Tag: 100-200

Recommanded Product: N-tert-ButoxycarbonylhydroxylamineIn 2022 ,《Metal-Free Direct Transformation of Aryl Boronic Acid to Primary Amines》 appeared in European Journal of Organic Chemistry. The author of the article were Kumar, Puneet; Verma, Saumya; Rathi, Komal; Chandra, Dinesh; Prakash Verma, Ved; Jat, Jawahar L.. The article conveys some information:

In this work, a transition-metal free approach for the construction of primary aromatic amines R/R1NH2 (R = 4-chlorophenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.)/(R1 = Ph, 4-methylphenyl, 4-hydroxyphenyl, 4-chlorophenyl, 2-cyanophenyl) from aryl boronic acids RB(OH)2 and esters R1Bpin with N-Boc-O-tosylhydroxylamine as an amine surrogate was reported. Bench stable TsONHBoc is easy to use and it produces a non-interfering water-soluble byproduct. The protocol is operative for both electron-rich and electron-deficient aryl boronic acids under acidic conditions, wherein, the former arenes affords a better yield of the desired product. Even, sterically hindered and halogenated substrates are easily amenable under this reaction condition. The current protocol can be scaled up to produce gram-scale primary aromatic amines. In the part of experimental materials, we found many familiar compounds, such as N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Recommanded Product: N-tert-Butoxycarbonylhydroxylamine)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: N-tert-Butoxycarbonylhydroxylamine

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide》 was written by Boehm, Philip; Roediger, Sven; Bismuto, Alessandro; Morandi, Bill. Electric Literature of C8H7FO2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined exptl. and computational studies support a reaction mechanism involving in situ generation of CO. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Electric Literature of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Electric Literature of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins》 was written by Yamaguchi-Sasaki, Toru; Tokura, Seiken; Ogata, Yuya; Kawaguchi, Takanori; Sugaya, Yutaka; Takahashi, Ryo; Iwakiri, Kanako; Abe-Kumasaka, Tomoko; Yoshida, Ippei; Arikawa, Kaho; Sugiyama, Hiroyuki; Kanuma, Kosuke. Safety of Diethyl 2-methylmalonate And the article was included in ACS Medicinal Chemistry Letters in 2020. The article conveys some information:

A series of macrocyclic pyrazolo[1,5-a]pyrimidine derivatives as respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors were designed and synthesized based on docking studies of acyclic inhibitors. This effort resulted in the discovery of several macrocyclic compounds with low nanomolar to subnanomolar activities against the wild-type RSV F protein A2. In addition, compound I showed a single-digit nanomolar potency against the previously reported drug-resistant mutant D486N. Mol. modeling and computational analyses suggested that I binds to the D486N mutant while maintaining a rigid bioactive conformation via macrocyclization and that it interacts with a hydrophobic cavity of the mutant using a new interaction surface of I. This report describes the rational design of macrocyclic compounds with dual inhibitory activities against wild-type and mutant RSV F proteins. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Safety of Diethyl 2-methylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Curcumin analogs: synthesis and biological activities》 was published in Medicinal Chemistry Research in 2020. These research results belong to Khudhayer Oglah, Mahmood; Fakri Mustafa, Yasser. Application In Synthesis of Ethyl 3-oxopentanoate The article mentions the following:

Curcumin has received great attention in the past three decades due to its versatile medicinal activities, which are attributed to the presence of certain functional groups in its structure. Despite this, the application of curcumin in therapy is limited by its poor aqueous solubility which results in low bioavailability, and also by its low chem. stability due to the keto-enol tautomerism. In this work, eight analogs of curcumin were synthesized starting from aminophenol to tackle these issues. Their chem. structures were characterized by detecting their IR, 1H-NMR, and 13C-NMR spectra. Biol. studies were performed on the synthesized analogs using curcumin as a pos. control. The tested activities included antioxidant capacity via DPPH and hydroxyl radical scavenging activity tests, preliminary antitumor activity by MTT test against MCF-7 and HeLa cancer cell lines, and antibacterial activity against Haemophilus influenzae, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia using disk diffusion technique. The results of antioxidant activity showed that the SC50 values of the synthesized analogs are closely related to the control, the same finding is reported in the preliminary antitumor activity. In the testing of antibacterial activity, the synthesized analogs displayed variable activities with a superior effect attributed to chloride-based analogs. In the course of performing these tests, it could be deduced that both stability and solubility of the analogs were improved in comparison with curcumin. It is proposed that such analogs with improved aqueous solubility may be useful guides to improve the therapeutic applications of curcumin. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Application In Synthesis of Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application In Synthesis of Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Enantioselective Pallada-Electrocatalyzed C-H Activation by Transient Directing Groups: Expedient Access to Helicenes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Dhawa, Uttam; Tian, Cong; Wdowik, Tomasz; Oliveira, Joao C. A.; Hao, Jiping; Ackermann, Lutz. Category: esters-buliding-blocks The article mentions the following:

Asym. pallada-electrocatalyzed C-H olefinations were achieved through the synergistic cooperation with transient directing groups. The electrochem., atroposelective C-H activations were realized with high position-, diastereo-, and enantio-control under mild reaction conditions to obtain highly enantiomerically-enriched biaryls and fluorinated N-C axially chiral scaffolds. Our strategy provided expedient access to, among others, novel chiral BINOLs, dicarboxylic acids and helicenes of value to asym. catalysis. Mechanistic studies by experiments and computation provided key insights into the catalyst’s mode of action. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4Category: esters-buliding-blocks) was used in this study.

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and Functionalization of 5-Alkyl-6-methyl-2-thiouracils》 was published in Russian Journal of General Chemistry in 2020. These research results belong to Babushkina, A. A.; Egorov, D. M.; Kaskevich, K. I.. Formula: C7H12O3 The article mentions the following:

Number of 5-alkyl-6-methyl-2-thiouracils were obtained, the further introduction of which into the reaction with dialkyl chloroethynylphosphonates afforded a series of new dialkyl (6-alkyl-5-oxo-7-methyl-5H-thiazolo[3,2-a]pyrimidin- 3-yl)phosphonates. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Formula: C7H12O3) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic Process Research & Development included an article by Kuwano, Ryoichi; Yokogi, Masashi; Sakai, Ken; Masaoka, Shigeyuki; Miura, Takashi; Won, Sungyong. Quality Control of Diethyl 2-methylmalonate. The article was titled 《Room-Temperature Benzylic Alkylation of Benzylic Carbonates: Improvement of Palladium Catalyst and Mechanistic Study》. The information in the text is summarized as follows:

The palladium catalyst for the nucleophilic substitution of benzyl carbonates was improved by using 1,1′-bis(diisopropylphosphino)ferrocene (DiPrPF) as the ligand. The [Pd(η3-C3H5)(cod)]BF4-DiPrPF catalyst allows the benzylic substitution with soft carbanions to proceed even at 30 °C, affording the desired products in high yields (up to 99% yield). Thermally unstable pyridylmethyl esters are employable as the electrophilic substrates for the benzylic alkylation with the improved catalyst. Furthermore, we investigated the mechanism of the catalytic benzylic alkylation by means of DiPrPF ligand. The palladium(0) complex bearing DiPrPF activates the benzylic C-O bond to form the (benzyl)palladium(II) intermediate at room temperature The coordination mode of the benzyl ligand would be equilibrium between the η1- and η3-manner. The nucleophile would preferentially react with the η3-benzyl ligand to give the desired product. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Quality Control of Diethyl 2-methylmalonate)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Quality Control of Diethyl 2-methylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Journal of the American Chemical Society included an article by Kim, Yoonseob; Wang, Yanming; France-Lanord, Arthur; Wang, Yichong; Wu, You-Chi Mason; Lin, Sibo; Li, Yifan; Grossman, Jeffrey C.; Swager, Timothy M.. HPLC of Formula: 609-08-5. The article was titled 《Ionic Highways from Covalent Assembly in Highly Conducting and Stable Anion Exchange Membrane Fuel Cells》. The information in the text is summarized as follows:

A major challenge in the development of anion exchange membranes for fuel cells is the design and synthesis of highly stable (chem. and mech.) conducting membranes. Membranes that can endure highly alk. environments while rapidly transporting hydroxides are desired. Herein, we present a design using cross-linked polymer membranes containing ionic highways along charge-delocalized pyrazolium cations and homoconjugated triptycenes. These ionic highway membranes show improved performance. Specifically, a conductivity of 111.6 mS cm-1 at 80°C was obtained with a low 7.9% water uptake and 0.91 mmol g-1 ion exchange capacity. In contrast to existing materials, ionic highways produce higher conductivities at reduced hydration and ionic exchange capacities. The membranes retain more than 75% of their initial conductivity after 30 days of an alk. stability test. The formation of ionic highways for ion transport is confirmed by d. functional theory and Monte Carlo studies. A single cell with platinum metal catalysts at 80°C showed a high peak d. of 0.73 W cm-2 (0.45 W cm-2 from a silver-based cathode) and stable performance throughout 400 h tests. After reading the article, we found that the author used Diethyl 2-methylmalonate(cas: 609-08-5HPLC of Formula: 609-08-5)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.HPLC of Formula: 609-08-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2018,Journal of the American Chemical Society included an article by Wang, Yin-Xia; Qi, Shao-Long; Luan, Yu-Xin; Han, Xing-Wang; Wang, Shan; Chen, Hao; Ye, Mengchun. HPLC of Formula: 329-59-9. The article was titled 《Enantioselective Ni-Al Bimetallic Catalyzed exo-Selective C-H Cyclization of Imidazoles with Alkenes》. The information in the text is summarized as follows:

A Ni-Al bimetallic catalyzed enantioselective C-H exo-selective cyclization of imidazoles with alkenes has been developed. A series of bi- or polycyclic imidazoles with β-stereocenter were obtained in up to 98% yield and >99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9HPLC of Formula: 329-59-9)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.HPLC of Formula: 329-59-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2015,Butler, Christopher R.; Brodney, Michael A.; Beck, Elizabeth M.; Barreiro, Gabriela; Nolan, Charles E.; Pan, Feng; Vajdos, Felix; Parris, Kevin; Varghese, Alison H.; Helal, Christopher J.; Lira, Ricardo; Doran, Shawn D.; Riddell, David R.; Buzon, Leanne M.; Dutra, Jason K.; Martinez-Alsina, Luis A.; Ogilvie, Kevin; Murray, John C.; Young, Joseph M.; Atchison, Kevin; Robshaw, Ashley; Gonzales, Cathleen; Wang, Jinlong; Zhang, Yong; O’Neill, Brian T. published 《Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design》.Journal of Medicinal Chemistry published the findings.Related Products of 6149-41-3 The information in the text is summarized as follows:

The identification of centrally efficacious β-secretase (BACE1) inhibitors for the treatment of Alzheimer’s disease (AD) has historically been thwarted by an inability to maintain alignment of potency, brain availability, and desired absorption, distribution, metabolism, and excretion (ADME) properties. In this paper, the authors describe a series of truncated, fused thioamidines that are efficiently selective in garnering BACE1 activity without simultaneously inhibiting the closely related cathepsin D or neg. impacting brain penetration and ADME alignment, as exemplified by I. Upon oral administration, these inhibitors exhibit robust brain availability and are efficacious in lowering central Amyloid β (Aβ) levels in mouse and dog. In addition, chronic treatment in aged PS1/APP mice effects a decrease in the number and size of Aβ-derived plaques. Most importantly, evaluation of I in a 2-wk exploratory toxicol. study revealed no accumulation of autofluorescent material in retinal pigment epithelium or histol. findings in the eye, issues observed with earlier BACE1 inhibitors. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Related Products of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics