Tag: 200-300

Formula: C12H15ClN2O2In 2020 ,《A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics》 was published in Tetrahedron Letters. The article was written by Yu, Tsz Tin; Bhadbhade, Mohan; Kuppusamy, Rajesh; Black, David St. C.; Kumar, Naresh. The article contains the following contents:

A series of meta- and para-terphenylglyoxamide peptidomimetics have been synthesized by the ring-opening of 5-(biphenylyl)-N-acylisatins with alcs., amines and amino acid Me esters. The starting 5-(biphenylyl)isatins were synthesized via the Suzuki-Miyaura coupling reaction in a convenient and efficient manner. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Formula: C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Formula: C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of tert-Butyl (5-aminopentyl)carbamateIn 2019 ,《Pd/TiO2-Photocatalyzed Self-Condensation of Primary Amines To Afford Secondary Amines at Ambient Temperature》 was published in Organic Letters. The article was written by Wang, Lyu-Ming; Kobayashi, Kensuke; Arisawa, Mitsuhiro; Saito, Susumu; Naka, Hiroshi. The article contains the following contents:

Sym. secondary amines were synthesized by the self-condensation of primary amines over a palladium-loaded titanium dioxide (Pd/TiO2) photocatalyst. The reactions afforded a series of secondary amines in moderate to excellent isolated yields at ambient temperature (30 °C, in cyclopentyl Me ether). Applicability for one-pot pharmaceutical synthesis was demonstrated by a photocatalytic reaction sequence of self-condensation of an amine followed by N-alkylation of the resulting secondary amine with an alc. After reading the article, we found that the author used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Reference of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Reference of tert-Butyl (5-aminopentyl)carbamate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of tert-Butyl (5-aminopentyl)carbamateIn 2018 ,《Design, synthesis and antileukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Zhang, Li; Chen, Yantao; Liu, Na; Li, Linjuan; Xiao, Senhao; Li, Xiaoliu; Chen, Kaixian; Luo, Cheng; Chen, Shijie; Chen, Hua. The article conveys some information:

A series of novel pyrimidylaminoquinoline derivatives 8(a-i) and 9(a-i) containing amino side chain, and the bisaminoquinoline analogs 3(b-e) have been designed and synthesized by structural modifications on a lead DOT1L inhibitor, 3a. All the compounds have been evaluated for their DOT1L inhibitory activities. The results showed that most of the compounds have strong anti DOT1L activities. Compounds 3e, 8h and 9e are the most potential ones from each category with the IC50 values of 1.06±0.35μM, 5.72±1.56μM and 3.55±1.28μM, resp. Such inhibitors expressed significant binding interactions with DOT1L by surface plasmon resonance (SPR)-based binding assay. The results of mol. docking experiments suggested that they could occupy the SAM binding pocket of DOT1L. Compounds 8h and 9e exhibited better inhibitory activities but poor selectivities against the both MLL-rearranged MV4-11 cells and the non MLL-rearranged Kasumi-1 cells than those of 3a and 3e, which suggested that the introduction of the amino side chain would be beneficial for their anti leukemia cells proliferation activities, possibly due to the improvement of the fat solubility Addnl., the direct cellular inhibition activities were found that compound 9e could effectively down-regulate both the level of H3k79 methylation and MLL-rearranged leukemia gene expression of Hoxa9 and Meis1 in MV4-11 in the qRT-PCR and western blot studies. These observations suggested DOT1L was one of the potential targets but perhaps not the most pivotal one for these compounds, which made their poor selectivities against leukemia cells proliferation. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Reference of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Reference of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,White, Dawanna S.; Mongeluzi, Daniel; Curry, Alyson M.; Donu, Dickson; Cen, Yana published an article in RSC Advances. The title of the article was 《Facile synthesis of photoactivatable adenosine analogs》.Recommanded Product: N-Boc-1,6-Diaminohexane The author mentioned the following in the article:

Adenosine and its derivatives are important building blocks of the biol. system. They serve as the universal energy currency, amplify intracellular signals for various signal transduction pathways, and can also be used as the co-substrates for enzymic transformations. The synthesis and regulation of adenosine and its analogs rely on the adenosine binding proteins (ABPs). Dysregulated ABP activity contributes to numerous diseases such as cancer, metabolic disorders, and neurodegenerative diseases. Presently, there is intense interest in targeting ABPs for therapeutic purposes. A large fraction of the human ABP family remains poorly characterized. The need for innovative chem. probes to investigate ABP function in the native biol. matrix is apparent. In this study, an adenosine analog, probe 1, with a photoaffinity group and biotin tag was synthesized using concise synthetic strategies. This probe was able to label and capture individual recombinant ABPs with good target selectivity. Probe 1 was also evaluated for its ability to label spiked ABP in complex cell lysates. This chem. probe, together with the labeling and enrichment assay, is of great value to interrogate the biol. functions of ABPs and to elucidate their diversity under different physiol. conditions. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRecommanded Product: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Catalytic dehydrative peptide synthesis with gem-diboronic acids》 was written by Michigami, Kenichi; Sakaguchi, Tatsuhiko; Takemoto, Yoshiji. Product Details of 7524-52-9 And the article was included in ACS Catalysis in 2020. The article conveys some information:

Alkane-gem-diboronic acids have emerged as versatile organoboron catalysts for dehydrative amidation of α-amino acids. A phenol-substituted multiboron catalyst with a B-C-B structure outperformed simple arylboronic acids in the condensation of α-amino acids with suppressed epimerization of electrophiles. gem-diboronic acid catalysis were compatible with various O, N, and S-functionalized α-amino acids bearing N-protecting groups including common carbamates used in peptide synthesis (Boc, Cbz, Fmoc). Gem-Diboronic acid catalysis were compatible with various O, N, and S-functionalized α-amino acids bearing N-protecting groups including common carbamates used in peptide synthesis (Boc, Cbz, Fmoc). N-trifluoroacetyl protection enabled an unprecedented catalytic dehydrative peptide synthesis at room temperature Preliminary mechanistic studies revealed carboxylate-binding nature of gem-diboronic acids, orthogonal to the activation of carboxylic acids by arylboronic acids. The distinctive reactivity of the gem-diboronic acids would open prospects for mild catalytic peptide condensation. The experimental part of the paper was very detailed, including the reaction process of H-Trp-OMe.HCl(cas: 7524-52-9Product Details of 7524-52-9)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Product Details of 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors》 was published in Scientific Reports in 2020. These research results belong to Ramzy, Lydia; Metwally, Abdelkader A.; Nasr, Maha; Awad, Gehanne A. S.. Application of 51857-17-1 The article mentions the following:

The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanopptn. technique using Eudragit S100 as polymeric shell. Conjugation of anisamide as a targeting ligand for sigma receptors overexpressed by colon cancer cells to Eudragit S100 was carried out via carbodiimide coupling reaction, and was confirmed by thin layer chromatog. and 1H-NMR. TQ nanocapsules were characterized for particle size, surface morphol., zeta potential, entrapment efficiency % (EE%), in vitro drug release and phys. stability. A cytotoxicity study on three colon cancer cell lines (HT-29, HCT-116, Caco-2) was performed. Results revealed that the polymeric nanocapsules were successfully prepared, and the in vitro characterization showed a suitable size, zeta potential, EE% and phys. stability. TQ exhibited a delayed release pattern from the nanocapsules in vitro. Anisamide-targeted TQ nanocapsules showed higher cytotoxicity against HT-29 cells overexpressing sigma receptors compared to their non-targeted counterparts and free TQ after incubation for 48 h, hence delineating anisamide as a promising ligand for active colon cancer targeting. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Application of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2018,Iwashita, Hidefumi; Sakurai, Hajime Tajima; Nagahora, Noriyoshi; Ishiyama, Munetaka; Shioji, Kosei; Sasamoto, Kazumi; Okuma, Kentaro; Shimizu, Shigeomi; Ueno, Yuichiro published 《Small fluorescent molecules for monitoring autophagic flux》.FEBS Letters published the findings.SDS of cas: 51644-96-3 The information in the text is summarized as follows:

We have developed two types of fluorescent probes, DALGreen and DAPGreen, for monitoring autophagy, that exhibit fluorescence upon being incorporated into autophagosomes. DALGreen enhances its fluorescence at acidic pH, which is favorable for monitoring late-phase autophagy, whereas DAPGreen remains fluorescent with almost constant brightness during the autophagic process. With these probes that stain autophagosomes as they are being formed, the real-time change of autophagic phenomena of live cells may be traced, which is an advantage over conventional approaches with small mols. that stain mature autophagosomes. The use of both dyes allows monitoring of the membrane dynamics of autophagy in any type of cell without the need for genetic engineering, and therefore, will be useful as a tool to study autophagic phenomena.tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3SDS of cas: 51644-96-3) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).SDS of cas: 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Salome, Christophe; Kohn, Harold published an article on January 10 ,2009. The article was titled 《Triphenylphosphine dibromide: a simple one-pot esterification reagent》, and you may find the article in Tetrahedron.Recommanded Product: 59410-82-1 The information in the text is summarized as follows:

We report a one-pot, expedient protocol for the conversion of carboxylic acids to their esters using excess triphenylphosphine dibromide, base, and the alc. The reaction gave the esterified product in moderate-to-high yields (30-95%). For chiral acids, the reaction proceeded with little or no racemization. Use of a chiral alc. in this transformation gave the ester with retention of configuration of the stereogenic center. Information is presented indicating that esterification proceeds through the intermediate generation of an acyloxyalkoxyphosphorane and where steric interactions play an important role in the energetics of the reaction.H-Phg-OEt.HCl(cas: 59410-82-1Recommanded Product: 59410-82-1) was used in this study.

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Recommanded Product: 59410-82-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Issa-Issa, Hanan; Guclu, Gamze; Noguera-Artiaga, Luis; Lopez-Lluch, David; Poveda, Rafael; Kelebek, Hasim; Selli, Serkan; Carbonell-Barrachina, Angel A. published an article in Food Chemistry. The title of the article was 《Aroma-active compounds, sensory profile, and phenolic composition of Fondilloń》.Safety of Diethyl 2-hydroxypentanedioate The author mentioned the following in the article:

The Fondilloń is a wine made from overripe grapes of the Monastrell variety, which is characterized by a high alc. content and a min. barrel ageing of 10 years. The objective of this study was to analyze the Fondilloń volatile composition, key aroma-active compounds, sensory profile and phenolic composition Fifty-four volatile compounds were identified, quantified and classified as alcs., esters, acids, aldehydes, lactones, phenols, hydrocarbons and ketone. From these compounds, 22 aroma-active compounds were identified, with phenylethyl alc., di-Et succinate and Et lactate having the highest flavor dilution factor. The Fondilloń wines were characterized by having high intensity of alc., fruity and toasted odor and flavor notes, and long aftertaste. Besides, 25 phenolic compounds were also identified and quantified; the phenolic acids (gallic, protocatechuic and syringic acids) were the predominant phenolic compounds The experimental process involved the reaction of Diethyl 2-hydroxypentanedioate(cas: 69134-53-8Safety of Diethyl 2-hydroxypentanedioate)

Diethyl 2-hydroxypentanedioate(cas: 69134-53-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Safety of Diethyl 2-hydroxypentanedioate Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Process improvement on the synthesis of 1-benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine》 was written by Wang, Xian-xun; Zhou, Guo-chuan. Product Details of 1000577-78-5 And the article was included in Hecheng Huaxue on April 30 ,2009. The article conveys some information:

1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine in total yield of 22.9% was synthesized by the reaction of ring-opening, cyclization, substitution, reduction and debenzylation from benzylamine and epichlorohydrin. The structure was determined by 1H NMR, 13C NMR and MS. After reading the article, we found that the author used tert-Butyl (1-benzylazetidin-3-yl)carbamate(cas: 1000577-78-5Product Details of 1000577-78-5)

tert-Butyl (1-benzylazetidin-3-yl)carbamate(cas:1000577-78-5) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 1000577-78-5 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics