Tag: 100-200

The author of 《Biosensing with Insect Odorant Receptor Nanodiscs and Carbon Nanotube Field-Effect Transistors》 were Murugathas, Thanihaichelvan; Zheng, Han Yue; Colbert, Damon; Kralicek, Andrew V.; Carraher, Colm; Plank, Natalie O. V.. And the article was published in ACS Applied Materials & Interfaces in 2019. Synthetic Route of C8H8O3 The author mentioned the following in the article:

Insect odorant receptors have been reconstituted into lipid nanodiscs and tethered to carbon nanotube field-effect transistors to function as a biosensor. Here, four different insect odorant receptors (ORs) from Drosophila melanogaster (DmelOR10a, DmelOR22a, DmelOR35a, and DmelOR71a) were expressed in Sf9 cells, purified, and reconstituted into lipid nanodiscs. We have demonstrated that each of these ORs produce a selective and highly sensitive elec. response to their resp. pos. ligands, Me salicylate, Me hexanoate, trans-2-hexen-1-al, and 4-ethylguaiacol, with limits of detection in the low femtomolar range. No detection was observed for each OR against control ligands, and empty nanodiscs showed no specific sensor signal for any of the odorant mols. Our results are the first evidence that insect ORs can be integrated into lipid nanodiscs and used as primary sensing elements for bioelectronic nose technologies. In the experiment, the researchers used Methyl Salicylate(cas: 119-36-8Synthetic Route of C8H8O3)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Synthetic Route of C8H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 119-36-8In 2020 ,《Diffusion modeling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose》 was published in European Journal of Pharmaceutics and Biopharmaceutics. The article was written by Liu, Xin; Yousef, Shereen; Anissimov, Yuri G.; van der Hoek, John; Tsakalozou, Eleftheria; Ni, Zhanglin; Grice, Jeffrey E.; Roberts, Michael S.. The article contains the following contents:

In this work, we developed a number of generalised skin diffusion based pharmacokinetic models to relate published in vivo urinary excretion data to matching exptl. generated in vitro human skin permeation test (IVPT) data for a series of topically applied salicylate esters. A simplified linear in vivo model was found to inadequately describe the time course of urinary excretion over the entire sampling period. We represented the skin barrier as both a one layer (stratum corneum) and a two-layer (stratum corneum with viable epidermis) diffusion model and convoluted their Laplace solutions with that for a single exponential disposition phase to describe the urinary excretion profiles in the Laplace domain. We also derived asymptotic approximations for the model and estimated the conditions under which they could be used. We then sought to develop in vitro – in vivo relationships (IVIVR) for topically applied Me, Et and glycol salicylates using our exptl. IVPT data and the literature urinary excretion data. Good linear IVIVRs for Et and glycol salicylates were obtained, but the IVIVR for Me salicylate was poor, perhaps because of topical stimulation of local skin blood flow by Me salicylate. The ratio of the hydrated to dehydrated skin permeation for all salicylate esters was the same in both the IVPT and in vivo studies. A diffusion based one compartment pharmacokinetic model was also developed to describe the urinary excretion of solutes after removal of topical products and to compare the Me salicylate skin permeation for five different body sites. The work presented here is consistent with the development of skin IVIVRs, but suggests that different skin conditions, application sites and local skin effects may affect model predictions. In the experiment, the researchers used Methyl Salicylate(cas: 119-36-8Application of 119-36-8)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Application of 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4949-44-4In 2020 ,《Mechanochemically Activated Asymmetric Organocatalytic Domino Mannich Reaction-Fluorination》 appeared in ACS Sustainable Chemistry & Engineering. The author of the article were Kristofikova, Dominika; Meciarova, Maria; Rakovsky, Erik; Sebesta, Radovan. The article conveys some information:

Mechanochem. activation effectively mediated asym. organocatalytic domino Mannich addition followed by diastereoselective fluorination. The Mannich reactions of pyrazolone and to a lesser extent of isoxazolones were effective under solvent-free ball-milling conditions. This reaction in combination with chiral squaramide catalyst provided corresponding products in high yields and enantiomeric purities up to 99:1 e.r. and as a single diastereomer. DFT calculations revealed reasons for high diastereoselectivity. Mechanochem. activation shortens reaction time and increase mass intensity of the stereoselective organocatalytic Mannich reaction-fluorination that afford chiral heterocyclic compoundsEthyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.HPLC of Formula: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Ren, Yuxuan; Ma, Junmei; Liu, Wanying; Huang, Caoxing; Lai, Chenhuan; Ling, Zhe; Yong, Qiang published an article in International Journal of Biological Macromolecules. The title of the article was 《Facile adjustment on cellulose nanocrystals composite films with glycerol and benzyl acrylate copolymer for enhanced UV shielding property》.Formula: C10H10O2 The author mentioned the following in the article:

In the present work, cellulose nanocrystals (CNCs) composite films with suitable applicable capabilities were prepared by facilely incorporating glycerol (Gly) and poly(benzyl acrylate) (PBA). Chem. and morphol. variations during the fabrication of the films were systematically characterized. The properties of modified CNCs composite films including UV blocking ability, mech. strength and thermal properties were characterized to assess their applicable potentials. As a result, the composite films have good UV shielding property in UVC (220-280 nm) region and UVB (280-320 nm) region. The shielding performance of the modified film in the UV absorption region reached 92.77% to 95.49% resp., without damaging the original chiral nematic structure of the films. Along with the modification, BACNC film improved the mech. properties, presenting the tensile strength 16 times higher compared to pure CNCs film. The nanocomposite films proposed in this work showed promising potentials in broad fields, such as food preservation, medical protection, and surface coating applications. In the experiment, the researchers used many compounds, for example, Benzyl acrylate(cas: 2495-35-4Formula: C10H10O2)

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Formula: C10H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Xuewen; Unglaube, Felix; Kragl, Udo; Mejia, Esteban published an article in 2022. The article was titled 《B(C6F5)3-Catalyzed transfer hydrogenation of esters and organic carbonates towards alcohols with ammonia borane》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Recommanded Product: Methyl 4-fluorobenzoate The information in the text is summarized as follows:

Herein, authors report an efficient metal-free system for the transfer hydrogenation of esters and carbonates by-passing the otherwise ubiquitous formation of transesterification side-products. The Lewis acid B(C6F5)3 is used as catalyst and ammonia borane as hydrogen donor. This methodol. shows broad substrate scope and functional group tolerance in excellent yields at very mild conditions. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tharra, Prabhakara R.; Mikhaylov, Andrey A.; Svejkar, Jiri; Gysin, Marina; Hobbie, Sven N.; Svenda, Jakub published an article in 2022. The article was titled 《Short Synthesis of (+)-Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis》, and you may find the article in Angewandte Chemie, International Edition.Application of 4949-44-4 The information in the text is summarized as follows:

We report a concise synthesis of the naturally occurring protein synthesis inhibitor (+)-actinobolin. The densely functionalized and stereochem. complex mol. structure of (+)-actinobolin was assembled from (-)-quinic acid, L-threonine, and L-alanine as the principal components. Our route is based around a convergent strategy that features conjugate addition of an α-amino radical in the key fragment-coupling step. The dramatically simplified synthesis of (+)-actinobolin proceeding in 9 steps with 18% overall yield has practical implications for analog preparation, as demonstrated herein.Ethyl 3-oxopentanoate(cas: 4949-44-4Application of 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Merzhyievskyi, Danylo O.; Shablykin, Oleh V.; Shablykina, Olga V.; Kozytskiy, Andriy V.; Rusanov, Eduard B.; Moskvina, Viktoriia S.; Brovarets, Volodymyr S. published an article in 2021. The article was titled 《Functionalized 5-Amino-4-cyanoxazoles, their Hetero- and Macrocyclic Derivatives: Preparation and Synthetic Applications》, and you may find the article in European Journal of Organic Chemistry.Category: esters-buliding-blocks The information in the text is summarized as follows:

An approach to a series of new 5-amino-4-cyanoxazoles is described. Synthesis of the title compounds relied on a two-step sequence including heterocyclization of 2-amido-3,3-dichloroacrylonitriles with aliphatic secondary amines (dimethylamine, morpholine), primary aliphatic amines with active functional groups (2-aminoethanol and glycine Et ester), and aniline. An efficient and straightforward protocol introduces a carboxylate group at the C-2 position of 5-amino-4-cyanoxazoles, connected to the heterocycle directly or through an aliphatic linker. This carboxylic group is an attractive motif that can be found in a variety of drug-relevant compounds and also used for further modifications. Furthermore, efficient transformations of selected trisubstituted compounds were used to demonstrate their rich synthetic potential – e. g., as precursors to 2-(4-cyano-5-(dimethylamino)oxazol-2-yl)acetamides, oxazole-containing macrocyclic structures, 2-(oxazol-2-yl)acetamides, amino pyrazoles, 3-(4-cyano-5-aminoxazol-2-yl)coumarins, and oxazole amino acids. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Desai, Asim H.; Patil, Sanjay N.; Patel, Mehul K.; Jain, Anandkumar B.; Desai, Jignasu T.; Choubey, Ajit Kumar published an article in 2021. The article was titled 《Development of purification process of edoxaban intermediate (ethyl-2- [(5-chloropyridine-2-Yl)amino]-2-oxoacetate hydrochloride)》, and you may find the article in Journal of Applicable Chemistry (Lumami, India).Application of 4755-77-5 The information in the text is summarized as follows:

Purification method for preparation of edoxaban intermediate, i.e., ethyl-2-[(5-chloropyridine-2- yl)amino]-2-oxoacetate hydrochloride formula using the alc. solvent at reflux condition was reported. The purity of edoxaban intermediate was increased by implementing these manufacturing processes. The process provided in the present invention involved convenient operations and high purity efficiency (<99%). The process was environmental-friendly and suitable for com. scale. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Application of 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Acute kidney injury among salicylate intoxication hospitalisations in the United States》 was written by Thongprayoon, Charat; Petnak, Tananchai; Kaewput, Wisit; Qureshi, Fawad; Mao, Michael A.; Pivovarova, Aleksandra I.; Boonpheng, Boonphiphop; Bathini, Tarun; Vallabhajosyula, Saraschandra; Medaura, Juan; Cheungpasitporn, Wisit. Name: Methyl Salicylate And the article was included in International Journal of Clinical Practice in 2021. The article conveys some information:

This study aimed to evaluate the risk factors and the association of acute kidney injury (AKI) with outcomes, and resource utilization in patients hospitalised because of salicylate intoxication in the United States. Hospitalised patients with a primary diagnosis of salicylate intoxication from 2003 to 2014 were identified in the National Inpatient Sample (NIS) database. End-stage kidney disease patients were excluded. The occurrence of AKI was identified using hospital diagnosis code. Clin. characteristics, in-hospital treatment, outcomes and resource utilization were compared between patients with and without AKI. A total of 13 787 eligible hospital admissions were included in the anal. AKI occurred in 1279 (9.3%) admissions. Older age, male sex, more recent year of hospitalisation, anemia, hypertension, congestive heart failure, chronic kidney disease, volume depletion, sepsis and ventricular arrhythmia/cardiac arrest were significantly associated with increased risk of AKI, whereas Hispanic race was associated with decreased risk. AKI was significantly associated with increased risk of organ failure, and in-hospital mortality. In addition, the need for ventilation support, blood component transfusion, renal replacement therapy, length of hospital stay and hospitalisation cost were higher in AKI patients. Approx. one tenth of salicylate intoxication patients developed AKI during hospitalisation. AKI was associated with higher morbidity, mortality and resource utilizations. In the part of experimental materials, we found many familiar compounds, such as Methyl Salicylate(cas: 119-36-8Name: Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Name: Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis, crystal structure and ADME prediction studies of novel imidazopyrimidines as antibacterial and cytotoxic agents》 was written by Abdel-Mohsen, Heba T.; Abood, Amira; Flanagan, Keith J.; Meindl, Alina; Senge, Mathias O.; El Diwani, Hoda I.. Name: Ethyl 3-oxopentanoate And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2020. The article conveys some information:

In the present study, a novel series of polyfunctionalized imidazopyrimidines I [R1 = H, 4-OMe, 2,5-di-OMe, 3,4,5-tri-OMe; R2 = H, 3,4-di-Cl, 2-OMe, etc.; R3 = H, CN] were efficiently constructed by a domino reaction between 2-imino-6-substituted-2,3-dihydropyrimidin-4(1H)-ones II [ R3 = H, CN; R4 = Me, Ph, 2,5-di-OMeC6H4, etc.] and 2-bromoacetophenones under mild basic conditions. The synthesized series were screened for their antibacterial activity against S. aureus and B. subtilis as Gram-pos. (+) bacteria, as well as against Gram-neg. (-) bacteria E. coli, K. pneumoniae, P. aeruginosa and S. typhi. Most of the synthesized derivatives of imidazopyrimidines I showed remarkable selectivity against Gram(-) bacteria over the Gram(+) ones. Compounds I [R1 = H; R2 = 4-Cl, 3,4-di-Cl, 2-OMe; R3 = CN] displayed potent and broad-spectrum antibacterial activity against all tested strains. Compounds I [R1 = H; R2 = 3,4-di-Cl, 2-OMe; R3 = CN] displayed promising inhibitory activity on GryB ATPase from E. coli with IC50 = 1.14 and 0.73μM, resp. Simultaneously, some of the synthesized imidazopyrimidines were screened for their antiproliferative activity against 60 cancer cell lines at a concentration of 10μM. Compound I [R1 = Ph; R2 = 4-F; R3 = H] showed potent activity against most of the tested cell lines, with a mean growth inhibition of 37%. The ADME (absorption, distribution, metabolism, and excretion) prediction study demonstrated that the synthesized hits had, in addition to their promising chemotherapeutic activity, acceptable pharmacokinetic properties, and a drug-likeness nature to be further developed. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-oxopentanoate(cas: 4949-44-4Name: Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Name: Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics