Tag: 100-200

In 2022,Wang, Yi-Feng; Wang, Chao-Jie; Feng, Qing-Zhou; Zhai, Jing-Jing; Qi, Suo-Suo; Zhong, Ai-Guo; Chu, Ming-Ming; Xu, Dan-Qian published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Copper-catalyzed asymmetric 1,6-conjugate addition of in situ generated para-quinone methides with β-ketoesters》.Related Products of 609-14-3 The author mentioned the following in the article:

A Cu-catalyzed asym. 1,6-conjugate addition of in situ generated para-quinone methides (p-QMs) with β-ketoester has been developed to construct a ketoester skeleton bearing an adjacent tertiary-quaternary carbon stereocenter in good yields and high enantioselectivities. This is the first example of metal-catalyzed asym. transformations of the in situ generated p-QMs, avoiding using pre-synthesized p-QMs requiring bulky 2,6-substitutions and highlighting a new dual catalytic activation with the chiral bis(oxazoline)-metal complex acting as a normal Lewis acid to activate the β-ketoesters and a source of Bronsted acid responsible for generating the p-QMs in situ. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Related Products of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Related Products of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wande; Wei, Shiqiang; Wang, Wenyao; Qu, Jingping; Wang, Baomin published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements》.Product Details of 4949-44-4 The article contains the following contents:

An organocatalytic asym. process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives I (R1 = Bn, Me, 1-naphthylmethyl, etc.; R2 = Et, Ph, 2-thienyl, etc.; R3 = H, Br; Ar = Ph, 2-bromophenyl, 2-thienyl, etc.) bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20 : 1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Product Details of 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of dynamic imine macrocyclic supramolecular polymers via synchronized self-assembly based on dynamic covalent bonds and noncovalent interactions》 was written by He, Zhenfeng; Huo, Yufeng; Wang, Chao; Pan, Duo; Dong, Binbin; Wang, Mingli; Guo, Li; Hu, Zhuolin; Guo, Zhanhu. Computed Properties of C5H11NO2 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The preparation of dynamic imine macrocycles and supramol. polymers is combined into a single step to form supramol. polymers (SPs). 1,4-Diazabicyclo[2.2.2]octane (DABCO) derived quaternary ammonium salts induce aldehyde and amine building blocks to covalently form imine macrocycles. Multiple noncovalent interactions between hosts (i.e., imine macrocycle) and guests (i.e., DABCO) act as driving forces. Thus, for the first time, dynamic imine macrocyclic supramol. polymers (DIMPs) have been achieved through the synchronized self-assembly of dynamic covalent bond formed imine macrocycles and noncovalent interactions of hosts-guests. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Computed Properties of C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Enantioselective Phenolic α-Oxidation Using H2O2 via an Unusual Double Dearomatization Mechanism》 were McLaughlin, Michael F.; Massolo, Elisabetta; Liu, Shubin; Johnson, Jeffrey S.. And the article was published in Journal of the American Chemical Society in 2019. HPLC of Formula: 36016-38-3 The author mentioned the following in the article:

Feedstock aromatic compounds are compelling low-cost starting points from which mol. complexity can be generated rapidly via oxidative dearomatization. Oxidative dearomatizations commonly rely heavily on hypervalent iodine or heavy metals to provide the requisite thermodn. driving force for overcoming aromatic stabilization energy. This article describes oxidative dearomatizations of 2-(hydroxymethyl)phenols via their derived bis(dichloroacetates) using hydrogen peroxide as a mild oxidant that intercepts a transient quinone methide. A stereochem. study revealed that the reaction proceeds by a new mechanism relative to other phenol dearomatizations and is complementary to extant methods that rely on hypervalent iodine. Using a new chiral phase-transfer catalyst, the first asym. syntheses of 1-oxaspiro[2.5]octa-5,7-dien-4-ones were reported. The synthetic utility of the derived 1-oxaspiro[2.5]octadienones products is demonstrated in a downstream complexity-generating transformation. The experimental part of the paper was very detailed, including the reaction process of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3HPLC of Formula: 36016-38-3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 36016-38-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,International Journal for Ion Mobility Spectrometry included an article by Ahrens, Andre; Hitzemann, Moritz; Zimmermann, Stefan. Application of 119-36-8. The article was titled 《Miniaturized high-performance drift tube ion mobility spectrometer》. The information in the text is summarized as follows:

Developing powerful hand-held drift tube ion mobility spectrometers (IMS) requires small, lightweight drift tubes with high anal. performance. In this work, we present an easy-to-manufacture, miniaturized drift tube ion mobility spectrometer, which is manufactured from polyether ether ketone, stainless steel foils and printed circuit boards. It is possible to operate the drift tube IMS with a radioactive 3H ionization source or a non-radioactive X-ray ionization source with 3 kV acceleration voltage. The drift tube design provides high resolving power of Rp = 63 at a drift length of just 40 mm, 15 mm × 15 mm in cross-section (outer dimensions) and a drift voltage of 2.5 kV. The limits of detection for less than one second of averaging are 40 pptv for dimethyl-methylphosphonate and 30 pptv for Me salicylate. For demonstration, the miniaturized drift tube IMS is integrated into a stand-alone battery-powered mobile device, including a closed gas-loop, high performance driver electronics and wireless data transmission. In a proof-of-concept study, this device was tested in an international field evaluation exercise to detect the release of a volatile, hazardous substance inside a large entry hall. In the experimental materials used by the author, we found Methyl Salicylate(cas: 119-36-8Application of 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Application of 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2021,Chemical Communications (Cambridge, United Kingdom) included an article by Zhang, Lili; Chen, Shuai; He, Hengchi; Li, Weipeng; Zhu, Chengjian; Xie, Jin. Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid. The article was titled 《Photoredox/nickel-catalyzed hydroacylation of ethylene with aromatic acids》. The information in the text is summarized as follows:

A general, practical and scalable hydroacylation reaction of ethylene with aromatic carboxylic acids with the synergistic combination of nickel and photoredox catalysis was reported. Under ambient temperature and pressure, feedstock chems. such as ethylene could be converted into high-value-added aromatic ketones in moderate to good yields (up to 92%) with reaction time of 2-6 h. The experimental part of the paper was very detailed, including the reaction process of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Visible-light-initiated manganese-catalyzed Giese addition of unactivated alkyl iodides to electron-poor olefins》 were Dong, Jianyang; Wang, Xiaochen; Wang, Zhen; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: 2495-35-4 The author mentioned the following in the article:

Herein, a mild protocol for direct visible-light-initiated Giese addition of unactivated alkyl iodides to electron-poor olefins (Michael acceptors) with catalysis by decacarbonyl dimanganese, Mn2(CO)10, an inexpensive earth-abundant-metal catalyst to afford esters R1CH2CH2R2 [R1 = Me, cyclohexyl, Bn, etc.; R2 = CO2Me, CO2Bn, SO2Ph, etc.] was reported. This protocol was compatible with a wide array of sensitive functional groups and had a broad substrate scope with regard to both the alkyl iodides and the Michael acceptors. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4Recommanded Product: 2495-35-4) was used in this study.

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Recommanded Product: 2495-35-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2014,Nicolussi, Simon; Chicca, Andrea; Rau, Mark; Rihs, Sabine; Soeberdt, Michael; Abels, Christoph; Gertsch, Jurg published 《Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: From ultrapotent to hyperpotent》.Biochemical Pharmacology (Amsterdam, Netherlands) published the findings.Category: esters-buliding-blocks The information in the text is summarized as follows:

Besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (AEA), this process is intrinsically coupled to AEA degradation by the fatty acid amide hydrolase (FAAH). Differential blockage of each mechanism is possible using specific small-mol. inhibitors. Starting from the natural product-derived 2E,4E-dodecadiene scaffold previously shown to interact with the endocannabinoid system (ECS), a series of diverse N-alkylcarbamates were prepared with the aim of generating novel ECS modulators. While being inactive at cannabinoid receptors and monoacylglycerol lipase, these N-alkylcarbamates showed potent to ultrapotent picomolar FAAH inhibition in U937 cells. Overall, a highly significant correlation (Spearman’s rho = 0.91) was found between the inhibition of FAAH and AEA cellular uptake among 54 compounds Accordingly, in HMC-1 cells lacking FAAH expression the effect on AEA cellular uptake was dramatically reduced. Unexpectedly, 3-(4,5-dihydrothiazol-2-yl)phenyl carbamates and the 3-(1,2,3-thiadiazol-4-yl)phenyl carbamates WOBE490, WOBE491 and WOBE492 showed a potentiation of cellular AEA uptake inhibition in U937 cells, resulting in unprecedented femtomolar (hyperpotent) IC50 values. Potential methodol. issues and the role of cellular accumulation of selected probes were investigated. It is shown that albumin impacts the potency of specific N-alkylcarbamates and, more importantly, that accumulation of FAAH inhibitors can significantly increase their effect on cellular AEA uptake. Taken together, this series of N-alkylcarbamates shows a FAAH-dependent inhibition of cellular AEA uptake, which can be strongly potentiated using specific head group modifications. These findings provide a rational basis for the development of hyperpotent AEA uptake inhibitors mediated by ultrapotent FAAH inhibition. In addition to this study using Methyl 3-hydroxypropanoate, there are many other studies that have used Methyl 3-hydroxypropanoate(cas: 6149-41-3Category: esters-buliding-blocks) was used in this study.

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2005,Ooka, Hirohito; Inoue, Tsutomu; Itsuno, Shinichi; Tanaka, Masato published 《Highly active and selective palladium catalyst for hydroesterification of styrene and vinyl acetate promoted by polymeric sulfonic acids》.Chemical Communications (Cambridge, United Kingdom) published the findings.COA of Formula: C4H8O3 The information in the text is summarized as follows:

Highly efficient, selective and recyclable palladium catalyst systems for hydroesterification of styrene and vinyl acetate were realized by using [1,2-phenylenebis(methylene)]bis[bis(1,1-dimethylethyl)phosphine] as ligand and polymeric sulfonic acids of limited SO3H loadings as promoter. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3COA of Formula: C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vasickova, Sona; Tichy, Milos published an article on February 28 ,1979. The article was titled 《Stereochemical studies. LXXXVIII. Infrared spectra and conformation of substituted methyl cyclohexanecarboxylates and 2-hydroxycyclohexanecarboxylates》, and you may find the article in Collection of Czechoslovak Chemical Communications.Synthetic Route of C8H14O3 The information in the text is summarized as follows:

The IR of the C:O and OH groups in thirty-two Me alkylcyclohexane- and alkyl-trans-decalin-2-carboxylates and their vicinal OH derivatives were computer assigned to the appropriate conformers. The conformational equilibrium thermodn. and attractive interaction between equatorial OH and equatorial CO2Me groups were calculated in Me trans-2-hydroxy-cis-4-isopropylcyclohexanecarboxylate.Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8Synthetic Route of C8H14O3) was used in this study.

Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Synthetic Route of C8H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics