Tag: 200-300

Qin, Nan; Peng, Li-Yuan; Jin, Mei-Na; Wu, Xiao-Ran; Jia, Miao; Gan, Chun-Chun; Zhu, Wen; Zhang, Pan; Liu, Xin-Qi; Duan, Hong-Quan published an article in 2022. The article was titled 《Target identification of anti-diabetic and anti-obesity flavonoid derivative (Fla-CN)》, and you may find the article in Bioorganic Chemistry.HPLC of Formula: 51644-96-3 The information in the text is summarized as follows:

Fla-CN is a flavonoid derivative with anti-diabetic and anti-obesity effects; however, its biol. targets are still unknown. In this study, we developed bifunctional affinity-based probes to identify the direct targets of Fla-CN. When using probe 3, we observed the co-location of probe 3 and mitochondria in both HepG2 and 3T3-L1 cells. The putative target proteomes were obtained using activity-based protein profiling (ABPP) and photo-affinity labeling. Pyruvate carboxylase, mitochondrial malate dehydrogenase, mitochondrial complex I, and F1FO-ATPase were validated as the direct targets of Fla-CN by surface plasmon resonance (SPR) and biochem. assays. It was elucidated that the Tyr651, Gln870 and Lys912 were the key amino acid residues near the binding site of pyruvate carboxylase with Fla-CN. The direct interaction of Fla-CN and the above four targets allowed elucidation of its complicated mol. mechanism, including the activation of adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK), and the inhibition of gluconeogenesis. Further investigation for activation of AMPK in normal and insulin resistance (IR) HepG2 cells, indicated that Fla-CN could target insulin resistance tissues. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3HPLC of Formula: 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).HPLC of Formula: 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brisdon, Brian J.; England, Richard; Reza, Khalid; Sainsbury, Malcolm published an article on January 29 ,1993. The article was titled 《Monofunctional chiral crowns. Part 1》, and you may find the article in Tetrahedron.Product Details of 59410-82-1 The information in the text is summarized as follows:

A siloxane oligomer bearing a chiral crown with high affinity for α-amino acids has been synthesized. The host is a modified form of a coronand first prepared by Cram, in which two 1,1′-binaphthol systems are linked through the oxygen atoms at the 2,2′-positions to form a 22-membered ring system containing six ether oxygen atoms attached to each other by four ethylene units. This was selectively mono-alkenylated to form an undec-10-en-1-yl derivative, which was bonded to linear siloxanes [HSiMe2O(SiMe2O)nSiMe2H] and [Me3SiO(Me2SiO)x(MeHSiO)ySiMe3] with total chain lengths of ca. 4 and 200 Si atoms resp., via a Pt catalyzed hydrosilylation reaction. The results came from multiple reactions, including the reaction of H-Phg-OEt.HCl(cas: 59410-82-1Product Details of 59410-82-1)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 59410-82-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 4522-93-4On March 7, 2016, Hu, Ji-Yun; Zhang, Jing; Wang, Gao-Xiang; Sun, Hao-Ling; Zhang, Jun-Long published an article in Inorganic Chemistry. The article was 《Constructing a Catalytic Cycle for C-F to C-X (X = O, S, N) Bond Transformation Based on Gold-Mediated Ligand Nucleophilic Attack》. The article mentions the following:

A tricoordinated gold(I) chloride complex, tBuXantphosAuCl, supported by a sterically bulky 9,9-dimethyl-4,5-bis(di-tert-butylphosphino)xanthene ligand (tBuXantphos) was synthesized. This complex features a remarkably longer Au-Cl bond length [2.632(1) Å] than bicoordinated linear gold complexes (2.27-2.30 Å) and tricoordinated XantphosAuCl [2.462(1) Å]. Single-crystal x-ray diffraction anal. of a cocrystal of tBuXantphosAuCl and pentafluoronitrobenzene (PFNB) and UV-visible spectroscopic titration experiments revealed the existence of an anion-π interaction between the Cl anion ligand and PFNB. Stoichiometric reaction between PFNB and tBuXantphosAuOtBu, after replacement of Cl by a more nucleophilic tBuO anion ligand, showed higher reactivity and para selectivity in the transformation of C-F to C-OtBu bond, distinctively different from that when only KOtBu was used (ortho selectivity) under the identical condition. Mechanistic studies including d. functional theory calculations suggested a gold-mediated nucleophilic ligand attack of the C-F bond pathway via an SNAr process. On the basis of these results, using trimethylsilyl derivatives TMS-X (X = OMe, SEt, NEt2) as the nucleophilic ligand source and the fluorine acceptor, catalytic transformation of the C-F bond of aromatic substrates to the C-X (X = O, S, N) bond was achieved with tBuXantphosAuCl as the catalyst (up to 20 turnover numbers). In the experiment, the researchers used many compounds, for example, Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Product Details of 4522-93-4)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Product Details of 4522-93-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C15H12O3On March 31, 1998, Blettner, Carsten G.; Koenig, Wilfried A.; Stenzel, Wolfgang; Schotten, Theo published an article in Synlett. The article was 《Poly(ethylene glycol)-supported liquid-phase synthesis of biaryls》. The article mentions the following:

The liquid-phase synthesis of biaryls via Suzuki cross-coupling reaction on poly(ethylene glycol) supports (PEGs) is described. The reaction is exemplified by parallel coupling of polymer-bound aryl halides with boronic acids. Four different PEGs were employed as soluble polymer supports for parallel synthesis. The generated libraries include both sterically hindered aryl halides and boronic acids. The reactions were run in the homogeneous phase and the synthetic sequences performed in parallel fashion. Quant. conversion in the Suzuki couplings was verified by 1H NMR. The polymer-bound products were isolated in 52-98% yield by either simple precipitation of the soluble support or column filtration.Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Electric Literature of C15H12O3) was used in this study.

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Electric Literature of C15H12O3 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of N-Boc-1,6-DiaminohexaneIn 2020 ,《One-pot thiol-amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation》 was published in Chemical Science. The article was written by Wall, Archie; Wills, Alfie G.; Forte, Nafsika; Bahou, Calise; Bonin, Lisa; Nicholls, Karl; Ma, Michelle T.; Chudasama, Vijay; Baker, James R.. The article contains the following contents:

Maleimide chem. is widely used in the site-selective modification of proteins. However, hydrolysis of the resultant thiosuccinimides is required to provide robust stability to the bioconjugates. Herein, we present an alternative approach that affords simultaneous stabilization and dual functionalisation in a one pot fashion. By consecutive conjugation of a thiol and an amine to dibromomaleimides, we show that aminothiomaleimides can be generated extremely efficiently. Furthermore, the amine serves to deactivate the electrophilicity of the maleimide, precluding further reactivity and hence generating stable conjugates. We have applied this conjugation strategy to peptides and proteins to generate stabilized trifunctional conjugates. We propose that this stabilization-dual modification strategy could have widespread use in the generation of diverse conjugates. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Quality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Targeted degradation of CD147 proteins in melanoma》 was published in Bioorganic Chemistry in 2020. These research results belong to Zhou, Zhe; Long, Jing; Wang, Yuan; Li, Ya Yun; Zhang, Xu; Tang, Ling; Chang, Qi; Chen, Zhuo; Hu, Gao Yun; Hu, Shuo; Li, Qian Bin; Peng, Cong; Chen, Xiang. Formula: C11H24N2O2 The article mentions the following:

CD147 is a transmembrane glycoprotein and a member of Ig superfamily, is strongly expressed in melanoma cells. CD147 has a pivotal role in tumor development. Therefore, it is a potential drug target for melanoma. In this article, we report the discovery of the first CD147 protein proteolysis targeting chimeras (PROTACs) derived from the natural product pseudolaric acid B (PAB). The representative compound 6a (I) effectively induced degradation of CD147 and inhibited melanoma cells in vitro and in vivo. 6A could be used as the novel type of anticancer agent or as a part of the mol. biol. research toolkit used in the gain-of-function study of the dynamic roles of CD147 in cancer networks. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Formula: C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Formula: C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Enhancement of the chiroptical response of α-amino acids via N-substitution for molecular structure determination using vibrational circular dichroism》 was published in Chirality in 2020. These research results belong to Polavarapu, Prasad L.; Santoro, Ernesto; Covington, Cody L.; Raghavan, Vijay. Product Details of 7524-52-9 The article mentions the following:

The chiroptical response in the form of vibrational CD (VCD) in the midinfrared region is found to be enhanced when a hydrogen of amino group of L-tryptophan is substituted with acetyl, acryloyl, or maleyl group. The order of preference for VCD enhancement is found to be acryloyl > acetyl > maleyl group. The resulting exptl. VCD spectra are also found to be satisfactorily reproduced by the quantum mech. (QM) predicted spectra. The QM predicted spectra were simulated using the conformer populations, (a) predicted by Gibbs energies and (b) optimized to maximize the similarity between exptl. and predicted VCD spectra. It is found that the conformer populations predicted by Gibbs energies do not yield the maximum possible similarity between exptl. and the QM predicted spectra. This work identifies the N-substitution of α-amino acids and determining the conformer populations that best reproduce the exptl. spectra as two new approaches for mol. structure determination The experimental process involved the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Product Details of 7524-52-9)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Product Details of 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Okayama, Toru; Burritt, Andrew; Hruby, Victor J. published an article in Organic Letters. The title of the article was 《4-Alkoxy-2-hydroxybenzaldehyde (AHB): A Versatile Aldehyde Linker for Solid-Phase Synthesis of C-Terminal Modified Peptides and Peptidomimetics》.Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate The author mentioned the following in the article:

A new and versatile 4-alkoxy-2-hydroxybenzaldehyde (AHB) linker for solid-phase syntheses is described. Acylation of the polymer-bound secondary amine obtained from reductive amination of the aldehyde in the AHB linker showed good reactivity. Following acylation of the phenolic OH group, the resulting carboxamide resin was stable to treatment with 95% CF3CO2H (TFA). The O-acyl functional group was removed with 20% piperidine, and the desired compound was cleaved from the resin by TFA treatment. In the experimental materials used by the author, we found Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Yue; Liu, Xinyong; An, Yunfei; Liu, Min; Han, Jun; Sun, Bin published an article in Bioorganic Chemistry. The title of the article was 《Potent arylamide derivatives as dual-target antifungal agents: Design, synthesis, biological evaluation, and molecular docking studies》.Electric Literature of C10H14ClNO2 The author mentioned the following in the article:

Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Ergosterol is an important structural component of the fungal cell membrane, its synthetases (squalene epoxidase (SE) and 14α-demethylase (CYP51)) are considered as the key points to block the ergosterol synthesis. In this study, we designed a series of dual-target arylamides derivatives based on the anal. of active sites (SE, CYP51). Subsequently, these target compounds were synthesized, and their antifungal activity was evaluated. Most of compounds demonstrate the potent antifungal activity against multiple Candida spp. and A. fum. In particular, the antifungal activities of compounds 10b (I) and 11c(II) are not only superior to pos. control drugs, but also have significant inhibitory effects on drug-resistant fungi (C.alb. Strain100, C.alb. Strain103). Therefore, their action mechanism was further studied. Cellular uptake and electron microscopy observation showed that target compounds were able to enter fungal cytoplasmic region through free diffusion, and destroyed cell membrane structure. At the same time, preliminary mechanisms have demonstrated that they can affect the synthesis of ergosterol by inhibiting the activity of dual targets. It is worth noting that they also can exhibit excellent antifungal activity and low toxic side effects in vivo. Their ADMET properties and binding models were established will be useful for further lead optimization. The experimental process involved the reaction of H-Phg-OEt.HCl(cas: 59410-82-1Electric Literature of C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Electric Literature of C10H14ClNO2 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 59410-82-1On June 1, 1999, Rossi, Elisabetta; Abbiati, Giorgio; Nava, Donatella published an article in Heterocycles. The article was 《1,2-Dihydro-1,3,5-triazines from 1,3-diaza-1,3-butadienes》. The article mentions the following:

4-Aryl-1-(4-methylphenyl)-2-phenyl- and 1-benzyl-2,4-diphenyl-1,3-diaza-1,3-butadienes are nearly quant. transformed into the corresponding 1,3,5-triazines when allowed to stand at room temperature in benzene solution The mechanism of the reaction is discussed. The experimental process involved the reaction of H-Phg-OEt.HCl(cas: 59410-82-1Related Products of 59410-82-1)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Related Products of 59410-82-1 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics