Tag: 200-300

Lebrun, M. H.; Nicolas, L.; Boutar, M.; Gaudemer, F.; Ranomenjanahary, S.; Gaudemer, A. published an article in 1988, the title of the article was Relationships between the structure and the phytotoxicity of the fungal toxin tenuazonic acid.HPLC of Formula: 53838-27-0 And the article contains the following content:

Tenuazonic acid (I) is a metabolite produced by the fungal pathogen of rice Pyricularia oryzae. It inhibits growth of plants by interfering with protein synthesis at the ribosome level. I with substituents at C3 and C5 were prepared Substituents at C5 other than sec-Bu or Pr, decrease the phytotoxicity of the analogs. But substitutions at C-3 abolish the toxicity. Thus, I seems to have the optimal structure for phytotoxicity. I induces rice leaf defense reactions (browning) of reactive varieties which are resistant to P. oryzae. Some of the analogs synthesized have a low level of phytotoxicity and are able to induce this leaf browning of the reactive rice varieties. Thus different structural features are required for phytotoxicity and for leaf browning. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).HPLC of Formula: 53838-27-0

The Article related to phytotoxicity tenuazonic acid analog, leaf rice phytotoxicity tenuazonate analog, root rice phytotoxicity tenuazonate analog, Toxicology: Venoms, Toxins, and Poisons and other aspects.HPLC of Formula: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 16, 2021, Courant, Thibaut; Gavel, Marine; Renard, Romain M. Q.; Gandon, Vincent; Joosten, Antoine Y. P.; Lecourt, Thomas published an article.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Zirconium-Catalyzed Hydroalumination of C=O Bonds: Site-Selective De-O-acetylation of Peracetylated Compounds and Mechanistic Insights. And the article contained the following:

An unprecedented hydroalumination of C = O bonds catalyzed by zirconocene dichloride is reported herein and applied to the site-selective deprotection of peracetylated functional substrates. A mixed metal hydride, with 1:1 zirconium/aluminum stoichiometry, is also shown to be the reductive species. A catalytic cycle is finally proposed for this transformation with no precedent in the field of zirconium catalysis. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to peracetylated compound zirconium dibal deacetylation catalyst, alc preparation, Carbohydrates: Monosaccharides, Glycals and other aspects.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 19, 2021, Liu, Miao; Luo, Zhao-Xiang; Li, Tian; Xiong, De-Cai; Ye, Xin-Shan published an article.SDS of cas: 2873-29-2 The title of the article was Electrochemical Trifluoromethylation of Glycals. And the article contained the following:

Carbohydrates play essential roles in various physiol. and pathol. processes. Trifluoromethylated compounds have wide applications in the field of medicinal chem. Herein, we report a practical and efficient trifluoromethylation of glycals by an electrochem. approach using CF3SO2Na as the trifluoromethyl source and MnBr2 as the redox mediator. A variety of trifluoromethylated glycals bearing different protective groups are obtained in 60-90% yields with high regioselectivity. The successful capture of a CF3 radical indicates that a radical mechanism is involved in this reaction. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).SDS of cas: 2873-29-2

The Article related to protective group fluoromethylation glycal catalyst electrochem redox, Carbohydrates: Monosaccharides, Glycals and other aspects.SDS of cas: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2022, Patel, Monal; Bartom, Elizabeth T.; Paudel, Bidur; Kocherginsky, Masha; O’Shea, Kaitlyn L.; Murmann, Andrea E.; Peter, Marcus E. published an article.Product Details of 2358-84-1 The title of the article was Identification of the toxic 6mer seed consensus for human cancer cells. And the article contained the following:

6Mer seed toxicity is a novel cell death mechanism that kills cancer cells by triggering death induced by survival gene elimination (DISE). It is based on si- or shRNAs with a specific G-rich nucleotide composition in position 2-7 of their guide strand. An arrayed screen of 4096 6mer seeds on two human and two mouse cell lines identified G-rich 6mers as the most toxic seeds. We have now tested two addnl. cell lines, one human and one mouse, identifying the GGGGGC consensus as the most toxic average 6mer seed for human cancer cells while slightly less significant for mouse cancer cells. RNA Seq and bioinformatics analyses suggested that an siRNA containing the GGGGGC seed (siGGGGGC) is toxic to cancer cells by targeting GCCCCC seed matches located predominantly in the 3 UTR of a set of genes critical for cell survival. We have identified several genes targeted by this seed and demonstrate direct and specific targeting of GCCCCC seed matches, which is attenuated upon mutation of the GCCCCC seed matches in these 3 UTRs. Our data show that siGGGGGC kills cancer cells through its miRNA-like activity and points at artificial miRNAs, si- or shRNAs containing this seed as a potential new cancer therapeutics. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Product Details of 2358-84-1

The Article related to human cancer cell toxic 6mer seed mirna, Biochemical Genetics: Genomic Processes and other aspects.Product Details of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 16, 2021, Becher, M.; Koerber, Th.; Doess, A.; Hinze, G.; Gainaru, C.; Boehmer, R.; Vogel, M.; Roessler, E. A. published an article.Formula: C13H10O3 The title of the article was Nuclear Spin Relaxation in Viscous Liquids: Relaxation Stretching of Single-Particle Probes. And the article contained the following:

Spin-lattice relaxation rates R1(ω,T), probed via high-field and field-cycling NMR (NMR), are used to test the validity of frequency-temperature superposition (FTS) for the reorientation dynamics in viscous liquids For several liquids, FTS is found to apply so that master curves can be generated. The susceptibility spectra are highly similar to those obtained from depolarized light scattering (DLS) and reveal an excess wing. Where FTS works, two approaches are suggested to access the susceptibility: (i) a plot of deuteron R1(T) vs the spin-spin relaxation rate R2(T) and (ii) a plot of R1(T) vs an independently measured reference time τref(T). Using single-frequency scans, (i) allows one to extract the relaxation stretching as well as the NMR coupling constant Surveying 26 data sets, we find Kohlrausch functions with exponents 0.39 < βK ≤ 0.67. Plots of the spin-spin relaxation rate R2-rescaled by the NMR coupling constant-as a function of temperature allow one to test how well site-specific NMR relaxations couple to a given reference process. Upon cooling of flexible mol. liquids, the site-specific dynamics is found to merge, suggesting that near Tg the mols. reorient essentially as a rigid entity. This presents a possible resolution for the much lower stretching parameters reported here at high temperatures that contrast with the ones that were reported to be universal in a recent DLS study close to Tg. Our anal. underlines that deuteron relaxation is a uniquely powerful tool to probe single-particle reorientation. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Formula: C13H10O3

The Article related to viscous liquid nuclear spin lattice relaxation stretching kohlrausch function, Magnetic Phenomena: Nuclear Resonances and other aspects.Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hutchinson, Douglas K. published an article in 2016, the title of the article was Lanthanum(III) chloride, complex with lithium chloride, solution in tetrahydrofuran.Category: esters-buliding-blocks And the article contains the following content:

A review. Preparation, properties, availability, handling and applications of Lanthanum(III) chloride, complex with lithium chloride useful as an additive to reduce side reactions in the addition of lithium or Grignard reagents to carbonyl compounds were reviewed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to review lanthanum lithium chloride complex preparation property safety application, Inorganic Chemicals and Reactions: Reviews and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Komsta, Lukasz; Skibinski, Robert; Wrobel, Joanna; Gadowski, Sebastian; Skrzypiec, Karolina published an article in 2019, the title of the article was Experimental evaluation of solvent elution strength in reversed-phase TLC on medium polarity phases.HPLC of Formula: 118-55-8 And the article contains the following content:

Seven chromatog. grade solvents miscible with water (acetone, acetonitrile, dioxane, ethanol, isopropanol, methanol, tetrahydrofuran), as well as water itself were investigated in the context of their eluotropic strength in reversed-phase chromatog. on four medium-polar adsorbents (cellulose, CN, NH2 and DIOL). The test set for this research consisted of 35 model compounds A modern chemometric mixture design concept allowed to estimate each solvent effect sep. with a relatively small error (about 0.05 of RM value for all adsorbents). The solvent effects were analyzed chemometrically in multivariate manner and a final model was fitted to achieve the solvent strength. The estimation error was computed both from regression and bootstrap approach. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).HPLC of Formula: 118-55-8

The Article related to solvent elution strength adsorbent reversed phase thin layer chromatog, Organic Analytical Chemistry: Separations and other aspects.HPLC of Formula: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 28, 2018, Kamata, Ryo; Nakajima, Daisuke; Shiraishi, Fujio published an article.SDS of cas: 118-55-8 The title of the article was Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. And the article contained the following:

The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. The authors used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects. Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, di-Ph ethers, organochlorines, and organophosphates. The ten most potent compounds were 4-tert-octylphenol (4tOP; reference substance), 4-nonylphenol, diethylstilbestrol, benzyl Bu phthalate, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, o,p’-DDT, methoxychlor, di-Pr phthalate, hexestrol, and octachlorostyrene. The activities of these nine non-reference compounds exceeded 10% of the 4tOP activity. Anal. of para-monoalkyl phenols suggests that branching of the alkyl group and chlorination at the ortho position raises potency. This study provides critical information for identifying the potential of CAR-mediated toxic hazards and for understanding the relevant mechanism. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).SDS of cas: 118-55-8

The Article related to xenobiotic constitutive androstane receptor, alkyl phenol, bisphenol, constitutive androstane receptor, organochlorine, recombinant yeast, styrene dimer, Toxicology: Methods (Including Analysis) and other aspects.SDS of cas: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nedaei, Maryam; Zarei, Ali Reza; Ghorbanian, Sohrab Ali published an article in 2018, the title of the article was Development of a new emulsification microextraction method based on solidification of settled organic drop: application of a novel ultra-hydrophobic tailor-made deep eutectic solvent.Recommanded Product: 118-55-8 And the article contains the following content:

In this research, a new microextraction method based on the solidification of settled organic drop (SSOD) was developed by coupling a novel tailor-made ultra-hydrophobic deep eutectic solvent (DES) with effervescence assisted emulsification microextraction The deep eutectic solvent of salol/DL-menthol (1 : 1) was used as an extraction solvent in this study. It has a low melting/f.p., low viscosity, ultra-hydrophobicity and bio-compatibility. An effervescent tablet was prepared by mixing the DES and effervescence precursors. Generation of CO2 bubbles due to effervescence distributes the DES homogenously into an aqueous sample, which enhances the mass transfer for target analytes to extract into the fine DES droplets. After centrifugation of the cloudy solution at 20 °C, the settled solidified extractant was isolated from the aqueous solution simply by decanting the tube. Predominant exptl. variables affecting the extraction efficiency of explosives were evaluated. This method was coupled with high performance liquid chromatog.-ultra violet detection for the anal. of nitroarom. compounds Under the optimized conditions, the limits of detection achieved were in the range of 0.03-0.05 μg L-1. The enrichment factors were between 576 and 702 and the relative standard deviations were <10%. The anal. of eight nitroarom. pollutants in water samples gave acceptable recoveries ranging from 89 to 105%. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: 118-55-8

The Article related to emulsification microextraction solidification nitroarom detection water, explosive nitroarom detection water microextraction, Organic Analytical Chemistry: Detections and other aspects.Recommanded Product: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 21, 2020, Vetter, Natasha D.; Jagdhane, Rajendra C.; Richter, Brett J.; Palmer, David R. J. published an article.Application of 2873-29-2 The title of the article was Carbocyclic Substrate Analogues Reveal Kanosamine Biosynthesis Begins with the α-Anomer of Glucose 6-Phosphate. And the article contained the following:

NtdC is an NAD-dependent dehydrogenase that catalyzes the conversion of glucose 6-phosphate (G6P) to 3-oxo-glucose 6-phosphate (3oG6P), the first step in kanosamine biosynthesis in Bacillus subtilis and other closely-related bacteria. The NtdC-catalyzed reaction is unusual because 3oG6P undergoes rapid ring opening, resulting in a 1,3-dicarbonyl compound that is inherently unstable due to enolate formation. We have reported the steady-state kinetic behavior of NtdC, but many questions remain about the nature of this reaction, including whether it is the α-anomer, β-anomer, or open-chain form that is the substrate for the enzyme. Here, we report the synthesis of carbocyclic G6P analogs by two routes, one based upon the Ferrier II rearrangement to generate the carbocycle and one based upon a Claisen rearrangement. We were able to synthesize both pseudo-anomers of carbaglucose 6-phosphate (C6P) using the Ferrier approach, and activity assays revealed that the pseudo-α-anomer is a good substrate for NtdC, while the pseudo-β-anomer and the open-chain analog, sorbitol 6-phosphate (S6P), are not substrates. A more efficient synthesis of α-C6P was achieved using the Claisen rearrangement approach, which allowed for a thorough evaluation of the NtdC-catalyzed oxidation of α-C6P. The requirement for the α-anomer indicates that NtdC and NtdA, the subsequent enzyme in the pathway, have co-evolved to recognize the α-anomer in order to avoid mutarotation between enzymic steps. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application of 2873-29-2

The Article related to glucose 6phosphate dehydrogenase anomer bacillus kanosamine, Placeholder for records without volume info and other aspects.Application of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics