Tag: 100-200

《Photo-Mediated Intermolecular Coupling of Alkenes with Ketones via Acyloxy Nitroso Compounds》 was written by Zheng, Danqing; Ploeger, Stefanie; Daniliuc, Constantin G.; Studer, Armido. Application of 2495-35-4 And the article was included in Angewandte Chemie, International Edition in 2021. The article conveys some information:

An atom-economic intermol. radical addition reaction of acyloxy nitroso compounds such as I to electron-deficient alkenes such as Ph vinyl ketone mediated by visible light to yield δ-acyloxy β-ketocarbonyl compound monooximes such as II is reported. The starting nitroso derivatives are readily prepared by oxidation of the corresponding oximes prepared from ketones and the overall transformation represents an oxidative coupling of a ketone with a Michael acceptor. The cascade proceeds smoothly under mild conditions, providing a series of valuable functionalized oximes in moderate to good yields. Mechanistic studies suggest that these cascades proceed via addition/coupling processes that are controlled by the persistent radical effect (PRE) with NO acting as the persistent species. After reading the article, we found that the author used Benzyl acrylate(cas: 2495-35-4Application of 2495-35-4)

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Application of 2495-35-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents》 was written by Zheng, Xian-Jing; Li, Chun-Shi; Cui, Ming-Yue; Song, Ze-Wen; Bai, Xue-Qian; Liang, Cheng-Wu; Wang, Hui-Yan; Zhang, Tian-Yi. Name: Methyl 4-fluorobenzoate And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Twenty benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety were synthesized and evaluated for their antioxidant and antiinflammatory activities. Among these compounds, 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole and 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)-2-methoxyphenoxy)methyl)-5-(2-chlorophenyl)-1,3,4-oxadiazole were appeared to have high radical scavenging efficacies as 0.05 ± 0.02 and 0.07 ± 0.03 mmol/L of IC50 values in ABTS+· bioassay, resp. In antiinflammatory tests, compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole displayed good activity with 57.35% inhibition after i.p. administration, which was more potent than the reference drug (indomethacin). Mol. modeling studies were performed to study the binding mode of the representative compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole into COX-2 enzyme. In vitro enzyme study implied that compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole exerted its antiinflammatory activity through COX-2 inhibition. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of 1,2,3-Triazoles Bearing a 4-Hydroxyisoxazolidine Moiety from 4,5-Unsubstituted 2,3-Dihydroisoxazoles》 was written by Stadaniova, Radka; Sahulcik, Michal; Dohanosova, Jana; Moncol, Jan; Janotka, Lubos; Simonicova, Kristina; Messingerova, Lucia; Fischer, Robert. SDS of cas: 36016-38-3 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A synthetic approach towards new 1,2,3-triazoles bearing the 3-hydroxymethylated 4-hydroxyisoxazolidine moiety has been described. The strategy has relied on dihydroxylation and epoxidation reactions of 4,5-unsubstituted 2,3-dihydroisoxazoles, allowing the introduction of the hydroxy group at the isoxazolidine ring in a trans stereoselective manner with respect to the substituent at C-3 carbon atom. The requisite 5-azidoisoxazolidines have been prepared from activated isoxazolidines possessing a good leaving group at C-5 carbon atom by treatment with trimethylsilyl azide and Lewis acid (isoxazolidinyl benzoates) or with sodium azide (chloroisoxazolidines). The 1,2,3-triazole moiety has been synthesized through copper(I)-catalyzed azide-alkyne cycloaddition In addition to this study using N-tert-Butoxycarbonylhydroxylamine, there are many other studies that have used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3SDS of cas: 36016-38-3) was used in this study.

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).SDS of cas: 36016-38-3

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Chemo- and Enantioselective Oxidative α-Azidation of Carbonyl Compounds》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Uyanik, Muhammet; Sahara, Naoto; Tsukahara, Mayuko; Hattori, Yuhei; Ishihara, Kazuaki. Synthetic Route of C7H12O3 The article mentions the following:

The authors report high-performance I+/H2O2 catalysis for the oxidative or decarboxylative oxidative α-azidation of carbonyl compounds by using sodium azide under biphasic neutral phase-transfer conditions. To induce higher reactivity especially for the α-azidation of 1,3-dicarbonyl compounds, the authors designed a structurally compact isoindoline-derived quaternary ammonium iodide catalyst bearing electron-withdrawing groups. The nonproductive decomposition pathways of I+/H2O2 catalysis could be suppressed using a catalytic amount of a radical-trapping agent. This oxidative coupling tolerates a variety of functional groups and could be readily applied to the late-stage α-azidation of structurally diverse complex mols. Moreover, the authors achieved the enantioselective α-azidation of 1,3-dicarbonyl compounds as the first successful example of enantioselective intermol. oxidative coupling with a chiral hypoiodite catalyst. In the experimental materials used by the author, we found Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Enantioselective remote C-H activation directed by a chiral cation》 was published in Science (Washington, DC, United States) in 2020. These research results belong to Genov, Georgi R.; Douthwaite, James L.; Lahdenpera, Antti S. K.; Gibson, David C.; Phipps, Robert J.. HPLC of Formula: 4248-19-5 The article mentions the following:

Chiral cations have been used extensively as organocatalysts, but their application to rendering transition metal-catalyzed processes enantioselective remains rare. This is despite the success of the analogous charge-inverted strategy in which cationic metal complexes are paired with chiral anions. We report here a strategy to render a common bipyridine ligand anionic and pair its iridium complexes with a chiral cation derived from quinine. We have applied these ion-paired complexes to long-range asym. induction in the desymmetrization of the geminal diaryl motif, located on a carbon or phosphorus center, by enantioselective C-H borylation. In principle, numerous common classes of ligand could likewise be amenable to this approach. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5HPLC of Formula: 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.HPLC of Formula: 4248-19-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics》 was published in Journal of the American Chemical Society in 2020. These research results belong to Nicolaou, K. C.; Das, Dipendu; Lu, Yong; Rout, Subhrajit; Pitsinos, Emmanuel N.; Lyssikatos, Joseph; Schammel, Alexander; Sandoval, Joseph; Hammond, Mikhail; Aujay, Monette; Gavrilyuk, Julia. Recommanded Product: 4248-19-5 The article mentions the following:

The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-F and yangpumicin A. This family of natural products provides opportunities in total synthesis, biol., and medicine due to their novel and challenging mol. structures, intriguing biol. properties and mechanism of action, and potential in targeted cancer therapies. Herein, the total syntheses of tiancimycins A and B, yangpumicin A, and a number of related anthraquinone-fused enediynes are described. Biol. evaluation of the synthesized compounds revealed extremely potent cytotoxicities against a number of cell lines, thus enriching the structure-activity relationships within this class of compounds The findings of these studies may facilitate future investigations directed toward antibody-drug conjugates for targeted cancer therapies and provide inspiration for further advances in total synthesis and chem. biol.tert-Butyl carbamate(cas: 4248-19-5Recommanded Product: 4248-19-5) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 4248-19-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Integrating Water-Soluble Polythiophene with Transition-Metal Dichalcogenides for Managing Photoinduced Processes》 were Canton-Vitoria, Ruben; Istif, Emin; Hernandez-Ferrer, Javier; Urriolabeitia, Esteban; Benito, Ana M.; Maser, Wolfgang K.; Tagmatarchis, Nikos. And the article was published in ACS Applied Materials & Interfaces in 2019. Electric Literature of C5H11NO2 The author mentioned the following in the article:

Transition-metal dichalcogenides (TMDs) attract increased attention for the development of donor-acceptor materials enabling improved light harvesting and optoelectronic applications. The development of novel donor-acceptor nanoensembles consisting of poly(3-thiophene sodium acetate) and ammonium functionalized MoS2 and WS2 was accomplished, while photoelectrochem. cells were fabricated and examined Attractive interactions between the neg. charged carboxylate anion on the polythiophene backbone and the pos. charged ammonium moieties on the TMDs enabled in a controlled way and in aqueous dispersions the electrostatic association of two species, evidenced upon titration experiments A progressive quenching of the characteristic fluorescence emission of the polythiophene derivative at 555 nm revealed photoinduced intraensemble energy and/or electron transfer from the polymer to the conduction band of the two TMDs. Photoelectrochem. assays further confirmed the establishment of photoinduced charge-transfer processes in thin films, with distinct responses for the MoS2- and WS2-based systems. The MoS2-based ensemble exhibited enhanced photoanodic currents offering addnl. channels for hole transfer to the solution, whereas the WS2-based one displayed increased photocathodic currents providing supplementary pathways of electron transfer to the solution Moreover, scan direction depending on photoanodic and photocathodic currents suggested the existence of yet unexploited photoinduced memory effects. These findings highlight the value of electrostatic interactions for the creation of novel donor-acceptor TMD-based ensembles and their relevance for managing the performance of photoelectrochem. and optoelectronic processes. The results came from multiple reactions, including the reaction of tert-Butyl carbamate(cas: 4248-19-5Electric Literature of C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Electric Literature of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Pakistan Journal of Pharmaceutical Sciences included an article by Jafri, Rehana; Imran, Hina; Ahmed, Amir; Sohail, Tehmina; Ahmed, Irshad; Yaqeen, Zahra. SDS of cas: 119-36-8. The article was titled 《Formulation and screening of analgesic activity of different analgesic gel preparations》. The information in the text is summarized as follows:

This study was aimed to investigate the dermal irritant test and the central analgesic effects of topical application of seven different formulations (A-G) of analgesic gel prepared from locally available raw material in animal model. The results of dermal irritant test revealed that no animal showed any kind of toxic effect i.e. redness, irritation, itching, inflammation, skin infection or any other injurious effects. All animals remained healthy, active, alert showing normal behavior and no mortality was observed during the claimed period. The analgesic activity was performed by tail flick test. The analgesic activity against tail flick test revealed that all samples of test gel had analgesic effect at 15, 30 and 60 min after sample application but sample D had highest analgesic effects (193%) followed by sample E (155%), sample C (122%), sample G (85%), sample B (84%),sample F (81%) while sample A exhibited (73%) analgesic activity. Wintogeno was run as standard drug and it showed 168% analgesic activity. In the experiment, the researchers used Methyl Salicylate(cas: 119-36-8SDS of cas: 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.SDS of cas: 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2014,Kandre, Shivaji; Bhagat, Pundlik Rambhau; Kumar Reddy, M. Mahesh; Dalal, Roda; Dixit, Amol; Deshmukh, Nitin J.; Anthony, Jessy; Bose, Julie; Anupindi, Raghuram; Sharma, Rajiv; Gupte, Amol published 《Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors》.European Journal of Medicinal Chemistry published the findings.Related Products of 16982-21-1 The information in the text is summarized as follows:

Diacylglycerol acyltransferase 1 (DGAT1) is known to play an important catalytic role in the final step of triglyceride biosynthesis. High fat diet fed DGAT1 knockout mice were resistant to weight gain and exhibited increased insulin and leptin sensitivity thereby indicating a plausible role for DGAT1 inhibitors in the treatment of obesity. 4-Phenylpiperidine-1-carbonyl cyclohexanecarboxylic acid has been lately reported as a potent DGAT1 inhibitor (DGAT1 IC50 = 57 nM). In the search for newer scaffolds possessing potent DGAT1 activity the authors undertook a systematic diversification of this compound to identify a 4-(5-phenylthiazole-2-carboxamido)cyclohexanecarboxylic acid scaffold I [R = PhNHCO, 3,5-F2C6H3CO, 3,5-F2C6H3SO2, etc.]. Further linker optimization of this scaffold identified compound I [R = 2-FC6H4NHCO] (DGAT1 IC50 = 14.8 nM) as a potent DGAT1 inhibitor. Coupled with its in vitro potency, the compound also exhibited 112% plasma triglyceride reduction at a 3 mpk dose in an oral fat tolerance test when studied in Swiss mice. After reading the article, we found that the author used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Related Products of 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Related Products of 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Kakadiya, Monika; Parmar, Bharti; Chethan, G. H.; Deka, Satyendra; Saravanan, J.; Mohan, S. published 《Synthesis of some novel triazole heterocyclic derivatives as antibacterial agents》.American Journal of PharmTech Research published the findings.Recommanded Product: Ethyl 2-amino-2-thioxoacetate The information in the text is summarized as follows:

Ethyl-4-(4′-chlorophenyl)-thiazol-2-carboxylate was treatment with hydrazine hydrate to obtain 4-(4′-chlorophenyl)-thiazol-2-carbohydrazide and subsequent reaction with alc. potassium hydroxide and carbon disulfide yielded potassium-[4-(4′-chlorophenyl)-thiazol]-2-dithiocarbazinate . Moreover 4-amino-5-(4′-(4”-chlorophenyl)thiazol-2′-yl)-3-mercapto-4H-1,2,4-triazole was obtained by the reaction of potassium salt of thiazolyl derv. with hydrazine hydrate in water under reflux conditions. Further condensation with substituted aromatic aldehydes generated the corresponding different triazole derivatives The structures of the compounds were confirmed by elemental anal. and spectral anal. Antibacterial activity of the synthesized compounds was evaluated by tube dilution method against two gram pos. and two gram neg. bacteria using ciprofloxacin as standard In the experiment, the researchers used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Recommanded Product: Ethyl 2-amino-2-thioxoacetate)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Recommanded Product: Ethyl 2-amino-2-thioxoacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics