Tag: 200-300

Experimental and computational insight of the supramolecular complexes of Irbesartan with 尾-cyclodextrin based nanosponges was written by Suvarna, Vasanti;Singh, Vikas;Sharma, Dhvani;Murahari, Manikanta. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Product Details of 102-09-0 The following contents are mentioned in the article:

Irbesartan (IRB), one of the extensively prescribed drugs, for treatment of hypertension has limited therapeutic potential attributed to its poor water solubility, slow dissolution rate and poor bioavailability. Cyclodextrin-based nanosponges (NSs) are novel nanosized delivery systems comprised of hyper-crosslinked solid nanoparticles with nanosized cavities. Nanosponges are widely explored to increase water solubility of active drug moieties, to protect labile actives, to achieve prolonged or sustained release and site-specific targeting. The aim of the study was to investigate enhancement of solubility of Irbesartan by its complexation with 尾-cyclodextrin (尾-CD) based nanosponges (NS). Blank NSs were fabricated by reacting 尾-CD, with pyromellitic dianhydride (PMDA) and di-Ph carbonate (DPC) as crosslinkers, in various molar ratios of 1:2, 1:4, 1:6 and 1:8. Solubility studies were performed to select drug nanosponge stoichiometric complex with highest degree of saturation solubilization. Irbesartan loaded nanosponges namely PMDA-CDNS and DPC-CDNS were prepared and characterized by differential scanning calorimetry, Fourier transform IR spectroscopy, powd. X-ray diffraction, SEM and NMR studies, to confirm the complexation of Irbesartan with nanosponges. PXRD studies revealed the shift from crystalline nature of Irbesartan to amorphous form in nanoponges. The average particle sizes of IRB-PMDA-CDNS and IRB-DPC-CDNS were 471.5 nm and 382.7 nm resp. Zeta Potential values were 34.9 mV and -29mV for IRB-PMDA-CDNS and IRB- DPC-CDNS resp. Entrapment efficiency varied from 9 to 38% weight/weight and 17 to 33%weight/weight for IRB-PMDA-CDNS and IRB-DPC-CDNS resp. Complexation of IRB with 尾-cyclodextrin based nanosponges, as IRB-PMDA-CDNS and IRB-DPC-CDNS, resulted in significant enhancement of 81.86 and 23.35 folds, in its water solubility and 1.91- and 1.96-folds enhancement in its percent dissolution efficiency (% D.E.) resp. Mol. docking calculations of IRB with DPC-CDNS and PMDA-CDNS have exhibited binding affinities of -8.97 and -9.51 kcal/mol resp. Mol. dynamics simulations have revealed that IRB with PMDA-CDNS is more stable and efficient nanocarrier. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Product Details of 102-09-0).

Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 102-09-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design and synthesis of gradient-refractive index isosorbide-based polycarbonates for optical uses was written by Chu, Junyu;Wang, Heng;Zhang, Yiwen;Li, Zhengkai;Zhang, Zhencai;He, Hongyan;Zhang, Qinqin;Xu, Fei. And the article was included in Reactive & Functional Polymers in 2022.Application of 102-09-0 The following contents are mentioned in the article:

The synthesis of bio-based polymers using renewable bio-monomers have received extensive research attention to meet the concept of environmental sustainability. Isosorbide (ISB) derived from biomass is commonly used in the polycarbonate industry as an alternative to bisphenol A (BPA) because it is green, non-toxic, and more widely available. Compared to BPA-based polycarbonate, isosorbide-based polycarbonate has excellent properties such as high transparency, easy coloration, and outstanding rigidity. However, the naturally low refractive index of isosorbide triggers the latter to fall outside the threshold of optical applications. In order to further improve the refractive index of isosorbide-based polycarbonate without affecting its transparency and rigidity, a copolymerization scheme of bisphenol monomers (BPs) with isosorbide is proposed in this work. A series of isosorbide-bisphenol copolycarbonates were synthesized by a melt polycondensation process using ionic liquid 1,4-(1,4-diazabicyclo[2.2.2]octane)butyl dibromide ([C₄(DABCO)₂][Br]₂) as the catalyst. As expected, the monomer structure had significant effect on the optical property and mol. weight of the copolycarbonates, the monomer bis(p-hydroxyphenyl) ether (BPO) had better reactivity among the screened seven monomers resulting in relatively higher mol. weight Moreover, poly(BPO-co-ISB carbonate) (POIC) using BPO as the monomer exhibited a high Abbe number (v_d = 39.7), low yellowness index (YI = 0.93), and a higher refractive index (n_d = 1.536), which was much higher than poly(isosorbide carbonate) (1.496). Therefore, a series of POICs were further prepared to investigate the effect of BPO content on the optical, thermal, mech., and hydrophobic properties of the materials. The results showed that the copolymers POICs had higher refractive indexes (1.511-1.573), better thermal stability, flexibility, hydrophobicity and processing-friendly glass transition temperature (T_g) and pencil hardness, and thus are expected to be sustainable materials for optical lenses. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Application of 102-09-0).

Diphenyl carbonate (cas: 102-09-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 102-09-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization of the volatile profile of Brazilian Merlot wines through comprehensive two dimensional gas chromatography time-of-flight mass spectrometric detection was written by Welke, Juliane Elisa;Manfroi, Vitor;Zanus, Mauro;Lazarotto, Marcelo;Alcaraz Zini, Claudia. And the article was included in Journal of Chromatography A in 2012.COA of Formula: C15H22O2 The following contents are mentioned in the article:

Wine aroma is an important characteristic and may be related to certain specific parameters, such as raw material and production process. The complexity of Merlot wine aroma was considered suitable for comprehensive two-dimensional gas chromatog. (GC 脳 GC), as this technique offers superior performance when compared to one-dimensional gas chromatog. (1D-GC). The profile of volatile compounds of Merlot wine was, for the first time, qual. analyzed by HS-SPME-GC 脳 GC with a time-of-flight mass spectrometric detector (TOFMS), resulting in 179 compounds tentatively identified by comparison of exptl. GC 脳 GC retention indexes and mass spectra with literature 1D-GC data and 155 compounds tentatively identified only by mass spectra comparison. A set of GC 脳 GC exptl. retention indexes was also, for the first time, presented for a specific inverse set of columns. Esters were present in higher number (94), followed by alcs. (80), ketones (29), acids (29), aldehydes (23), terpenes (23), lactones (16), furans (14), sulfur compounds (9), phenols (7), pyrroles (5), C13-norisoprenoids (3), and pyrans (2). GC 脳 GC/TOFMS parameters were improved and optimal conditions were: a polar (polyethylene glycol)/medium polar (50% Ph 50% di-Me arylene siloxane) column set, oven temperature offset of 10 掳C, 7 s as modulation period and 1.4 s of hot pulse duration. Co-elutions came up to 138 compounds in ¹D and some of them were resolved in ²D. Among the co-eluted compounds, thirty-three volatiles co-eluted in both ¹D and ²D and their tentative identification was possible only due to spectral deconvolution. Some compounds that might have important contribution to aroma notes were included in these superimposed peaks. Structurally organized distribution of compounds in the 2D space was observed for esters, aldehydes and ketones, alcs., thiols, lactones, acids and also inside subgroups, as occurred with esters and alcs. The Fischer Ratio was useful for establishing the analytes responsible for the main differences between Merlot and non-Merlot wines. Differentiation among Merlot wines and wines of other grape varieties were mainly perceived through the following components: Et dodecanoate, 1-hexanol, Et nonanoate, Et hexanoate, Et decanoate, dehydro-2-methyl-3(2H)thiophenone, 3-Me butanoic acid, Et tetradecanoate, Me octanoate, 1,4 butanediol, and 6-methyloctan-1-ol. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7COA of Formula: C15H22O2).

2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C15H22O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Initiation reactivity of anionic polymerization of fluorinated acrylates and methacrylates with diethyl(ethyl cyanoacetato)aluminum was written by Umino, Youhei;Narita, Tadashi;Hamana, Hiroshi. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2008.Formula: C7H6F6O2 The following contents are mentioned in the article:

Pseudo first-order rate constants of the reaction of diethyl(Et cyanoacetato)aluminum [(C₂H₅)₂Al(NCCHCOOC₂H₅)] with 17 fluorinated acrylates and methacrylates and five hydrocarbon analogs for references were investigated to examine the initiation reactivities of the anionic polymerization of fluorinated vinyl monomers to afford the reactivity order: CH₂=C(CF₃)COOC₂H₅ > CH₂=C(CF₃)COOCH(CH₃)₂ > CH₂=CHCOOCH₂C₆F₅ > CH₂=C(CF₃)COOC(CH₃)₃ > CH₂=C(CF₃)COOCH₂C₆F₅ > CH₂=C(CF₃)COOCH(CF₃)₂ 鈮?CH₂=CHCOOCH₃ > CH₂=CHCOOCH₂C₆H₅ 鈮?CH₂=C(CF₃)COOCH₂CF₃ > CH₂=C(CH₃)COOCH₂C₆F₅ > CH₂=CHCOOCH₂CF₃ > CH₂=CHCOOCH₂C₂F₅ > CH₂=CHCOOCH(CF₃)₂ > CH₂=C(CH₃)COOCH₃ > CH₂=C(CH₃)COOCH₂C₆H₅ 鈮?CH₂=C(CH₃)COOCH₂CH₂ C₈F₁₇ > CH₂=C(CH₃)COOCH(CH₃)₂ > CH₂=C(CH₃)COOCH₂C₂F₅ 鈮?CH₂=C(CH₃)COOCH₂CF₃. No rate constants for CH₂=C(CH₃)COOCH(CF₃)₂, CH₂=CFCOOC(CH₃)₃, and CH₂=CFCOOCH₂C₂F₅ were obtained because of too fast polymerization The incorporation of a trifluoromethyl group into the vinyl group enhanced the reactivity toward the delocalized carbanion. The reactivity of other fluorinated acrylates and methacrylates was concluded to approx. be controlled by the fluorine contents and the bulkiness of substituents of monomers. The reactivity was generally decreased by increasing fluorine contents of fluoroalkyl substituents in ester groups. This study involved multiple reactions and reactants, such as 1,1,1,3,3,3-Hexafluoroisopropylmethacrylate (cas: 3063-94-3Formula: C7H6F6O2).

1,1,1,3,3,3-Hexafluoroisopropylmethacrylate (cas: 3063-94-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120掳 C鈥揅鈥揙 and O鈥揅鈥揙 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C鈥揙鈥揅 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C7H6F6O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Profile analysis of volatile flavor compounds of quantitative marinated chicken during processing was written by Sun, Zhen;Han, Dong;Zhang, Chun-hui;Li, Hai;Li, Xia;Liu, Zhi-bin;Xu, Shi-ming. And the article was included in Zhongguo Nongye Kexue (Beijing, China) in 2016.Application In Synthesis of 2-Ethylhexyl benzoate The following contents are mentioned in the article:

Objective: This research was conducted to study the compositions and contents of volatile flavor compounds during quant. marinating process and the taste characteristics of flavor substances in detail. The study was expected to provide theor. supports to the flavor control technol. of quant. marinating. Method: The headspace-solid phase microextraction combined with gas chromatog.-mass spectrometry (HS-SPME/GC-MS) was used to determine the components and contents of volatile flavor compounds from raw chicken meat, four stages of quant. marinating process (tumbling, baked 1, steamed, baked 2) and traditional marinating by qual. and quant. methods, to calculate odor activity values of the volatile flavor substances by the odor threshold in the water, to determine characteristic flavor substances, main flavor substances and modify flavor substances, then the odor activity value of volatile compounds was analyzed by principal component anal. (PCA) and cluster anal. (CA) procedures. Result: The results indicated that 54, 60, 60 and 60 kinds of volatile flavor compounds were identified from quant. marinating process, which were higher than 9 kinds of volatile flavor compounds in the raw and 44 kinds of volatile flavor compounds from traditional marinating. Quant. anal. revealed that the volatile flavor compounds at tumbling phase mainly from spice liquid Chicken thigh at baked 1 stage began to appear characteristic flavor substances trans, trans-2,4-decadienal, 1-octene-3-ol and so on, the contents of volatile flavor compounds were the highest at steaming stage, and chicken thigh meat was matured by steaming at this stage, the main stage for the formation of flavor. The contents of total volatile flavor compounds of chicken thigh quant. marinated at baked 2 stage was much higher than traditional marinating, explaining that quant. marinating is more intense than traditional marinating in flavor presenting. The characteristic flavor compounds were mainly hexanal, octanal, nonanal, (E)-2-nonenal, (E,E)-2,4-decadienal, (E,E)-2,4-nonadienal, benzeneacetaldehyde, eucalyptol and β-myrcene from quant. marinated chicken thigh during processing, and the odor activity value of them were significantly higher than that of raw meats and traditional marinated chicken. The main flavor compounds were mainly octanal, (E)-2-decenal, (E,E)-2,4-decadienal, 1-octen-3-ol and β-linalool from quant. marinated chicken thigh during processing. The modified flavor compounds were mainly ketones, esters and alcs. from quant. marinated chicken thigh during processing. By principal component anal. and clustering anal., there were significant differences in odor outline from raw chicken meat, four stages of quant. marinating process and traditional marinating, and the main flavor compounds clustered into four categories, and each category has characteristic flavor compounds represented quant. marinating process. Conclusion: The flavor profile results showed that compositions and development laws of flavor active substances stewed chicken, comparing with traditional marinating, quant. marinating can present volatile flavor compounds better. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Application In Synthesis of 2-Ethylhexyl benzoate).

2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of 2-Ethylhexyl benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《PET probe with Aggregation Induced Emission characteristics for the specific turn-on of aromataseã€?was written by Wu, Renbo; Liu, Song; Liu, Yajing; Sun, Yuli; Xiao, Hao; Huang, Yong; Yang, Zequn; Wu, Zehui. Application of 51857-17-1 And the article was included in Talanta in 2020. The article conveys some information:

Aromatase is an attractive target for the diagnosis and treatment of breast cancer. To combine the anti-photobleaching properties of Aggregation Induced Emission (AIE) with the high sensitivity and whole-body imaging characteristics of positron emission tomog. (PET), the authors designed a bifunctional complexing agent with AIE characteristics by modifying the structure of tetraphenylethene, which is linked with triazole derivatives capable of complexing with naTGA3+/68Ga3+ to obtain [natGa/68Ga] 2 for targeting the aromatase. [natGa] 2 has typical AIE characteristics, which can form uniform nanomicelles above the critical micelle concentration, and illuminate estrogen receptor (+) MCF-7 cells. [natGa] 2 itself is almost nonemissive in PBS buffer solution, but it turns on its fluorescence upon interaction with human aromatase, with a detection limit of 0.15μg/mL [68Ga] 2 is easy to prepare and has high stability. Compared to the estrogen receptor that is neg. expressed by MDA-MB-231 cells, MCF-7 cells pos. expressing estrogen have a higher uptake of [naTGA] 2. The distribution of aromatase in a tumor can be co-localized by using [68Ga] 2. These results can be used to effectively assess estrogen receptor status and aromatase levels at the cellular level. The authors anticipate that this research could provide a new strategy for the fabrication of PET probes with AIE characteristics, providing useful probes for PET- FL (Fluorescence imaging) bimodal imaging. In the experiment, the researchers used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsApplication of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

SDS of cas: 7524-52-9In 2019 ,《Design, synthesis and evaluation of PD176252 analogues for ameliorating cisplatin-induced nephrotoxicityã€?appeared in MedChemComm. The author of the article were Yao, Sen; Wei, Biao; Yu, Mingjun; Meng, Xiaoming; He, Meng; Yao, Risheng. The article conveys some information:

Cisplatin is a clin. chemotherapy drug for cancers; however, its remarkably high kidney toxicity and other toxicities pose a danger to patients. As the small mol. inhibitor of GRPR, PD176252 can inhibit the growth and proliferation of various cancer cells, but the characteristics of high toxicity and poor water solubility has limited its use as a drug. When we studied PD176252 for the reduction of toxicity of cisplatin, we modified its structure to synthesize 16 analogs. Surprisingly, the analogs showed reduced cisplatin-induced renal toxicity, and unlike PD176252, the analogs 5d and 5m were almost non-toxic to the normal HK2 cells. Furthermore, the analog 5d and PD176252 were subjected to cisplatin-induced inflammatory response in vitro. The results showed that 5d was able to better prevent this condition by effectively inhibiting its inflammatory response. Thus, this study will help in clin. reducing the side effects of cisplatin.H-Trp-OMe.HCl(cas: 7524-52-9SDS of cas: 7524-52-9) was used in this study.

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.SDS of cas: 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Xuejiao; Shen, Yuhe; Liu, Jiayu; Wang, Yuefei; Qi, Wei; Su, Rongxin; He, Zhimin published their research in Langmuir in 2021. The article was titled 《Rational Design of Chiral Nanohelices from Self-Assembly of Meso-tetrakis (4-Carboxyphenyl) Porphyrin-Amino Acid Conjugates》.Computed Properties of C12H15ClN2O2 The article contains the following contents:

In this article, meso-tetrakis (4-carboxyphenyl) porphyrins modified with different amino acids were designed, synthesized, and researched. The chiral self-assembly behavior of these porphyrin-amino acid mols. can be precisely controlled by adjusting the pH, constituent amino acids, and temperature, thereby giving rise to chiral nanostructures with precisely tailored helical pitch and handedness. This research provides a certain reference for the design and preparation of chiral nanomaterials and has potential application prospects in chiral resolution and chiral catalysis. After reading the article, we found that the author used H-Trp-OMe.HCl(cas: 7524-52-9Computed Properties of C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Computed Properties of C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Youji Huaxue included an article by Wang, Zhen; Zhang, Ling; Zhang, Fugeng; Wang, Bin. Application of 7524-52-9. The article was titled 《Synthesis of β-carbolines through tetra-n-butylammonium bromide mediated cycloaromatization reaction of N-methylaniline with tryptophan derivatives》. The information in the text is summarized as follows:

A mild and efficient nBu4NBr-mediated oxidative cycloaromatization to prepare β-carbolines from readily available tryptophans and N-methylaniline is described. The present metal free protocol is complementary to the existing methods for the synthesis of aromatic β-carbolines. In the experiment, the researchers used H-Trp-OMe.HCl(cas: 7524-52-9Application of 7524-52-9)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Application of 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《One-pot ring-opening peptide synthesis using α,α-difluoro-β-lactams》 was written by Tarui, Atsushi; Ueo, Masakazu; Morikawa, Marino; Tsuta, Masahiko; Iwasaki, Sumika; Morishita, Noriko; Karuo, Yukiko; Sato, Kazuyuki; Kawai, Kentaro; Omote, Masaaki. Formula: C12H15ClN2O2 And the article was included in Synthesis in 2020. The article conveys some information:

α,α-Difluoro-β-lactams successfully underwent ring-opening aminolysis with various amino acids in 2,2,2-trifluoroethanol to afford fluorine-containing peptides. In this aminolysis, it was found that 2,2,2-trifluoroethanol first attacked the α,α-difluoro-β-lactams with cleavage of lactam ring to form the corresponding open-chain 2,2,2-trifluoroethyl esters as reactive intermediates. The trifluoroethyl esters were more electrophilic compared with the corresponding Me ester and thereby accelerated the aminolysis with various amino acids to form β-amino acid peptides with α,α-difluoromethylene unit. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Formula: C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Formula: C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics