Tag: 100-200

Determination and comparation of volatile components in three kinds of characteristic honeys of Yunnan province was written by Wang, Tao-hong;Zhang, Yun-shuang;Jiang, Xiao-lin;Guan, Zhi-bin;Jia, Guang-qun;Zhang, Jin-jie;Cui, Zong-yan. And the article was included in Xiandai Shipin Keji in 2021.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

In order to explore the composition and difference of the volatile components in three characteristic honeys from Yunnan province, headspace solid phase microextraction coupled to gas chromatog.-mass spectrometry was used to determine the volatile components of the three honeys (Vicia villosa Roth honey, Macadamia integrifolia honey, and Hevea brasiliensis honey), combined with principal component anal. (PCA) and partial least squares discriminant anal. (PLS-DA). The results showed that a total of one hundred and five volatile compounds were detected in the three honeys, with 61 in Vicia villosa Roth honey, 55 in Macadamia integrifolia honey, and 62 in Hevea brasiliensis honey. Aldehydes, acids and alcs. were main volatile compounds in Vicia villosa Roth honey (n-nonanal and acetic acid had higher contents). Alcs. terpenes and aldehydes were the main volatile compounds in Macadamia integrifolia honey, cis-linalool oxide and furanoid linalool oxide had higher contents, and trans-linalool 3,7-oxide was the characteristic volatile component. Aldehydes, alcs. and acids were the main volatile compounds in Hevea brasiliensis hone, and(nonaldehyde and trans-linalool oxide were of higher contents. The results of PCA and PLS-DA anal. showed that there were significant differences in volatile components among Vicia villosa Roth honey, Macadamia integrifolia honey, and Hevea brasiliensis honey, and the three kinds of honey were well classified with a 100% accuracy. The research shows that Vicia villosa Roth honey, Macadamia integrifolia honey and Hevea brasiliensis honey have their own unique volatile components, and the PCA and PLS-DA models established based on these volatile compounds can realize the effective classification and identification of the three honeys in Yunan. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hydrolytic resolution of (R,S)-2-hydroxycarboxylic acid esters in biphasic media: implication for rate-limiting formation or breakdown of tetrahedral intermediates in acylation step was written by Wang, Pei-Yun;Chen, Teh-Liang;Tsai, Shau-Wei;Kroutil, Wolfgang. And the article was included in Biotechnology and Bioengineering in 2007.Computed Properties of C11H14O3 This article mentions the following:

A thermally stable esterase (SNSM-87) from Klebsiella oxytoca is explored as an enantioselective biocatalyst for the hydrolytic resolution of (R,S)-2-hydroxycarboxylic acid esters in biphasic media, where the best Me esters possessing the highest enantioselectivity and reactivity are selected and elucidated in terms of the structure-enantioselectivity correlations and substrate partitioning in the aqueous phase. With (R,S)-2-chloromandelates as the model substrates, an expanded Michaelis-Menten mechanism for the rate-limiting acylation step is adopted for the kinetic anal. The Bronsted slope of 25.7 for the fast-reacting (S)-2-chloromandelates containing a difficult leaving alc. moiety, as well as that of 4.13 for the slow-reacting (R)-2-chloromandelates in the whole range of leaving alc. moieties, indicates that the breakdown of tetrahedral intermediates to acyl-enzyme intermediates is rate-limiting. However, the rate-limiting step shifts to the formation of tetrahedral intermediates for the (S)-2-chloromandelates containing an easy leaving alc. moiety, and leads to an optimal enantioselectivity for the Me ester substrate. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Computed Properties of C11H14O3).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C11H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Classification structure-activity relationship (CSAR) studies for prediction of genotoxicity of thiophene derivatives was written by Du, Hongying;Wang, Jie;Watzl, June;Zhang, Xiaoyun;Hu, Zhide. And the article was included in Toxicology Letters in 2008.Formula: C7H8O2S This article mentions the following:

The grid search support vector machine (GS-SVM) was used to build a classification structure-activity relationship (CSAR) model and to predict the genotoxicity property of 140 thiophene derivatives with the information derived from the compounds’ mol. structures. The seven descriptors selected by linear discriminant anal. (LDA) were used as the inputs to develop the GS-SVM model. Using the Grid Search method, a satisfactory model with a good predictive capability was obtained. The quality of the models was evaluated by the number of right classified compounds The total accuracy of the LDA model was 81.4% and 85.2% for the training set and test set, resp., and to the GS-SVM model was 92.9% and 92.6%, resp. It was proved that the GS-SVM method was a very useful modeling approach with good classification ability for the genotoxicity of the thiophene derivatives This work also provides a new idea and an alternative method to investigate the genotoxicity of the similar structures with thiophene derivatives, and can be extended to other toxicity studies. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Formula: C7H8O2S).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C7H8O2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH was written by Singh, Vinayak;Pacitto, Angela;Donini, Stefano;Ferraris, Davide M.;Boros, Sandor;Illyes, Eszter;Szokol, Balint;Rizzi, Menico;Blundell, Tom L.;Ascher, David B.;Pato, Janos;Mizrahi, Valerie. And the article was included in European Journal of Medicinal Chemistry in 2019.SDS of cas: 16413-26-6 This article mentions the following:

In prior work, (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone) was identified and showed that its anti-tubercular activity is attributable to inhibition of inosine-5′-monophosphate dehydrogenase (IMPDH) in Mycobacterium tuberculosis. In the present study, the structure-activity relationship around (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone) was explored by synthesizing and evaluating the inhibitory activity of analogs against M. tuberculosis IMPDH in biochem. and whole-cell assays. X-ray crystallog. was performed to elucidate the mode of binding of selected analogs to IMPDH. The importance of the cyclohexyl, piperazine and isoquinoline rings was estabilished for activity and reported the identification of an analog with IMPDH-selective activity against a mutant of M. tuberculosis that is highly resistant to (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone). It was showed that the nitrogen in urea analogs is required for anti-tubercular activity and identify benzylurea derivatives as promising inhibitors that warrant further investigation. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6SDS of cas: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ultrasonic-Assisted condensation of aromatic and aliphatic aldehydes with 3-(Thiophen-2-yl)-5-Pyrazolone: Synthesis, characterization and Stereoselective application was written by Rizk, Hala F.;Noser, Ahmed A.;Ibrahim, Seham A.;Fares, Amira K.. And the article was included in Journal of Heterocyclic Chemistry.Electric Literature of C9H10O3S This article mentions the following:

A green and efficient protocol for a one-pot condensation of 1-(2,4-dinitrophenyl)-3-(thiophen-2-yl)-1H-pyrazol-5(4H)-one with aromatic and aliphatic aldehydes in different ratios to synthesize novel heterocyclic compounds containing pyrazolone and pyranopyrazole moieties was developed. The reactions were conducted using the ultrasonic and traditional methods. The sonication ensured more efficiency in the rate and yield of the reactions. The structures of the synthesized compounds were elucidated by different spectroscopic methods. Addnl., an enantioselective synthesis of (R)- and (S)-α-alkylated acid was achieved using 1-(2,4-dinitrophenyl)-4-(hydroxymethyl)-3-(thiophen-2-yl)-1H-pyrazol-5(4H)-one as chiral auxiliary, (S)-4-methyl-5-nonanol the aggregation pheromone of red palm weevil was efficiently prepared and used for trapping the red palm weevil. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Electric Literature of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Elucidation of antimicrobial and antioxidant activities of selected plant-based mayonnaise-derived essential oils against lactic acid bacteria was written by Munoz-Gonzalez, Rodrigo;Pino, Carla;Henriquez, Hector;Villanueva, Francisca;Riquelme, Angeline;Montealegre, Romina;Agostini, Davide;Batista-Gonzalez, Ana;Leiva, Gabriela;Contreras, Rodrigo A.. And the article was included in Journal of Food Processing and Preservation in 2022.Electric Literature of C12H20O2 This article mentions the following:

There is significant growth in the market for plant-based products at the com. level in recent times. One of the biggest challenges of this industry is to find consumer-approved natural preservatives that can control the microorganism proliferation found in plant-based products. In this study, we investigated the antimicrobial and antioxidant activities of several essential oils against Lactobacillus parabuchneri, a lactic acid bacterium found in plant-based mayonnaise. We show that the oregano-derived essential oil had the highest in vitro and in food antimicrobial activity against L. parabuchneri and had minimal impact on the organoleptic properties of mayonnaise. Physicochem. anal. of the oils revealed volatile compounds to be the most prominent ingredients. Addnl., the clove and cinnamon essential oils showed the highest antioxidant activity, which could be attributed to their degrees of phenolic content. These results collectively indicated the potential application of essential oils as preservatives for plant-based mayonnaises. Novelty impact statement : The market for plant-based products is growing sustained and consumers are increasingly concerned with quality and demand clean labeling. The present research shows an alternative based on essential oils for the control of lactic acid bacteria in mayonnaise-like dressings to avoid deterioration and offer a clean label. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Electric Literature of C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

N-acylhydrazones containing thiophene nucleus: a new anticancer class was written by Cardoso, Laura N. F.;Nogueira, Thais C. M.;Rodrigues, Felipe A. R.;Oliveira, Augusto Cesar Aragao;Luciano, Maria Claudia dos Santos;Pessoa, Claudia;de Souza, Marcus V. N.. And the article was included in Medicinal Chemistry Research in 2017.COA of Formula: C7H8O2S This article mentions the following:

In this study, the authors present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC₅₀) ranged from 0.82 to 12.90 μM. The compound (E)-N’-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed good cytotoxic activity in all cell lines (IC₅₀ = 0.82-5.36 μM) and yielded the best result in this series; therefore, it is an important lead compound in this new class. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9COA of Formula: C7H8O2S).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C7H8O2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Molecular characterization of an atypical coconut-like odor in cocoa was written by Porcelli, Caterina;Steinhaus, Martin. And the article was included in European Food Research and Technology in 2022.Electric Literature of C10H18O2 This article mentions the following:

Parallel application of an aroma extract dilution anal. (AEDA) to the volatiles isolated from a sample of fermented cocoa with an atypically pronounced coconut note and to the volatiles isolated from a reference cocoa sample revealed coconut-like smelling compounds δ-octalactone, δ-2-octenolactone, γ-nonalactone, γ-decalactone, δ-decalactone, and δ-2-decenolactone as potential causative odorants. Quantitation of these six compounds and calculation of odor activity values as ratios of the concentrations to the odor threshold values suggested δ-2-decenolactone as the crucial compound Chiral anal. showed the presence of pure (R)-δ-2-decenolactone, commonly referred to as massoia lactone. Its key role for the coconut note was finally demonstrated in a spiking experiment: the addition of (R)-δ-2-decenolactone to the reference cocoa in an amount corresponding to the concentration difference between the two samples was able to provoke a coconut note in an intensity comparable to the one in the atypically smelling cocoa. To avoid an undesired coconut note caused by (R)-δ-2-decenolactone in the final products, the chocolate industry may consider its odor threshold value, that is 100μg/kg, as a potential limit for the acceptance of fermented cocoa in the incoming goods inspection. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Electric Literature of C10H18O2).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C10H18O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Antidiabetic and neuroprotective effects of a novel repaglinide analog was written by Foroumadi, Roham;Baeeri, Maryam;Asgarian, Sara;Emamgholipour, Zahra;Goli, Fereshteh;Firoozpour, Loghman;Keykhaei, Mohammad;Gholami, Mahdi;Dehpour, Ahmad R.;Abdollahi, Mohammad;Foroumadi, Alireza. And the article was included in Journal of Biochemical and Molecular Toxicology in 2022.Computed Properties of C9H10O4 This article mentions the following:

Repaglinide (RPG) is an oral insulin secretagogue used in the treatment of diabetes. In this study, a new RPG analog was synthesized. Its antidiabetic and neuroprotective effects on dorsal root ganglions (DRG) in streptozotocin (STZ)-induced diabetic rats were examined compared to RPG. To assess the effects of 2-methoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)amino)-2-oxoethoxy)benzoic acid (OXR), the impact of OXR on oxidative stress biomarkers, motor function, and the expression of the glutamate dehydrogenase 1 (GLUD1), SLC2A2/glucose transporter 2 (GLUT2), and glucokinase (GCK) genes in STZ-induced diabetic rats were assessed. DRGs were examined histol. using hemotoxylin and eosin staining. Mol. docking was used to investigate the interactions between OXR and the binding site of RPG, the ATP-sensitive potassium (KATP) channel. Following 5 wk of treatment, OXR significantly increased the level of total antioxidant power, decreased reactive oxygen species, and lipid peroxidation in the DRGs of diabetic rats. OXR restored STZ-induced pathophysiol. damages in DRG tissues. Administration of OXR improved motor function of rats with diabetic neuropathy. Administration of 0.5 mg/kg OXR reduced blood glucose while promoting insulin, mainly through upregulation of mRNA expression of GLUD1, GLUT2, and GCK in the pancreas. Mol. docking revealed a favorable binding mode of OXR to the KATP channel. In conclusion, OXR has neuroprotective effects in diabetic rats by lowering oxidative stress, lowering blood glucose, and stimulating insulin secretion. We report that 0.5 mg/kg OXR administration was the most effective concentration of the compound in this study. OXR may be a promising target for further research on neuroprotective antidiabetic mols. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Computed Properties of C9H10O4).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C9H10O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Physical and sensory properties of lemon-flavored acidic beverages formulated with nonfat dry milk during storage was written by Li, Nan;Choi, Inseob;Vuia-Riser, Jennifer;Carter, Brandon;Drake, MaryAnne;Zhong, Qixin. And the article was included in Journal of Dairy Science in 2022.HPLC of Formula: 105-87-3 This article mentions the following:

Sensory and phys. properties of 2 lemon-flavored beverages with 5% and 7.5% wt/wt nonfat dry milk (NFDM) at pH 2.5 were studied during storage. The 2 beverages had similar volatile compounds, but the 5% NFDM had higher aroma and lemon flavor, with a preferred appearance by consumers due to the lower turbidity and viscosity. After 28 d of storage at 4°C, lemon flavor decreased in the 5% NFDM beverage but was still more intense than the 7.5% one. During 70 d of storage, no microorganisms were detected, and the beverages were more stable when stored at 4°C than at room temperature according to changes of phys. properties measured for appearance, turbidity, color, particle size, zeta potential, rheol. properties, and transmission electron microscopy morphol. Findings of the present study suggest that NFDM may be used at 5% wt/wt to produce stable acidic dairy beverages with low turbidity when stored at 4°C. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3HPLC of Formula: 105-87-3).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 105-87-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics