Tag: 200-300

On July 19, 2019, Verdelet, Tristan; Benmahdjoub, Sara; Benmerad, Belkacem; Alami, Mouad; Messaoudi, Samir published an article.Formula: C12H16O7 The title of the article was Copper-Catalyzed Anomeric O-Arylation of Carbohydrate Derivatives at Room Temperature. And the article contained the following:

Direct and practical anomeric O-arylation of sugar lactols with substituted arylboronic acids has been established. Using copper catalysis at room temperature under an air atm., the protocol proved to be general, and a variety of aryl O-glycosides have been prepared in good to excellent yields. Furthermore, this approach was extended successfully to unprotected carbohydrates, including α-mannose, and it was demonstrated here how the interaction between carbohydrates and boronic acids can be combined with copper catalysis to achieve selective anomeric O-arylation. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7

The Article related to aryl glycoside preparation anomeric arylation sugar lactol arylboronic acid, Carbohydrates: Oligosaccharides and other aspects.Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2019, Sau, Abhijit; Palo-Nieto, Carlos; Galan, M. Carmen published an article.Recommanded Product: 2873-29-2 The title of the article was Substrate-Controlled Direct α-Stereoselective Synthesis of Deoxyglycosides from Glycals Using B(C6F5)3 as Catalyst. And the article contained the following:

B(C6F5)3 enables the metal-free unprecedented substrate-controlled directαstereoselective synthesis of deoxyglycosides from glycals. 2,3-UnsaturatedαO-glycoside products are obtained with deactivated glycals at 75 degrees C in the presence of the catalyst, while 2-deoxyglycosides are formed using activated glycals that bear no leaving group at C-3 at lower temperatures The reaction proceeds in good to excellent yields via concomitant borane activation of glycal donor and nucleophile acceptor. The method is exemplified with the synthesis of a series of rare and biol. relevant oligosaccharide analogs. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Recommanded Product: 2873-29-2

The Article related to stereoselective glycosylation catalyst boron glycal disaccharide, Carbohydrates: Oligosaccharides and other aspects.Recommanded Product: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 3, 2020, Malinowski, Maciej; Thanh, Van Tran; de Robichon, Morgane; Lubin-Germain, Nadege; Ferry, Angelique published an article.Computed Properties of 2873-29-2 The title of the article was Mild Palladium-Catalyzed Cyanation of Unprotected 2-Iodoglycals in Aqueous Media as Versatile Tool to Access Diverse C2-Glyco-analogs. And the article contained the following:

Access to unprotected 2-cyano-glycals via a mild palladium-catalyzed cyanation of protecting groups-free 2-iodoglycals in aqueous media has been developed. Diverse glycal substrates including disaccharide-type were successfully obtained in good to excellent yields. These unprotected 2-cyano-glycal scaffolds were successfully derivatized to different C2-glyco-analogs. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Computed Properties of 2873-29-2

The Article related to palladium catalyzed cyanation iodoglycal glycal, Carbohydrates: Oligosaccharides and other aspects.Computed Properties of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 18, 2020, Roy, Arpita; Samanta, Subhendu; Singha, Koushik; Maity, Pritiprasanna; Kumari, Nimmy; Ghosh, Animesh; Dhara, Santanu; Pal, Sagar published an article.Formula: C12H18O5 The title of the article was Development of a Thermoresponsive Polymeric Composite Film Using Cross-Linked β-Cyclodextrin Embedded with Carbon Quantum Dots as a Transdermal Drug Carrier. And the article contained the following:

Polymeric nanocomposite films are used as promising transdermal drug carriers because of the improved patient compliance, easy application on skin, and noninvasiveness. A thermoresponsive polymeric composite film has been developed here through the deposition of carbon quantum dots (CQDs) on functionalized β-cyclodextrin (β-CD). The composite has been developed by grafting of poly(N-vinyl caprolactam) on β-CD, followed by crosslinking of diethylene glycol dimethacrylate and subsequent deposition of CQDs. CQDs have been prepared from waste pomegranate peels via a hydrothermal method. To enlighten the thermoresponsive nature of the composite film, lower critical solution temperature, as well as temperature-dependent swelling behavior, has been studied. The composite demonstrates excellent rheol. features. The developed polymeric composite film is nontoxic toward NIH 3T3 fibroblast cell lines. On the deposition of CQDs on the copolymer, the penetration power and fluorescent property have been improved, which help to track the cells in vitro. This film is worthy to be applied to the skin. It can efficiently load lidocaine hydrochloride monohydrate (LHM). In vitro and ex vivo skin permeation profiles reveal the sustained release behavior of loaded LHM at average skin temperature and pH. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Formula: C12H18O5

The Article related to field carbon quantum dot transdermal drug carrier polymer cyclodextrin, biocompatible, carbon quantum dots, composite film, cyclodextrin, drug delivery, hydrogel, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Besli, Nur Sena Okten; Orakdogen, Nermin published an article in 2021, the title of the article was One-shot preparation of polybasic ternary hybrid cryogels consisting of halloysite nanotubes and tertiary amine functional groups: an efficient and convenient way by freezing-induced gelation.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

A convenient method for the preparation of polybasic ternary hybrid cryogels consisting of Halloysite nanotubes (HNTs) and tertiary amine functional groups by freezing-induced gelation is proposed. Ternary hybrid gels were produced via one-shot radical terpolymn. of 2-hydroxyethyl methacrylate (HEMA), 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS), and DEAEMA in the presence of HNTs. The equilibrium swelling in various swelling media and the mech. properties of the produced ternary hybrid gels were analyzed to investigate their network structure and determine their final performance. The swelling ratio of HNT-free gels was significantly higher than the ternary hybrid gels composed of high amount of HNTs. The addition of HNTs to terpolymer network did not suppress pH- and temperature-sensitive behavior. While DEAEMA groups were effective for pH-sensitive swelling, it was determined that both HEMA and DEAEMA groups were effective in temperature-sensitive swelling. Ternary hybrid gels simultaneously demonstrated both neg. and pos. temperature-responsive swelling behavior. The swelling ratio changed considerably according to swelling temperature Both DEAEMA and HEMA monomers in terpolymer structure were dominant in temperature-sensitive swelling. Mech. tests in compression of both as-prepared and swollen-state demonstrated that strength and modulus of hybrid cryogels significantly increased with addition of HNTs without significant loss of mech. strength. Ultimately, the results of the current system can benefit characterization with anal. tools for the application of innovative materials. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to polybasic ternary hybrid cryogels halloysite nanotubes tertiary amine gelation, cryogel, elasticity, halloysite, hybrid, smart-responsive, swelling, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saito, Sayuri; Yamakoshi, Hiroyuki; Nakamura, Seiichi published an article in 2019, the title of the article was Second-generation synthesis of a chiral building block for oxygenated terpenoids via a ring-contractive coupling with a secondary alcohol.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate And the article contains the following content:

A much improved second-generation synthesis of a chiral building block, developed for the syntheses of C17-oxygenated steroids/triterpenoids e.g., cortisol and C9-oxygenated labdane diterpenoids (marrubiin and marrulibacetal), was accomplished by exploiting a ring-contractive coupling between an α-bromo-δ-valerolactone (3R)/(3S)-I and (R)-seudenol, wherein the use of t-BuOK as a base allowed clean conversion to the corresponding tetrahydrofuran-2-carboxylate (2S)/(2R)-II even with a small excess of the alc. component. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to terpenoid preparation, seudenol bromo valerolactone ring contraction coupling, Terpenes and Terpenoids: General and other aspects.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 11, 2010, Jarvis, Ashley; Allerston, Charles K.; Jia, Haiyan; Herzog, Birger; Garza-Garcia, Acely; Winfield, Natalie; Ellard, Katie; Aqil, Rehan; Lynch, Rosemary; Chapman, Chris; Hartzoulakis, Basil; Nally, James; Stewart, Mark; Cheng, Lili; Menon, Malini; Tickner, Michelle; Djordjevic, Snezana; Driscoll, Paul C.; Zachary, Ian; Selwood, David L. published an article.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the article was Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction. And the article contained the following:

We report the mol. design and synthesis of EG00229, 2, the first small mol. ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization of NRP1-ligand complexes by NMR spectroscopy and X-ray crystallog. Mutagenesis studies localized VEGF-A binding in the NRP1 b1 domain and a peptide fragment of VEGF-A was shown to bind at the same site by NMR, providing the basis for small mol. design. Compound 2 demonstrated inhibition of VEGF-A binding to NRP1 and attenuated VEGFR2 phosphorylation in endothelial cells. Inhibition of migration of endothelial cells was also observed The viability of A549 lung carcinoma cells was reduced by 2, and it increased the potency of the cytotoxic agents paclitaxel and 5-fluorouracil when given in combination. These studies provide the basis for design of specific small mol. inhibitors of ligand binding to NRP1. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to neuropilin vegf inhibitor design antitumor combination chemotherapy, Pharmacology: Structure-Activity and other aspects.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 18, 1996, Klein, Scott; Molino, Bruce F.; Czekaj, Mark; Dener, Jeffrey S.; Leadley, Robert J.; Sabatino, Ralph; Dunwiddie, Christopher T.; Chu, Valeria published an article.HPLC of Formula: 53838-27-0 The title of the article was Non-peptide fibrinogen receptor antagonists based upon a 4-substituted piperidine scaffold. And the article contained the following:

Structure-activity relationships developed from work with peptide based fibrinogen receptor antagonists have been successfully applied to the development of simple and highly potent nonpeptide agents of the same class. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).HPLC of Formula: 53838-27-0

The Article related to fibrinogen receptor antagonist trimethylene dipiperidine derivative, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 10, 2013, Betschart, Claudia; Hintermann, Samuel; Behnke, Dirk; Cotesta, Simona; Fendt, Markus; Gee, Christine E.; Jacobson, Laura H.; Laue, Grit; Ofner, Silvio; Chaudhari, Vinod; Badiger, Sangamesh; Pandit, Chetan; Wagner, Juergen; Hoyer, Daniel published an article.SDS of cas: 1198284-94-4 The title of the article was Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia. And the article contained the following:

Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, 1 (SB-649868), or suvorexant have shown promise for the treatment of insomnias and sleep disorders in several recent clin. trials in volunteers and primary insomnia patients. The relative contribution of antagonism of OX1R and OX2R for sleep induction is still a matter of debate. We therefore initiated a drug discovery project with the aim of creating both OX2R selective antagonists and DORAs. Here we report that the OX2R selective antagonist 26 induced sleep in mice primarily by increasing NREM sleep, whereas the DORA suvorexant induced sleep largely by increasing REM sleep. Thus, OX2R selective antagonists may also be beneficial for the treatment of insomnia. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).SDS of cas: 1198284-94-4

The Article related to preparation orexin receptor antagonist sleep insomnia, Pharmacology: Structure-Activity and other aspects.SDS of cas: 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 26, 2010, Huang, Adrian; Moretto, Alessandro; Janz, Kristin; Lowe, Michael; Bedard, Patricia W.; Tam, Steve; Di, Li; Clerin, Valerie; Sushkova, Natalia; Tchernychev, Boris; Tsao, Desiree H. H.; Keith, James C. Jr.; Shaw, Gray D.; Schaub, Robert G.; Wang, Qin; Kaila, Neelu published an article.Application of 141940-37-6 The title of the article was Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury. And the article contained the following:

Previously, we reported the discovery of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor. It is active in a variety of animal models of cardiovascular disease. Compound 1a has also been shown to be well tolerated and safe in healthy volunteers at doses of up to 1200 mg in a phase 1 single ascending dose study. However, its oral bioavailability was low. Our goal was to identify a back up compound with equal potency, increased solubility, and increased exposure. We expanded our structure-activity studies in this series by branching at the α position of the C-2 benzyl side chain and through modification of substituents on the carboxylic A-ring of the quinoline. This resulted in discovery of PSI-421 with marked improvement in aqueous solubility and pharmacokinetic properties. This compound has shown oral efficacy in animal models of arterial and venous injury and was selected as a preclin. development compound for potential treatment of such diseases as atherosclerosis and deep vein thrombosis. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application of 141940-37-6

The Article related to quinoline preparation p selectin inhibitor sar, Pharmacology: Structure-Activity and other aspects.Application of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics