Tag: 100-200

Marsicano, Vincenzo; Arcadi, Antonio; Chiarini, Marco; Fabrizi, Giancarlo; Goggiamani, Antonella; Iazzetti, Antonia published an article in 2021. The article was titled 《Sequential condensation/biannulation reactions of β-(2-aminophenyl)-α,β-ynones with 1,3-dicarbonyls》, and you may find the article in Organic & Biomolecular Chemistry.Reference of Ethyl 3-oxopentanoate The information in the text is summarized as follows:

A divergent domino condensation/biannulation reaction of β-(2-aminophenyl) α,β-ynones with 1,3-dicarbonyls to construct a polycyclic 4H-pyrano[3,4-c]quinoline core was developed. The p-TsOH·H2O catalyzed reaction of β-(2-aminophenyl) α,β-ynones with β-ketoesters in ethanol proceeded with good to excellent yields to provide a simple and effective method for the synthesis of functionalized 4H-pyrano[3,4-c]quinolinones. Further elaboration of these latter derivatives with an excess of 20% NH4OH in EtOH at 50°C helped to achieve the synthesis of the perlodinine analogs benzo[c][2,7]naphthyridin-4(3H)-one derivatives in high yields. Moreover, the p-TsOH·H2O mediated reaction of β-(2-aminophenyl) α,β-ynones with β-di-ketones led to the formation of a variety of structurally diverse 4H-pyrano[3,4-c]quinoline polycyclic ketals by the incorporation of an alc. solvent mol. in a cascade fashion. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Reference of Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Reference of Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mallik, Sumitava; Bhajammanavar, Vinod; Baidya, Mahiuddin published an article in 2021. The article was titled 《Regioselective Nitrosocarbonyl Aldol Reaction of Deconjugated Butyrolactams: Synthesis of γ-Heterosubstituted α,β-Unsaturated γ-Lactams》, and you may find the article in Asian Journal of Organic Chemistry.Application of 36016-38-3 The information in the text is summarized as follows:

The nitrosocarbonyl aldol reaction of deconjugated butyrolactams is developed employing quinidine as organocatalyst. The nitrosocarbonyl species generated in situ from hydroxamic acids react with a variety of deconjugated butyrolactams at room temperature, offering valuable α,β-unsaturated γ-lactams bearing heterosubstituted quaternary carbon center in very high yields. This nitrosocarbonyl aldol reaction is O-selective and proceeds exclusively at the γ-center of deconjugated butyrolactams. The reaction is scalable, accommodates diverse functional groups, and is also effective with azodicarboxylates. In the experiment, the researchers used many compounds, for example, N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Application of 36016-38-3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Application of 36016-38-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Hong-Yu; Yang, Zibing; Zhang, Huizhen; Han, Ya-Ping; Zhao, Jiquan; Zhang, Yuecheng published their research in European Journal of Organic Chemistry in 2021. The article was titled 《The Cross-Dehydrogenative Coupling Reaction of β-Ketoesters with Quinoxalin-2(1H)-ones》.Quality Control of Ethyl 3-oxopentanoate The article contains the following contents:

The cross-dehydrogenative coupling (CDC) reaction of β-ketoesters with quinoxalin-2(1H)-one derivatives has been successfully performed by using a readily available Cu salt as the catalyst in moderate to excellent yields under mild conditions [e.g, 1-methylquinoxalin-2(1H)-one + Et acetoacetate → I (80%, imine/enamine ≈ 1.46:1) in presence of Cu(OAc)2, TBHP and NaHCO3 in DMSO under Ar]. Owing to the characteristic of handy operation and good functional group tolerance, this protocol affords a convenient access to α-quinoxalinone-substituted β-ketoesters. Preliminary mechanistic investigations show this transformation possibly underwent an unusual ionic pathway. In addition to this study using Ethyl 3-oxopentanoate, there are many other studies that have used Ethyl 3-oxopentanoate(cas: 4949-44-4Quality Control of Ethyl 3-oxopentanoate) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Quality Control of Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qian, Deyun; Bera, Srikrishna; Hu, Xile published their research in Journal of the American Chemical Society in 2021. The article was titled 《Chiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates》.Quality Control of tert-Butyl carbamate The article contains the following contents:

A nickel-catalyzed hydroalkylation method to assemble a wide range of chiral alkyl amines from enecarbamates (N-Cbz-protected enamines) and alkyl halides with high regio- and enantioselectivity was reported. The method works for both nonactivated and activated alkyl halides and was able to produce enantiomerically enriched amines with two minimally differentiated α-alkyl substituents. The mild conditions led to high functional group tolerance, which is demonstrated in the postproduct functionalization of many natural products and drug mols., as well as the synthesis of chiral building blocks and key intermediates to bioactive compoundstert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Quality Control of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jeon, Hyun Ji; Lee, Wongyu; Seo, Sangwon; Chang, Sukbok published their research in Organic Process Research & Development in 2021. The article was titled 《N-Chloro-N-sodio-carbamates as a Practical Amidating Reagent for Scalable and Sustainable Amidation of Aldehydes under Visible Light》.Product Details of 4248-19-5 The article contains the following contents:

Herein, the scalability and sustainability investigations toward the visible light-mediated amidation of aldehydes with N-chloro-N-sodio-carbamates was described. The practicality credentials of N-chloro-N-sodio-carbamates for their use in multigram scale amidation reactions were proven by scale-up productions and thermogravimetric anal. The described amidation, which was previously hampered in sustainability perspectives by the use of α,α,α-trifluorotoluene solvent, was then improved through re-optimizations using Et acetate as an alternative green solvent. The generality of multigram scale amidations was demonstrated by the conversion of a selected list of aldehydes, in which the corresponding amides I [R1 = n-hexyl, cyclohexyl, Ph, etc.; R2 = CO2t-Bu, CO2Bn] could be isolated in high purity without the need for special purification procedures. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Product Details of 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Product Details of 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Krishna Sai, Gajula; Divya Rohini, Yennamaneni; Narender, Nama published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Metal-free Catalytic Esterification of Aryl Alkyl Ketones with Alcohols via Free-radical Mediated C(sp3)-H Bond Oxygenation》.SDS of cas: 403-33-8 The article contains the following contents:

A novel metal-free catalytic one-pot approach has been developed for the esterification of aralkyl ketones RC(O)R1 (R = Ph, naphth-2-yl, 2-bromophenyl, etc.; R1 = Me, Et, benzyl) with alcs. R2OH (R2 = Me, Et, i-Pr, n-Bu) under open-air atm. conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp3)-H bond oxygenation, selective C-C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one-pot. This mild, convenient and economically viable catalytic method tolerates the various functional groups to provide the corresponding alkyl benzoates RC(O)OR2 in up to 98% yields with up to 99% selectivity. The efficiency and feasibility of scale-up of the present catalytic system were demonstrated with gram scale experiments (up to 10 g scale).Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis, crystal structures, computational studies and α-amylase inhibition of three novel 1,3,4-oxadiazole derivatives》 was written by Hamdani, Syeda Shamila; Khan, Bilal Ahmad; Ahmed, Muhammad Naeem; Hameed, Shahid; Akhter, Kulsoom; Ayub, Khurshid; Mahmood, Tariq. Synthetic Route of C8H7FO2 And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

In this study, the synthesis, X-ray diffraction, d. functional theory (DFT) and α-amylase inhibition activities of three 1,3,4-oxadiazole derivatives I (R = F, MeO; R1 = 2-CF3, 3-CF3) have been reported. The compounds I are synthesized in good yields (70-83%) and their structures are confirmed through different spectro-anal. techniques and single crystal X-ray diffraction. D. functional theory (DFT) calculations are performed to validate not only X-ray results, but also to investigate the dispersion of charges and reactivity through frontier MOs and mol. electrostatic potential (MEP) analyses. α-Amylase inhibition assay is performed in order to find out the enzyme inhibitory potential of the synthesized compounds I. The low IC50 value (86.83 ± 0.23 μg/mL) of compound I (R = MeO, R1 = 2-CF3) reflects the potential α-amylase inhibitory activity of the compound as compared to others. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Synthetic Route of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Synthetic Route of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Multimode Vibrational Strong Coupling of Methyl Salicylate to a Fabry-Pérot Microcavity》 was written by Takele, Wassie Mersha; Wackenhut, Frank; Piatkowski, Lukasz; Meixner, Alfred J.; Waluk, Jacek. Name: Methyl Salicylate And the article was included in Journal of Physical Chemistry B in 2020. The article conveys some information:

The strong coupling of an IR-active mol. transition with an optical mode of the cavity results in vibrational polaritons, which opens a new way to control chem. reactivity via confined electromagnetic fields of the cavity. In this study, we design a voltage-tunable open microcavity and we show the formation of multiple vibrational polaritons in Me salicylate. A Rabi splitting and polariton anticrossing behavior is observed when the cavity mode hybridizes with the C=O stretching vibration of Me salicylate. Furthermore, the proposed theor. model based on coupled harmonic oscillators reveals that the absorption of uncoupled mols. must also be considered to model the exptl. spectra properly and that simultaneous coupling of multiple mol. vibrations to the same cavity mode has a significant influence on the transmission spectral profile. In addition to this study using Methyl Salicylate, there are many other studies that have used Methyl Salicylate(cas: 119-36-8Name: Methyl Salicylate) was used in this study.

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Name: Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《π-Coordinating Chiral Primary Amine/Palladium Synergistic Catalysis for Asymmetric Allylic Alkylation》 was written by Wang, Yaning; Chai, Junli; You, Chang; Zhang, Jie; Mi, Xueling; Zhang, Long; Luo, Sanzhong. Synthetic Route of C7H12O3 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

We report an arene-containing chiral primary amine as a dual aminocatalyst and ligand: the π-coordinating aminocatalyst/palladium synergistic catalysis for asym. allylic alkylation of α-branched β-ketocarbonyls. The use of arene-containing chiral primary amine catalyst led to not only enhanced reaction rate but also reversed chiral induction compared with its sterically bulky derivative Both enantiomers of the allylic adducts bearing acyclic all-carbon quaternary stereocenters could be obtained from the same configured chiral aminocatalysts with high efficiency and excellent regio-, stereo-, and enantioselectivity. Mechanistic studies revealed a distinctive Pd-arene π-coordination mode for effective catalysis. The π-coordinating chiral primary amine catalyst could be successfully applied in the asym. allylation reactions of vinylethylene carbonates, vinyl epoxides, or simple allylic alcs. In the experimental materials used by the author, we found Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Organocatalytic Enantioselective 1,6-aza-Michael Addition of Isoxazolin-5-ones to p-Quinone Methides》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Toran, Ricardo; Vila, Carlos; Sanz-Marco, Amparo; Munoz, M. Carmen; Pedro, Jose R.; Blay, Gonzalo. Formula: C7H12O3 The article mentions the following:

A thiourea-Bronsted base bifunctional catalyst allowed the enantioselective 1,6-aza-Michael addition of isoxazolin-5-ones to p-quinone methides to give isoxazolin-5-ones having a chiral diarylmethyl moiety attached to the N atom with fair to good yields and enantiomeric excesses. To the best of our knowledge this reaction represents the first example of enantioselective N-alkylation of isoxazolin-5-ones as well as the first example of enantioselective 1,6-aza-Michael reaction involving p-quinone methides. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Formula: C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics