Tag: 200-300

On November 7, 1997, Plummer, Mark S.; Holland, Debra R.; Shahripour, Aurash; Lunney, Elizabeth A.; Fergus, James H.; Marks, James S.; McConnell, Patrick; Mueller, W. Thomas; Sawyer, Tomi K. published an article.Formula: C10H19NO4 The title of the article was Design, Synthesis, and Cocrystal Structure of a Nonpeptide Src SH2 Domain Ligand. And the article contained the following:

The specific association of an SH2 domain with a phosphotyrosine (pTyr)-containing sequence of another protein precipitates a cascade of intracellular mol. interactions (signals) which effect a wide range of intracellular processes. The nonreceptor tyrosine kinase Src, which has been associated with breast cancer and osteoporosis, contains an SH2 domain. Inhibition of Src SH2-phosphoprotein interactions by small mols. will aid biol. proof-of-concept studies which may lead to the development of novel therapeutic agents. Structure-based design efforts have focused on reducing the size and charge of Src SH2 ligands while increasing their ability to penetrate cells and reach the intracellular Src SH2 domain target. In this report we describe the synthesis, binding affinity, and Src SH2 cocrystal structure of a small, novel, nonpeptide, urea-containing SH2 domain ligand. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Formula: C10H19NO4

The Article related to src sh2 domain nonpeptide ligand preparation, Pharmacology: Structure-Activity and other aspects.Formula: C10H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Darbem, Mariana P.; Esteves, Henrique A.; de Oliveira, Isadora M.; Pimenta, Daniel C.; Stefani, Helio A. published an article in 2020, the title of the article was Palladium-Catalyzed Thio- and Selenocarbonylation of 2-Iodoglycals.SDS of cas: 2873-29-2 And the article contains the following content:

The carbonylative cross-coupling reactions of 2-iodoglycals with thiols and selenols in the presence of molybdenum hexacarbonyl as a solid source of carbon monoxide is described. This methodol. permitted the synthesis of 29 C2-glycosides bearing thioester and selenoester functionalities in moderate to excellent yields and high functional group tolerance. Moreover, this communication describes the first catalytic carbonylative coupling reaction of selenols with a carbon electrophile. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).SDS of cas: 2873-29-2

The Article related to glycoside thioester selenoester catalytic thiocarbonylation coupling monosaccharide, thiol iodoglycal cross coupling molybdenum hexacarbonyl carbon monoxide disaccharide, Carbohydrates: Oligosaccharides and other aspects.SDS of cas: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kelemen, Viktor; Bege, Miklos; Eszenyi, Daniel; Debreczeni, Nora; Benyei, Attila; Stuerzer, Tobias; Herczegh, Pal; Borbas, Aniko published an article in 2019, the title of the article was Stereoselective Thioconjugation by Photoinduced Thiol-ene Coupling Reactions of Hexo- and Pentopyranosyl D- and L-Glycals at Low-Temperature-Reactivity and Stereoselectivity Study.Electric Literature of 2873-29-2 And the article contains the following content:

A comprehensive optimization and mechanistic study on the photoinduced hydrothiolation of different D- and L- hexo- and pentoglycals with various thiols was performed, at the temperature range of RT to -120 °C. Addition of thiols onto 2-substituted hexoglycals proceeded with complete 1,2-cis-α-stereoselectivity in all cases. Hydrothiolation of 2-substituted pentoglycals resulted in mixtures of 1,2-cis-α- and -β-thioglycosides of varying ratio depending on the configuration of the reactants. Hydrothiolation of unsubstituted glycals at -80 °C proceeded with excellent yields and, except for galactal, provided the axially C2-S-linked isomers with high selectivity. Cooling was always beneficial to the efficacy, increased the yields and in most cases significantly raised the stereoselectivity. The suggested mechanism explains the different conformational preferences of the intermediate carbon-centered radicals, which is a crucial factor in the stereoselectivity of the reactions. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Electric Literature of 2873-29-2

The Article related to low temperature stereoselective photoinduced thiol ene coupling glycal thiol, glycal, photoactivation, stereoselective synthesis, thioglycoside, thiyl radical addition, Carbohydrates: Oligosaccharides and other aspects.Electric Literature of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2019, Dong, Youxian; Ding, Zekun; Guo, Hong; Zhou, Le; Jiang, Nan; Chen, Heshan; Qiu, Saifeng; Xu, Xiaoxia; Zhang, Jianbo published an article.Computed Properties of 2873-29-2 The title of the article was A Highly Efficient Magnetic Iron(III) Nanocatalyst for Ferrier Rearrangements. And the article contained the following:

A novel and highly efficient magnetic Fe 3O 4@C@Fe(III) core-shell catalyst, in which the carbon shell was prepared from lotus leaf, was fabricated. This nanocatalyst was successfully applied in the synthesis of a series of 2,3-unsaturated O-glycosides in excellent yields and with high selectivity, especially in the case of 2-halo O-glycosides, which differ in reactivity from nonsubstituted O-glycosides, but which have scarcely been explored before. Moreover, the catalyst could be easily separated from the reaction by the application of an external magnetic force and reused a min. of five times without any significant decrease in the yields of the products. In addition, the reaction proceeded readily on a gram scale, which provides a bright prospect for future applications. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Computed Properties of 2873-29-2

The Article related to magnetic iron carbon shell nanocatalyst green synthesis ferrier rearrangement, unsaturated glycoside preparation ferrier rearrangement glycal alc magnetic nanocatalyst, Carbohydrates: Oligosaccharides and other aspects.Computed Properties of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 22, 2020, Soares-Paulino, Antonio Augusto; Stefani, Helio A. published an article.Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Synthesis of Diverse C2-Glyco-Acyl Azides and -Ureas by Palladium-Catalyzed Carbonylation Coupling of 2-Iodoglycals. And the article contained the following:

Herein, we describe the synthesis of acyl azides and acyl urea glycals, a new class of C-2 branched glycoconjugates, employing Pd-catalyzed carbonylative coupling. A new strategy was developed to obtain acyl azides by carbonylative coupling between 2-iodo-glycals and NaN3 catalyzed by Pd(dba)2/Xantphos and carbon monoxide as a carbonyl source. Acyl azide glycals were used as synthetic intermediates in obtaining new acyl urea glycals via carbonylative coupling catalyzed by Pd(OAc)2 and 1,10-Phen. Different glycal substrates, including disaccharide-type, were studied, and various acyl azides and acyl ureas were prepared Reaction yields were moderate to high (31-99%) and reaction time varying from short to long (0.5-20 h). The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to iodoglycal coupling glycoconjugate urea glycal azide carbonylation catalyst disaccharide, solvent effect acyl azide urea synthesis palladium catalyzed carbonylation, Carbohydrates: Oligosaccharides and other aspects.Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 2, 2019, Mizia, J. Colin; Bennett, Clay S. published an article.SDS of cas: 2873-29-2 The title of the article was Reagent Controlled Direct Dehydrative Glycosylation with 2-Deoxy Sugars: Construction of the Saquayamycin Z Pentasaccharide. And the article contained the following:

The first synthesis of the pentasaccharide fragment of the angucycline antibiotic saquayamycin Z is described. By using our sulfonyl chloride mediated reagent controlled dehydrative glycosylation, we are able to assemble the glycosidic linkages with high levels of anomeric selectivity. The total synthesis was completed in 25 total steps, and in 2.5% overall yield with a longest linear sequence of 15 steps. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).SDS of cas: 2873-29-2

The Article related to stereoselective glycosylation catalyst oligosaccharide, dehydrative glycosylation deoxy sugar saquayamycin pentasaccharide preparation angucycline antibiotic, Carbohydrates: Oligosaccharides and other aspects.SDS of cas: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Antipchik, Mariia; Polyakov, Dmitry; Sinitsyna, Ekaterina; Dzhuzha, Apollinariia; Shavlovsky, Mikhail; Korzhikova-Vlakh, Evgenia; Tennikova, Tatiana published an article in 2020, the title of the article was Towards the development of a 3-D biochip for the detection of hepatitis C virus.Synthetic Route of 2358-84-1 And the article contains the following content:

The early diagnostics of hepatitis C virus (HCV) infections is currently one of the most highly demanded medical tasks. This study is devoted to the development of biochips (microarrays) that can be applied for the detection of HCV. The anal. platforms of suggested devices were based on macroporous poly(glycidyl methacrylate-co-di(ethylene glycol) dimethacrylate) monolithic material. The biochips were obtained by the covalent immobilization of specific probes spotted onto the surface of macroporous monolithic platforms. Using the developed biochips, different variants of bioassay were investigated. This study was carried out using hepatitis C virus-mimetic particles (VMPs) representing polymer nanoparticles with a size close to HCV and bearing surface virus antigen (E2 protein). At the first step, the main parameters of bioassay were optimized. Addnl., the dissociation constants were calculated for the pairs “ligand-receptor” and “antigen-antibody” formed at the surface of biochips. As a result of this study, the anal. of VMPs in model buffer solution and human blood plasma was carried out in a format of direct and “sandwich” approaches. It was found that bioassay efficacy appeared to be similar for both the model medium and real biol. fluid. Finally, limit of detection (LOD), limit of quantification (LOQ), spot-to-spot and biochip-to-biochip reproducibility for the developed systems were evaluated. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Synthetic Route of 2358-84-1

The Article related to biochip 3d gma degdma antigen antibody hepatitis c virus, biochips, hepatitis c, macroporous monolithic polymer layers, microarray, virus-mimetic particles, Biochemical Methods: Biological and other aspects.Synthetic Route of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 27, 2017, Frings, Marcus; Bolm, Carsten; Blum, Andreas; Gnamm, Christian published an article.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Sulfoximines from a Medicinal Chemist’s Perspective: Physicochemical and in vitro Parameters Relevant for Drug Discovery. And the article contained the following:

Sulfoximines, sulfondiimides and sulfonimidamides are fascinating but not yet fully explored variants of the common sulfone or sulfonamide motif. In this study, we report the physicochem. and in vitro properties of sulfoximines and compare them with related analogs and isosteres. Furthermore, we present a matched mol. pair anal. of compounds from drug discovery projects within Boehringer Ingelheim. We demonstrate that the sulfoximine moiety is a chem. stable, comparatively polar and weakly basic functional group, often leading to favorable aqueous solubility, permeability and metabolic stability. Moreover, their addnl. vectors at nitrogen enable simple chem. modifications and thus facilitate exploration and fine-tuning of the mol. properties. We conclude that sulfoximines and their congeners do not exhibit any intrinsic flaw but significantly enrich the toolbox of medicinal chemists. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to sulfoximine preparation physicochem property drug discovery, metabolic stability, permeability, solubility, sulfondiimides, sulfonimidamides, sulfoximines, synthesis, Pharmacology: Structure-Activity and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2020, Maciuszek, Magdalena; Pijanowski, Lukasz; Pekala-Safinska, Agnieszka; Verburg-van Kemenade, B. M. Lidy; Chadzinska, Magdalena published an article.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was 17β-Estradiol affects the innate immune response in common carp. And the article contained the following:

Abstract: Inflammation is the evolutionary conserved immune response to harmful stimuli such as pathogens or damaged cells. This multistep process acts by removing injurious stimuli and initiating the healing process. In the present work, we studied the immunoregulatory properties of 17β-estradiol (E2) in common carp. We determined the in vitro effects of E2 on the activity/polarization of macrophages and the in vivo effects during Aeromonas salmonicida-induced inflammation. In vitro, E2 reduced the lipopolysaccharide (LPS)-stimulated expression of pro- and anti-inflammatory mediator genes but did not change the gene expression of the estrogen receptors and of aromatase CYP19. In contrast, in vivo in the head kidney of A. salmonicida-infected fish, E2-treated feeding induced an upregulation of gene expression of pro-inflammatory (il-12p35 and cxcb2) and anti-inflammatory (arginase 1, arginase 2, il-10, and mmp9) mediators. Moreover, in infected fish fed with E2-treated food, a higher gene expression of the estrogen receptors and of the aromatase CYP19 was found. Our results demonstrate that estrogens can modulate the carp innate immune response, though the in vitro and in vivo effects of this hormone are contrasting. This implies that estradiol not only induces a direct effect on macrophages but rather exerts immunomodulatory actions through indirect mechanisms involving other cellular targets. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to innate immunity beta estradiol aeromonas infection cyprinus, bacterial infection, estrogens, fish, inflammation, macrophage polarization, Immunochemistry: Immunopathology and other aspects.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 15, 2019, Zeng, Xiaoming; Luo, Meiming; Zhang, Xue; Ling, Liang published a patent.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Method for synthesizing cis-trifluoromethyl cyclohexane derivative and heterocyclic compound by hydrogenation. And the patent contained the following:

The title method comprises adding trifluoromethyl arene or trifluoromethyl heterocyclic compound, cyclic (alkyl) (amino) carbene ruthenium complex catalyst and 4Å mol. sieve in organic solvent (n-hexane or 1,2-dichloroethane), introducing hydrogen gas, reacting under stirring at 40-60°C for 24 h, filtering, washing with dichloromethane, purifying by silica gel column chromatog. to obtain cis-trifluoromethyl cyclohexane derivative or cis-trifluoromethyl heterocyclic compound The invention has simple process, easily available raw material, mild reaction condition, wild application range and high selectivity. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to trifluoromethyl cis cycloalkane saturated heterocycle diastereoselective preparation, heteroarene arene cycloalkyl amino carbene rhodium catalyst dearomative reduction, Alicyclic Compounds: Cyclohexanes and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics