Tag: 100-200

Yu, Xiaoye; Luebbesmeyer, Maximilian; Studer, Armido published an article in 2021. The article was titled 《Oligosilanes as Silyl Radical Precursors through Oxidative Si-Si Bond Cleavage Using Redox Catalysis》, and you may find the article in Angewandte Chemie, International Edition.Application of 2495-35-4 The information in the text is summarized as follows:

Oligosilanes are of great interest in the fields of organic photonics and electronics. In this communication, a highly efficient visible-light-mediated hydrosilylation of electron-deficient alkenes through cleavage of a trimethylsilyl-polysilanyl Si-Si bond is explored. These reactions smoothly occur on readily available organo(tristrimethylsilyl)silanes and other oligosilanes in the presence of an IrIII-based photo-redox catalyst under visible light irradiation Silyl radicals are generated through single electron oxidation of the oligosilane assisted by the solvent. The introduced method exhibits broad substrate scope and high functional group tolerance with respect to the organo(tristrimethylsilyl)silane and alkene components, enabling the construction of functionalized trisilanes. In addition, this catalytic system can be also applied to highly strained bicyclo[1.1.0]butanes as silyl radical acceptors. The results came from multiple reactions, including the reaction of Benzyl acrylate(cas: 2495-35-4Application of 2495-35-4)

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Application of 2495-35-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Annibaletto, Julien; Martzel, Thomas; Levacher, Vincent; Oudeyer, Sylvain; Briere, Jean-Francois published an article in 2021. The article was titled 《Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin-5-Ones》, and you may find the article in Advanced Synthesis & Catalysis.COA of Formula: C5H11NO3 The information in the text is summarized as follows:

Herein a strategy was reported to afford a multicomponent catalytic enantioselective synthesis of β-substituted isoxazolidin-5-ones I [R = Ph, 2-naphthyl, 3-pyridyl, etc.; R1 = NMe2, N(i-Pr)2, NPh2, N-morpholinyl] via a Knoevenagel-aza-Michael-cyclocondensation (KMC) process promoted by a suited cupreine used as bifunctional organocatalyst. The hydroxamic acid component, with a sterically hindered amide moiety, proved to be key for the successful formation and transformation of the obtained original N-amide isoxazolidin-5-ones.N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3COA of Formula: C5H11NO3) was used in this study.

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.COA of Formula: C5H11NO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Sheng-Nan; Chen, Yu; Luo, Xiao-Dong; Li, Yi published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Sustainable Cascades to Difluoroalkylated Polycyclic Imidazoles》.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate The article contains the following contents:

Herein a visible light promoted difluoroalkylated cascade of imidazoles and alkenes e.g., I to afford highly functionalized polycyclic imidazoles e.g., II was reported. This method features a direct radical cyclization of imidazoles with alkenes e.g., I using BrCF2R (R = C(O)OEt, N-cyclohexylcarbamoyl, (thiomorpholin-4-yl)carbonyl, etc.) as radical sources. The reaction conditions tolerate a wide range of substrate scope and afford the desired products e.g., II with up to 95% isolated yield under mild conditions. Radical-trapping and light-on/off experiments indicated a photocatalytic radical mechanism. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Xigong; Zhao, Changyin; Zhu, Rongxiu; Liu, Lei published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition》.Reference of Ethyl 2-methyl-3-oxobutanoate The article contains the following contents:

The asym. construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. A solution involving diastereo- and enantioselective oxidative 1,6-conjugate addn was disclosed. The practical asym. cross-dehydrogenative coupling of 2,2-diarylacetonitriles and diverse α-substituted cyclic 1,3-dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach was further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β-ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo- and enantioselectivity. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Reference of Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Reference of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choi, Jin; Laudadio, Gabriele; Godineau, Edouard; Baran, Phil S. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Practical and Regioselective Synthesis of C-4-Alkylated Pyridines》.Application of 36016-38-3 The article contains the following contents:

The direct position-selective C-4 alkylation of pyridines has been a long-standing challenge in heterocyclic chem., particularly from pyridine itself. Historically this has been addressed using prefunctionalized materials to avoid overalkylation and mixtures of regioisomers. This study reports the invention of a simple maleate-derived blocking group for pyridines that enables exquisite control for Minisci-type decarboxylative alkylation at C-4 that allows for inexpensive access to these valuable building blocks. The method is employed on a variety of different pyridines and carboxylic acid alkyl donors, is operationally simple and scalable, and is applied to access known structures in a rapid and inexpensive fashion. Finally, this work points to an interesting strategic departure for the use of Minisci chem. at the earliest possible stage (native pyridine) rather than current dogma that almost exclusively employs Minisci chem. as a late-stage functionalization technique. In the part of experimental materials, we found many familiar compounds, such as N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Application of 36016-38-3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Application of 36016-38-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jin, Liang; Zhang, Peng; Li, Ya; Yu, Xin; Shi, Bing-Feng published their research in Journal of the American Chemical Society in 2021. The article was titled 《Atroposelective Synthesis of Conjugated Diene-Based Axially Chiral Styrenes via Pd(II)-Catalyzed Thioether-Directed Alkenyl C-H Olefination》.Application of 2495-35-4 The article contains the following contents:

The highly atroposelective synthesis of axially chiral styrenes with a conjugated 1,3-diene scaffold via a Pd(II)-catalyzed thioether-directed alkenyl C-H olefination strategy was reported. This strategy features easy operation, mild reaction conditions, high functional group tolerance (69 examples), complete Z-selectivity, and excellent enantioselectivities (up to 99% ee). Notably, the highly enantioselective synthesis of atropisomers with two stereogenic axes were also achieved using this strategy (up to 99% ee and 97:3 dr). Moreover, the reaction could be scaled up, and the resulting axially chiral styrenes could be easily oxidized into chiral sulfoxide derivatives with high diastereoselectivities, which showed great promise as a new type of sulfur-olefin ligand. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4Application of 2495-35-4) was used in this study.

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Application of 2495-35-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Hydrogen-Bonding Assisted Catalytic Kinetic Resolution of Acyclic β-Hydroxy Amides》 was written by Porey, Arka; Mondal, Bhaskar Deb; Guin, Joyram. Application In Synthesis of Diethyl 2-methylmalonate And the article was included in Angewandte Chemie, International Edition in 2021. The article conveys some information:

Enantioenriched acyclic α-substituted β-hydroxy amides are valuable compounds in chem., material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alc. with a cinnamaldehyde in the presence of an N-heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.Diethyl 2-methylmalonate(cas: 609-08-5Application In Synthesis of Diethyl 2-methylmalonate) was used in this study.

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Application In Synthesis of Diethyl 2-methylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Human Serum Phenylpyruvate Quantification Using Responsive 2D Photonic Crystal Hydrogels via Chemoselective Oxime Ligation: Progress toward Developing Phenylalanine-Sensing Elements》 was written by Jang, Kyeongwoo; Horne, W. Seth; Asher, Sanford A.. Recommanded Product: N-tert-Butoxycarbonylhydroxylamine And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

There is a need to develop at-home phenylalanine (Phe) test kits, analogous to home glucose meters, for phenylketonuria patients who must measure their blood Phe levels frequently to adjust their diet. Unfortunately, such test kits are not available yet because of the lack of simple and inexpensive Phe-sensing elements. With the goal of developing a Phe-sensing element, we fabricated two-dimensional photonic crystal (2DPC) hydrogels that quantify human serum phenylpyruvate (PhPY), which is the product of the reaction between Phe and the enzyme phenylalanine dehydrogenase. The PhPY-sensing hydrogels have oxyamine recognition groups that link PhPY to the hydrogel polymer network via chemoselective oxime ligation. This structural modification induces the hydrogel to swell, which then increases interparticle spacings within the embedded 2DPC. The PhPY-induced particle spacing changes are measured from light diffraction and used to quantify the PhPY concentrations The estimated limit of detection of PhPY in human serum for a detection time of 30 min is 19μM, which is comparable to the min. blood Phe concentrations of healthy people. Besides the potential application for developing Phe-sensing elements, this new hydrogel sensing approach via chemoselective oxime ligation is generalizable to the development of other chem. sensors working in complex biol. environments. In the experiment, the researchers used many compounds, for example, N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Recommanded Product: N-tert-Butoxycarbonylhydroxylamine)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: N-tert-Butoxycarbonylhydroxylamine

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《pH-Controlled Hierarchical Assembly/Disassembly of Multicompartment Micelles in Water》 was written by Nghiem, Tai-Lam; Chakroun, Ramzi; Janoszka, Nicole; Chen, Chen; Klein, Kai; Wong, Chin Ken; Groeschel, Andre H.. COA of Formula: C10H10O2 And the article was included in Macromolecular Rapid Communications in 2020. The article conveys some information:

Multicompartment micelles (MCMs) have become attractive drug delivery systems as they allow the sep. storage of two or more incompatible cargos in their core compartments (e.g., drugs and dyes for imaging). A recent hierarchical self-assembly process for hydrophobic terpolymers in organic solvents showed the ability to form very homogeneous MCM populations, yet the transfer of this process into water requires a better understanding of the formation mechanism and influence of chain mobility during assembly. Here, the synthesis of a linear poly(oligo(ethylene glycol) methacrylate)-block-poly(benzyl acrylate)-block-poly(4-vinylpyridine) (POEGMA-b-PBzA-b-P4VP) triblock terpolymer by reversible addition-fragmentation chain transfer (RAFT) polymerization is reported as well as its step-wise assembly into MCMs in water with POEGMA corona, PBzA patches, and P4VP core. Reversible assembly/disassembly of the MCMs is investigated through protonation/deprotonation of the P4VP core. Interestingly, the low glass transition temperature (Tg) of the hydrophobic PBzA middle block causes MCMs to directly disassemble into molecularly dissolved chains instead of patchy micelles due to mech. stress from electrosteric repulsion of the protonated P4VP corona chains. In addition, pH resistant MCMs are created by core-crosslinking and fluorescent properties are added by covalent anchoring of fluorescent dyes via straightforward click chem. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4COA of Formula: C10H10O2) was used in this study.

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.COA of Formula: C10H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Application of Nickel Complexes with 1,3-Dicarbonyl Compounds for Synthesis of Fused 4-Aminopyridine-Based Systems》 was written by Vydzhak, R. N.; Panchishin, S. Ya.; Brovarets, V. S.. Synthetic Route of C7H12O3 And the article was included in Russian Journal of General Chemistry in 2020. The article conveys some information:

A potential of using nickel complexes with 1,3-dicarbonyl compounds for the transformation of heterocyclic aminonitriles into fused systems with a 4-aminopyridine core was evaluated. A possibility of introducing acidophobic groups into the mols. of fused compounds was shown. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics