Tag: 100-200

The author of 《Asymmetric Dearomatization of Indole Derivatives with N-Hydroxycarbamates Enabled by Photoredox Catalysis》 were Cheng, Yuan-Zheng; Zhao, Qing-Ru; Zhang, Xiao; You, Shu-Li. And the article was published in Angewandte Chemie, International Edition in 2019. Safety of N-tert-Butoxycarbonylhydroxylamine The author mentioned the following in the article:

Under blue LED irradiation and aerobic conditions in the presence of an iridium photoredox catalyst and a nonracemic binaphthylphosphoric acid, indoles with nucleophiles appended at the 3-position such as I underwent enantioselective dearomatization and cyclization reactions with N-hydroxycarbamates such as HONHCO2R (R = 2,4,6-Me3C6H2CH2) to yield nonracemic furoindoles such as II (R = 2,4,6-Me3C6H2CH2), pyrroloindoles, and indoloquinolines. The mechanism of the reaction was studied using fluorescence quenching, measurement of oxidation potentials, and reaction inhibition by TEMPO; sequential single-electron transfer oxidations of the indole moiety are needed to generate the configurationally biased carbocation species while providing the source of stereochem. induction for the reaction. After reading the article, we found that the author used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Safety of N-tert-Butoxycarbonylhydroxylamine)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of N-tert-Butoxycarbonylhydroxylamine

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In 2010,Tyagarajan, Sriram; Chakravarty, Prasun K.; Zhou, Bishan; Fisher, Michael H.; Wyvratt, Mathew J.; Lyons, Kathy; Klatt, Tracy; Li, Xiaohua; Kumar, Sanjeev; Williams, Brande; Felix, John; Priest, Birgit T.; Brochu, Richard M.; Warren, Vivien; Smith, McHardy; Garcia, Maria; Kaczorowski, Gregory J.; Martin, William J.; Abbadie, Catherine; McGowan, Erin; Jochnowitz, Nina; Parsons, William H. published 《Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers》.Bioorganic & Medicinal Chemistry Letters published the findings.Electric Literature of C4H7NO2S The information in the text is summarized as follows:

Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low mol. weight biaryl substituted imidazole, e.g. I, oxazole, e.g. II, and thiazole, e.g. III, carboxamides were identified with good in vitro and in vivo potency. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Electric Literature of C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C4H7NO2S

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The author of 《Stereochemical studies, XXVII. Studies on 2-hydroxycycloalkanoates, VI》 were Bernath, Gabor; Sohar, Pal; Lang, Kornelia L.; Gondos, Gyorgy; Gera, Lajos; Pal, A.. And the article was published in Acta Chimica Academiae Scientiarum Hungaricae in 1977. Reference of Cis-methyl 2-hydroxycyclohexanecarboxylate The author mentioned the following in the article:

The saponification kinetics of I (R = Et, n = 1, 2, 3, 4) and II (R = Et, R1 = OH, n = 1, 2, 3, 4) in 70% aqueous dioxane are accelerated by a factor of 10-21 by the neighboring OH group with respect to II [R = Et, R1 = H (III), n = 1, 2, 3, 4]; the ratio of reaction rates occurring with or without OH participation is ester concentration dependent. There is no difference between the cis and trans isomers in the cyclopentane or cycloheptane series; I (R = Et, n = 4) reacts faster than II (R = Et, R1 = OH, n = 4) while I (R = Et, n = 2) reacts slower then II (R = Et, R1 = OH, n = 2). The isokinetic temperatures for the saponification of I and II (R1 = OH) is 151 ± 12 K. The slope with III in steeper than that with I (R = Et) or II (R = Et, R1 = OH) indicating that the 2 reactions occur by different mechanisms. The rate enhancing effect of the neighboring OH group is due to mostly to solvent sorting by the OH group. H-bonding in I and II (R1 = OH) and the IR and NMR of I (R = Et, Me) and II (R = Me, Et; R1 = OH) are discussed. After reading the article, we found that the author used Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8Reference of Cis-methyl 2-hydroxycyclohexanecarboxylate)

Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Reference of Cis-methyl 2-hydroxycyclohexanecarboxylate Polyesters are important plastics, with monomers linked by ester moieties.

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A study on the ultraviolet spectroscopy of pyrrolecarboxylic acid esters》 was written by Rhee, Kyu Hyun; Han, In Sook. Category: esters-buliding-blocks And the article was included in Nonchong – Han’guk Saenghwal Kwahak Yonguwon in 1979. The article conveys some information:

The UV spectra of 32 pyrrolecarboxylic acid esters and 13 pyrrolecarboxylic acids were examined and their absorption wavelengths and absorption coefficients were classified according to π-π* or ET transition. The absorption maximum of N-arylpyrrole derivatives with electron-withdrawing substituents were linearly related according to the Hammett equation. The experimental part of the paper was very detailed, including the reaction process of Dimethyl 1H-pyrrole-2,3-dicarboxylate(cas: 2818-08-8Category: esters-buliding-blocks)

Dimethyl 1H-pyrrole-2,3-dicarboxylate(cas: 2818-08-8) belongs to pyrroles. Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme.Category: esters-buliding-blocks

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Ester – Wikipedia,
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Name: Ethyl 2-amino-2-thioxoacetateIn 2008 ,《Synthesis of 5-(Thiazol-5-yl)-4,5-dihydroisoxazoles from 3-Chloropentane-2,4-dione》 was published in Journal of Combinatorial Chemistry. The article was written by Milinkevich, Kristin A.; Ye, Long; Kurth, Mark J.. The article contains the following contents:

Condensation of 3-chloropentane-2,4-dione with thioamides gives 1-(thiazol-5-yl)ethanones and subsequent Wittig olefination, followed by nitrile oxide 1,3-dipolar cycloaddition to the resulting prop-1-en-2-yl moiety, delivers racemic 5-(thiazol-5-yl)-4,5-dihydroisoxazoles, e.g. I. When this thiazole and isoxazoline diheterocyclic scaffold has a carboethoxy substituent at C2 of the thiazole ring, aminolysis provides for effective diversification. A 50-member library of various 5-(thiazol-5-yl)-4,5-dihydroisoxazoles is reported. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Name: Ethyl 2-amino-2-thioxoacetate)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Name: Ethyl 2-amino-2-thioxoacetate

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Ester – Wikipedia,
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Product Details of 2495-35-4In 2019 ,《Ruthenium(II) Catalysed Highly Regioselective C-3 Alkenylation of Indolizines and Pyrrolo[1,2-a]quinolines》 was published in European Journal of Organic Chemistry. The article was written by Jadhav, Pankaj Pandit; Kahar, Nilesh Machhindra; Dawande, Sudam Ganpat. The article contains the following contents:

Discovered the ruthenium(II) catalyzed highly stereo- and regioselective protocol for the oxidative C-3 alkenylation of indolizines and pyrrolo[1,2-a]quinolines. The methodol. represents the first example for the directing group assisted C-C bond formation reaction of the indolizines. Under mild reaction conditions, this method provides an ample substrate scope to produce C-3 alkenyl indolizines in excellent to moderate yields. However, pyrrolo[1,2-a]quinolines underwent alkenynation at elevated temperature to furnish C-3 alkenyl derivatives The functionalized indolizines were selectively reduced to obtain their saturated derivatives The experimental process involved the reaction of Benzyl acrylate(cas: 2495-35-4Product Details of 2495-35-4)

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Product Details of 2495-35-4

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HPLC of Formula: 119-36-8In 2019 ,《Methyl salicylate delays peel yellowing of ‘Zaosu’ pear (Pyrus bretschneideri) during storage by regulating chlorophyll metabolism and maintaining chloroplast ultrastructure》 appeared in Journal of the Science of Food and Agriculture. The author of the article were Zhang, Huaiyu; Wang, Rui; Wang, Tian; Fang, Chunxia; Wang, Junjie. The article conveys some information:

BACKGROUND : In some cultivars, yellowing resulting from chlorophyll breakdown has a direct and neg. effect on food supply and health. The ‘Zaosu’ pear (Pyrus bretschneideri Rehd.), a com. Asian pear cultivar in China, rapidly turns yellow when stored at room temperature after harvest. To develop techniques that delay or suppress chlorophyll degradation, the effects of Me salicylate (MeSA) on yellowing in ‘Zaosu’ pear fruit during storage were evaluated. RESULTS : Compared with the untreated fruit, the application of 0.05 mmol L-1 MeSA delayed the decline of the total chlorophyll, chlorophyll a and chlorophyll b content, and maintained more intact chloroplasts with fewer and smaller plastoglobuli. Me salicylate suppressed enzyme activities, including chlorophyllase, chlorophyll-degrading peroxidase, Mg dechelatase, and pheophytinase, and the expression levels of NYC, NOL, CLH, SGR, PPH, PAO and RCCR in treated fruit. CONCLUSION : Me salicylate could delay chlorophyll breakdown in the fruit. The results also suggested that the conversion from chlorophyll a to pheophorbide a could proceed via two pathways, and that alternative pathways for the breakdown of chlorophyll a exist in ‘Zaosu’ pears. © 2019 Society of Chem. Industry. After reading the article, we found that the author used Methyl Salicylate(cas: 119-36-8HPLC of Formula: 119-36-8)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.HPLC of Formula: 119-36-8

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2010,El-Essawi, Aschraf; Hajek, Tomas; Skorpil, Jirji; Böning, Andreas; Sabol, Frantisek; Hausmann, Harald; Ostrovsky, Yuri; Harringer, Wolfgang published 《A prospective randomised multicentre clinical comparison of a minimised perfusion circuit versus conventional cardiopulmonary bypass.》.European journal of cardio-thoracic surgery published the findings.HPLC of Formula: 329-59-9 The information in the text is summarized as follows:

OBJECTIVE: Minimised perfusion circuits (MPCs) are expected to reduce the side effects of conventional cardiopulmonary bypass (CCPB); however, conclusive data from sufficiently powered clinical trials are lacking. The purpose of this study was to evaluate the safety and efficacy of the ROCsafeRX minimised perfusion circuit. METHODS: A randomised, controlled, multicentre clinical trial comparing both perfusion circuits in patients subjected to elective coronary artery bypass and/or aortic valve replacement is described. The primary end points of safety, defined as procedure success without device-related complications, and secondary end point of efficacy, including reduction of transfusion requirement and incidence of atrial fibrillation, are analysed. RESULTS: To date, 291 patients have been enrolled and randomised (146 MPC vs 145 CCPB). With the exception of a significantly higher male population in the MPC group (83.6% vs 71.0%, p=0.01), both groups were well matched for demographic data and type of surgery. There were no device-related complications but a hard-shell reservoir had to be integrated in one MPC because of a tear in the right atrium that was managed uneventfully. Total transfusion requirement (329+/-599 ml vs 783+/-1638 ml, p < or = 0.001) and erythrocyte transfusion (181+/-341 ml vs 434+/-798 ml, p < or = 0.001) were significantly reduced in the MPC group. The incidence of atrial fibrillation was significantly lower in the MPC group (7.1% vs 19.5%, p < or = 0.01), while freedom of major adverse events showed no significant difference. CONCLUSIONS: Lack of device-related complications combined with a significant reduction in postoperative atrial fibrillation and transfusion requirements have shown the ROCsafeRX MPC to be both safe and efficient for large-scale use in cardiac patients. Additional data are expected to confirm these initial findings. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9HPLC of Formula: 329-59-9)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.HPLC of Formula: 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

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Ester – Wikipedia,
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The author of 《Squaramide-decorated covalent organic framework as a new platform for biomimetic hydrogen-bonding organocatalysis》 were Li, Xia; Wang, Zhifang; Sun, Jiaxing; Gao, Jia; Zhao, Yu; Cheng, Peng; Aguila, Briana; Ma, Shengqian; Chen, Yao; Zhang, Zhenjie. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Computed Properties of C6H10O3 The author mentioned the following in the article:

A squaramide-decorated COF was synthesized and used as a highly efficient heterogeneous catalyst for hydrogen-bonding organocatalysis as exemplified in the context of catalyzing Michael addition reactions under mild conditions. Our work lays a foundation for the development of functional COFs as a new platform for biomimetic organocatalysis. After reading the article, we found that the author used Methyl 3-oxovalerate(cas: 30414-53-0Computed Properties of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Computed Properties of C6H10O3

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SDS of cas: 16982-21-1In 2008 ,《Synthesis and reactions of some new substituted thiazolidin-4-ones derivatives with antioxidant properties》 was published in Organic Chemistry: An Indian Journal. The article was written by El Nzhawy, Ahmed O. H.; Ramla, Mostafa M.; Khalifa, Nagy M.; Abdulla, Mohamed M.. The article contains the following contents:

Several hetero substituted 2-(4-fluorophenyl)thiazolidin-4-one derivatives, e.g., I, have been synthesized. The newly prepared series of substituted thiazolodinone derivatives were screened for their in vitro antioxidant activity. The detailed synthesis and antioxidant activity data are reported. Structures of the compounds have been established by elemental analyses and spectral data. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1SDS of cas: 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.SDS of cas: 16982-21-1

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics