Tag: 100-200

Visible-Light-Promoted Carbene Insertion and Decarbonylation for the Synthesis of α-Substituted γ-Ketoesters was written by Li, Weina;Yang, Yingying;Tang, Zhiliang;Yu, Xianglin;Lin, Jun;Jin, Yi. And the article was included in Journal of Organic Chemistry in 2022.Related Products of 584-74-7 This article mentions the following:

Herein, a blue visible-light-promoted approach to prepare a variety of α-substituted γ-ketoesters derivatives RC(O)CH₂C(COOR¹)R²R³ [R = Ph, 3-FC₆H₄, 4-MeC₆H₄, etc.; R¹ = Me, Et; R² = H, CHO; R³ = Ph, 4-ClC₆H₄, 3-thienyl, etc.] through carbene insertion and the decarbonylation of enaminones and diazoesters was reported. These reactions used readily available starting materials, as well as transition-metal-free, eco-friendly procedures that were amenable to gram-scale synthesis and wide functional group tolerance. This methodol. might be useful for constructing polysubstituted heterocycles with potential biol. activity. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Related Products of 584-74-7).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 584-74-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Exploring the regional typicality of Australian Shiraz wines using untargeted metabolomics was written by Li, S.;Blackman, J. W.;Schmidtke, L. M.. And the article was included in Australian Journal of Grape and Wine Research in 2021.COA of Formula: C9H10O3 This article mentions the following:

Shiraz is the most widely planted winegrape cultivar in Australia. Sensory studies have indicated that different grapegrowing regions in Australia produce distinct styles of Shiraz wines that differ in flavor characteristics. The current project aimed to characterize the underlying volatile composition associated with regional Shiraz wine styles. Wines were selected from six geog. distinct regions and the volatile compounds were analyzed using gas chromatog. time-of-flight mass spectrometry to provide a comprehensive and holistic overview of the wine volatilome. A suite of R language based software enabled feature extraction and importance ranking, following an untargeted metabolomics approach. A classification model based on the random forests algorithm using the 80 most important compounds correctly associated all samples to regions. A range of these compounds, including terpenoids, benzenoids, esters, furan derivatives and aliphatic alcs., has been associated with grape composition, winemaking influences and the ageing process. The results suggest that the regional compositional differences in varietal wines may be influenced by all processes in the entire wine production chain. The current study highlighted the chem. basis underlying the regional typicality of Australian Shiraz wines, and identified specific volatile compounds that may be associated with a region. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6COA of Formula: C9H10O3).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C9H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Volatile Composition of Juniperus pingii var. wilsonii and Its Inhibitory Effect on Nitric Oxide Production of Macrophage Cells was written by Zhu, Mengxia;Ling, Lijun;De, Ji;Lu, Yan;Chen, Daofeng. And the article was included in Journal of Essential Oil-Bearing Plants in 2018.Quality Control of Isopentyl 3-methylbutanoate This article mentions the following:

The leaves and twigs of Juniperus pingii var. wilsonii (Cupressaceae) smell aromatic and are traditionally used as the Tibetan medicine Xuba. Their essential oil obtained by ultrasonic-assisted hydrodistillation and volatiles collected by GC headspace technique were analyzed and compared by GC-MS. The analyses revealed the presence of thirty-nine components in the essential oil, representing 95.8% in content of the total oil, mainly including sabinene (22.6%), elemol (15.5%) and (-)-terpinen-4-ol (9.6%). Thirty-eight components accounting for 99.4% of the headspace volatiles were identified, mainly including sabinene (32.5%), β-pinene (21.9%) and α-thujene (10.3%). The compositions of the oil and headspace volatiles were quite similar, and twenty-five compounds identified were in common, which was 91.3% of the oil and 96.0% of the headspace volatiles in content. The essential oil could obviously inhibit Nitric oxide production in LPS-stimulated RAW 264.7 cells with no significant effect on cell viability, indicating its good anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Quality Control of Isopentyl 3-methylbutanoate).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Isopentyl 3-methylbutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach was written by Gaonkar, Roopa;Singh, Jitender;Chauhan, Arushi;Avti, Pramod K.;Hegde, Gurumurthy. And the article was included in Phytochemistry (Elsevier) in 2022.Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate This article mentions the following:

Lemongrass essential oil has antifungal and anti-cancerous properties. Heat-shock protein (HSP90), an ATP-dependent mol. chaperone found in eukaryotes, is involved in protein folding, stability, and disease, making it a promising research topic. Both in silico and in vitro approaches were used to provide a clear insight into the HSP90-ATPase 3D structures, activity, and their interaction with the essential oil constituents among various species such as fungi (S. cerevisiae), parasites (P. falciparum), and humans. For in silico studies, sequence alignment, docking (AutoDock), and absorption, distribution, metabolism, and excretion (ADME) properties were evaluated to obtain hit compounds specifically against each HSP90-ATPase. The hit compounds obtained were evaluated for their efficacy in the in vitro studies of S. cerevisiae. In vitro studies were carried out targeting HSP90-ATPases via lemongrass essential oil components individually and in combination as a function of concentration and various salt concentrations Results suggest that sequence alignment exists of over 75% among these three species. The best docking score was possessed by Geraniol and its constituent (geldanamycin â‰?-4.93 kcal/mol) (a known antifungal and antitumor against HSP90) in all the above species. Lemongrass oil and the combination of Geraniol and Citral at concentrations of 80μg/mL showed the maximum inhibition of ATPase and HSP90-ATPase activity compared to their individual treatment. Therefore, both in silico and in vitro studies provide clear evidence of specific inhibitory action of lemongrass oil, Geraniol, and Citral against the ATPase and HSP90-ATPase activities and might show potential as antifungal and antitumor drugs. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of aroma-active compounds in Cheddar cheese imparted by wood smoke was written by Rizzo, P. V.;Del Toro-Gipson, R. S.;Cadwallader, D. C.;Drake, M. A.. And the article was included in Journal of Dairy Science in 2022.Related Products of 695-06-7 This article mentions the following:

Cheddar cheese is the most popular cheese in the United States, and the demand for specialty categories of cheese, such as smoked cheese, are rising. The objective of this study was to characterize the flavor differences among Cheddar cheeses smoked with hickory, cherry, or apple woods, and to identify important aroma-active compounds contributing to these differences. First, the aroma-active compound profiles of hickory, cherry, and apple wood smokes were analyzed by solid-phase microextraction (SPME) gas chromatog.-olfactometry (GCO) and gas chromatog.-mass spectrometry (GC-MS). Subsequently, com. Cheddar cheeses smoked with hickory, cherry, or apple woods, as well as an unsmoked control, were evaluated by a trained sensory panel and by SPME GCO and GC-MS to identify aroma-active compounds Selected compounds were quantified with external standard curves. Seventy-eight aroma-active compounds were identified in wood smokes. Compounds included phenolics, carbonyls, and furans. The trained panel identified distinct sensory attributes and intensities among the 3 cheeses exposed to different wood smokes (P < 0.05). Hickory smoked cheeses had the highest intensities of flavors associated with characteristic “smokiness” including smoke aroma, overall smoke flavor intensity, and meaty, smoky flavor. Cherry wood smoked cheeses were distinguished by the presence of a fruity flavor. Apple wood smoked cheeses were characterized by the presence of a waxy, green flavor. Ninety-nine aroma-active compounds were identified in smoked cheeses. Phenol, guaiacol, 4-methylguaiacol, and syringol were identified as the most important compounds contributing to characteristic “smokiness.” Benzyl alc. contributed to the fruity flavor in cherry wood smoked cheeses, and 2-methyl-2-butenal and 2-ethylfuran were responsible for the waxy, green flavor identified in apple wood smoked cheeses. These smoke flavor compounds, in addition to diacetyl and acetoin, were deemed important to the flavor of cheeses in this study. from this study identified volatile aroma-active compounds contributing to differences in sensory perception among Cheddar cheeses smoked with different wood sources. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Related Products of 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity was written by Khalaf, Abedawn I.;Waigh, Roger D.;Drummond, Allan J.;Pringle, Breffni;McGroarty, Ian;Skellern, Graham G.;Suckling, Colin J.. And the article was included in Journal of Medicinal Chemistry in 2004.Electric Literature of C7H8N2O4 This article mentions the following:

Forty-eight heterocyclic amino acid trimers, analogs of distamycin, with a number of features that enhance lipophilicity are described. They contain alkyl or cycloalkyl groups larger than methyl; some are N-terminated by acetamide or methoxybenzamide and are C-terminated by dimethylaminopropyl or aliphatic heterocyclic aminopropyl substituents. The ability of these compounds to bind principally to AT tracts of DNA has been evaluated using capillary zone electrophoresis. Significant antimicrobial activity against key organisms such as MRSA and Candida albicans is shown by several compounds, especially those containing a thiazole. Moreover, these compounds have low toxicity with respect to several mammalian cell lines. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Electric Literature of C7H8N2O4).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C7H8N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mitigation of membrane biofouling using quorum-quenching bacteria in a continuously operated membrane bioreactor was written by Dong, Xinjiao;Qin, Jing;Zhang, Ying;Chen, Xiaohui;Ge, Shimei. And the article was included in International Biodeterioration & Biodegradation in 2022.Recommanded Product: 695-06-7 This article mentions the following:

Quorum-quenching (QQ) has become an attractive strategy for the mitigation of membrane biofouling known as biocake or biofilm. In this study, a QQ system, which exploited two QQ bacteria (Serratia sp. Z4 and Klebsiella sp. Q2) and γ-caprolactone (GCL), was established and used to effectively mitigate biofouling. This system could delay the increase in transmembrane pressure by half during a 40-day operation in a continuous membrane bioreactor (MBR) with low effluent COD and ammonium nitrogen. GCL improved the biofouling-mitigation ability of the QQ bacteria without stimulating bacterial growth. The reduction in soluble microbial products was consistent with the delay in transmembrane pressure increase. Furthermore, soluble microbial products (SMP) in the reactors were significantly influenced by the QQ system, suggesting that SMP was important for the occurrence of biofouling. Microbial community anal. showed that the relative abundance of some main genera was not greatly influenced by the QQ system. The two most abundant genera of quorum sensing (QS)-related bacteria found in the sludge mixture were Alicycliphilus and Thauera. The results indicated that a QQ strategy based on the disturbance of QS among the microbes should be effective for biofouling mitigation in MBR. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Recommanded Product: 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Volatile compounds released by acid hydrolysis in jackfruit (Artocarpus heterophyllus Lam.). A comparative study by using SDE and HS-SPME techniques was written by Barros-Castillo, Julio Cesar;Calderon-Santoyo, Montserrat;Garcia-Magana, Maria de Lourdes;Calderon-Chiu, Carolina;Ragazzo-Sanchez, Juan Arturo. And the article was included in Journal of Food Composition and Analysis in 2022.Recommanded Product: 659-70-1 This article mentions the following:

The volatile compounds of jackfruit (Artocarpus heterophyllus Lam.) released using acid hydrolysis were comprehensively investigated by using simultaneous distillation-extraction (SDE) and headspace-solid phase microextraction (HS-SPME); both coupled to gas chromatog.-mass spectrometry (GC-MS). Hydrolyzes were carried out at pH 3 to promote the release of aglycons and pH 7 to inhibit enzymic reactions. Volatile profiles were analyzed by extraction technique. Besides, the aroma potential (AP) of jackfruit was determined Sixty-nine volatile compounds were identified. Limonene, pentyl 3-methylbutanoate, 1-butanol, Bu 3-methylbutanoate, butanal, and β-cyclocitral were the prominent compounds The AP of jackfruit was 3.1 and 3.8 mg/kg by utilizing SDE and HS-SPME resp. The AP of jackfruit released by acid hydrolysis suggests its use as raw material for foodstuffs prepared under thermal and acid conditions at low pH values, promoting the release of aroma precursors and enhancing the flavor of the final product. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Recommanded Product: 659-70-1).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 659-70-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis, crystal structure and reactivity of homobimetallic vanadium(V) complexes derived from oxaloyldihydrazone ligands was written by Syiemlieh, Ibanphylla;Asthana, Mrityunjaya;Kurbah, Sunshine D.;Lal, Ram A.. And the article was included in Polyhedron in 2019.Related Products of 118-61-6 This article mentions the following:

Treatment of V₂O₅ with dihydrazone ligands (H₄L) (disalicylaldehydeoxaloyldihydrazone (H₄L₁ = H₄slox), bis(2-hydroxy-1-naphthaldehyde)oxaloyldihydrazone (H₄L₂ = H₄nph) and bis(5-bromosalicylaldehyde)oxaloyldihydrazone (H₄L₃ = H₄sloxBr)) in methanol leads to the formation of homobimetallic vanadium(V) complexes of the composition [(CH₃)₂NH₂]₂[(VO₂)₂(L)]·nH₂O, where n = 2 (1, 2) and n = 4 (3). The reaction of complexes 1–3 with H₂O₂ results in the formation of bis(monooxidoperoxidovanadate(V)) complexes[{VO(O₂)}₂(L)]^2- and the reaction with HCl leads to the formation of oxidohydroxido species of the composition [(VO)(OH)(L)]^2-. The complexes show great potential for the oxidation of alcs. and the oxidative bromination of some organic substrates. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Related Products of 118-61-6).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 118-61-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Supercritical and ultrasound-assisted extracts from Pleurotus pulmonarius mushroom: chemical profiles, antioxidative, and enzyme-inhibitory properties was written by Milovanovic, Ivan;Zengin, Gokhan;Maksimovic, Svetolik;Tadic, Vanja. And the article was included in Journal of the Science of Food and Agriculture in 2021.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

This study provides an insight into the impact of ultrasound-assisted extraction with water as solvent (UAEW) and extraction by supercritical carbon dioxide (SC-CO₂) with 5% EtOH on antioxidant and enzyme inhibitory activity in regard to the chem. profile of the edible and medicinal mushroom, Pleurotus pulmonarius. Extraction efficiency was between 0.36% and 63.32%, depending on the extraction technique. The main compounds in the extracts were fatty acids. Supercritical CO₂ extraction with co-solvent was the most suitable method for obtaining extracts that were rich in ergosterol content, reaching a value of 40.1 mg g^-1. The UAEW of crude mushroom powder ensured the highest yield, as well as the extracts with best antioxidative activity. The measurements of enzyme inhibitory activity revealed that all types of investigated extracts exhibited only tyrosinase and amylase inhibition at a significant level. Based on our results, the extraction methods significantly affected the chem. profile and bioactivity of P. pulmonarius. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics