Tag: 100-200

《Regioselective Formation of Substituted Indoles: Formal Synthesis of Lysergic Acid》 was written by Points, Gary L. III; Stout, Kenneth T.; Beaudry, Christopher M.. Quality Control of tert-Butyl carbamate And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

A Diels-Alder reaction-based strategy for the synthesis of indoles and related heterocycles is reported. An intramol. cycloaddition of alkyne-tethered 3-aminopyrones gives 4-substituted indolines in good yield and with complete regioselectivity [e.g., I → II (99%)]. Addnl. substitution is readily tolerated in the transformation, allowing synthesis of complex and non-canonical substitution patterns. Oxidative conditions give the corresponding indoles. The strategy also allows the synthesis of carbazoles. The method was showcased in a formal synthesis of lysergic acid. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Quality Control of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Rapid access to 3-acyl indoles using ethyl acetate/triflic acid couple as the acylium donor and Cu(OAc)2 catalysed aerial oxidation of indole benzoins》 was written by Talukdar, Ranadeep. Reference of Methyl 4-fluorobenzoate And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

A facile installation of acyl groups at the C-3 position of indoles under triflic acid catalyzed conditions with easily available and cheap esters as new acylating agents was described. Furthermore, heterocycles like N-protected pyrrole, furan and thiophene were also suitable substrates for similar C-2 acylation. Analogous C-3 benzoylated products of indole were obtained, albeit in lower yields, by using Me benzoate as a benzoyl donor. The benzoylated products were synthesized in much better yields via a copper(II) catalyzed aerial oxidation of indole containing benzoins. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Reference of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Reference of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Sterically Controlled C-H Olefination of Heteroarenes》 was written by Chen, Hao; Farizyan, Mirxan; Ghiringhelli, Francesca; van Gemmeren, Manuel. Electric Literature of C10H10O2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

The regioselective functionalization of heteroarenes is a highly attractive synthetic target due to the prevalence of multiply substituted heteroarenes in nature and bioactive compounds Some substitution patterns remain challenging: While highly efficient methods for the C2-selective olefination of 3-substituted five-membered heteroarenes are reported, analogous methods to access the 5-olefinated products have remained limited by poor regioselectivities and/or the requirement to use an excess of the valuable heteroarene starting material. Herein the authors report a sterically controlled C-H olefination using heteroarenes as the limiting reagent. The method enables the highly C5-selective olefination of a wide range of heteroarenes and is useful in the context of late-stage functionalization. The results came from multiple reactions, including the reaction of Benzyl acrylate(cas: 2495-35-4Electric Literature of C10H10O2)

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Electric Literature of C10H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors》 was written by Tsang, Jonathan E.; Urner, Lorenz M.; Kim, Gyudong; Chow, Kingsley; Baufeld, Lynn; Faull, Kym; Cloughesy, Timothy F.; Clark, Peter M.; Jung, Michael E.; Nathanson, David A.. HPLC of Formula: 4248-19-5 And the article was included in ACS Medicinal Chemistry Letters in 2020. The article conveys some information:

The epidermal growth factor receptor (EGFR) is genetically altered in nearly 60% of glioblastoma tumors; however, tyrosine kinase inhibitors (TKIs) against EGFR have failed to show efficacy for patients with these lethal brain tumors. This failure is attributed to the inability of clin. tested EGFR TKIs to cross the blood-brain barrier (BBB) and achieve adequate pharmacol. levels to inhibit various oncogenic forms of EGFR that drive glioblastoma. Through SAR anal., we developed compound 5 (JCN037)(I) from an anilinoquinazoline scaffold by ring fusion of the 6,7-dialkoxy groups to reduce the number of rotatable bonds and polar surface area and by introduction of an ortho-fluorine and meta-bromine on the aniline ring for improved potency and BBB penetration. Relative to the conventional EGFR TKIs erlotinib and lapatinib, JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model. In addition to this study using tert-Butyl carbamate, there are many other studies that have used tert-Butyl carbamate(cas: 4248-19-5HPLC of Formula: 4248-19-5) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A General and Practical Synthesis of Chiral 1,2-Oxazetidines》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Yang, Jinggang; Wu, Binyu; Hu, Lin. COA of Formula: C5H11NO3 The article mentions the following:

Herein, a general and practical method to access a series of structurally diverse chiral 1,2-oxazetidines I [R = R1 = H, i-Pr, Ph, etc.; RR1 = (CH2)4; stereo = R, S] from readily available chiral epoxides and α-bromo esters in 3-4 steps by using mild Mitsunobu reactions as an efficient ring-closure approach to form the highly strained four-membered rings was reported. The new method was operationally simple, and a range of N-nosyl-protected 3- and 4-substituted as well as 3,4-disubstituted chiral 1,2-oxazetidines could be conveniently prepared in gram-scale with excellent enantioselectivities (93-99% ee) and good overall yields for the first time. In the experiment, the researchers used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3COA of Formula: C5H11NO3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).COA of Formula: C5H11NO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and characterization of vinazene end capped dipyrrolo[2,3-b:2′,3′-e]pyrazine-2,6(1H,5H)-dione small molecules as non-fullerene acceptors for bulk heterojunction organic solar cells》 was published in Materials Chemistry and Physics in 2020. These research results belong to Sivakumar, Gangala; Bernardo, Douglas Rosa; Marchezi, Paulo Ernesto; Nogueira, Ana Flavia. Recommanded Product: Ethyl oxalyl monochloride The article mentions the following:

Two dipyrrolo[2,3-b:2′,3′-e]pyrazine-2,6(1H,5H)-dione (PzDP)-based small mols. DPDV and DPEV with PzDP as the core building block and 4,5-dicyano-2-vinylimdazole (vinazene) as end-cap units were synthesized by Heck coupling reaction. The photophys., electrochem. properties of DPDV and DPEV were investigated and applied as non-fullerene acceptors (NFAs) for solution-processed bulk heterojunction (BHJ) organic solar cells (OSCs). Theor. evaluated optical and electrochem. properties were well matched with exptl. values. Solution processed BHJOSCs employing poly[(4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b’]dithiophene-2,6-diyl)-alt-(3-fluoro-2-[(2-ethylhexy)carbonyl]thieno[3,4-b]thiophene-4,6-diyl)] (PTB7) as the donor polymer and DPDV/DPEV as NFAs exhibited short-circuit c.d. (JSC) of 2.23/2.44 mA cm-2, open-circuit voltage (VOC) of 0.54/0.55 V, fill factor (FF) of 36.97/38.62 and power conversion efficiency (PCE) of 0.45/0.52%, resp. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Acylation of oxindoles using methyl/phenyl esters via the mixed Claisen condensation-an access to 3-alkylideneoxindoles》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Sreedharan, Ramdas; Rajeshwaran, Purushothaman; Panyam, Pradeep Kumar Reddy; Yadav, Saurabh; Nagaraja, C. M.; Gandhi, Thirumanavelan. Quality Control of Methyl 4-fluorobenzoate The article mentions the following:

Herein, simple acyl sources, viz. Me and Ph esters, which acylate oxindoles via the mixed Claisen condensation are reported. This straightforward protocol is mediated by LiHMDS and KOtBu and successfully applied to a wide range of substrates. It is a noteworthy transformation that skips the stepwise generation of enolates and acylation, and the reaction is performed at a moderate temperature with no side reactions. This protocol produces the first examples of ortho-substituents in an aryl ring flanked with electron-donating and electron-withdrawing substrates. Interestingly, robust organometallic ferrocenyl Me ester cleaved under these conditions with ease. Furthermore, biol. important Tenidap’s analog was synthesized by this protocol. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Adsorptive Separation of Benzene, Cyclohexene, and Cyclohexane by Amorphous Nonporous Amide Naphthotube Solids》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Yao, Huan; Wang, Yu-Mei; Quan, Mao; Farooq, M. Umar; Yang, Liu-Pan; Jiang, Wei. HPLC of Formula: 4248-19-5 The article mentions the following:

Benzene hydrogenation is an important industrial process. The reaction is incomplete, resulting in a mixture of benzene, cyclohexane, and/or cyclohexene that have to be separated before any further reactions. The currently used extractive and azeotropic distillations are operationally complex and energy intensive. Adsorptive separation provides an alternative energy-efficient method. However, the separation of the ternary mixture by adsorptive separation has not yet been reported. In the present research, we report two macrocyclic hosts with hydrogen-bonding sites in their cavities that are able to sep. the ternary mixture of benzene, cyclohexene, and cyclohexane. N-H···π interactions were found to play a key role in the selective separation In addition, fast adsorption, high loading ratios, and easy recycling are achieved with the present system, which is promising for practical applications. After reading the article, we found that the author used tert-Butyl carbamate(cas: 4248-19-5HPLC of Formula: 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.HPLC of Formula: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors》 were Liu, Ruiqi; Zhang, Zhuqing; Yang, Hong; Zhou, Kaixin; Geng, Meiyu; Zhou, Weicheng; Zhang, Mingming; Huang, Xun; Li, Yingxia. And the article was published in European Journal of Medicinal Chemistry in 2019. HPLC of Formula: 4949-44-4 The author mentioned the following in the article:

In order to find potent p300 inhibitors with good drug-like properties, C646 was chosen as the lead compound and a series of new p300 inhibitors were designed based on the principle of bioisosterism and reasonable scaffold hopping and the structure-activity relationship was systematically explored. Ten of them were found to show comparable inhibitory activity as C646. The most potent pyrazolylidene compound, e.g., I (IC50 = 0.16 μM), showed better p300 inhibitory activity than C646 with improved drug-like properties. Western blotting experiment confirmed that pyrazolylidene compound, e.g., I could reduce the level of H3K27 acetylation more significantly than C646. Further cellular assay indicated that it could inhibit the proliferation of human breast ductal carcinoma cell T47D and human breast cancer cell MCF7 with the IC50 values of 5.08 μM and 22.54 μM, resp. Docking study of pyrazolylidene compound, e.g., I with p300 protein showed the possible reasons for its higher inhibition activity. Thus, pyrazolylidene compound, e.g., I might be with potential for development as a novel epigenetic agent targeting p300. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.HPLC of Formula: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateIn 2004 ,《Traceless Solid-Phase Synthesis of Substituted Benzimidazolones》 was published in Journal of Combinatorial Chemistry. The article was written by Wang, Chih-Chung; Li, Wen-Ren. The article contains the following contents:

A new approach to substituted benzimidazolones is described. The key step of the sequence involved the introduction of one of the nitrogens by nucleophilic addition of a carbamate to an o-fluoronitrobenzene. Spontaneous cyclization and detachment of the benzimidazolones from the resin occurred in high yields under reductive conditions on solid supports. To further expand the scale and incorporate a third element of diversity into the library of target mols., the benzimidazolones were treated with NaH and various alkyl halides in DMF to afford fully functionalized benzimidazolones. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics