Tag: 200-300

On September 3, 2020, Rojas, A. H.; Lafuente, L.; Echeverria, G. A.; Piro, O. E.; Vetere, V.; Ponzinibbio, A. published an article.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Synthesis and structure of novel iodinated N-glycosyl-sulfonamides through Aza-Ferrier reaction of 2-substituted glycals. And the article contained the following:

We obtained a series of novel N-(2-iodo-2,3-dideoxy-2-en-glycopyranosides)-sulfonamides via the Aza-Ferrier rearrangement of protected-2-iodoglycals in good yields and high stereoselectivity. Their structure and conformation features were determined by NMR. Moreover, we report here the first in detail structure anal. by X-ray diffraction techniques of a 2-iodo-pseudoglycal. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to iodinated glycosyl sulfonamide preparation aza ferrier rearrangement glycal, Carbohydrates: Glycosides and other aspects.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 7, 2019, Chen, Peiran; Ding, Yajun; Guo, Saisai; Zhang, Xiaoying published an article.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Ferrier Reaction: The first synthesis of 2,3-unsaturated seleno-glycosides by using alkyl(aryl) hydroselenides as the nucleophile and Hf(OTf)4 as the catalyst. And the article contained the following:

By using Hf(OTf)4 as the catalyst, a series of 2,3-unsaturated-Se-glucosides have been synthesized for the first time from tri-O-acetyl-D-glucal, 2,4,6-tri-O-benzyl-D-glucal, 3,4-di-O-acetyl-L-rhamnal and ((2R,3S)-3-acetoxy-2,3-dihydrofuran-2-yl) Me acetate with PhSeH or alkyl(aryl) hydroselenides as the nucleophile in good yield and high anomeric selectivity. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to stereoselective ferrier rearrangement selenoglycoside, Carbohydrates: Glycosides and other aspects.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 15, 2019, Vibha, C.; Lizymol, P. P. published an article.SDS of cas: 118-55-8 The title of the article was Synthesis and characterization of a novel radiopaque dimethacrylate zirconium containing pre-polymer for biomedical applications. And the article contained the following:

Novel radiopaque dimethacrylate zirconium containing pre-polymer [ZrR1] was synthesized using a simple single-pot modified sol gel method. The objective of the work is to check the feasibility of developing photocured polymeric composite composites [ZrR1Q] using the novel zirconium containing pre-polymer [ZrR1] and to investigate radiopacity and cytocompatibility of the composite. ZrR1Q exhibited cytocompatibility, comparable radiopacity with tooth structure and low polymerization shrinkage. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).SDS of cas: 118-55-8

The Article related to radiopaque dimethacrylate zirconium prepolymer biomedical technol, Pharmaceuticals: General and other aspects.SDS of cas: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 15, 2020, Zhou, Tingting; Wan, Guofeng; Kong, Xueping; Li, Bao; Wu, Lixin published an article.Computed Properties of 2358-84-1 The title of the article was Biocompatible Polymer Nanocomposites Integrating Magnetic Polyoxomolybdates for Enhanced MRI and On-Site Activated Photothermal Properties. And the article contained the following:

This work reports the ionic composition of a PEGylated and chem. crosslinked polyethyleneimine with a gadolinium-coordinated polyoxomolybdate cluster, K17[Gd(P2Mo17O61)2], via electrostatic interaction. The prepared composites form nanoobjects with an average size of �7 nm at dried state and maintain structural stability in aqueous solution While the biocompatibility on HeLa cells is demonstrated, the polymer-shielded multifunctional nanoplatform shows both the combined magnetic resonance imaging and redox-triggered photothermal conversion effect. As a contrast agent, the T1-weighed relaxivity reaches up to 22.77 mM-1 s-1. The photothermal conversion of the prepared composites can be aroused by yielding a broad near IR (NIR) adsorption through on-site reduction of the glutathione that is enriched in the tumor environment. The high efficiency �1.0% under the irradiation of 808 nm NIR laser illustrates a distinct treatment capability according to cell counting Kit-8 assay while the obvious inhibition for the growth of tumor cells is observed The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Computed Properties of 2358-84-1

The Article related to mri tumor nanocomposite polyoxomolybdate, mri, magnetic polyoxomolybdate, nanocomposites, photothermal effects, redox-activation, Pharmaceuticals: Other and other aspects.Computed Properties of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Akifuji, Chiaki; Iwasaki, Mio; Kawahara, Yuka; Sakurai, Chiho; Cheng, Yu-Shen; Imai, Takahiko; Nakagawa, Masato published an article.HPLC of Formula: 2358-84-1 The title of the article was MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains. And the article contained the following:

Human induced pluripotent stem cells (hiPSCs) can differentiate into cells of the three germ layers and are promising cell sources for regenerative medicine therapies. However, current protocols generate hiPSCs with low efficiency, and the generated iPSCs have variable differentiation capacity among different clones. Our previous study reported that MYC proteins (c-MYC and MYCL) are essential for reprogramming and germline transmission but that MYCL can generate hiPSC colonies more efficiently than c-MYC. The mol. underpinnings for the different reprogramming efficiencies between c-MYC and MYCL, however, are unknown. In this study, we found that MYC Box 0 (MB0) and MB2, two functional domains conserved in the MYC protein family, contribute to the phenotypic differences and promote hiPSC generation in MYCL-induced reprogramming. Proteome analyses suggested that in MYCL-induced reprogramming, cell adhesion-related cytoskeletal proteins are regulated by the MB0 domain, while the MB2 domain regulates RNA processes. These findings provide a mol. explanation for why MYCL has higher reprogramming efficiency than c-MYC. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1

The Article related to mycl ipsc colony formation myc box domain, Mammalian Biochemistry: Blood and other aspects.HPLC of Formula: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2020, Meng, Xin; Lian, Xujing; Li, Xiao; Ya, Qiang; Li, Tingshen; Zhang, Yongmin; Yang, Yang; Zhang, Yan published an article.HPLC of Formula: 2873-29-2 The title of the article was Synthesis of 2′-paclitaxel 2-deoxy-2-fluoro-glucopyranosyl carbonate for specific targeted delivery to cancer cells. And the article contained the following:

A novel 2-fluorodeoxyglucose conjugated derivative of paclitaxel was efficiently synthesized using a linker between 2′-OH of paclitaxel and C1-hydroxyl group of 2-fluorodeoxyglucose. In preparation of the prodrug, allyl carbonates were selected as the protective group and the efficient one-step removal of allyloxycarbonyl groups at the end of the synthesis using palladium chem. gave the target mol. in good yield. The prodrug not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also demonstrated enhanced cytotoxicity and selectivity for cancer cells and less toxicity toward normal HUVEC cells. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).HPLC of Formula: 2873-29-2

The Article related to paclitaxel deoxyfluoro glucopyranosyl carbonate preparation cancer prodrug delivery, chemotherapy, fluorodeoxyglucose, paclitaxel, prodrug, targeting drug delivery, Carbohydrates: Glycosides and other aspects.HPLC of Formula: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2019, Singh, Adesh Kumar; Venkatesh, Rapelly; Kandasamy, Jeyakumar published an article.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Palladium-Catalyzed One-Pot Stereospecific Synthesis of 2-Deoxy Aryl C-Glycosides from Glycals and Anilines in the Presence of tert -Butyl Nitrite. And the article contained the following:

The palladium-catalyzed one-pot synthesis of 2,3-deoxy-3-keto aryl C-glycosides is achieved from glycals and anilines in the presence of tert-Bu nitrite and aqueous HBF4 under mild conditions. This one-pot method stereospecifically provides α- and β-aryl glycosides (â‰?9:1 by NMR) in good yields at room temperature The configuration at the C-3 position in the glycal determines the anomeric selectivity (i.e., α or β) of the desired products. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to nitrite catalyst palladium stereoselective glycosylation preparation, stereoselective glycosylation aryl c glycoside preparation glycal aniline catalyst, Carbohydrates: Glycosides and other aspects.Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2021, Vieira Veloso, Rodinei; Shamim, Anwar; Lamarrey, Yann; Stefani, Helio A.; Mozer Sciani, Juliana published an article.Category: esters-buliding-blocks The title of the article was Antioxidant and anti-sickling activity of glucal-based triazoles compounds – An in vitro and in silico study. And the article contained the following:

The sickle cell disease (SCD) has a genetic cause, characterized by a replacement of glutamic acid to valine in the β-chain of Hb. The disease has no effective treatment so far, and patients suffer a range from acute to chronic complications that include chronic hemolytic anemia, vaso-occlusive ischemia, pain, acute thoracic syndrome, cerebrovascular accident, nephropathy, osteonecrosis and reduced lifetime. The oxidation in certain regions of the Hb favors the reactive oxygen species (ROS) formation, which is the cause of many clin. manifestations. Antioxidants have been studied to reduce the Hb ROS levels, and in this sense, we have searched for new antioxidants glucal-based triazoles compounds with anti-sickling activity. Thirty analogs were synthesized and tested in in vitro antioxidant assays. Two of them were selected based in their effects and concentration-response activity and conducted to in cell assays. Both mols. did not cause any hemolysis and could reduce the red blood cell damage caused by hydrogen peroxide, in a model of oxidative stress induction that mimics the SCD. Moreover, one mol. I, besides reducing the hemolysis, was able to prevent the cell damage caused by the hydrogen peroxide. Later on, by in silico pharmacokinetics anal., we could see that I has appropriated properties for druggability and the probable mechanism of action is the binding to Peroxiredoxin-5, an antioxidant enzyme that reduces the hydrogen peroxide levels, verified after mol. docking assays. Thus, starting from 30 glucal-based triazoles mols. in a structure-activity relationship, we could select one with antioxidant properties that could act on RBC to reduce the oxidative stress, being useful for the treatment of SCD. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Category: esters-buliding-blocks

The Article related to glucal triazole preparation pharmacokinetics mol docking antioxidant antisickling, antioxidant, glucal-based triazoles compounds, sickle cell disease, Carbohydrates: Glycosides and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lebedel, Ludivine; Arda, Ana; Martin, Amelie; Desire, Jerome; Mingot, Agnes; Aufiero, Marialuisa; Aiguabella Font, Nuria; Gilmour, Ryan; Jimenez-Barbero, Jesus; Bleriot, Yves; Thibaudeau, Sebastien published an article in 2019, the title of the article was Structural and Computational Analysis of 2-Halogeno-Glycosyl Cations in the Presence of a Superacid: An Expansive Platform.COA of Formula: C12H16O7 And the article contains the following content:

An expansive NMR-based structural anal. of elusive glycosyl cations derived from natural and non-natural monosaccharides in superacids is disclosed. For the first time, it has been possible to explore the consequence of deoxygenation and halogen substitution at the C2 position in a series of 2-halogenoglucosyl, galactosyl, and mannosyl donors in the condensed phase. These cationic intermediates were characterized using low-temperature in situ NMR experiments supported by DFT calculations The 2-bromo derivatives display intramol. stabilization of the glycosyl cations. Introducing a strongly electron-withdrawing fluorine atom at C2 exerts considerable influence on the oxocarbenium ion reactivity. In a superacid, these oxocarbenium ions are quenched by weakly coordinating SbF6- anions, thereby demonstrating their highly electrophilic character and their propensity to interact with poor nucleophiles. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).COA of Formula: C12H16O7

The Article related to nmr dft conformational analysis haloglycosyl cation superacid, conformation analysis, fluorine, glycosylation, reaction mechanisms, superacids, Carbohydrates: Glycosides and other aspects.COA of Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2019, de Robichon, Morgane; Bordessa, Andrea; Lubin-Germain, Nadege; Ferry, Angelique published an article.Related Products of 2873-29-2 The title of the article was “CO” as a Carbon Bridge to Build Complex C2-Branched Glycosides Using a Palladium-Catalyzed Carbonylative Suzuki-Miyaura Reaction from 2-Iodoglycals. And the article contained the following:

Development of a palladium-catalyzed carbonylative Suzuki-Miyaura coupling reaction between 2-iodoglycal partners and diverse aryl- and alkenyl-boronic acids is presented, leading to original 2-ketoglycals. The newly formed carbonyl link could be exploited to access 2-aryl/alkenyl-methylene-α-glucopyranoside scaffolds via a three-step sequence including an indium-mediated Ferrier-type reaction. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to indium catalyst ferrier suzuki miyaura glycoside preparation, palladium catalyzed carbonylative suzuki miyaura iodoglycal glycoside ketoglycal, Carbohydrates: Glycosides and other aspects.Related Products of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics