Tag: 100-200

《Distal γ-C(sp3)-H Olefination of Ketone Derivatives and Free Carboxylic Acids》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Park, Han Seul; Fan, Zhoulong; Zhu, Ru-Yi; Yu, Jin-Quan. COA of Formula: C10H10O2 The article mentions the following:

Reported herein is the distal γ-C(sp3)-H olefination of ketone derivatives and free carboxylic acids. Fine tuning of a previously reported imino-acid directing group and using the ligand combination of a mono-N-protected amino acid (MPAA) and an electron-deficient 2-pyridone were critical for the γ-C(sp3)-H olefination of ketone substrates. In addition, MPAAs enabled the γ-C(sp3)-H olefination of free carboxylic acids to form diverse six-membered lactones. Besides alkyl carboxylic acids, benzylic C(sp3)-H bonds also could be functionalized to form 3,4-dihydroisocoumarin structures in a single step from 2-Me benzoic acid derivatives The utility of these protocols was demonstrated in large scale reactions and diversification of the γ-C(sp3)-H olefinated products.Benzyl acrylate(cas: 2495-35-4COA of Formula: C10H10O2) was used in this study.

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.COA of Formula: C10H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Changes in volatile flavor compounds of peppers during hot air drying process based on headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS)》 was published in Journal of the Science of Food and Agriculture in 2020. These research results belong to Ge, Shuai; Chen, Yuyu; Ding, Shenghua; Zhou, Hui; Jiang, Liwen; Yi, Youjin; Deng, Fangming; Wang, Rongrong. Safety of Methyl Salicylate The article mentions the following:

BACKGROUND : Flavor plays a critical role in defining sensory and consumer acceptance of dried pepper, and it can be affected by temperature and moisture content during hot air drying (HAD). Thus, headspace-gas chromatog.-ion mobility spectrometry (HS-GC-IMS) was used to analyze changes in volatile compounds of pepper during the HAD process with different drying temperatures RESULTS : A total of 45 volatile flavor compounds were identified, including 11 esters, 11 aldehydes, nine alcs., five ketones, three furans, three acids, two pyrazines, and one ether. The results showed that with the loss of moisture during drying, aldehydes and alcs. decreased, esters initially increased and then decreased. However, Pr acetate, 2,3-butanediol, 2-acetylfuran, and 2-methylpyrazine increased. Moreover, drying temperature was closely related to the change of volatile flavor compounds Aldehydes, alcs., and some other volatile flavor compounds (Me salicylate, Et acetate, 2-methylpyrazine, di-Pr disulfide) decreased with an increase of temperature (60-80°C) at the same moisture content, while high temperature could promote the formation of Et octanoate, Me octanoate, benzaldehyde, furfurol, acetal, 5-methylfurfural, and 2-acetylfuran. Based on principal components anal. and heat map clustering anal., peppers dried at 70 or 80°C presented similar composition, and the loss of volatile flavor compounds was more than samples died at 60°C during the HAD process. CONCLUSION : Overall, the flavor quality of peppers dried at 60°C was better than that of other treatments during the HAD process. HS-GC-IMS was a reliable and effective means of analyzing volatile flavor compounds in peppers during the drying process. The experimental part of the paper was very detailed, including the reaction process of Methyl Salicylate(cas: 119-36-8Safety of Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Safety of Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Selective 1,2-Aryl-Aminoalkylation of Alkenes Enabled by Metallaphotoredox Catalysis》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Zheng, Songlin; Chen, Zimin; Hu, Yuanyuan; Xi, Xiaoxiang; Liao, Zixuan; Li, Weirong; Yuan, Weiming. Category: esters-buliding-blocks The article mentions the following:

A highly chemo- and regioselective intermol. 1,2-aryl-aminoalkylation of alkenes by photoredox/nickel dual catalysis is described here. This three-component conjunctive cross-coupling is highlighted by its first application of primary alkyl radicals, which were not compatible in previous reports. The readily prepared α-silyl amines could be transferred to α-amino radicals by photo-induced single electron transfer step. The radical addition/cross-coupling cascade reaction proceeds under mild, base-free and redox-neutral conditions with good functional group tolerance, and importantly, provides an efficient and concise method for the synthesis of structurally valuable α-aryl substituted γ-amino acid derivatives motifs. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4Category: esters-buliding-blocks) was used in this study.

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Bioactive Patchy Nanoparticles with Compartmentalized Cargoes for Simultaneous and Trackable Delivery》 were Wong, Chin Ken; Chen, Fan; Walther, Andreas; Stenzel, Martina H.. And the article was published in Angewandte Chemie, International Edition in 2019. Safety of Benzyl acrylate The author mentioned the following in the article:

Recent years have seen an increased interest in the use of ABC triblock terpolymers to bottom-up assemble multicompartment patchy nanoparticles. Despite these exptl. and theor. efforts, the applications of polymer-based patchy nanoparticles remain rather limited. One of the major challenges that eclipses their potential is the lack of knowledge to selectively encapsulate cargoes within different compartments that are separated in the nanometer length scale. Here, strategies are reported to segregate two chem. distinct mols. in either the patches or core compartment of patchy nanoparticles that bear a (bioactive) sugar corona. The potential use of these bioactive patchy nanoparticles containing compartmentalized cargoes for simultaneous drug delivery with real-time release monitoring capabilities is further demonstrated. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4Safety of Benzyl acrylate) was used in this study.

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Safety of Benzyl acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Roles of Iron Complexes in Catalytic Radical Alkene Cross-Coupling: A Computational and Mechanistic Study》 were Kim, Dongyoung; Rahaman, S. M. Wahidur; Mercado, Brandon Q.; Poli, Rinaldo; Holland, Patrick L.. And the article was published in Journal of the American Chemical Society in 2019. HPLC of Formula: 2495-35-4 The author mentioned the following in the article:

A growing and useful class of alkene coupling reactions involve hydrogen atom transfer (HAT) from a metal-hydride species to an alkene to form a free radical, which is responsible for subsequent bond formation. Here, we use a combination of exptl. and computational investigations to map out the mechanistic details of iron-catalyzed reductive alkene cross-coupling, an important representative of the HAT alkene reactions. We are able to explain several observations that were previously mysterious. First, the rate-limiting step in the catalytic cycle is the formation of the reactive Fe-H intermediate, elucidating the importance of the choice of reductant. Second, the success of the catalytic system is attributable to the exceptionally weak (17 kcal/mol) Fe-H bond, which performs irreversible HAT to alkenes in contrast to previous studies on isolable hydride complexes where this addition was reversible. Third, the organic radical intermediates can reversibly form organometallic species, which helps to protect the free radicals from side reactions. Fourth, the previously accepted quenching of the postcoupling radical through stepwise electron transfer/proton transfer is not as favorable as alternative mechanisms. We find that there are two feasible pathways. One uses concerted proton-coupled electron transfer (PCET) from an iron(II) ethanol complex, which is facilitated because the O-H bond dissociation free energy is lowered by 30 kcal/mol upon metal binding. In an alternative pathway, an O-bound enolate-iron(III) complex undergoes proton shuttling from an iron-bound alc. These kinetic, spectroscopic, and computational studies identify key organometallic species and PCET steps that control selectivity and reactivity in metal-catalyzed HAT alkene coupling, and create a firm basis for elucidation of mechanisms in the growing class of HAT alkene cross-coupling reactions. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4HPLC of Formula: 2495-35-4) was used in this study.

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.HPLC of Formula: 2495-35-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Petti, Alessia; Leech, Matthew C.; Garcia, Anthony D.; Goodall, Iain C. A.; Dobbs, Adrian P.; Lam, Kevin. SDS of cas: 4755-77-5. The article was titled 《Economical, Green, and Safe Route Towards Substituted Lactones by Anodic Generation of Oxycarbonyl Radicals》. The information in the text is summarized as follows:

A new electrochem. methodol. has been developed for the generation of oxycarbonyl radicals under mild and green conditions from readily available hemioxalate salts. Mono- and multi-functionalised γ-butyrolactones were synthesized through exo-cyclization of these oxycarbonyl radicals with an alkene, followed by the sp3-sp3 capture of the newly formed carbon-centered radical. The synthesis of functionalised valerolactone derivatives was also achieved, demonstrating the versatility of the newly developed methodol. This represents a viable synthetic route towards pharmaceutically important fragments and further demonstrates the practicality of electrosynthesis as a green and economical method to activate small organic mols.Ethyl oxalyl monochloride(cas: 4755-77-5SDS of cas: 4755-77-5) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.SDS of cas: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Journal of the American Chemical Society included an article by Bahamonde, Ana; Al Rifaie, Buthainah; Martin-Heras, Victor; Allen, Jamie R.; Sigman, Matthew S.. Electric Literature of C5H11NO2. The article was titled 《Enantioselective Markovnikov Addition of Carbamates to Allylic Alcohols for the Construction of α-Secondary and α-Tertiary Amines》. The information in the text is summarized as follows:

In the presence of Pd(MeCN)2(OTs)2 and a nonracemic pyridinyloxazoline, trisubstituted allylic alcs. such as I or (Z)-disubstituted allylic alcs. underwent regioselective and enantioselective addition and isomerization reactions with benzyl and tert-Bu carbamates to yield (after aldehyde reduction with NaBH4) protected secondary and tertiary β-amino alcs. such as II. Three of the β-amino alcs. were oxidized to β-amino acids with little loss of enantiopurity. Reaction of a dideuterated allylic alc. indicated that C-N bond formation occurs by syn-aminopalladation. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Electric Literature of C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Electric Literature of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Baumann, Thomas; Brueckner, Reinhard. Synthetic Route of C8H14O4. The article was titled 《Atropselective Dibrominations of a 1,1′-Disubstituted 2,2′-Biindolyl with Diverging Point-to-Axial Asymmetric Inductions. Deriving 2,2′-Biindolyl-3,3′-diphosphane Ligands for Asymmetric Catalysis》. The information in the text is summarized as follows:

On the 1H NMR timescale, 2,2′-biindolyls with (R)-configured (1-alkoxyprop)-2-yl, (1-hydroxyprop)-2-yl, or (1-siloxyprop)-2-yl substituents at C-1 and C-1′ are atropisomerically stable at <0° and interconvert at >30°. A 1,1′-Bis[(R)-1-hydroxyprop-2-yl]-2,2′-biindolyl a of that kind and achiral (!) brominating reagents gave the atropisomerically stable 3,3′-dibromobiindolyls (M)- and/or (P)-18 a at best atropselectively-because of point-to-axial asym. inductions-and atropdivergently, exhibiting up to 95% (M)- and as much (P)-atropselectivity. This route to atropisomerically pure biaryls is novel and should extend to other substrates and/or different functionalizations. The dibromobiindolyls (M)- and (P)-18 a furnished the biindolyldiphosphines (M)- and (P)-14 without atropisomerization. These syntheses did not require the resolution of a racemic mixture, which distinguishes them from virtually all biaryldiphosphine syntheses known to date. (M)- and (P)-14 acted as ligands in catalytic asym. allylations and hydrogenations. Remarkably, the Et tetralonecarboxylate was hydrogenated trans-selectively with 98% ee; this included a dynamic kinetic resolution In the experiment, the researchers used many compounds, for example, Diethyl 2-methylmalonate(cas: 609-08-5Synthetic Route of C8H14O4)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Synthetic Route of C8H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Tsuji, Hiroaki; Yamamoto, Hisashi published 《Hydroxy-Directed Amidation of Carboxylic Acid Esters Using a Tantalum Alkoxide Catalyst》.Journal of the American Chemical Society published the findings.Application of 6149-41-3 The information in the text is summarized as follows:

We describe herein a new strategy for the chemoselective synthesis of amides by using a metal-catalyzed hydroxy-directed reaction. A hydroxy group located at the β-position of an ester group promoted the activation of a carbonyl group with a tantalum alkoxide catalyst followed by amidation reactions, leading to a wide variety of β-hydroxyamides with excellent chemoselectivity. The chemoselective amidation strategy can be extended to the catalytic synthesis of dipeptide derivatives, which remains challenging research subjects in modern organic synthesis. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-hydroxypropanoate(cas: 6149-41-3Application of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2009,Dietrich, Silvia Anthoine; Lindauer, Renate; Stierlin, Claire; Gertsch, Juerg; Matesanz, Ruth; Notararigo, Sara; Diaz, Jose Fernando; Altmann, Karl-Heinz published 《Epothilone Analogues with Benzimidazole and Quinoline Side Chains: Chemical Synthesis, Antiproliferative Activity, and Interactions with Tubulin》.Chemistry – A European Journal published the findings.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:

A series of epothilone B and D analogs bearing isomeric quinoline or functionalized benzimidazole side chains has been prepared by chem. synthesis in a highly convergent manner. All analogs, e.g. I, have been found to interact with the tubulin/microtubule system and to inhibit human cancer cell proliferation in vitro, albeit with different potencies (IC50 values between 1 and 150 nM). The affinity of quinoline-based epothilone B and D analogs for stabilized microtubules clearly depends on the position of the N-atom in the quinoline system, while the induction of tubulin polymerization in vitro appears to be less sensitive to N-positioning. The potent inhibition of human cancer cell growth by epothilone analogs bearing functionalized benzimidazole side chains suggests that these systems might be conjugated with tumor-targeting moieties to form tumor-targeted prodrugs. The results came from multiple reactions, including the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics