Tag: 100-200

In 2007,Koenig, Andreas; Roegler, Carolin; Lange, Kathrin; Daiber, Andreas; Glusa, Erika; Lehmann, Jochen published 《NO donors. Investigations on structure-activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent vasodilator》.Bioorganic & Medicinal Chemistry Letters published the findings.Category: esters-buliding-blocks The information in the text is summarized as follows:

The vasoactive properties of 14 organic mononitrates were investigated in vitro using PGF2α-precontracted porcine pulmonary arteries. A surprisingly wide range of vasorelaxant potencies was observed (pD2: 3.36-7.50). Activities showed to be highly sensitive to the mol. structure and the substituents at the mol. carrier of the nitrate group. A correlation between lipophilicity and vasorelaxant potency could not be recognized. 2-Nitrooxyethylammoniumnitrate (1) was found to be slightly superior to the high potency trinitrate GTN. After reading the article, we found that the author used Methyl 3-hydroxypropanoate(cas: 6149-41-3Category: esters-buliding-blocks)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2004,Parkkari, Teija; Savinainen, Juha R.; Rauhala, Anu L.; Tolonen, Tiina L.; Nevalainen, Tapio; Laitinen, Jarmo T.; Gynther, Jukka; Jarvinen, Tomi published 《Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives》.Bioorganic & Medicinal Chemistry Letters published the findings.SDS of cas: 6149-41-3 The information in the text is summarized as follows:

Novel derivatives of arachidonyl alc. were synthesized and evaluated for their CB1 receptor activity by [35S]GTPγS assay using rat cerebellar membranes. The results came from multiple reactions, including the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3SDS of cas: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zogota, Rimants; Kinena, Linda; Withers-Martinez, Chrislaine; Blackman, Michael J.; Bobrovs, Raitis; Pantelejevs, Teodors; Kanepe-Lapsa, Iveta; Ozola, Vita; Jaudzems, Kristaps; Suna, Edgars; Jirgensons, Aigars published an article on February 1 ,2019. The article was titled 《Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D》, and you may find the article in European Journal of Medicinal Chemistry.Product Details of 1877-71-0 The information in the text is summarized as follows:

Following up the open initiative of anti-malarial drug discovery, a GlaxoSmithKline (GSK) phenotypic screening hit was developed to generate hydroxyethylamine based plasmepsin (Plm) inhibitors exhibiting growth inhibition of the malaria parasite Plasmodium falciparum at nanomolar concentrations Lead optimization studies were performed with the aim of improving Plm inhibition selectivity vs. the related human aspartic protease cathepsin D (Cat D). Optimization studies were performed using Plm IV as a readily accessible model protein, the inhibition of which correlates with anti-malarial activity. Guided by sequence alignment of Plms and Cat D, selectivity-inducing structural motifs were modified in the S3 and S4 sub-pocket occupying substituents of the hydroxyethylamine inhibitors. This resulted in potent anti-malarials with an up to 50-fold Plm IV/Cat D selectivity factor. More detailed investigation of the mechanism of action of the selected compounds revealed that they inhibit maturation of the P. falciparum subtilisin-like protease SUB1, and also inhibit parasite egress from erythrocytes. Our results indicate that the anti-malarial activity of the compounds is linked to inhibition of the SUB1 maturase plasmepsin subtype Plm X. In the experiment, the researchers used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Product Details of 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Product Details of 1877-71-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Zhang, Guodong; Hu, Zhiyong; Belitz, Florian; Ou, Yang; Pirkl, Nico; Goossen, Lukas J.. SDS of cas: 1877-71-0. The article was titled 《Rhodium-Catalyzed Annelation of Benzoic Acids with α,β-Unsaturated Ketones with Cleavage of C-H, CO-OH, and C-C Bonds》. The information in the text is summarized as follows:

In the presence of a [Cp*RhCl2]2 catalyst, the Lewis acid In(OTf)3, and the mild base Na2CO3, aromatic carboxylates and α,β-unsaturated ketones undergo a unique hydroarylation/Claisen/retro-Claisen process to give the corresponding indanones. In this carboxylate-directed ortho-C-H annelation, the C-COR bond of the ketone and the CO-OH group of the aromatic carboxylate are cleaved, and the hydroxy group is transferred from the aromatic to the aliphatic acyl residue. This reactivity is synthetically useful, particularly when starting from cyclic ketones, which are converted into indanones bearing aliphatic carboxylate side chains, thus greatly increasing the mol. complexity of aromatic carboxylates in a single step.3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0SDS of cas: 1877-71-0) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.SDS of cas: 1877-71-0 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Unexpected Preference of the E. coli Translation System for the Ester Bond during Incorporation of Backbone-Elongated Substrates》 was written by Sando, Shinsuke; Abe, Kenji; Sato, Nobuhiko; Shibata, Toshihiro; Mizusawa, Keigo; Aoyama, Yasuhiro. Recommanded Product: Methyl 3-hydroxypropanoateThis research focused ontranslation ribosome tRNA protein oligopeptide hydroxypropionic acid stereochem. The article conveys some information:

There have been recent advances in the ribosomal synthesis of various mols. composed of nonnatural ribosomal substrates. However, the ribosome has strict limitations on substrates with elongated backbones. Here, we show an unexpected loophole in the E. coli translation system, based on a remarkable disparity in its selectivity for β-amino/hydroxy acids. We challenged β-hydroxypropionic acid (β-HPA), which is less nucleophilic than β-amino acids but free from protonation, to produce a new repertoire of ribosome-compatible but main-chain-elongated substrates. PAGE anal. and mass-coupled S-tag assays of amber suppression experiments using yeast suppressor tRNAPheCUA confirmed the actual incorporation of β-HPA into proteins/oligopeptides. We investigated the side-chain effects of β-HPA and found that the side chain at position α and R stereochem. of the β-substrate is preferred and even notably enhances the efficiency of incorporation as compared to the parent substrate. These results indicate that the E. coli translation machinery can utilize main-chain-elongated substrates if the pKa of the substrate is appropriately chosen. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Rapid Bis-Coupling Reactivity with Triarylbismuth Reagents: Synthesis of Structurally Diverse Scaffolds and Step-economic Convergent Synthesis of Quebecol》 was written by Rao, Maddali L. N.; Murty, Venneti N.; Nand, Sachchida. Product Details of 4755-77-5This research focused ontriarylbismuth dibromo ester palladium cross coupling; quebecol synthesis cross coupling; trisubstituted acrylate preparation. The article conveys some information:

The cross-coupling study of gem-dibromoesters with triarylbismuths as threefold arylating reagents was investigated under palladium-catalyzed conditions. This study using triarylbismuth reagents explored the cross-coupling reactivity with various functionalized gem-dibromoesters. It furnished a variety of multi-functional trisubstituted acrylates embedded with aryl, alkene and alkyne scaffolds in high yields. The present study in turn, provided easy access to various triarylated acrylates and functionalized 1,3-dienyl and 1,3-enyne esters. Further, the established method applied in the step-economic and convergent synthesis of quebecol (I) natural product in good yield. In the experimental materials used by the author, we found Ethyl oxalyl monochloride(cas: 4755-77-5Product Details of 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Pd(II)-Catalyzed Synthesis of Bicyclo[3.2.1] Lactones via Tandem Intramolecular β-C(sp3)-H Olefination and Lactonization of Free Carboxylic Acids》 was written by Tomanik, Martin; Qian, Shaoqun; Yu, Jin-Quan. Safety of Benzyl acrylateThis research focused onunsaturated carboxylic acid palladium catalyst tandem olefination lactonization; bicyclo lactone preparation. The article conveys some information:

Herein, the detail development of a novel palladium(II)-catalyzed tandem intramol. β-C(sp3)-H olefination and lactonization reaction that rapidly transforms linear carboxylic acid possessing a tethered olefin into the bicyclo[3.2.1] lactone motif was reported. This transformation features a broad substrate scope, shows excellent functional group compatibility, and was extended to the preparation of the related seven-membered bicyclo[4.2.1] lactones. Addnl., the synthetic potential of this annulation by constructing the 6,6,5-tricyclic lactone core structure of the meroterpenoid cochlactone A was demonstrated. It was anticipated that this compelling reaction may provide a novel synthetic disconnection that can be broadly applied toward the preparation of a variety of bioactive natural products. In the experiment, the researchers used many compounds, for example, Benzyl acrylate(cas: 2495-35-4Safety of Benzyl acrylate)

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Safety of Benzyl acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Cobalt(III)-Catalyzed Enantioselective Intermolecular Carboamination by C-H Functionalization》 was written by Ozols, Kristers; Onodera, Shunsuke; Wozniak, Lukasz; Cramer, Nicolai. Related Products of 2495-35-4This research focused onunnatural tyrosine enantioselective preparation intermol carboamination acrylate bicyclic olefin; aminobicycle enantioselective preparation intermol carboamination acrylate bicyclic olefin; C−H functionalization; asymmetric catalysis; carboamination; chiral cyclopentadienyl; cobalt. The article conveys some information:

High-valent cyclopentadienyl cobalt catalysis is a versatile tool for sustainable C-H bond functionalizations. To harness the full potential of this strategy, control of the stereoselectivity of these processes is necessary. Herein, we report highly enantioselective intermol. carboaminations of alkenes through C-H activation of N-phenoxyamides catalyzed by CoIII-complexes equipped with chiral cyclopentadienyl (Cpx) ligands. The method converts widely available acrylates as well as bicyclic olefins into attractive enantioenriched isotyrosine derivatives as well as elaborated amino-substituted bicyclic scaffolds under very mild conditions. The outlined reactivity is unique to the CpxCoIII complexes and is complementary to the reactivity of 4d- and 5d- precious-metal catalysts. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4Related Products of 2495-35-4) was used in this study.

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Related Products of 2495-35-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Carbon-13 NMR spectra of some methyl cyclohexanecarboxylates》 was written by Senda, Yasuhisa; Ishiyama, Junichi; Imaizumi, Shin. Application of 936-03-8 And the article was included in Bulletin of the Chemical Society of Japan in 1976. The article conveys some information:

13C NMR spectra of a series of 18 stereoisomeric substituted Me cyclohexanecarboxylates were determined The resonances for ring C atoms of the isomers in which both the methoxycarbonyl and the other groups had equatorial orientations usually appeared at a field lower than those of the isomers in which 1 of the 2 substituents had axial orientation. No appreciable difference in shift due to configurational change was observed in the resonances for the substituents. Observed chem. shifts were compared with predicted values. In the experimental materials used by the author, we found Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8Application of 936-03-8)

Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Application of 936-03-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C8H6FNO4In 2009 ,《Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Miyashiro, Julie; Woods, Keith W.; Park, Chang H.; Liu, Xuesong; Shi, Yan; Johnson, Eric F.; Bouska, Jennifer J.; Olson, Amanda M.; Luo, Yan; Fry, Elizabeth H.; Giranda, Vincent L.; Penning, Thomas D.. The article conveys some information:

Based on screening hit I, a series of tricyclic quinoxalinones e.g. II, have been designed and evaluated for inhibition of PARP-1. Substitutions at the 7- and 8-positions of the quinoxalinone ring led to a number of compounds with good enzymic and cellular potency. The tricyclic quinoxalinone class is sensitive to modifications of both the amine substituent and the tricyclic core. The synthesis and structure-activity relationship studies are presented. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9COA of Formula: C8H6FNO4)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.COA of Formula: C8H6FNO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics