Tag: 100-200

Zhu, Jian; Zhao, Guofeng; Meng, Chao; Chen, Pengjing; Shi, Xue-Rong; Lu, Yong published an article in 2021. The article was titled 《Superb Ni-foam-structured nano-intermetallic InNi3C0.5 catalyst for hydrogenation of dimethyl oxalate to ethylene glycol》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Recommanded Product: 6149-41-3 The information in the text is summarized as follows:

A high-performance Ni-foam-structured nano-intermetallic InNi3C0.5 catalyst is developed for the gas-phase hydrogenation of di-Me oxalate (DMO) to ethylene glycol (EG). The InNi3C0.5/Ni-foam catalyst is obtainable by hydrothermal growth of NiC2O4 onto the Ni-foam, impregnation with In2O3 precursor, subsequent calcination and carburization in a syngas. Despite DMO cascade hydrogenation to MG, then to EG, and finally to EtOH, such catalyst hydrogenates DMO dexterously until to EG with a high turnover frequency of 636 h-1, because the 3Ni-In and 3Ni-C sites on InNi3C0.5(1 1 1) effectively activate DMO but hinder EG over-hydrogenation to EtOH. Favorable reaction pathway on the InNi3C0.5(1 1 1) surface predicted theor. is DMO* → CH3OCOCO* → CH3OCOCHO* → CH3OCOCHOH* → MG* → CH3OCHOCH2OH* → CHOCH2OH* → HOCHCH2OH* → EG*. Moreover, the neutral Ni-foam diminishes the formation of ethers and diols. The catalyst achieves full DMO conversion with 96-98% EG selectivity and is stable for at least 2500 h under industrial-relevant conditions, and can also hydrogenate a broad scope of carbonyl compounds to corresponding alcs. with high yields. In the experiment, the researchers used Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Shaolei; He, Zhi-Juan; Zhang, Ling-Hui; Huang, Bo-Lun; Chen, Xiao-Wei; Zhan, Zong-Song; Zhang, Fu-Min published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters》.Related Products of 403-33-8 The article contains the following contents:

Com. available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Related Products of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Related Products of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lamhauge, Johannes N.; Corti, Vasco; Liu, Yidong; Joergensen, Karl Anker published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Enantioselective α-Etherification of Branched Aldehydes via an Oxidative Umpolung Strategy》.HPLC of Formula: 36016-38-3 The article contains the following contents:

A survey of benzoquinone oxidants identified p-fluoranil and DDQ as suitable reaction partners. p-Fluoranil enables the preparation of α-aryloxylated aldehydes using phenol nucleophiles in up to 91% ee, following either a one-step or a two-step, one-pot protocol. DDQ allowed for a more general etherification protocol in combination with a broader range of alc. nucleophiles with enantioselectivities up to 95% ee. Control experiments and isolation of a key quinol intermediate supports a mechanism proceeding via an SN2 dynamic-kinetic resolution These studies provided the basis for an aminocatalytic umpolung concept that allows for the asym. construction of tertiary ethers in the α-position of aldehydes. In the experiment, the researchers used many compounds, for example, N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3HPLC of Formula: 36016-38-3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.HPLC of Formula: 36016-38-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Ruthenium-catalyzed benzylic substitution of benzyl esters with stabilized carbon nucleophiles》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Suzuki, Koki; Tsuji, Hiroaki; Kawatsura, Motoi. Product Details of 609-14-3 The article mentions the following:

A [Cp*RuCl2]2/picolinic acid catalyst system promoted the reaction of 2-naphthylmethyl-2,3,4,5,6-pentafluorobenzoates with a series of stabilized carbon nucleophiles such as malonates, β-ketoesters, and diketones to give the corresponding benzylic alkylation products in moderate to high yields. A plausible reaction mechanism that could involve a (π-benzyl)ruthenium intermediate is proposed. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion》 were Cao, Shuhua; Fan, Jiangli; Sun, Wen; Li, Fahui; Li, Kaoxue; Tai, Xishi; Peng, Xiaojun. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: 4755-77-5 The author mentioned the following in the article:

A bimetallic complex, containing Mn(II) and Cu(II) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (·OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT. In the experiment, the researchers used Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Lentz, Christian S.; Halls, Victoria; Hannam, Jeffrey S.; Niebel, Bjoern; Struebing, Uta; Mayer, Guenter; Hoerauf, Achim; Famulok, Michael; Pfarr, Kenneth M. published 《A Selective Inhibitor of Heme Biosynthesis in Endosymbiotic Bacteria Elicits Antifilarial Activity In Vitro》.Chemistry & Biology (Oxford, United Kingdom) published the findings.COA of Formula: C8H6FNO4 The information in the text is summarized as follows:

Lymphatic filariasis and onchocerciasis are severe diseases caused by filarial worms and affect more than 150 million people worldwide. Endosymbiotic α-proteobacteria Wolbachia are essential for these parasites throughout their life cycle. Using a high-throughput chem. screen, we identified a benzimidazole compound, wALADin1, that selectively targets the δ-aminolevulinic acid dehydratase (ALAD) of Wolbachia (wALAD) and exhibits macrofilaricidal effects on Wolbachia-containing filarial worms in vitro. wALADin1 is a mixed competitive/noncompetitive inhibitor that interferes with the Mg2+-induced activation of wALAD. This mechanism inherently excludes activity against the Zn2+-dependent human ortholog and might be translatable to Mg2+-responsive orthologs of other bacterial or protozoan pathogens. The specificity profile of wALADin1 derivatives reveals chem. features responsible for inhibitory potency and species selectivity. Our findings validate wALADins as a basis for developing potent leads that meet current requirements for antifilarial drugs. The results came from multiple reactions, including the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9COA of Formula: C8H6FNO4)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.COA of Formula: C8H6FNO4Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2003,Samaritoni, Jack G.; Demeter, David A.; Gifford, James M.; Watson, Gerald B.; Kempe, Margaret S.; Bruce, Timothy J. published 《Dihydropiperazine Neonicotinoid Compounds. Synthesis and Insecticidal Activity》.Journal of Agricultural and Food Chemistry published the findings.Formula: C4H7NO2S The information in the text is summarized as follows:

Various isomeric piperazines were prepared successfully via regioselective monothionation of their resp. diones. Preparation of the precursor unsym. N-substituted piperazinediones from readily available diamines is the key to this selectivity. The piperazine ring system, as exemplified in I [X = NCN, Y = O, Z = H2, R1 = Me; (II)] and III (R2 = 2-chloro-1,3-thiazol-5-yl), has been shown to be a suitable bioisosteric replacement for the imidazolidine ring system contained in neonicotinoid compounds However, placement of the cyanoimino electron-withdrawing group further removed from the pyridine ring, as in I (X = O, Y = NCN, Z = H2, R1 = H), or relocation of the carbonyl group, as in I (X = NCN, Y = H2, Z = O, R1 = Me), results in significantly decreased bioisosterism. The piperazine ring system of II and III (R = 2-chloro-1,3-thiazol-5-yl) also lends a degree of rigidity to the mol. that is not offered by the inactive acyclic counterpart 2-[(6-chloropyridin-3-yl)-methyl-(methyl)amino]-2-(cyanoimino)-N,N-dimethylacetamide. A pharmacophore model is proposed that qual. explains the results on the basis of good overlap of the key pharmacophore elements of II and imidacloprid; the less active regioisomers feature a smaller degree of overlap. The experimental process involved the reaction of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Formula: C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Solladie-Cavallo, A.; Baram, A.; Choucair, E.; Norouzi-Arasi, H.; Schmitt, M.; Garin, F. published their research in Journal of Molecular Catalysis A: Chemical on August 1 ,2007. The article was titled 《Heterogeneous hydrogenation of substituted phenols over Al2O3 supported ruthenium》.HPLC of Formula: 936-03-8 The article contains the following contents:

Catalytic heterogeneous hydrogenation over Ru/Al2O3 of mono- and di-substituted phenols works and provides mixtures of the two or four possible isomers. Although cis and all-cis isomers (corresponding to all-syn H2 additions) are less stable, they are always major. Also large alkyl substituents and carbomethoxy groups have a tendency to increase the diastereoselectivity and formation of larger amounts of the trans isomers is related to the presence of an OH group thus supporting intermediate formation of the corresponding ketone as already suggested. After reading the article, we found that the author used Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8HPLC of Formula: 936-03-8)

Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.HPLC of Formula: 936-03-8 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matos, Jeishla L. M.; Vasquez-Cespedes, Suhelen; Gu, Jieyu; Oguma, Takuya; Shenvi, Ryan A. published their research in Journal of the American Chemical Society on December 12 ,2018. The article was titled 《Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes》.Name: Ethyl (2S)-2-amino-3,3-dimethylbutanoate The article contains the following contents:

Radical hydrofunctionalization occurs with ease using metal-hydride hydrogen atom transfer (MHAT) catalysis to couple alkenes and competent radicalophilic electrophiles. Traditional two-electron electrophiles have remained unreactive. Herein we report the reductive coupling of electronically unbiased olefins with imines and aldehydes. Iron catalysis allows addition of alkyl-substituted olefins into imines through the intermediacy of free radicals, whereas a combination of catalytic Co(Salt-Bu,t-Bu) and chromium salts enables a branch-selective coupling of olefins and aldehydes through the formation of a putative alkyl chromium intermediate. The results came from multiple reactions, including the reaction of Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Name: Ethyl (2S)-2-amino-3,3-dimethylbutanoate)

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Name: Ethyl (2S)-2-amino-3,3-dimethylbutanoate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and antimicrobial activity of some disperse dyes derived from pyridones》 was published in International Journal of ChemTech Research in 2019. These research results belong to Al-Etaibi, Alya M.. Category: esters-buliding-blocks The article mentions the following:

Pyridone derivatives 4a,b are prepared by reacting N-alkyl-2-cyanoacetamide 1a,b with Me propionylacetate. Compounds 4a,b are coupled with aromatic diazonium salts to produce the corresponding new azo disperse dyes 6a,b. The antimicrobial activity of the synthesized azo disperse dyes are evaluated. In addition to this study using Methyl 3-oxovalerate, there are many other studies that have used Methyl 3-oxovalerate(cas: 30414-53-0Category: esters-buliding-blocks) was used in this study.

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics