid (NODAPA-NCS), 1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenyl-acetic acid (NODAPA-(NCS)2) and 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenyl-acetic acid (NODAPA-OH), versatile bifunctional chelators with potential for mol. imaging. Protein binding and exemplified conjugation are also reported. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Formula: C12H15NO4

The Article related to nodapa oh ncs preparation chelator gallium 68 imaging, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Formula: C12H15NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 21, 2015, Vlahov, Iontcho R.; Leamon, Christopher P.; Low, Philip S.; Parham, Garth L.; Chen, Qingshou published a patent.Application of 53838-27-0 The title of the patent was Compounds for positron emission tomography. And the patent contained the following:

Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomog. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application of 53838-27-0

The Article related to pet contrast agent conjugate, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Application of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ham, Seungmin; Harrison, Craig; de Kretser, David; Wallace, Euan M.; Southwick, Graeme; Temple-Smith, Peter published an article in 2021, the title of the article was Potential treatment of keloid pathogenesis with follistatin 288 by blocking the activin molecular pathway.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Keloids are benign tumors caused by abnormal wound healing driven by increased expression of cytokines, including activin A. This study compared effects of activins on normal and keloid-derived human dermal fibroblasts and investigated a novel treatment for keloids using follistatin. Normal skin and keloid tissue samples from 11 patients were used to develop primary fibroblast cultures, which were compared in terms of their histol. and relevant gene (qRT-PCR and RNAseq) and protein (ELISA) expression. Activin A (INHBA) and connective tissue growth factor (CTGF) gene expression were significantly upregulated in keloid fibroblasts, as was activin A protein expression in cell lysates and culture medium. Activator protein 1 inhibitor (SR11302) significantly decreased INHBA and CTGF expression in keloid fibroblasts and a single treatment of follistatin over 5 days significantly inhibited activin and various matrix-related genes in keloid fibroblasts when compared to controls. Follistatin, by binding activin A, suppressed CTGF expression suggesting a novel therapeutic role in managing keloids and perhaps other fibrotic diseases. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to follistatin keloid pathogenesis activin mol pathway, rnaseq and elisa, activins, follistatin, gene expression, human dermal fibroblasts, keloid, Mammalian Pathological Biochemistry: Surgery and Trauma and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 1983, Van der Walle, H. B.; Waegemaekers, T.; Bensink, T. published an article.HPLC of Formula: 1985-51-9 The title of the article was Sensitizing potential of 12 di(meth)acrylates in the guinea pig. And the article contained the following:

The sensitizing potential of 12 di(meth)acrylates was investigated in the Guinea Pig Maximization Test and Freund’s Complete Adjuvant Test (FCAT). In these tests, the same (molar) concentration was used for intradermal induction. Dimethacrylates were moderate to strong sensitizers in the guinea pig. In diacrylates, no sensitization to diethylene glycol diacrylate  [4074-88-8] was observed 1,2-ethanediol diacrylate  [2274-11-5] And 1,6-hexanediol diacrylate  [13048-33-4] sensitized a number of animals. The challenge reaction pattern of the FCAT with 1,4-butanediol diacrylate  [1070-70-8], neopentanediol diacrylate  [2223-82-7] and 5-pentanediol diacrylate  [36840-85-4] differed form that commonly observed with sensitizers. Pos. reactions were seen only to the maximum nonirritant concentration at 24 h in the challenge at day 21. At 48 h and in the 2nd challenge at day 35, the reactivity had decreased or disappeared. This different reaction pattern made it difficult to classify these monomers with certainty as sensitizers. In most of the FCATs, a decrease in reactivity in successive challenges was found. Possible explanations for this decrease and for the different challenge reaction patterns of some diacrylates were discussed. The skin irritant capacity of di(meth)acrylates was estimated after 1 open application. Diacrylates were very strong irritants on guinea pig skin. Dimethacrylates were weak irritants. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).HPLC of Formula: 1985-51-9

The Article related to dimethacrylate allergy, skin irritation methacrylate, acrylate allergy, sensitization skin acrylate methacrylate, Toxicology: Chemicals (Household, Industrial, General) and other aspects.HPLC of Formula: 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 1, 2000, Nishihara, Tsutomu; Nishikawa, Junichi; Kanayama, Tomohiko; Dakeyama, Fumi; Saito, Koichi; Imagawa, Masayoshi; Takatori, Satoshi; Kitagawa, Yoko; Hori, Shinjiro; Utsumi, Hideo published an article.COA of Formula: C13H20O4 The title of the article was Estrogenic activities of 517 chemicals by yeast two-hybrid assay. And the article contained the following:

One of the urgent tasks in understanding endocrine disruptors (EDs) is to compile a list of suspected substances among the huge number of chems. by using the screening test method. We developed a simple and rapid screening method using the yeast two-hybrid system based on the ligand-dependent interaction of nuclear hormone receptors with coactivators. To date, we have tested the estrogenic activity of more than 500 chems. including natural substances, medicines, pesticides, and industrial chems. Sixty-four compounds were evaluated as pos., and most of these demonstrated a common structure; phenol with a hydrophobic moiety at the para-position without bulky groups at the ortho-position. These results are expected to facilitate further risk assessment of chems. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).COA of Formula: C13H20O4

The Article related to estrogenic activity chem substance risk assessment, endocrine disruptor risk assessment yeast assay, Toxicology: Chemicals (Household, Industrial, General) and other aspects.COA of Formula: C13H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 1987, Roberts, D. W. published an article.SDS of cas: 1985-51-9 The title of the article was Structure-activity relationships for skin sensitization potential of diacrylates and dimethacrylates. And the article contained the following:

Apparently conflicting guinea pig sensitization data on diacrylates and dimethacrylates, published by 3 groups of authors, are analyzed in terms of the relative alkylation index model. This model, correlating sensitization score with a combination of induction dose, chem. reactivity, and lipophilicity, enables the major discrepancies to be rationalized. The data provide a striking example of the overload effect, in that some of the diacrylates have failed to show sensitization when tested at high induction doses, but are revealed as strong sensitizers when tested by other authors at lower induction doses. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).SDS of cas: 1985-51-9

The Article related to mol structure sensitization acrylate methacrylate, allergy diacrylate dimethacrylate mol structure, Toxicology: Chemicals (Household, Industrial, General) and other aspects.SDS of cas: 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 2, 2021, Gomez, Ana M.; Uriel, Clara; Oliden-Sanchez, Ainhoa; Banuelos, Jorge; Garcia-Moreno, Inmaculada; Lopez, J. Cristobal published an article.Application of 2873-29-2 The title of the article was A Concise Route to Water-Soluble 2,6-Disubstituted BODIPY-Carbohydrate Fluorophores by Direct Ferrier-Type C-Glycosylation. And the article contained the following:

Novel, linker-free, BODIPY-carbohydrate derivatives containing sugar residues at positions C2 and C6 are efficiently obtained by, hitherto unreported, Ferrier-type C-glycosylation of 8-aryl-1,3,5,7-tetramethyl BODIPYs with com. available tri-O-acetyl-D-glucal followed by saponification This transformation, which involves the electrophilic aromatic substitution (SEAr) of the dipyrrin framework with an allylic oxocarbenium ion, provides easy access to BODIPY-carbohydrate hybrids with excellent photophys. properties and a weaker tendency to aggregate in concentrated water solutions The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application of 2873-29-2

The Article related to bodipy carbohydrate fluorophore preparation fluorescence dft calculation, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics