Tag: 200-300

Caruthers, J. M.; Medvedev, G. A. published an article in 2018, the title of the article was Quantitative model of super-Arrhenian behavior in glass forming materials.HPLC of Formula: 118-55-8 And the article contains the following content:

The key feature of glass forming liquids is the super-Arrhenian temperature dependence of the mobility, where the mobility can increase by ten orders of magnitude or more as the temperature is decreased if crystallization does not intervene. A fundamental description of the super-Arrhenian behavior has been developed; specifically, the logarithm of the relaxation time is a linear function of 1/Ux, where Ux is the independently determined excess molar internal energy and B is a material constant This one-parameter mobility model quant. describes data for 21 glass forming materials, which are all the materials where there are sufficient exptl. data for anal. The effect of pressure on the loga mobility is also described using the same Ux(T,p) function determined from the difference between the liquid and crystalline internal energies. It is also shown that B is well correlated with the heat of fusion. The prediction of the B/Ux model is compared to the Adam and Gibbs 1/TSx model, where the B/Ux model is significantly better in unifying the full complement of mobility data. The implications of the B/Ux model for the development of a fundamental description of glass are discussed. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).HPLC of Formula: 118-55-8

The Article related to glass forming material super arrhenian mobility math model, Placeholder for records without volume info and other aspects.HPLC of Formula: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2020, Cook, David P.; Vanderhyden, Barbara C. published an article.HPLC of Formula: 2358-84-1 The title of the article was Context specificity of the EMT transcriptional response. And the article contained the following:

Epithelial-mesenchymal plasticity contributes to many biol. processes, including tumor progression. Various epithelial-mesenchymal transition (EMT) responses have been reported and no common, EMT-defining gene expression program has been identified. Here, we have performed a comparative anal. of the EMT response, leveraging highly multiplexed single-cell RNA sequencing (scRNA-seq) to measure expression profiles of 103,999 cells from 960 samples, comprising 12 EMT time course experiments and independent kinase inhibitor screens for each. We demonstrate that the EMT is vastly context specific, with an average of only 22% of response genes being shared between any two conditions, and over half of all response genes were restricted to 1-2 time course experiments Further, kinase inhibitor screens revealed signaling dependencies and modularity of these responses. These findings suggest that the EMT is not simply a single, linear process, but is highly variable and modular, warranting quant. frameworks for understanding nuances of the transition. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1

The Article related to lung prostate cancer progression tgm2 tgfb1 cdh1 emt, Placeholder for records without volume info and other aspects.HPLC of Formula: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Choudhary, Ishita; Vo, Thao; Paudel, Kshitiz; Wen, Xue; Gupta, Richa; Kesimer, Mehmet; Patial, Sonika; Saini, Yogesh published an article.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease. And the article contained the following:

Lung epithelial lining fluid (ELF) harbors a variety of proteins that influence homeostatic and stress responses in the airspaces. Exosomes, nano-sized extracellular vesicles, contain many proteins that vary in abundance and composition based on the prevailing conditions. Ozone causes inflammatory responses in the airspaces of exptl. animals and humans. However, the exosomal protein signatures contained within the ELF from ozone-exposed lung airspaces remain poorly characterized. To explore this, we hypothesized that ozone triggers the release of exosome-bound inflammatory proteins from various cells that reflect mucoobstructive lung disease. Accordingly, we repetitively exposed adult male and female C57BL/6 mice to HEPA-filtered air (air) or 0.8 ppm ozone (4 h per day) for 14 days (five consecutive days of exposure, 2 days of rest, five consecutive days of exposure, 2 days of rest, four consecutive days of exposure). Exosome-bound proteomic signatures, as well as the levels of soluble inflammatory mediators in the bronchoalveolar lavage fluid (BALF), were determined 12-16 h after the last exposure. Principal component analyses of the exosome-bound proteome revealed a clear distinction between air-exposed and ozone-exposed mice, as well as between ozone-exposed males and ozone-exposed females. In addition to 575 proteins that were enriched in both sexes upon ozone exposure, 243 and 326 proteins were enriched uniquely in ozone-exposed males and females, resp. Ingenuity pathway analyses on enriched proteins between ozone- and air-exposed mice revealed enrichment of pro-inflammatory pathways. More specifically, macrophage activation-related proteins were enriched in exosomes from ozone-exposed mice. Cytokine analyses on the BALF revealed elevated levels of G-CSF, KC, IP-10, IL-6, and IL-5 in ozone-exposed mice. Finally, the histopathol. assessment revealed significantly enhanced intracellular localization of mucoinflammatory proteins including MUC5B and FIZZ1 in ozone-exposed mice in a cell-specific manner indicating the cellular sources of the proteins that are ferried in the exosomes upon ozone-induced lung injury. Collectively, this study identified exosomal, secretory, and cell-specific proteins and biol. pathways following repetitive exposure of mice to ozone. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to human mucoinflammatory lung disease protein analyses, Placeholder for records without volume info and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Shrivastava, Vipul; Lee, Megan; Lee, Daniel; Pretorius, Marle; Radford, Bethany; Makkar, Guneet; Huang, Carol published an article.SDS of cas: 2358-84-1 The title of the article was Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells. And the article contained the following:

Pancreatic islets adapt to insulin resistance of pregnancy by up regulating β-cell mass and increasing insulin secretion. Previously, using a transgenic mouse with global, heterozygous deletion of prolactin receptor (Prlr+/-), we found Prlr signaling is important for this adaptation. However, since Prlr is expressed in tissues outside of islets as well as within islets and prolactin signaling affects β-cell development, to understand β-cell-specific effect of prolactin signaling in pregnancy, we generated a transgenic mouse with an inducible conditional deletion of Prlr from β-cells. Here, we found that β-cell-specific Prlr reduction in adult mice led to elevated blood glucose, lowed β-cell mass and blunted in vivo glucose-stimulated insulin secretion during pregnancy. When we compared gene expression profile of islets from transgenic mice with global (Prlr+/-) vs. β-cell-specific Prlr reduction (βPrlR+/-), we found 95 differentially expressed gene, most of them down regulated in the Prlr+/- mice in comparison to the βPrlR+/- mice, and many of these genes regulate apoptosis, synaptic vesicle function and neuronal development. Importantly, we found that islets from pregnant Prlr+/- mice are more vulnerable to glucolipotoxicity-induced apoptosis than islets from pregnant βPrlR+/- mice. These observations suggest that down regulation of prolactin action during pregnancy in non-β-cells secondarily and neg. affect β-cell gene expression, and increased β-cell susceptibility to external insults. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).SDS of cas: 2358-84-1

The Article related to pregnancy prolactin action beta cell adaptation, Placeholder for records without volume info and other aspects.SDS of cas: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 15, 2006, Tao, Haiyan; Peralta-Yahya, Pamela; Lin, Hening; Cornish, Virginia W. published an article.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the article was Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation. And the article contained the following:

Glycosynthases catalyze the formation of a glycosidic bond between a glycosyl fluoride donor substrate and a glycosyl acceptor substrate with high yield, thus providing a valuable approach for the synthesis of carbohydrates and glycoconjugates. Chem. complementation can be used to link glycosynthase activity to the transcription of a reporter gene in vivo, providing a selection for the directed evolution of glycosynthase enzymes with improved properties. In this approach, glycosynthase activity is detected as covalent coupling between a small mol. disaccharide acceptor substrate and a small mol. disaccharide α-fluoro donor substrate. Here the authors report the optimized design and synthesis of these small mol. substrates. These optimized substrates are shown to give a robust, glycosynthase-dependent transcriptional read-out in the chem. complementation assay. The full synthesis and characterization of these substrates are reported for the first time. These optimized chem. dimerizer substrates should allow the potential of chem. complementation for the directed evolution of glycosynthases with diverse substrate specificities and improved properties to be fully realized. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to glycosynthase substrate design preparation, Enzymes: Analysis (Determination-Detection) and other aspects.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 28, 2022, Orikasa, Isamu; Osada, Takuma; Inatomi, Yuko; Ueno, Ichiro; Suzuki, Shinsuke published an article.COA of Formula: C13H10O3 The title of the article was Natural convection induced by unintended horizontal temperature distribution in a narrow-closed container heated from above. And the article contained the following:

This study aims at expressing the velocity fields of the liquids held in a narrow-closed container heated from above as a function of the dimensions of the container to estimate the diffusion-dominant condition. The motions of tracer particles in liquid salol held in a quasi-two-dimensional glass cell were tracked in cavities of various inner width W through the series of experiments The mean velocity of the tracer particles, Vmean, decreased almost linearly with the decrease in the values of W. Thermal flow fields were successfully reproduced by the series of numerical simulations. We found that the unintended horizontal temperature difference is realized, which induces the natural convection in the closed narrow cavity heated from above. We derived the correlation between the Reynolds and Grashof numbers, which are described as a function of the mean velocity and the unintended horizontal temperature difference, resp. The threshold of the convection onset in the present geometry was then proposed. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).COA of Formula: C13H10O3

The Article related to container heat natural convection horizontal temperature distribution, Placeholder for records without volume info and other aspects.COA of Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Shilun; Li, Simeng; Chang, Junlei published an article in 2022, the title of the article was Discovery of Cobimetinib as a novel A-FABP inhibitor using machine learning and molecular docking-based virtual screening.Recommanded Product: Phenyl Salicylate And the article contains the following content:

Adipocyte fatty acid-binding protein (A-FABP, also called FABP4, aP2) is an adipokine identified as a critical regulator of metabolic function due to its dual functions of fatty acid transport and pro-inflammation. Because of the high therapeutic potential of A-FABP inhibition for the treatment of metabolic diseases and related vascular complications, numerous inhibitors have been developed against A-FABP. However, none of these inhibitors have been approved for use in patients due to severe side effects. Here, we used a virtual screening (VS) strategy to identify potential inhibitors of A-FABP in the latest FDA-approved drug library (∼2600 compounds), aiming to explore the existing drugs with proven safety profiles. We firstly combined ligand-based machine learning and structure-based mol. docking to develop a screening pipeline for identifying A-FABP inhibitors. The screening of FDA-approved drugs identified four compounds (Cobimetinib, Larotrectinib, Pantoprazole, and Vildagliptin) with the highest scores, whose inhibitory effects on A-FABP were further assessed in cellular assays. Among the selected compounds, Cobimetinib significantly inhibited the activation of the JNK/c-Jun signaling pathway by A-FABP in mouse macrophages without causing obvious cytotoxicity. In summary, we present an integrated VS pipeline for A-FABP inhibitor screening, and identified Cobimetinib as a novel A-FABP inhibitor that may be repurposed for the treatment of metabolic diseases and associated vascular complications. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: Phenyl Salicylate

The Article related to cobimetinib antimetabolic agent fabp4 drug target metabolic disease, Placeholder for records without volume info and other aspects.Recommanded Product: Phenyl Salicylate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2020, Li, Xuefeng; Chen, Lingying; Han, Weifang; Ge, Chunhua; Guan, Hongyu; Zhang, Rui; Zhang, Xiangdong published an article.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Preparation and Thermal Properties of Shape-stabilized Paraffin/ NPGDMA/BN Composite for Phase Change Energy Storage. And the article contained the following:

Paraffin, as an excellent phase change material (PCM), is limited by the leakage problem and low thermal conductivity In this research, a novel paraffin/neopentyl glycol dimethacrylate/boron nitride (paraffin/NPGDMA/BN) composite PCM was successfully prepared via a phys. mixing process. NPGDMA in paraffin/NPGDMA/BN composite PCM was cured by UV light under the action of photo initiator, which can improve the shape stability to avoid the leakage of paraffin in the process of phase change. By comparing the leakage rate, latent heat, and thermal conductivity, the optimal mass ratio of paraffin and NPGDMA was selected to be 7 : 3. It was showed that the presence of 5 wt% BN led to increasing in thermal conductivity by up to 59%. The microstructure of the composite PCMs was characterized by SEM, FTIR, and XRD. The composite PCMs can be processed into a variety of shapes by using molds. The paraffin/NPGDMA/BN composite PCM exhibited a significantly improved shape stability and large phase change enthalpy of 123.0 J/g. The leakage rate of paraffin/NPGDMA/BN was much improved after being soaked with petroleum ether. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to stabilized paraffin npgdma bn composite phase change energy storage, Placeholder for records without volume info and other aspects.Recommanded Product: 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kusumoto, Sotaro; Koga, Atsushi; Kobayashi, Fumiya; Ohtani, Ryo; Kim, Yang; Lindoy, Leonard F.; Hayami, Shinya; Nakamura, Masaaki published an article in 2019, the title of the article was Weak ferromagnetism derived from spin canting in an amido-bridged homochiral Mn(III) 1-D coordination polymer.Application of 118-55-8 And the article contains the following content:

A homochiral one-dimensional (1D) Mn(III) coordination polymer [MnL]n (1) was synthesized employing the N3O-donor tetradentate ligand (L = 2-hydroxy-N-[2-[[(2-aminophenyl)methylene]amino]-2-methylpropyl]-benzamide). The X-ray structure of 1 and its magnetic properties were investigated in detail. The crystal structure of 1 shows a homochiral helical arrangement in which spontaneous resolution has occurred, despite the ligand being achiral. Magnetic characterization revealed an antiferromagnetic interaction between manganese(III) ions (J = -2.48 cm-1, g = 1.96) that leads to an antiferromagnetic spin-ordering phase transition at TN ≈ 7 K. Noteworthily, 1 exhibits weak ferromagnetism with a relatively large coercive field of 3.0 kOe based on the spin canting, indicating the formation of a homochiral weak ferromagnet. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Application of 118-55-8

The Article related to polymer amido bridge manganese complex spin canting ferromagnetism, Placeholder for records without volume info and other aspects.Application of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chakraborty, Moubani; Haag, Stephanie L.; Bernards, Matthew T.; Waynant, Kristopher V. published an article in 2021, the title of the article was Synthesis of a zwitterionic N-Ser-Ser-C dimethacrylate cross-linker and evaluation in polyampholyte hydrogels.COA of Formula: C12H18O5 And the article contains the following content:

Polyampholyte hydrogels are attractive materials for tissue engineering scaffolds as they offer a wide variety of features including nonfouling, selective protein delivery, and tunable phys. characteristics. However, to improve the potential performance of these materials for in vivo applications, there is a need for a higher diversity of zwitterionic cross-linker species to replace commonly used ethylene glycol (EG) based chemistries. Toward this end, the synthesis of a dipeptide based zwitterionic cross-linker, N-Ser-Ser-C dimethacrylate (S-S) from N-Boc-L-serine is presented. The strategy utilized a convergent coupling of methacrylated serine partners followed by careful global deprotection to yield the zwitterionic cross-linker with good overall yields. This novel cross-linker was incorporated into a polyampholyte hydrogel and its phys. properties and biocompatibility were compared against a polyampholyte hydrogel synthesized with an EG-based cross-linker. The S-S cross-linked hydrogel demonstrated excellent nonfouling performance, while promoting enhanced cellular adhesion to fibrinogen delivered from the hydrogel. Therefore, the results suggest that the S-S cross-linker will demonstrate superior future performance for in vivo applications. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to polyampholyte hydrogel zwitterionic dimethacrylate cross linker, Placeholder for records without volume info and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics