Tag: 100-200

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Chakraborty, Poulami; Dastidar, Parthasarathi. Reference of Methyl Salicylate. The article was titled 《An easy access to topical gels of an anti-cancer prodrug (5-fluorouracil acetic acid) for self-drug-delivery applications》. The information in the text is summarized as follows:

An easy access to topical gels (both hydro- and organogels) derived from an anti-cancer prodrug namely 5-fluorouracil acetic acid (5-FuA) achieved by exploiting a simple salt formation strategy is reported for the first time. Nearly 85% of the salts synthesized were gelators. Single crystal structures of some of the gelator salts revealed an intriguing hydrogen bonding network including double stranded 1D chains stabilized through uracil-uracil complementary interactions and the crystal structures of the gelator salts corroborated well with the hypothesis based on which the gelators were designed. Studies indicated that both the hydrogel and the Me salicylate gel of the gelator salt FuA-15 were suitable for self-drug-delivery application. In the experimental materials used by the author, we found Methyl Salicylate(cas: 119-36-8Reference of Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Reference of Methyl Salicylate

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Kizhakkayil Mangadan, Arun Raj; Liu, Ji; Aponick, Aaron published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Enantioselective Lactonization by π-Acid-Catalyzed Allylic Substitution: A Complement to π-Allylmetal Chemistry》.Name: Ethyl 2-methyl-3-oxobutanoate The article contains the following contents:

Asym. allylic alkylation (AAA) is a powerful method for the formation of highly useful, non-racemic allylic compounds A complementary enantioselective process that generates allylic lactones via π-acid catalysis was presented. More specifically, a catalytic enantioselective dehydrative lactonization of allylic alcs. using a novel PdII-catalyst containing the imidazole-based P,N-ligand (S)-StackPhos is reported. The high-yielding reactions are operationally simple to perform with enantioselectivities up to 99% ee. This strategy facilitates the replacement of a poor leaving group with what would ostensibly be a better leaving group in the product avoiding complications arising from racemization by equilibration. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Name: Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Name: Ethyl 2-methyl-3-oxobutanoate

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The author of 《Photo-auxiliary approach to control excited state reactivity of cross [2+2]-photocycloaddition of oxazolidinone based hydrazides》 were Ahuja, Sapna; Iyer, Akila; Kandappa, Sunil Kumar; Sivaguru, Jayaraman. And the article was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2019. Recommanded Product: N-tert-Butoxycarbonylhydroxylamine The author mentioned the following in the article:

Chiral oxazolidinone based hydrazides undergo efficient cross [2 + 2]-photocycloaddition upon visible light illumination. Oxazolidinone functionality acted as an energy harvesting photo-auxiliary. The cross [2 + 2]-photocycloaddition proceeded efficiently from the excited state with moderate to excellent isolated yield of the photoproduct. The photo-auxiliary can be conveniently removed post-photoreaction, which highlights the versatility of this strategy. The experimental part of the paper was very detailed, including the reaction process of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Recommanded Product: N-tert-Butoxycarbonylhydroxylamine)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Recommanded Product: N-tert-Butoxycarbonylhydroxylamine

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In 2016,Chaitra, Turuvekere K.; Mohana, Kikkeri N.; Gurudatt, Doddahosuru M.; Tandon, Harmesh C. published 《Inhibition activity of new thiazole hydrazones towards mild steel corrosion in acid media by thermodynamic, electrochemical and quantum chemical methods》.Journal of the Taiwan Institute of Chemical Engineers published the findings.SDS of cas: 16982-21-1 The information in the text is summarized as follows:

The mild steel anti-corrosion potential by newly synthesized thiazole hydrazones, 4-(4-methoxy-phenyl)-thiazole-2-carboxylic acid benzylidene-hydrazide (TH-1), 4-(4-methoxy-phenyl)-thiazole-2-carboxylic acid (3-hydroxy-benzylidene)-hydrazide (TH-2) and 4-(4-methoxy-phenyl)-thiazole-2-carboxylic acid (4-hydroxy-benzylidene)-hydrazide (TH-3) in 0.5 M hydrochloric acid was studied by gravimetric and electrochem. techniques. Thermodn. parameters were evaluated for activation and adsorption processes. Adsorption of the inhibitors followed Langmuir isotherm. Electrochem. measurements showed that addition of inhibitors simultaneously decreased corrosion c.d. and double layer capacitance but increased charge transfer resistance. Potentiodynamic polarization studies revealed that thiazole hydrazones effectively suppressed both the anodic and cathodic processes of mild steel corrosion in acid solution and hence acted as mixed-type inhibitors. Quantum chem. parameters like EHOMO, ΔE, softness and hardness were very well correlated with exptl. data. SEM characterized the film formed on the mild steel. In addition to this study using Ethyl 2-amino-2-thioxoacetate, there are many other studies that have used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1SDS of cas: 16982-21-1) was used in this study.

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.SDS of cas: 16982-21-1

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2010,Gaikwad, Sudhakar A.; Patil, Amol A.; Deshmukh, Madhukar B. published 《An efficient, uncatalyzed, and rapid synthesis of thiazoles and aminothiazoles under microwave irradiation and investigation of their biological activity》.Phosphorus, Sulfur and Silicon and the Related Elements published the findings.COA of Formula: C4H7NO2S The information in the text is summarized as follows:

A convenient method for the synthesis of thiazoles by treatment of α-bromoketones with thioamides (Hantzsch synthesis) in the absence of catalysts under microwave irradiation was developed. The products were formed rapidly in excellent yields. An efficiency comparison of time, yield, and effort clearly proved the microwave technique to be superior. The structures of the newly synthesized compounds were characterized by spectroscopic data and elemental analyses. The synthesized compounds were tested for their biol. activity. Depending on the substituents, some of the thiazoles exhibit very good antibacterial or antifungal activity. In the experiment, the researchers used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1COA of Formula: C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.COA of Formula: C4H7NO2S

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 16982-21-1In 2018 ,《Synthesis and QSAR study of novel thiazole moieties having antioxidant activity》 was published in International Journal of Pharmaceutical Sciences and Research. The article was written by Kashid, G. A.; Singh, S. K.; Saravanan, J.. The article contains the following contents:

Thiazoles derivatives are an important class of heterocyclic compounds, reported to possess a wide spectrum of biol. activities. Moreover, thiazole nucleus occupies a very important place in the field of antioxidant agents. The above observations prompted us to synthesize some novel thiazole derivatives with various substitutions at along with heterocyclic rings in the same framework for synergistic action. We here in report the synthesis, antioxidant screening & QSAR studies of the new title compounds Concentrated research on N-((Substituted) benzylidene)-4-(4-chlorophenyl) thiazole-2-carbohydrazides I [R = 4-Cl; R1 = 4-Me, 4-Cl, 3-nitro, etc.] & were synthesized, screened for antioxidant activities & QSAR studies. All new entities have good yield and results. From antioxidant activity results, it was observed that the compounds with both electron donating and electron withdrawing groups on the aldehydic Ph ring influenced the activity. Among all the compounds, compounds I [R = 4-Cl, R1 = 4-hydroxy-3-methoxy, 3,4,5-trihydroxy, 4-methoxy, 4-Cl, 4-hydroxy] showed the good % inhibition and were found to be more significant compound among all the compounds tested. Compounds GS-5i-j were showed moderate % inhibition and were found to be significant among all the tested compounds 2D & 3D-QSAR models with moderate to high predictive ability of thiazole derivatives were derived. The role of hydrophobicity as a 3D property was confirmed and also electrostatic and steric effects were found to contribute to antioxidant activity. The experimental process involved the reaction of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Product Details of 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 16982-21-1

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《A hydroxylamine probe for profiling S-acylated fatty acids on proteins》 were Schulte-Zweckel, Janine; Dwivedi, Mridula; Brockmeyer, Andreas; Janning, Petra; Winter, Roland; Triola, Gemma. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: N-tert-Butoxycarbonylhydroxylamine The author mentioned the following in the article:

Reversible S-palmitoylation is a key regulatory mechanism of protein function and localization. There is increasing evidence that S-acylation is not restricted to palmitate but it includes shorter, longer, and unsaturated fatty acids. However, the diversity of this protein modification has not been fully explored. Herein, we report a chem. probe that combined with MS-based anal. allows the rapid detection and quantification of fatty acids linked to proteins. We have used this approach to profile the S-acylome and to show that the oncogene N-Ras is heterogeneously acylated with palmitate and palmitoleate. Studies on protein distribution in membrane subdomains with semisynthetic proteins revealed that unsaturated N-Ras presents an increased tendency toward clustering and higher insertion kinetic rate constants In the experimental materials used by the author, we found N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Recommanded Product: N-tert-Butoxycarbonylhydroxylamine)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: N-tert-Butoxycarbonylhydroxylamine

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Chemoselective 18F-incorporation into pyridyl acyltrifluoroborates for rapid radiolabelling of peptides and proteins at room temperature》 was written by Chiotellis, Aristeidis; Ahmed, Hazem; Betzel, Thomas; Tanriver, Matthias; White, Christopher J.; Song, Haewon; Da Ros, Sara; Schibli, Roger; Bode, Jeffrey W.; Ametamey, Simon M.. Electric Literature of C5H11NO3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A new prosthetic group is reported for 18F-labeling of peptides and proteins based on the chemoselective ligation of potassium acyltrifluoroborates (KATs) and hydroxylamines without any detectable 18F/19F isotope exchange at the acyltrifluoroborate moiety. The new building block is appended via a common amide bond at room temperature with no need for protecting groups which enables an effective orthogonal 18F-radiolabelling. In addition to this study using N-tert-Butoxycarbonylhydroxylamine, there are many other studies that have used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Electric Literature of C5H11NO3) was used in this study.

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C5H11NO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Ethyl oxalyl monochlorideIn 2019 ,《Visible-light mediated carbamoyl radical addition to heteroarenes》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Jatoi, Ashique Hussain; Pawar, Govind Goroba; Robert, Frederic; Landais, Yannick. The article contains the following contents:

The generation of carbamoyl radicals, followed by their addition to heteroarenes, was performed under mild conditions through a metal-free photocatalyzed decarboxylation of oxamic acids. The process has been applied to the carbamoylation of heteroaromatic bases using α-aminoacid-derived oxamic acids, leading to the corresponding amides without racemization. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Quality Control of Ethyl oxalyl monochloride) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Quality Control of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of C7H12O3In 2021 ,《Synthesis and pharmacological evaluation of novel benzimidazole derivatives as antiulcer and H+ K+ ATPase inhibitor》 appeared in Journal of Advances in Medical and Pharmaceutical Sciences. The author of the article were Khan, Farhan R.; Farooqui, Mohd. Saleemuddin. The article conveys some information:

A series of new 2-[(substituted-pyrimidin-4-yl) sulfinyl]-1H-benzimidazoles I [R1 = H, Me, nitro; R2 = Me, Et, propyl] were synthesized by the condensation of O-phenylenediamine, KOH and CS2 resulting potassium 1-H-benzimidazole 2-thiolate further treated with glacial acetic acid gives 1H-benzimidazole 2- thiol (2-mercaptobenzimidazole). 4-Chloro 2 Me, 6-Alkylpyrimidine- 4-ol prepared by ethanimidamide and alkyl acetoacetate gives 2-Me, 6-Alkylpyrimidine-4-ol by chlorination using thionyl chloride 4-Chloro 2 Me, 6-Alkylpyrimidine- 4-ol was obtained. Further reacted with sodium oxide followed by m-chloroperbenzoic finally gives 2-[(substituted-pyrimidin-4-yl) sulfinyl]- 1H-benzimidazole. Structural characterization of these synthesized compounds I was confirmed by FT-IR, 1HNMR, and Mass spectral data. Later synthesized derivatives evaluated for their antiulcer and H+ K+ ATPase inhibitory activity by aspirin induced method and assays of H+/K+-ATPase activity resp. Compound I [R1 = H; R2 = methyl] (74.03%), I [R1 = methyl; R2 = propyl] (72.87%) and I [R1 = nitro; R2 = propyl] (75.15%) shows highly significant antiulcer activity compared to standard drug and compound I [R1 = H; R2 = propyl] (88.88%), I [R1 = R2 = methyl] (91.03%), I [R1 = methyl; R2 = propyl] (86.48%) and I [R1 = nitro; R2 = methyl] (84.21%) shows highly significant antisecretory activity when compare to standard drug. These research work provoked further to work for development of different derivatives of 2-(pyrimidinyl-sulfinyl) benzimidazole I which have lesser side effect and better action than few of marketed drugs. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

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Ester – an overview | ScienceDirect Topics