Tag: 200-300

On June 21, 2020, Raj, Danuta published an article.Formula: C13H10O3 The title of the article was Thin-layer chromatography with eutectic mobile phases-preliminary results. And the article contained the following:

The presented paper is the first to show thin layer chromatog. (TLC) anal. based on eutectic mobile phases (Deep Eutectic Solvents – DES). During the experiment 25 eutectic mixtures were investigated for their chromatog. properties. Most of them belong to the natural deep eutectic solvents (NADES) group. Also, new eutectic liquids based on phenolics and terpenes, not previously employed in anal. practice, were tested. The eutectic liquids were investigated as pure or diluted with solvents used in chromatog. routine: methanol, water, acetone, chloroform or di-Et ether. The analyses were carried out using classic and high performance silica gel plates. The working solution was a mixture of five alkaloids found in genus Chelidonium, namely sanguinarine, coptisine, chelerythrine, chelidonine, and berberine, with UV light detection of 366 nm. This report proves that eutectic TLC is possible and that the eutectic interactions play a crucial role in the separation process. In most of the tested modifications at least partial separation was achieved. The most successful mobile phase, which enabled separation of all the tested alkaloids, was the equimolar mixture of menthol and phenol with a 35% addition of methanol. The system was also effective in separating alkaloids in the real Chelidonium maius extract sample. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Formula: C13H10O3

The Article related to thin layer chromatog eutectic mobile phase, chelidonium, chromatography, eutectic solvents, isoquinoline alkaloids, nades, tlc, Biochemical Methods: Spectral and Related Methods and other aspects.Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amin, Hassan B.; Taylor, Roger published an article in 1978, the title of the article was The mechanism of the gas-phase pyrolysis of esters. Part 6. Pyrolysis of 1-arylethyl benzoates and tert-butyl phenylacetates.HPLC of Formula: 29704-38-9 And the article contains the following content:

Rate coefficients for pyrolysis of RC6H4CH(OAc)Me (R = H, p-, m-Me, -Cl, -NO2, p-CF3) were determined at 617.9-68.4 K and the log krelative values give an excellent correlation with σ+ values with ρ -0.72 at 600 K; this confirms that the polarity of the transition state for benzoate pyrolysis is greater than that for acetates and less than for carbonates. Rate coefficients for pyrolysis of RC6H4CH2CO2CMe3 (R = p-OMe, -Me, -F, -Cl, -NO2, m-Me, -Cl, H), determined at 543.3-600.8 K, give log krelative values which correlate with σ0 values with ρ 0.39 at 600 K, confirming that the polarity of the transition state for phenylacetate pyrolysis is less than that for benzoates and N-phenylcarbamates. The phenylacetate data correlate better with σn values, confirming that these are more accurate resonance-free substituent constants than are σ0 values. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).HPLC of Formula: 29704-38-9

The Article related to kinetics pyrolysis phenylethyl benzoate, butyl phenylacetate pyrolysis kinetics, Physical Organic Chemistry: Degradation Reactions and other aspects.HPLC of Formula: 29704-38-9

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On May 31, 2010, Perez-Garrido, Alfonso; Helguera, Aliuska Morales; Rodriguez, Francisco Giron; Cordeiro, M. Natalia D. S. published an article.Electric Literature of 1985-51-9 The title of the article was QSAR models to predict mutagenicity of acrylates, methacrylates and α, β-unsaturated carbonyl compounds. And the article contained the following:

The purpose of this study is to develop a quant. structure-activity relationship (QSAR) model that can distinguish mutagenic from nonmutagenic species with α,β-unsaturated carbonyl moiety using two endpoints for this activity, i.e. Ames test and mammalian cell gene mutation test, and also to gather information about the mol. features that most contribute to eliminate the mutagenic effects of these chems. Two data sets were used for modeling the two mutagenicity endpoints: (1) Ames test and (2) mammalian cells mutagenesis. The former comprised 220 mols., while the latter comprised 48 substances, ranging from acrylates and methacrylates to α,β-unsaturated carbonyl compounds The QSAR models were developed by applying linear discriminant anal. (LDA) along with different sets of descriptors computed using the DRAGON software. For both endpoints, there was a concordance of 89% in the prediction and 97% confidentiality by combining the three models for the Ames test mutagenicity. We have also identified several structural alerts to assist the design of new monomers. These individual models and especially their combination are attractive from the point of view of mol. modeling and could be used for the prediction and design of new monomers that do not pose a human health risk. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Electric Literature of 1985-51-9

The Article related to qsar model mutagenicity acrylate methacrylate unsaturated carbonyl compound, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Electric Literature of 1985-51-9

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Ester – an overview | ScienceDirect Topics

On March 31, 1990, Poncet, Joel; Jouin, Patrick; Castro, Bertrand; Nicolas, Louisette; Boutar, Mohamed; Gaudemer, Alain published an article.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the article was Tetramic acid chemistry. Part 1. Reinvestigation of racemization during the synthesis of tetramic acids via Dieckmann cyclization. And the article contained the following:

Epimerization during the synthesis of tetramic acids by Dieckmann cyclization of chiral N-acyl-α-amino esters was investigated. In the case of the isoleucine derivative, the extent of epimerization was directly evaluated by 1H-NMR anal. of the 3-acylated tetramic acids I (R = Me) and its (5R)-isomer and I (R = OMe). A chem. correlation was carried out in the case of the 5-benzyl derivative II. The moderate overall yield and the partial epimerization at position C-5 limit the usefulness of this approach for tetramic acid preparation The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to dieckmann acylamino ester racemization, tetramate racemization, Biomolecules and Their Synthetic Analogs: General and other aspects.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 1984, Waegemaekers, T. H. J. M.; Bensink, M. P. M. published an article.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Nonmutagenicity of 27 aliphatic acrylate esters in the Salmonella microsome test. And the article contained the following:

The mutagenicity of 27 acrylate esters was assessed in the Salmonella/microsome assay. None of the acrylate esters appeared to be mutagenic in the standard Ames assay with TA 1535, 1537, 1538, 98, and 100 both with and without Aroclor 1254 or phenobarbital-induced S9 mix. A liquid incubation assay of methyl methacrylate  [80-62-6], Me acrylate  [96-33-3], Bu acrylate  [141-32-2], and hexyl acrylate  [2499-95-8] with TA 100, neither gave any indication of mutagenic activity. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to acrylate ester mutagenicity, methacrylate ester mutagenicity, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2010, Perez-Garrido, Alfonso; Helguera, Aliuska Morales; Lopez, Gabriel Caravaca; Cordeiro, M. Natalia D. S.; Escudero, Amalio Garrido published an article.Application of 1985-51-9 The title of the article was A topological substructural molecular design approach for predicting mutagenesis end-points of α , β -unsaturated carbonyl compounds. And the article contained the following:

Chem. reactive, α, β -unsaturated carbonyl compounds are common environmental pollutants able to produce a wide range of adverse effects, including, e.g., mutagenicity. This toxic property can often be related to chem. structure, in particular to specific mol. substructures or fragments (alerts), which can then be used in specialized software or expert systems for predictive purposes. In the past, there have been many attempts to predict the mutagenicity of α, β -unsaturated carbonyl compounds through quant. structure activity relationships (QSAR) but considering only one exclusive endpoint: the Ames test. Besides, even though those studies give a comprehensive understanding of the phenomenon, they do not provide substructural information that could be useful forward improving expert systems based on structural alerts (SAs). This work reports an evaluation of classification models to probe the mutagenic activity of α, β -unsaturated carbonyl compounds over two endpoints – the Ames and mammalian cell gene mutation tests – based on linear discriminant anal. along with the topol. Substructure mol. (TOPS-MODE) approach. The obtained results showed the better ability of the TOPS-MODE approach in flagging structural alerts for the mutagenicity of these compounds compared to the expert system TOXTREE. Thus, the application of the present QSAR models can aid toxicologists in risk assessment and in prioritizing testing, as well as in the improvement of expert systems, such as the TOXTREE software, where SAs are implemented. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Application of 1985-51-9

The Article related to unsaturated carbonyl compound mutagenicity tops mode qsar, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Application of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2008, Johannsen, F. R.; Vogt, Barbara; Waite, Maureen; Deskin, Randy published an article.Recommanded Product: 1985-51-9 The title of the article was Mutagenicity assessment of acrylate and methacrylate compounds and implications for regulatory toxicology requirements. And the article contained the following:

Esters of acrylic acid and methacrylic acid, more commonly known as acrylates and methacrylates, resp., are key raw materials in the coatings and printing industry, with several of its chem. class used in food packaging. The results of over 200 short-term in vitro and in vivo mutagenicity studies available in the open literature have been evaluated. Despite differences in acrylate or methacrylate functionality or in the number of functional groups, a consistent pattern of test response was seen in a typical regulatory battery of mutagenicity tests. No evidence of point mutations was observed when acrylic acid or over 60 acrylates and methacrylates were investigated in Salmonella bacterial tests or in hprt mutation tests mammalian cells, and no evidence of a mutagenic effect was seen when tested in whole animal clastogenicity and/or aneuploidy (chromosomal aberration/micronucleus) studies. Consistent with the in vivo testing results, acrylic acid exhibited no evidence of carcinogenicity in chronic rodent cancer bioassays. In contrast, acrylic acid and the entire acrylate and methacrylate chem. class produced a consistently pos. response when tested in the mouse lymphoma assay and/or other in vitro mammalian cell assays designed to detect clastogenicity. The biol. relevance of this in vitro response is questioned based on the non-concordance of in vitro results with those of in vivo studies addressing the same mutagenic endpoint (clastogenicity). Thus, in short-term mutagenicity tests, the acrylates and methacrylates behave as a single chem. category, and genotoxicity behavior of a similar chem. can be predicted with confidence by inclusion within this chem. class, thus avoiding unnecessary testing. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 1985-51-9

The Article related to mutagenicity acrylate methacrylate toxicol genotoxicity, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Recommanded Product: 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahn, Dongchan published an article in 2003, the title of the article was Improved self-priming silicone adhesives through selective interface enrichment.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) And the article contains the following content:

The interplay of the addition cure reactions and adhesion promoter (AP) migration was examined in a hydrosilylation-cured PDMS network modified with a model AP (neopentylglycol dimethacrylate). A combination of thermal anal. by differential scanning calorimetry (DSC) and Raman microscopy was used to demonstrate the desired order of reactivity. Surface anal. by attenuated total reflectance IR spectroscopy and XPS confirms significant levels of AP enrichment at both the substrate and air interfaces of resulting cured silicone slabs. The anal. methods of DSC and Raman microscopy were combined to provide direct evidence of a sequential cure mechanism, whereby the siloxane network forms before a methacrylate-functional adhesion promoter is cured into the matrix. Surface compositional profiles by ATR-IR microscopy and XPS have provided direct evidence of AP enrichment at interfaces in an addition cured silicone matrix. The resulting understanding can be exploited to develop systems with tailored interfaces for in-situ surface modification and control of a range of interface-dependent properties such as adhesion or release. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to polysiloxane adhesive adhesion promoter interface enrichment, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Quality Control of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Yijun; Wang, Youbin; Xiao, Yingjie; Shan, Mengjie; Hao, Yan; Zhang, Lingyun published an article in 2022, the title of the article was Identification of a diagnostic signature and immune cell infiltration characteristics in keloids.Electric Literature of 2358-84-1 And the article contains the following content:

Keloid disorder is a recurrent fibroproliferative cutaneous tumor. Due to the lack of early identification of keloid patients before the formation of keloids, it is impossible to carry out pre-traumatic intervention and prevention for these patients. This led us to identify and determine signatures with diagnostic significance for keloids. Public series of matrix files were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were calculated from expression profiling data, and the diagnostic signature was identified by constructing a protein-protein interaction (PPI) network. The diagnostic efficacy of the screened signature was assessed by employing receiver operating characteristic (ROC) curves. Furthermore, we calculated the proportion of different immune cells in the gene expression matrix microenvironment by the “ssGSEA” algorithm, and assessed the difference in immune cell abundance between keloids and control groups and the relationship between the signature and immune cell infiltration. Clin. keloid and normal skin tissues were collected, and the expression of the screened diagnostic signature was validated by RT-qPCR and immunohistochem. assay. By screening the key genes in PPI, TGM2 was recognized and validated as a diagnostic signature and the infiltrating abundance of 10 immune cells was significantly correlated with TGM2 expression. Gene ontol. enrichment anal. demonstrated that TGM2 and mols. interacting with it were mainly enriched in processes involving wound healing and collagen fiber organization. TGM2 correlated pos. with HIF-1A (R = 0.82, p-value = 1.4e-05), IL6 (R = 0.62, p-value = 0.0053), and FN1 (R = 0.66, p-value = 0.0019). Besides, TGM2 was significantly upregulated in clin. keloid samples compared to normal skin tissues. TGM2 may serve as an auxiliary diagnostic indicator for keloids. However, the role of TGM2 in keloids has not been adequately reported in the current literature, which may provide a new direction for mol. studies of keloids. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to immune cell infiltration protein interaction skin keloids diagnosis human, tgm2, diagnostic signature, immune cell infiltration, keloid, ssgsea, Mammalian Pathological Biochemistry: Skin Diseases and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Liping; Zhang, Yapeng; Xu, Zhihong; Li, Jing; Zhu, Weiming published an article in 2022, the title of the article was Total synthesis of the indolocarbazole alkaloid ZHD-0501 and its seven isomers.HPLC of Formula: 2873-29-2 And the article contains the following content:

An indolocarbazole alkaloid, ZHD-0501, and its seven stereoisomers were totally synthesized from D/L-glucose and 2,3-dibromomaleimide in 22 step reactions, and the absolute configuration of ZHD-0501 was confirmed for the first time. Indolocarbazole alkaloid, ZHD-0501, and its seven stereoisomers showed significant inhibition against PKC α/β and the proliferation of A549, HeLa, K562 and BEL-7402 tumor cell lines. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).HPLC of Formula: 2873-29-2

The Article related to indolocarbazole alkaloid zhd 0501 preparation antitumor protein kinase inhibitor, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.HPLC of Formula: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics