Tag: 100-200

The author of 《Matrix assisted antibacterial activity of polymer conjugates with pendant antibiotics, and bioactive and biopassive moieties》 were Mukherjee, Ishita; Ghosh, Anwesha; Bhadury, Punyasloke; De, Priyadarsi. And the article was published in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2019. Electric Literature of C5H11NO2 The author mentioned the following in the article:

Antibacterial activity against a series of potentially pathogenic bacterial strains was evaluated in both liquid and solid matrixes using ciprofloxacin (a well-known fluoroquinolone antibiotic) based polymeric systems with pendant cationic charge and zwitterionic units. The ciprofloxacin containing polymeric architecture was designed to incorporate bioactive killing properties of cationic moieties, whereas biopassive activity was regulated by the bacterial cell repelling capacity of the zwitterionic group. tert-Bu carbamate (Boc)-leucine hydroxyethylmethacrylate (Boc-Leu-HEMA), Boc-ciprofloxacin hydroxyethylmethacrylate (Boc-Cipro-HEMA) and zwitterionic sulphabetaine methacrylate (SBMA) are copolymerized, followed by deprotection of Boc groups from the copolymer under acidic conditions. Boc deprotection resulted in water soluble polymers with cationic charge from the leucine moiety and retained the antibiotics in their active original form. The antibacterial activity of the polymeric system was evaluated against several bacterial species, namely, Escherichia coli (E. coli), Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), Vibrio alginolyticus (V. alginolyticus), and Vibrio chemaguriensis Iso1 (V. chemaguriensis), in both liquid and solid matrixes. The copolymer displayed significant bactericidal efficacy against non-biofilm forming E. coli and B. subtilis in both liquid and solid matrixes. However, the antibacterial effect on biofilm forming V. chemaguriensis was comparatively less prominent in the liquid matrix. Optical microscope images of Gram staining revealed an enhanced surface area of individual cells and chain formation in cells of V. chemaguriensis. The non-cytotoxic profile of the polymer towards mammalian red blood cells (RBCs) and enhanced bactericidal effect in the physiol. to basic pH (7.0-9.5) range against potentially pathogenic V. chemaguriensis using a multitude of microscopic techniques hinted toward the need to develop new antibiotics to combat possible clin. infections in the near future.tert-Butyl carbamate(cas: 4248-19-5Electric Literature of C5H11NO2) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Electric Literature of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Polyacrylonitrile fiber with strongly acidic electrostatic microenvironment: Highly efficient and recyclable heterogeneous catalyst for the synthesis of heterocyclic compounds》 were Xiao, Jian; Xu, Gang; Wang, Lu; Li, Pengyu; Zhang, Wenqin; Ma, Ning; Tao, Minli. And the article was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2019. Synthetic Route of C7H12O3 The author mentioned the following in the article:

Four categories of sulfonic acid functionalized fiber catalysts with different surface microenvironments were synthesized by covalent grafting using polyacrylonitrile fiber (PANF) as the support. After the effect of acid structure on catalytic activity was investigated by Friedlander reaction, PANEOSF was chosen for the synthesis of quinolines and coumarin derivatives with high yields and extensive substrate scope (51 examples) in ethanol or water. The effect of electrostatic microenvironment and solvent was discussed and a “”release-catch-release-catch”” catalytic pattern was proposed accordingly. PANEOSF can be easily recycled for 20 times without any decrease of catalytic activity. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2007,Portilla, Jaime; Mata, Ernesto G.; Nogueras, Manuel; Cobo, Justo; Low, John N.; Glidewell, Christopher published 《Hydrogen-bonded chains of rings in methyl 4-[(5-methyl-1H-pyrazol-3-yl)amino]-3-nitrobenzoate and hydrogen-bonded sheets in methyl 1-(5-methyl-1H-pyrazol-3-yl)-1H-benzimidazole-5-carboxylate》.Acta Crystallographica, Section C: Crystal Structure Communications published the findings.COA of Formula: C8H6FNO4 The information in the text is summarized as follows:

Mols. of Me 4-[(5-Me-1H-pyrazol-3-yl)amino]-3-nitrobenzoate, C12H12N4O4, (I), exhibit a polarized (charge-separated) structure in the nitroaniline portion. The mols. are linked into chains of edge-fused R22(16) and R22(22) rings by a combination of N-H···O(carbonyl) and C-H···O(nitro) H bonds. Me 1-(5-Me-1H-pyrazol-3-yl)-1H-benzimidazole-5-carboxylate, C13H12N4O2, (II), which is readily formed from (I) by reduction followed by ring formation, crystallizes with Z’ = 2 in the space group P1̅. Each of the 2 independent mol. types is linked into sheets of R44(28) rings by a combination of N-H···N and C-H···O(carbonyl) H bonds. After reading the article, we found that the author used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9COA of Formula: C8H6FNO4)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.COA of Formula: C8H6FNO4Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2007,Portilla, Jaime; Mata, Ernesto G.; Cobo, Justo; Low, John N.; Glidewell, Christopher published 《Two isomeric reaction products: hydrogen-bonded sheets in methyl 4-(5-amino-3-phenyl-1H-pyrazol-1-yl)-3-nitrobenzoate and hydrogen-bonded chains of edge-fused rings in methyl 3-nitro-4-[(5-phenyl-1H-pyrazol-3-yl)amino]benzoate》.Acta Crystallographica, Section C: Crystal Structure Communications published the findings.Recommanded Product: 329-59-9 The information in the text is summarized as follows:

In Me 4-(5-amino-3-phenyl-1H-pyrazol-1-yl)-3-nitrobenzoate, C17H14N4O4, the mols. are linked into complex sheets by a combination of N-H···N, N-H···O, and C-H···O hydrogen bonds. In the isomeric Me 3-nitro-4-[(5-phenyl-1H-pyrazol-3-yl)amino]benzoate, mols. exhibit a polarized mol.-electronic structure and are linked into chains of edge-fused rings by a combination of N-H···O and C-H···O hydrogen bonds. The results came from multiple reactions, including the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: 329-59-9)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Almeida, Santos Claudia Lais Araujo; Macedo, Santos Jonh Anderson; Alves, Caiana Rodrigo Ribeiro; Maria, Souza Silvia; Rufino, Freitas Jucleiton Jose; Gadelha, Militao Gardenia Carmem; Rufino, Freitas Juliano Carlo published an article in 2021. The article was titled 《Synthesis, antineoplastic activity and in silico studies of (S)-N-(1-hydroxy-3-methylbutan-2-yl)-3-(p-tolyl)-1,2,4-oxadiazole-5-carboxamide》, and you may find the article in Research Journal of Chemistry and Environment.Electric Literature of C4H5ClO3 The information in the text is summarized as follows:

In this work, authors reports the synthesis, antineoplastic evaluation and in silico study of a new 1,2,4-oxadiazole. The (S)-N-(1-hydroxy-3-methylbutan-2-yl)-3-(p-toluyl)-1,2,4-oxadiazole-5-carboxamide was obtained after two reaction steps in excellent yield. Although it has shown low activity in relation to the MCF-7, HCT116 and HL60 tumor cell lines, the mol. docking study indicates that this compound acts in the colchicine site and can inhibit tubulin polymerization From the calculation of pharmacokinetic properties by the SwissADME and Osiris Property Explorer programs, it is possible to infer that the compound meets the Lipinski rules presenting good oral bioavailability and low toxicity. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Electric Literature of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Electric Literature of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Cortes, Edwar; Abonia, Rodrigo; Cobo, Justo; Glidewell, Christopher published 《Hydrogen-bonded sheet structures in methyl 4-(4-chloroanilino)-3-nitrobenzoate and methyl 1-benzyl-2-(4-chlorophenyl)-1H-benzimidazole-5-carboxylate》.Acta Crystallographica, Section C: Crystal Structure Communications published the findings.COA of Formula: C8H6FNO4 The information in the text is summarized as follows:

In Me 4-(4-chloroanilino)-3-nitrobenzoate, C14H11ClN2O4, (I), there is an intramol. N-H···O hydrogen bond and the intramol. distances provide evidence for electronic polarization of the o-quinonoid type. The mols. are linked into sheets built from N-H···O, C-H···O and C-H···π(arene) hydrogen bonds, together with an aromatic π-π stacking interaction. The mols. of Me 1-benzyl-2-(4-chlorophenyl)-1H-benzimidazole-5-carboxylate, C22H17ClN2O2, (II), are also linked into sheets, this time by a combination of C-H···π(arene) hydrogen bonds and aromatic π-π stacking interactions. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9COA of Formula: C8H6FNO4)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.COA of Formula: C8H6FNO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 1964,Ricerca Scientifica, Parte 2: Rendiconti, Sezione A: Abiologica included an article by Chierici, Luigi; Scapini, Giancarlo. Safety of Dimethyl 1H-pyrrole-2,3-dicarboxylate. The article was titled 《Chromatographic study of pyrrole acids. Gas chromatography of the C-pyrrolecarboxylic acids》. The information in the text is summarized as follows:

Mixtures of C-pyrrolecarboxylic acids are separated as Me esters on a 100-cm. column packed with 3% ethylene-glycol-succinate on Chromosorb W. The instrument is operated with a 300° injection port temperature, a flame ionization detector, a 15 ml./min. N flow, and the column is temperature-programmed from 150 to 210° at 25°/min. The temperature program starts after separation of the 2-pyrrolecarboxylic acid.Dimethyl 1H-pyrrole-2,3-dicarboxylate(cas: 2818-08-8Safety of Dimethyl 1H-pyrrole-2,3-dicarboxylate) was used in this study.

Dimethyl 1H-pyrrole-2,3-dicarboxylate(cas: 2818-08-8) belongs to pyrroles. Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme.Safety of Dimethyl 1H-pyrrole-2,3-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Infrared and ultraviolet spectra of pyrrolecarboxylic acid esters》 were Scrocco, Marisa; Nicolaus, Rodolfo. And the article was published in Atti accad. nazl. Lincei. Rend., Classe sci. fiz., mat. e nat. in 1957. Application of 2818-08-8 The author mentioned the following in the article:

Infrared and ultraviolet spectra of Me 2-pyrrolecarboxylate (I), Me 1-pyrrolecarboxylate (II), di-Et 2,3-pyrroledicarboxylate (III), di-Me 1,4-pyrroledicarboxylate (IV), di-Me 1,2-pyrroledicarboxylate (V), di-Me 1,3-pyrroledicarboxylate (VI), tri-Et 1,2,3-pyrroletricarboxylate (VII), and tri-Me 1,2,4-pyrroletricarboxylate (VIII) were examined to determine conjugation effects and relation to pKa for the NH group. Δν in the infrared for bound and free NH bands in cm.-1 was I 170, II 146, IV 170, V 140, VI 162, VII 170. Ultraviolet maximum were I 247, II 267, III 250, IV 277, V 246, 282, VI 267, VII 267, VIII 275 mμ. It was shown that substitution in α-position has greater conjugation effects than in β, that the spectra are affected by intramol. chelation with α-substituents, and that the spectra and the effects on the NH band can be explained on the basis of resonance contributions and relative inductive effects. In addition to this study using Dimethyl 1H-pyrrole-2,3-dicarboxylate, there are many other studies that have used Dimethyl 1H-pyrrole-2,3-dicarboxylate(cas: 2818-08-8Application of 2818-08-8) was used in this study.

Dimethyl 1H-pyrrole-2,3-dicarboxylate(cas: 2818-08-8) belongs to pyrroles. Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme.Application of 2818-08-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 1877-71-0On November 30, 2021 ,《Aziridine-2-carboxylic acid derivatives and its open-ring isomers as a novel PDIA1 inhibitors》 appeared in Chemistry of Heterocyclic Compounds (New York, NY, United States). The author of the article were Leite, Irena; Andrianov, Victor; Zelencova-Gopejenko, Diana; Loza, Einars; Kazhoka-Lapsa, Iveta; Domracheva, Ilona; Stoyak, Marta; Chlopicki, Stefan; Kalvins, Ivars. The article conveys some information:

Acyl derivatives of aziridine-2-carboxylic acid have been synthesized and tested as PDIA1 inhibitors. Calculations of charge value and distribution in aziridine ring system and some alkylating agents were performed. For the first time was found that acyl derivatives of aziridine-2-carboxylic acid are weak to moderately active PDIA1 inhibitors. In addition to this study using 3-(Methoxycarbonyl)benzoic acid, there are many other studies that have used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Related Products of 1877-71-0) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Related Products of 1877-71-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2021 ,《Identification of Novel Simulants for Toxic Industrial Chemicals and Chemical Warfare Agents for Human Decontamination Studies: A Systematic Review and Categorisation of Physicochemical Characteristics》 appeared in International Journal of Environmental Research and Public Health. The author of the article were James, Thomas; Collins, Samuel; Marczylo, Tim. The article conveys some information:

A review. Chem. simulants have long been used in human trials of mass decontamination to determine the efficacy of decontamination interventions against more toxic agents. Until now, reliance has mostly been on individual chems. as surrogates to specific agents (e.g., Me salicylate for sulfur mustard). A literature review was conducted to identify chems. that had been previously tested on human volunteers and that represent diverse physicochem. characteristics in order to create a repository for chem. simulants. Of the 171 unique chems. identified, 78 were discounted for the risk they could pose to human volunteers, 39 were deemed suitable for use, and a further 54 were considered to be possible simulants but would require further research. Suitable simulants included both solid and liquid chems. spanning a wide range of physicochem. properties including mol. weight, octanol/water partition coefficient, vapor pressure, and solubility This review identifies an array of potential simulants suitable for use in human volunteer decontamination studies and is of relevance to future studies on systemic absorption and surface decontamination. After reading the article, we found that the author used Methyl Salicylate(cas: 119-36-8Category: esters-buliding-blocks)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics