Tag: 200-300

On January 15, 2019, Solunov, Hristo Aleksandrov published an article.Electric Literature of 118-55-8 The title of the article was Relations between the sub-molecula and the cooperative scales in the molecular dynamics of the glass-forming liquids. And the article contained the following:

The mols. of the supercooled liquids in the cooperative mol. dynamics are partitioning to specific dynamic units, known as “beads”. The beads have been defined as the smallest units, forming the heat capacity of the supercooled liquids The beads appear as a sub-mol. scale in the dynamics of the glass-forming liquids In the Adam-Gibbs theory the number of mols., rearranging simultaneously, has been defined as the size of the cooperative rearranging region and these regions form the second larger mol. scale in mol. dynamics. Due to a noticeable discrepancy in estimating the number of beads in the mols. by the empirical rules as well as by theor. models the relations between these two scales are not well known. Recently, a new thermodn. method for estimating the number of the beads in the mols. and a rule for the examination of their temperature dependence have been suggested. By these methods 48 low-mol. supercooled liquids are investigated and the relations between these two mol. scales and the structure of the mols. have been found. The estimated number of configuration beads is compared with the number of the structural units (the chem. groups, the ions and the atoms), with the assigned number by the empirical rules and with the ones calculated, based on a Lennar-Jones model of the random first order transition theory. A constant and two kinds of temperature dependence of the number of the beads in the mols. of different liquids have been revealed. A mol. basis, forming the fragility of the supercooled liquids, has been found. From the results obtained, the investigated liquids are classified in several groups following the logical line in the formation of the beads. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Electric Literature of 118-55-8

The Article related to glass forming supercooled liquid mol dynamics, General Physical Chemistry: Macroscopic Properties and other aspects.Electric Literature of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2020, Kupriyanova, O. V.; Milyukov, V. A.; Shevyrin, V. A.; Sadykova, R. G.; Mustafin, R. I. published an article.Recommanded Product: 118-55-8 The title of the article was Development and Validation of a Gas Chromatographic Method for Quantitative Determination of the Active Ingredient in Phenyl Salicylate Drug Substance. And the article contained the following:

Anew method for quant. determination of the active ingredient in Ph salicylate drug substance using gas chromatog. with flame-ionization detection (GC-FID) was developed and validated. The experiments used an HP-5 quartz capillary column with a grafted stationary phase of diphenyl- (5%) and dimethylpolysiloxane (95%) (Agilent Technologies, USA). The conditions for the chromatog. separation and the chromatog. system suitability parameters were determined The Ph salicylate content in the drug substance was determined by the internal standard method. The method was validated for specificity, linearity, precision, and stability (robustness) and was found to meet the main acceptance criteria. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: 118-55-8

The Article related to phenyl salicylate determination gas chromatog, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Recommanded Product: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2020, Sar, Pintu; Roy, Saswati Ghosh; De, Priyadarsi; Ghosh, Sipra published an article.SDS of cas: 2358-84-1 The title of the article was Synthesis of Glutamic Acid Derived Organogels and their Applications in Dye Removal from Aqueous Medium. And the article contained the following:

To develop glutamic acid derived crosslinked polymeric organogels for dye adsorption from aqueous media, di-Me 2-(methacrylamido)pentanedioate (Glu-MAC) is polymerized using diethylene glycol dimethacrylate as crosslinker via the reversible addition-fragmentation chain transfer (RAFT) technique to synthesize crosslinked polymeric organogels with pendant glutamate moieties. The mech. properties of organogels are examined by rheol. study. The organogels exhibit higher value of storage modulus (G’) than the loss modulus (G”) within the linearity limits of deformation, and strong dependence of G’ values on the extent of crosslinking in the gel matrix. Field emission SEM shows porous structure of the gel matrix, therefore, organogels are able to exhibit swelling behaviors in organic solvents such as dichloromethane, N,N-dimethylformamide, THF, acetone, and methanol. Dye adsorption properties of these organogels are investigated using different aqueous dye solutions, such as crystal violet (CV), malachite green (MG), rhodamine-B, and uranine. The gels show high dye adsorption capacities (≥97%) toward cationic dyes like CV and MG. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).SDS of cas: 2358-84-1

The Article related to glutamic acid derived organogel adsorbent dye removal raft polymerization, swelling rheol property, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.SDS of cas: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 24, 2016, Semeraro, Teresa; Tarsi, Luca; Micheli, Fabrizio; Luker, Tim; Cremonesi, Susanna published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of 2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4.5]decan-10-one derivatives useful as inhibitors of human dopamine active transporter (DAT) protein. And the patent contained the following:

The invention relates to compounds of formula I, and in particular 2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4.5]decan-10-one derivatives and related compounds, method for their preparation and their use as inhibitors of human dopamine active transporter (DAT) protein for the treatment of sexual dysfunction, affective disorders, anxiety, depression, attention deficit hyperactivity disorder (ADHD), obesity, etc. Compounds of formula I, wherein Q is C=NOH, NH, Ncycloalkyl, etc.; X is CO, NH, Nalkyl, etc.; Y is O, SO0-2, Nalkyl, etc.; Z is O, S and CR11R12; A is (CHR5R6)0-2; B is (CR1R2)0-2; M is (R9R10)0-2; R1 and R2 are independently H, OH, F, alkyl, etc., or R1R2 together form =O; R3, R4, R7 and R8 are independently H, OH, alkoxy and alkyl, or R3 and R4, R7 and R8 may both be O, wherein said O atoms are linked by an alkylene group to form a straight chain or branched alkylenedioxy group; R5 and R6 are independently H and alkyl, or R5 and R6 from =O; R13 is substituted phenyl; R14 is (un)substituted phenyl; R9, R10, R11 and R12 are independently H and alkyl, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their affinity to the human transporters DAT, NET, SERT and hERG. From the assay, it was determined that example compound II exhibited pIC50 value of 6.89, 5.42, 4.65 and 5.7 towards human transporters DAT, NET, SERT and hERG resp. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Category: esters-buliding-blocks

The Article related to bisfluorophenylmethyldiazaspirodecanone preparation human dopamine active transporter inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 4, 2010, Mikamiyama, Hidenori; Ni, Chiyou; Shao, Bin; Tafesse, Laykea published a patent.Application In Synthesis of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate The title of the patent was Preparation of tetrahydropyridine and dihydropyrrole compounds as calcium channel blockers for treatment of pain and other disorders. And the patent contained the following:

The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of formula I (wherein X = CO, CH2, or is part of a bridge; R9 = H or is part of a bridge; Hy = a 6- or 5-membered heteroaromatic ring, or a 5-membered heterocyclic ring; Z = SO2-aryl; SO2-cycloalkenyl, CH2-aryl, etc.; R1 = CN, OH-alkyl, CO2H, etc.; R2 = alkyl, alkenyl, alkynyl, etc.; m = 0-3; n = 0-1) and pharmaceutically acceptable salts, prodrugs, or solvates thereof. The invention is also directed to the use of compounds of formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain. Exemplary methods for synthesizing compounds of the invention were described, e.g., II was prepared by a multi-step synthesis involving the preparation of intermediate N-cyclopropyl-6-(1,2,3,6-tetrahydropyridin-4-yl)picolinamide and subsequent reaction with 4-trifluoromethoxybenzaldehyde to give II. Compounds of the invention were tested as N-type calcium channel (NTCC) blockers, and II demonstrated an IC50 value of 0.03 μM. II was also tested in the calcium mobilization assay for L-type calcium channel (LTCC) blocking activity and it showed an LTCC IC50 value of >20 μM in that assay. The experimental process involved the reaction of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate(cas: 1206550-93-7).Application In Synthesis of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

The Article related to tetrahydropyridine dihydropyrrole compound preparation pain calcium channel disorder treatment, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhong, Sabilla; Hafner, Andreas; Hussal, Christoph; Nieger, Martin; Braese, Stefan published an article in 2015, the title of the article was Metal-free radical perfluoroalkylation of (hetero)arenes.Category: esters-buliding-blocks And the article contains the following content:

A metal-free radical perfluoroalkylation method which used inexpensive and com. available perfluorocarboxylic anhydrides as an easy to use source of perfluoroalkyl radicals was reported. This approach allowed the perfluoroalkylation of different arenes, such as benzene derivatives, furans, thiophenes, and pyrroles, including highly functionalized compounds The experimental process involved the reaction of Ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate(cas: 1414887-27-6).Category: esters-buliding-blocks

The Article related to perfluoroalkylated arene preparation, arene perfluorocarboxylic anhydride perfluoroalkylation, Aliphatic Compounds: Halides and Halonium Compounds and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 19, 2009, Castro Palomino Laria, Julio Cesar; Terricabras Belart, Emma; Erra Sola, Montserrat; Navarro Romero, Eloisa; Fonquerna Pou, Silvia; Cardus Figueras, Aranzazu; Lozoya Toribio, Maria Estrella published a patent.Recommanded Product: 141940-37-6 The title of the patent was Preparation of azabiphenylaminobenzoic acid derivatives as DHODH inhibitors. And the patent contained the following:

The title compounds I [R1 = H, halo, alkyl, etc.; R2 = H, halo, alkyl; R3 = CO2R5, CONHR5, tetrazolyl, SO2NHR5, CONHSO2R5 (wherein R5 = H, alkyl); R4 = H, alkyl; R9 = H, Ph; G1 = N, CR6 (R6 = H, halo, alkyl, etc.); G2 = H, OH, halo, cycloalkyl, etc.], useful as inhibitors of the dihydroorotate dehydrogenase (DHODH), were prepared and formulated. Thus, heating 2-amino-5-cyclopropylbenzoic acid with 5-bromo-2-phenylpyrimidine (preparations given) in the presence of Cu2O, Cu and K2CO3 in DME at 130°C afforded 57% II which showed IC50 of 105 nM against hDHODH. Pharmaceutical compositions comprising I, alone or in combination with other therapeutic agent, were disclosed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: 141940-37-6

The Article related to azabiphenylaminobenzoic acid preparation dihydroorotate dehydrogenase dhodh inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 8, 2019, Khan, M. Amin published a patent.SDS of cas: 1198284-94-4 The title of the patent was Preparation of spiro-lactam NMDA receptor modulators and uses thereof. And the patent contained the following:

The title compounds I [R1 = (independently) H, alkyl, C(O)alkyl, etc.; q = 0-3; R3 = H, alkyl, C(O)R31, C(O)OR32; R6, if present, = (independently) H, (un)substituted alkyl, OH, halo; m = 0-4; R31 and R32 = (independently) H, (un)substituted alkyl, cycloalkyl] or pharmaceutically acceptable salts and/or stereoisomers thereof, having potency in the modulation of NMDA receptor activity, and therefore useful in the treatment of conditions such as depression and related disorders as well as other disorders, were prepared and/or claimed. E.g., a multi-step synthesis of II, starting from piperidine-4-carboxylic acid, was described. Exemplified compounds I were evaluated in the NMDA receptor agonist assays (data given). Representative compounds I were also tested in the pharmacokinetics assays (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).SDS of cas: 1198284-94-4

The Article related to spiro lactam pren nmda receptor modulator antidepressant pharmacokinetic, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 31, 1982, Van der Walle, H. B.; Delbressine, L. P. C.; Seutter, E. published an article.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Concomitant sensitization to hydroquinone and p-methoxyphenol in the guinea pig: inhibitors in acrylic monomers. And the article contained the following:

Concomitant sensitization to hydroquinone and p-methoxyphenol occurred in sensitization experiments with acrylic monomers in guinea pigs. No relation between the concentration of the inhibitor in the monomers and the incidence of these concomitant sensitizations could be detected. Concomitant sensitization did not influence the cross reaction pattern of the acrylic monomers. The sensitizing potential of acrylic monomers is not influenced by the inhibitors, but some acrylic monomers seem to interfere with the sensitizing potential of the inhibitors. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to allergy hydroquinone methoxyphenol acrylic monomer, skin sensitization inhibitor acrylic monomer, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 29, 2008, Ishihara, Mariko; Fujisawa, Seiichiro published an article.Recommanded Product: 1985-51-9 The title of the article was Quantum-chemical descriptors for estimating hemolytic activity of aliphatic and aromatic methacrylates. And the article contained the following:

Methacrylates such as Me methacrylate , triethyleneglycol dimethacrylate and bisphenol A glycidyldimethacrylate, bis-GMA, are widely used as materials in dental resins perturbation of the phosphatidylcholine-cholesterol interaction. Such effects of aromatic methacrylates may be involved in their marked hemolytic action. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 1985-51-9

The Article related to quantum descriptor hemolysis aliphatic aromatic methacrylate, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Recommanded Product: 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics