Tag: 200-300

On December 31, 1989, Kawai, Keiji; Torii, Mitsuo; Tsuchitani, Yasuhiko published an article.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Effect of several resin monomers on water insoluble glucan formation by glucosyltransferase of Streptococcus sobrinus. And the article contained the following:

A possible mechanism by which more plaque accumulate on composite resins than on any other restorative materials was investigated by clarifying the effects of several monomers on the glycosyltransferase activity from S. sobrinus. In the individual resin monomers, di-, tri-, and tetra-ethylene glycol dimethacrylate (2G, 3G, and 4G), Bis-GMA and UDMA showed a stimulatory tendency of water insoluble glucan (WIG) formation. However, ethylene glycol dimethacrylate (1G), polyethylene glycol dimethacrylate (9G and 14G, and MMA diminished the synthesis of water soluble glucan as the concentration of monomers was increased. In addition, the eluate from exptl. resin consisted of 1G and Bis-GMA decreased the production of WIG when compared to that from 3G and Bis-GMA-based resin. Thus, it was possible to develop a composite resin which inhibits plaque accumulation by using some antienzymic monomers. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to dental composite plaque antienzymic monomer, glycosyltransferase plaque dental composite monomer, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 1978, Okubo, H.; Kato, M.; Kaetsu, I. published an article.Synthetic Route of 1985-51-9 The title of the article was Casting of organic glass by radiation-induced polymerization of glass-forming monomers at low temperatures. V. Casting and polymer properties of CR-39 modified monomer systems. And the article contained the following:

CR-39 [diethylene glycol bis(allyl carbonate)] [142-22-3]-polyfunctional monomer and CR-39-Me methacrylate-polyfunctional monomer, e.g., tetraethylene glycol dimethacrylate [64111-89-3], systems are suitable for casting by a 2-step polymerization method consisting of preirradiation and post-catalytic polymerization The systems could be cast in a much shorter time cycle than the conventional catalytic method with no optical strain. The phys. properties of the cast polymer, e.g., impact and heat resistance, were sufficient for practical use. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Synthetic Route of 1985-51-9

The Article related to casting polymerization diethylene glycol derivative, gamma irradiation casting organic glass, Synthetic High Polymers: Reactions Of Monomers and other aspects.Synthetic Route of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rosowsky, Andre; Freisheim, James H.; Bader, Henry; Forsch, Ronald A.; Susten, Sandra A.; Cucchi, Carol A.; Frei, Emil III published an article in 1985, the title of the article was Methotrexate analogs. 25. Chemical and biological studies on the γ-tert-butyl esters of methotrexate and aminopterin.Synthetic Route of 53838-27-0 And the article contains the following content:

γ-tert-Bu aminopterin (I; R = R1 = H, R2 = CMe3) (II) was prepared, and new routes to the known γ-tert-Bu methotrexate (I; R = Me, R1 = H, R2 = CMe3) (III) were developed. Thus, pteridine IV (R3 = OH) was brominated by Br2/PPh3 to give IV (R3 = Br), which was treated in situ with p-H2NC6H4CO2H to give pteroic acid V (R = H), which was formylated to give V (R = CHO). The latter was condensed with H-Glu(OCMe3)-OMe.HCl by ClCO2CH2CHMe2 in DMF containing Et3N to give I (R = CHO, R1 = Me, R2 = CMe3), which was hydrolyzed and then deformylated to give II. II was also prepared by treating IV.HBr (R3 = Br) with p-RNHC6H4CO-Glu(OCMe3)-OR1 (VI, R = R1 = H) in AcNMe2 containing Me2CHNEt2. III was prepared by brominating IV (R3 = OH), treating the resulting IV (R3 = Br) with VI (R = R1 = Me), and hydrolyzing the resulting I (R = R1 Me, R2 = CMe3). The inhibitory effects of II on the activity of dihydrofolate reductase (DHFR) from L1210 murine leukemia cells, the growth of 4210 cells and CEM human leukemic lymphoblasts in suspension culture, and the growth of human squamous cell carcinoma of the head and neck in monolayer culture were compared with the effects of III and the parent acids aminopterin (I, R-R2 = H) and methotrexate (I, R = Me, R1 = R2 = H). The activity of II was close to that of III in the DHFR inhibition assay, but II was more potent than III against cells in culture and against L1210 leukemia in mice. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Synthetic Route of 53838-27-0

The Article related to tertiary butyl ester aminopterin methotrexate, dihydrofolate reductase inhibitor aminopterin ester, leukemia inhibitor aminopterin methotrexate ester, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Synthetic Route of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 1988, Pozdnev, V. F. published an article.Application of 29704-38-9 The title of the article was Activation of carboxylic acids by pyrocarbonates. Synthesis of tert-butyl esters of N-substituted amino acids from di-tert-butyl pyrocarbonate in the presence of pyridine and 4-(dimethylamino)pyridine. And the article contained the following:

Several N-protected amino acids as well as 4-O2NC6H4CH2CO2H were converted into their tert-Bu esters by treatment with (Boc)2O (Boc = Me3CO2C) in the presence of pyridine and 4-(dimethylamino)pyridine. The Boc-protected amino acid tert-Bu esters were deblocked by treatment with p-MeC6H4SO3H in MeCN. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Application of 29704-38-9

The Article related to tertbutyl ester protected amino acid, ditertbutyl pyrocarbonate esterification amino acid, pyridine tertbutyl esterification agent, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Application of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 25, 2011, Xu, Le-Cun; Vlahov, Iontcho Radoslavov; Leamon, Christopher Paul; Santhapuram, Hari Krishna; Li, Chunhong published a patent.Computed Properties of 53838-27-0 The title of the patent was Synthesis and purification of pteroic acid and conjugates thereof. And the patent contained the following:

Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof are also described. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Computed Properties of 53838-27-0

The Article related to pteroic acid conjugate preparation immunostimulant, antitumor activity folate fluorescein conjugate preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Computed Properties of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 28, 2006, Xu, Le-Cun; Vlahov, Iontcho Radoslavov; Leamon, Christopher Paul; Santhapuram, Hari Krishna; Li, Chunhong published a patent.SDS of cas: 53838-27-0 The title of the patent was Synthesis and purification of pteroic acid and conjugates thereof. And the patent contained the following:

Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof were also described. Thus, folate-fluorescein conjugate I via a synthetic sequence starting from FITC N10-trifluoroacetyl-protected pteroic acid, glutamate α-tert-butyl-γ-Me diester and ethylene diamine. I was tested for its effect on the growth of solid tumors. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0

The Article related to pteroic acid conjugate preparation immunostimulant, antitumor activity folate fluorescein conjugate preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.SDS of cas: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 5, 1995, Oshida, Junichi; Kawabata, Hiroshi; Kato, Yoshinori; Kokubo, Masayuki; Ueshima, Yasuhide; Sato, Osami; Fujii, Katsuhiko published a patent.Product Details of 53838-27-0 The title of the patent was Preparation of amino acid moiety-containing benzoxazines as elastase inhibitors. And the patent contained the following:

The title compounds I [R1 = H, alkyl; X = Y1A1, Y2(A2)mA3; when X is Y1A1 : R2, R3 = H, (carboxy)alkyl, or NR2R3 = ring; when X is Y2(A2)mA3 : R2 = alkyl, R3 = H; Y1 = amino-protecting group; Y2 = H, sulfonyl; A1, A2 = amino acid residue, etc.; A3 = lysine residue, etc.; m = 0 or 1] are prepared 7-(N-benzyloxycarbonyl-L-phenylalanyl)amino-5-methyl-2-(1-carboxyethyl)amino-4H-3,1-benzoxazin-4-one (preparation given) in vitro showed IC50 values of 5.1 x 10-8 M and 1.5 x 10-6 M against elastase and chymotrypsin, resp. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0

The Article related to amino acid benzoxazine preparation elastase inhibitor, elastase inhibitor amino acid benzoxazine preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 1996, Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B. published an article.Recommanded Product: 29704-38-9 The title of the article was New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy: Alternatives to the Amide Link. And the article contained the following:

Antibody-directed enzyme prodrug therapy (ADEPT) is a two-step approach for the treatment of cancer which seeks to generate a potent cytotoxic agent selectively at a tumor site. In this work described the cytotoxic agent is generated by the action of an enzyme CPG2 on a relatively nontoxic prodrug. The prodrug I (R = MeSO3, X = CO), currently on clin. trial is a benzamide and is cleaved by CPG2 to a benzoic acid mustard drug II (R1 = CO2H). The authors have synthesized a series of new prodrugs I (R = Cl, X = O2C, NHCO, CH2CO, SCO, COS, CH2CS) where the benzamide link has been replaced by, for example, carbamate or ureido. Some of these alternative links are good substrates for CPG2 and therefore new candidates for ADEPT. The active drugs II (R = Cl, R1 = OH, NH2), derived from the best of these prodrugs are potent cytotoxic agents (1-2 μM) some 100 times more than I( R= MeSO3, R1 = CO2H). The prodrugs I (R = Cl, X = O2C, NHCO) are some 100-200-fold less cytotoxic, in a proliferating cell assay, than their corresponding active drugs II. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Recommanded Product: 29704-38-9

The Article related to glutamate mustard prodrug preparation cytotoxicity, antibody directed enzyme prodrug therapy substrate, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghosh, Arun K.; Allu, Srinivasa Rao; Reddy, Guddeti Chandrashekar; Lopez, Adriana Gamboa; Mendez, Patricia; Jurica, Melissa S. published an article in 2021, the title of the article was Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing.Synthetic Route of 2873-29-2 And the article contains the following content:

Herboxidiene is a potent antitumor agent that targets the SF3B subunit of the spliceosome. Herboxidiene possesses a complex structural architecture with nine stereocenters and design of potent less complex structures would be of interest as a drug lead as well as a tool for studying SF3B1 function in splicing. We investigated a number of C-6 modified herboxidiene derivatives in an effort to eliminate this stereocenter and, also to understand the importance of this functionality. The syntheses of structural variants involved a Suzuki-Miyaura cross-coupling reaction as the key step. The functionalized THF core has been constructed from com. available optically active tri-O-acetyl-D-glucal. We investigated the effect of these derivatives on splicing chem. The C-6 alkene derivative showed very potent splicing inhibitory activity similar to herboxidiene. Furthermore, the C-6 gem-di-Me derivative also exhibited very potent in vitro splicing inhibitory activity comparable to herboxidiene. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to herboxidiene derivative preparation splicing inhibitor suzuki miyaura cross coupling, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Synthetic Route of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 16, 2022, Dussoyer, Melissa; Page, Adeline; Delolme, Frederic; Rousselle, Patricia; Nystrom, Alexander; Moali, Catherine published an article.COA of Formula: C12H18O5 The title of the article was Comparison of extracellular matrix enrichment protocols for the improved characterization of the skin matrisome by mass spectrometry. And the article contained the following:

A striking feature of skin organization is that the extracellular matrix (ECM) occupies a larger volume than the cells. Skin ECM also directly contributes to aging and most cutaneous diseases. In recent years, specific ECM enrichment protocols combined with in silico approaches allowed the proteomic description of the matrisome of various organs and tumor samples. Nevertheless, the skin matrisome remains under-studied and protocols allowing the efficient recovery of the diverse ECM found in skin are still to be described. Here, we compared four protocols allowing the enrichment of ECM proteins from adult mouse back skin and found that all protocols led to a significant enrichment (up to 65%) of matrisome proteins when compared to total skin lysates. The protocols based on decellularization and solubility profiling gave the best results in terms of numbers of proteins identified and confirmed that skin matrisome proteins exhibit very diverse solubility and abundance profiles. We also report the first description of the skin matrisome of healthy adult mice that includes 236 proteins comprising 95 core matrisome proteins and 141 associated matrisome proteins. These results provide a reliable basis for future characterizations of skin ECM proteins and their dysregulations in disease-specific contexts. Extracellular matrix proteins are key players in skin physiopathol. and have been involved in several diseases such as genetic disorders, wound healing defects, scleroderma and skin carcinoma. However, skin ECM proteins are numerous, diverse and challenging to analyze by mass spectrometry due to the multiplicity of their post-translational modifications and to the heterogeneity of their solubility profiles. Here, we performed the thorough evaluation of four ECM enrichment protocols compatible with the proteomic anal. of mouse back skin and provide the first description of the adult mouse skin matrisome in homeostasis conditions. Our work will greatly facilitate the future characterization of skin ECM alterations in preclin. mouse models and will inspire new optimizations to analyze the skin matrisome of other species and of human clin. samples. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to skin matrisome extracellular matrix mass spectrometry, decellularization, extracellular matrix, matrisome, mouse, proteomics, skin, Biochemical Methods: Spectral and Related Methods and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics