Tag: 200-300

On October 5, 2021, Hu, Hui; Zhang, Xiao-Wei; Li, Lin; Hu, Ming-Ning; Hu, Wen-Qian; Zhang, Jing-Ying; Miao, Xiao-Kang; Yang, Wen-Le; Mou, Ling-Yun published an article.Recommanded Product: 2358-84-1 The title of the article was Inhibition of autophagy by YC-1 promotes gefitinib induced apoptosis by targeting FOXO1 in gefitinib-resistant NSCLC cells. And the article contained the following:

Non-small cell lung cancer (NSCLC) is the most common cancer in the world. Gefitinib, an inhibitor of EGFR tyrosine kinase, is highly effective in treating NSCLC patients with activating EGFR mutations (L858R or Ex19del). However, despite excellent disease control with gefitinib therapy, innate resistance and inevitable acquired resistance represent immense challenges in NSCLC therapy. Gefitinib potently induces cytoprotective autophagy, which has been implied to contribute to both innate and acquired resistance to gefitinib in NSCLC cells. Currently, abrogation of autophagy is considered a promising strategy for NSCLC therapy. In the present study, YC-1, an inhibitor of HIF-1α, was first found to significantly inhibit the autophagy induced by gefitinib by disrupting the fusion of autophagosomes and lysosomes and thereby enhancing the proapoptotic effect of gefitinib in gefitinib-resistant NSCLC cells. Furthermore, the combinational anti-autophagic and pro-apoptotic effect of gefitinib and YC-1 was demonstrated to be associated with an enhanced of forkhead box protein O1 (FOXO1) transcriptional activity which resulted from an increase in the p-FOXO1 protein level in gefitinib-resistant NSCLC cells. Our data suggest that inhibition of autophagy by targeting FOXO1 may be a feasible therapeutic strategy to overcome both innate and acquired resistance to EGFR-TKIs. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: 2358-84-1

The Article related to autophagy yc1 promote apoptosis foxo1 gefitinib nsclc, apoptosis, autophagy, epidermal growth factor receptor, foxo, gefitinib, lung cancer, Placeholder for records without volume info and other aspects.Recommanded Product: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2020, Vasiliu, Silvia; Lungan, Maria-Andreea; Racovita, Stefania; Popa, Marcel published an article.COA of Formula: C12H18O5 The title of the article was Porous microparticles based on methacrylic copolymers and gellan as drug delivery systems. And the article contained the following:

Two types of porous microparticles based on glycidyl methacrylate, dimethacrylic monomers (ethylene glycol dimethacrylate, diethylene glycol dimethacrylate and triethylene glycol dimethacrylate) and gellan were prepared by two methods. The first method was aqueous suspension polymerization in the presence of N-Bu acetate as porogenic agent when the crosslinking and grafting reactions were achieved in a single step. The second method was based on the reaction between hydroxyl groups belonging to gellan and the epoxy groups situated on the surface of porous microparticles based on glycidyl methacrylate and dimethacrylic monomers in basic medium. The microparticles with and without gellan were characterized by Fourier transform IR spectroscopy, SEM, AFM and TGA. Also, the porous structure was investigated in terms of pore volume, porosity and sp. surface. The swelling behavior in aqueous solution with different pH values as well as sorption studies of cefuroxime sodium salt onto porous microparticles were investigated. The presence of gellan in the structure of the microparticles leads to porous materials characterized by higher sp. surface areas (Ssp = 78-140 m2 g-1), higher swelling capacities (Sw = 162%-365%) and higher sorption capacities of the drug (qe = 101-147 mg g-1) compared to microparticles without gellan in their structures (Ssp = 73-85 m2 g-1; Sw = 139%-209%; qe = 70-110 mg g-1). The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to porous microparticle methacrylic copolymer drug delivery, Pharmaceuticals: Formulation and Compounding and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 6, 2013, Zhang, Ningning; Yang, Rui; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang published an article.Reference of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Direct Conversion of N-Alkoxyamides to Carboxylic Esters through Tandem NBS-Mediated Oxidative Homocoupling and Thermal Denitrogenation. And the article contained the following:

Treatment of N-alkoxyamides with NBS in toluene was found to conveniently afford the corresponding carboxylic esters, including those bearing a bulky or long-chain substituent, in satisfactory to excellent yields. This approach not only represents a convenient and economical approach to a direct transformation of an alkoxyamide moiety into the carboxylic ester functional group, via oxidative homocoupling and the subsequent thermal denitrogenation, but also facilitates the synthesis of sterically hindered carboxylic esters. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Reference of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to alkoxy amide preparation conversion carboxylic ester nbs, General Organic Chemistry: Synthetic Methods and other aspects.Reference of tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2021, Lahaye, Clement; Gladine, Cecile; Pereira, Bruno; Berger, Juliette; Chinetti-Gbaguidi, Giulia; Laine, Fabrice; Mazur, Andrzej; Ruivard, Marc published an article.Category: esters-buliding-blocks The title of the article was Does iron overload in metabolic syndrome affect macrophage profile? A case control study. And the article contained the following:

Dysmetabolic iron overload syndrome (DIOS) is common but the clin. relevance of iron overload is not understood. Macrophages are central cells in iron homeostasis and inflammation. We hypothesized that iron overload in DIOS could affect the phenotype of monocytes and impair macrophage gene expression. This study compared 20 subjects with DIOS to 20 subjects with metabolic syndrome (MetS) without iron overload, and 20 healthy controls. Monocytes were phenotyped by Fluorescence-Activated Cell Sorting (FACS) and differentiated into anti-inflammatory M2 macrophages in the presence of IL-4. The expression of 38 genes related to inflammation, iron metabolism and M2 phenotype was assessed by real-time PCR. FACS showed no difference between monocytes across the three groups. The macrophagic response to IL-4-driven differentiation was altered in four of the five genes of M2 phenotype (MRC1, F13A1, ABCA1, TGM2 but not FABP4), in DIOS vs Mets and controls demonstrating an impaired M2 polarization. The expression profile of inflammatory genes was not different in DIOS vs MetS. Several genes of iron metabolism presented a higher expression in DIOS vs MetS: SCL11A2 (a free iron transporter, +76%, p = 0.04), SOD1 (an antioxidant enzyme, +27%, p = 0.02), and TFRC (the receptor 1 of transferrin, +59%, p = 0.003). In DIOS, macrophage polarization toward the M2 alternative phenotype is impaired but not associated with a pro-inflammatory profile. The up regulation of transferrin receptor 1 (TFRC) in DIOS macrophages suggests an adaptive role that may limit iron toxicity in DIOS. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Category: esters-buliding-blocks

The Article related to human iron overload metabolic syndrome macrophage polarization, dysmetabolic iron overload syndrome, ferritin, inflammation, macrophage polarization, metabolic syndrome, Placeholder for records without volume info and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 6, 2013, Hama, Takuo; Ge, Shaozhong; Hartwig, John F. published an article.Name: tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Palladium-Catalyzed α-Arylation of Zinc Enolates of Esters: Reaction Conditions and Substrate Scope. And the article contained the following:

The intermol. α-arylation of esters by palladium-catalyzed coupling of aryl bromides with zinc enolates of esters is reported. Reactions of three different types of zinc enolates have been developed. α-Arylation of esters occurs in high yields with isolated Reformatsky reagents, with Reformatsky reagents generated from α-bromo esters and activated zinc, and with zinc enolates generated by quenching alkali metal enolates of esters with zinc chloride. The use of zinc enolates, instead of alkali metal enolates, greatly expands the scope of the arylation of esters. The reactions occur at room temperature or at 70° with bromoarenes containing cyano, nitro, ester, keto, fluoro, enolizable hydrogen, hydroxyl, or amino functionality and with bromopyridines. The scope of esters encompasses acyclic acetates, propionates, and isobutyrates, α-alkoxyesters, and lactones. The arylation of zinc enolates of esters was conducted with catalysts bearing the hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos) or the highly reactive dimeric Pd(I) complex {[P(t-Bu)3]PdBr}2. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Name: tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to palladium catalysis alpha arylation ester aryl bromide zinc enolate, General Organic Chemistry: Synthetic Methods and other aspects.Name: tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2020, Brazhkin, V. V. published an article.Computed Properties of 118-55-8 The title of the article was Kinetic Model of Softening of Glasses. And the article contained the following:

A liquid-glass transition (vitrification) has been analyzed in terms of the softening of a solid phase through diffusion jumps. It has been shown that the assumption of a Gibbs momentum distribution (in fact, local thermalization) in glass automatically results in the existence of diffusion in glasses at any temperatures In view of this conclusion, the possibility of a virtual “thermodn.” transition responsible for vitrification is questionable. A model of jumps of “hot” particles has been proposed that predicts the existence of two characteristic temperatures TA and TB and describes qual. changes in the temperature dependence of the viscosity of a liquid upon cooling (“Arrhenius”-“super-Arrhenius”-“;Arrhenius”). The temperatures TA and TB are related to the number of particles in the first coordination sphere and the number of particles in the region of structural correlations (intermediate order region) in disordered media. The concept of ergodicity is discussed in application to glasses. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Computed Properties of 118-55-8

The Article related to glass transition temperature softening kinetic model vitrification, Ceramics: Glass (Oxide and Nonoxide Glasses) and other aspects.Computed Properties of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2021, Chiari, Marina D. S.; Alania, Yvette; Bedran-Russo, Ana K.; Braga, Roberto R. published an article.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Experimental dentin adhesives containing calcium orthophosphate particles: Effect on dentin bond strength, micro-permeability and collagen degradation. And the article contained the following:

To assess the effect of dicalcium phosphate dihydrate (DCPD) or mineral trioxide aggregate (MTA) particles on the microtensile bond strength (ΜTBS), micro-permeability and enzymic activity at the adhesive-dentin interface of exptl. dental adhesives. An exptl. ethanol-based, two-step etch-and-rinse adhesive system was prepared Four exptl. groups were tested, based on the type of particle added: (1) DCPD functionalized with diethylene glycol dimethacrylate (DCPD_DEGDMA), (2) citric acid (DCPD_CA), (3) calcium silicate (MTA) and (4) unfilled (control). All particles were added at 10 wt%. Human third molars had their occlusal enamel removed and dentin surface polished. After acid etching, the adhesives were applied on the dentin surfaces and the teeth were restored with a com. nanofilled resin composite. The μTBS and micro-permeability were tested after 24 h or 2 mo of storage in simulated body fluid (SBF) at 37°C. Bonded interfaces were observed using scanning electron microcopy (SEM). Gelatinolytic activity at the adhesive interfaces was assessed by in situ zymog. at 24 h and 2 mo in SBF/37°C. The results were described as relative florescent units (RFU). μTBS data were analyzed by ANOVA/Games-Howell test. Data from micro-permeability and in situ zymog. were analyzed by Kruskal-Wallis/Mann-Whitney test (alpha: 5%). Differences in μTBS were found among adhesives (control = MTA > DCPD_CA > DCPD_DEGDMA, p < 0.001), but not between storage times. The control group showed the lowest permeability at both observation periods. Except for DCPD_CA, no significant increases in micro-permeability were observed after 2 mo. All groups presented significant reductions in RFU values between 24 h and 2 mo. DCPD_DEGDMA (at 24 h) and MTA (at 2 mo) presented statistically lower RFU than the control (p < 0.01). Evidence of reduced MMP activity was observed at adhesive interfaces with the use of exptl. adhesives containing calcium-releasing particles. However, after two months, bond strength and micro-permeability results suggest that interfacial stability was not affected by adhesive formulation. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to calcium orthophosphate dentin adhesive bond strength micropermeability collagen degradation, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2022, Tominaga, Kohji; Orikasa, Isamu; Tomaru, Momoko; Osada, Takuma; Hashimoto, Yoshitaka; Inatomi, Yuko; Suzuki, Shinsuke published an article.Formula: C13H10O3 The title of the article was Diffusion coefficient analysis method using data statistical processing to reduce interference fringe noise effects. And the article contained the following:

A simple statistical anal. method is proposed of minute concentration changes for measuring diffusion coefficient with reduced interference fringe noise effect. In the Soret-Facet Mission, the one-dimensional diffusion equation discretized by the finite difference method was applied for temporal homogenization processes of the minute concentration gradient induced by the Soret effect with random noises. Measured diffusion coefficient, Dexp, was determined by evaluating the obtained apparent diffusion coefficient distributions D. The measured value Dexp obtained by the proposed processes was found to be valid because the measured value Dexp was close to the theor. one, Dth, calculated by the Darken equation and the reference one Dref calculated in Facet Mission in the same solution system, resp. In addition, by analyzing ∼ 1/16th of the total field of view, it was possible to obtain a diffusion coefficients that are ≥ 95% convergent for the measured value Dexp obtained from the full field of view anal. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Formula: C13H10O3

The Article related to diffusion data statistical processing interference fringe noise effect reduction, Unit Operations and Processes: Mass Transfer and other aspects.Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 1, 2015, Zhang, Xiaomin; Wang, Jian; Wan, Zehong published an article.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was New Reagent for Highly Efficient Synthesis of Trifluoromethyl-Substituted Arenes and Heteroarenes. And the article contained the following:

A new reagent trimethylsilyl chlorodifluoroacetate (TCDA) is reported for the introduction of a -CF3 group to arenes and heteroarenes. Compared with current known reagents, TCDA shows very broad scope with respect to electron-deficient, -neutral, and -rich aryl/heteroaryl iodides as well as excellent functional group tolerance, including ester, amide, aldehyde, hydroxyl, and carboxylic acid. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to trifluoromethylation aryl heteroaryl iodide trimethylsilyl chlorodifluoroacetate, General Organic Chemistry: Synthetic Methods and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2022, Borredon, Claudia; Miccio, Luis A.; Phan, Anh D.; Schwartz, Gustavo A. published an article.Product Details of 118-55-8 The title of the article was Estimating glass transition temperature and related dynamics of molecular glass formers combining artificial neural networks and disordered systems theory. And the article contained the following:

Glass transition temperature and related dynamics play an essential role in amorphous materials research since many of their properties and functionalities depend on mol. mobility. However, the temperature dependence of the structural relaxation time for a given glass former is only exptl. accessible after synthesizing it, implying a time-consuming and costly process. In this work, we propose combining artificial neural networks and disordered systems theory to estimate the glass transition temperature and the temperature dependence of the main relaxation time based on the knowledge of the mol.’s chem. structure. This approach provides a way to assess the dynamics of mol. glass formers, with reasonable accuracy, even before synthesizing them. We expect this methodol. to boost industrial development, save time and resources, and accelerate the scientific understanding of structure-properties relationships. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Product Details of 118-55-8

The Article related to glass former transition temperature artificial neural network disordered theory, General Physical Chemistry: General Theories and other aspects.Product Details of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics