Tag: 100-200

In 2022,Wang, Fei; Nishimoto, Yoshihiro; Yasuda, Makoto published an article in Angewandte Chemie, International Edition. The title of the article was 《Lewis Acid-Catalyzed Diastereoselective C-C Bond Insertion of Diazo Esters into Secondary Benzylic Halides for the Synthesis of α,β-Diaryl-β-haloesters》.Related Products of 609-14-3 The author mentioned the following in the article:

A formal carbon-carbon (C-C) bond insertion via the reaction of secondary benzylic halides (fluorides, chlorides, and bromides) with α-diazo esters catalyzed by Lewis acid catalysts was reported. Secondary benzylic halides underwent elongation to afford α,β-diaryl-β-haloesters diastereoselectively. D. functional theory calculation revealed that the present formal C-C bond insertion was the result of Lewis acid-promoted cleavage and the re-formation of a carbon-halogen bond and that the aryl-migration step determined the diastereoselectivity. Various diarylmethyl halides and α-diazo esters were applicable to this reaction system. In addition, ring expansion in cyclic benzylic chlorides was accomplished. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Related Products of 609-14-3) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Related Products of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Kumar Saini, Manoj; Kant Verma, Shashi; Basak, Ashok K. published an article in Advanced Synthesis & Catalysis. The title of the article was 《Catalytic Cycloisomerization of Enyne Diesters Derived From 2-Propargyloxyarylaldehydes》.Quality Control of tert-Butyl carbamate The author mentioned the following in the article:

A catalytic cycloisomerization of enyne diesters derived from 2-propargyloxyarylaldehydes is described. The cycloisomerization, catalyzed by 10 mol% In(OTf)3, provides access to 2H-chromenes bearing di-Et 2-(hetero)arylidene malonates at 3-position. This enyne metathesis-type reaction is also useful for the synthesis of thia-, aza- and quinoline analogs of the 3-substituted 2H-chromenes. DDQ mediated oxidative C-N bond formation and further synthetic manipulation enables the conversion of 3-substituted 2H-chromene into chromene-fused mol. scaffold. Pd(0)-catalyzed intramol. Heck reaction on suitably substituted 2H-chromene provides indene-based mol. scaffold. The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Quality Control of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Ming-Hua; Tao, Jing-Qi; Yang, Fan; Xin, Hong; Gao, Shu-Xin; Guo, Li-Na; Gao, Pin published an article in 2022. The article was titled 《Iron-Catalyzed Ring-Opening/Allylation of Cycloalkyl Hydroperoxides with Allylic Sulfones》, and you may find the article in Asian Journal of Organic Chemistry.COA of Formula: C10H10O2 The information in the text is summarized as follows:

An efficient iron-catalyzed allylation of cycloalkyl hydroperoxides with allylic sulfones via C-C bond cleavage is presented. This protocol provides an efficient approach to a wide range of distally allylated ketones with good functional group tolerance and high regioselectivity under redox-neutral conditions. Preliminary mechanistic study implies a radical process might be involved in this reaction. The experimental process involved the reaction of Benzyl acrylate(cas: 2495-35-4COA of Formula: C10H10O2)

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.COA of Formula: C10H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Murphy, Brett J.; Carlson, Richard E.; Howa, John D.; Wilson, Tyler M.; Buch, R. Michael published an article in 2021. The article was titled 《Determining the authenticity of methyl salicylate in Gaultheria procumbens L. and Betula lenta L. essential oils using isotope ratio mass spectrometry》, and you may find the article in Journal of Essential Oil Research.Related Products of 119-36-8 The information in the text is summarized as follows:

The essential oils of wintergreen and birch are composed primarily of Me salicylate. Because this compound can easily be synthesized, wintergreen and birch oils are frequently adulterated. By using Gas chromatog.-combustion/pyrolysis-isotope ratio mass spectrometry (GC-C/P-IRMS) in conjunction with TC/EA-IRMS, GC-FID, GC-MS, and 14C radiocarbon dating, criteria will be established that can be used to distinguish authentic and natural wintergreen and birch essential oils from adulterated ones or from synthetic Me salicylate. Com. purchased samples were compared to both synthetic ′oil of wintergreen′ (Me salicylate) and to natural birch and wintergreen essential oils obtained from trusted sources or from the steam distillation of fresh plant material. δ2HVSMOW, δ13CVPDB, and δ18OVSMOW IRMS results provide a clear distinction between authentic and adulterated essential oil samples. The experimental process involved the reaction of Methyl Salicylate(cas: 119-36-8Related Products of 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Related Products of 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,European Journal of Medicinal Chemistry included an article by Li, Zheng; Chen, Yueming; Zhou, Zongtao; Deng, Liming; Xu, Yawen; Hu, Lijun; Liu, Bing; Zhang, Luyong. HPLC of Formula: 16982-21-1. The article was titled 《Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents》. The information in the text is summarized as follows:

The free fatty acid receptor 1 (FFA1 or GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have attracted a lot of attention due to their role in promoting insulin secretion and sensibility, resp., which are two major features of diabetes. Therefore, the dual FFA1/PPARδ agonists would increase insulin secretion and sensibility by FFA1 and PPARδ activation. In this study, we hybrid FFA1 agonist AM-4668 with PPARδ agonist GW501516, leading to the identification of orally bioavailable dual agonist 32(I), which revealed high selectivity over other PPARs. Moreover, compound 32 exhibited good pharmacokinetic profiles with high plasma concentration, sustained half-life and low clearance in vivo. During the hypoglycemic test, a dual agonist 32 enhanced the tolerance of ob/ob mice for glucose loading in a dose-dependent manner. Our results suggest that dual FFA1/PPARδ agonist could be a valuable therapy for type 2 diabetes. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1HPLC of Formula: 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.HPLC of Formula: 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Chemistry – A European Journal included an article by Bachon, Anne-Katrin; Hermann, Alina; Bolm, Carsten. Recommanded Product: 2495-35-4. The article was titled 《3D Heterocycles from Sulfonimidamides by Sequential C-H Bond Alkenylation/Aza-Michael Cyclization》. The information in the text is summarized as follows:

Starting from NH-sulfonimidamides RS(O)=NHR1 (R = 4-FC6H4, 3-CH3C6H4, naphth-1-yl, etc.; R1 = piperidin-1-yl, dimethylaminyl, morpholin-4-yl, etc.), rhodium-catalyzed C-H bond alkenylation followed by aza-Michael cyclization leads to unprecedented benzoisothiazole 1-oxides I (R2 = CH3, Et, n-Bu, Bn, t-Bu; R3 = H, Me, MeO, etc.; R4 = H, Me, Cl; R5 = H, Cl; R3R4 = CH=CH-CH=CH; R4R5 = CH=CH-CH=CH). The applicability and robustness of the method are demonstrated in 25 examples with yields up to 95%. The resulting scaffolds are partly saturated, 3D heterocycles with potential significance for medicinal and agricultural chem. The experimental part of the paper was very detailed, including the reaction process of Benzyl acrylate(cas: 2495-35-4Recommanded Product: 2495-35-4)

Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Recommanded Product: 2495-35-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2018,Ramanjulu, Joshi M.; Pesiridis, G. Scott; Yang, Jingsong; Concha, Nestor; Singhaus, Robert; Zhang, Shu-Yun; Tran, Jean-Luc; Moore, Patrick; Lehmann, Stephanie; Eberl, H. Christian; Muelbaier, Marcel; Schneck, Jessica L.; Clemens, Jim; Adam, Michael; Mehlmann, John; Romano, Joseph; Morales, Angel; Kang, James; Leister, Lara; Graybill, Todd L.; Charnley, Adam K.; Ye, Guosen; Nevins, Neysa; Behnia, Kamelia; Wolf, Amaya I.; Kasparcova, Viera; Nurse, Kelvin; Wang, Liping; Li, Yue; Klein, Michael; Hopson, Christopher B.; Guss, Jeffrey; Bantscheff, Marcus; Bergamini, Giovanna; Reilly, Michael A.; Lian, Yiqian; Duffy, Kevin J.; Adams, Jerry; Foley, Kevin P.; Gough, Peter J.; Marquis, Robert W.; Smothers, James; Hoos, Axel; Bertin, John published 《Design of amidobenzimidazole STING receptor agonists with systemic activity》.Nature (London, United Kingdom) published the findings.Related Products of 329-59-9 The information in the text is summarized as follows:

Stimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that propagates innate immune sensing of cytosolic pathogen-derived and self DNA1. The development of compounds that modulate STING has recently been the focus of intense research for the treatment of cancer and infectious diseases and as vaccine adjuvants2. To our knowledge, current efforts are focused on the development of modified cyclic dinucleotides that mimic the endogenous STING ligand cGAMP; these have progressed into clin. trials in patients with solid accessible tumors amenable to intratumoral delivery3. Here we report the discovery of a small mol. STING agonist that is not a cyclic dinucleotide and is systemically efficacious for treating tumors in mice. We developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. I.v. administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumors elicited strong anti-tumor activity, with complete and lasting regression of tumors. Our findings represent a milestone in the rapidly growing field of immune-modifying cancer therapies.Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Related Products of 329-59-9) was used in this study.

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Related Products of 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2015,Chudinov, M. V.; Matveev, A. V.; Zhurilo, N. I.; Prutkov, A. N.; Shvets, V. I. published 《An Efficient Route to Ethyl 5-Alkyl- (Aryl)-1H-1,2,4-triazole-3-carboxylates》.Journal of Heterocyclic Chemistry published the findings.Computed Properties of C4H7NO2S The information in the text is summarized as follows:

An efficient general route to the synthesis of 5-substituted 1H-1,2,4-triazole-3-carboxylates was developed. N-acylamidrazones were obtained from carboxylic acid hydrazides and Et thiooxamate or Et 2-ethoxy-2-iminoacetate hydrochloride and then were reacted with chloroanhydride of the same carboxylic acid. As the next step, diacylamidrazones were cyclized to 5-substituted 1H-1,2,4-triazole-3-carboxylates in one pot in mild conditions. In the experiment, the researchers used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Computed Properties of C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Computed Properties of C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,D’Agostino, Carmine; Kotionova, Tatyana; Mitchell, Jonathan; Miedziak, Peter J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.; Gladden, Lynn F.; Mantle, Mick D. published 《Solvent Effect and Reactivity Trend in the Aerobic Oxidation of 1,3-Propanediols over Gold Supported on Titania: NMR Diffusion and Relaxation Studies》.Chemistry – A European Journal published the findings.Formula: C4H8O3 The information in the text is summarized as follows:

In recent work, it was reported that changes in solvent composition, precisely the addition of water, significantly inhibits the catalytic activity of Au/TiO2 catalyst in the aerobic oxidation of 1,4-butanediol in methanol due to changes in diffusion and adsorption properties of the reactant. In order to understand whether the inhibition mechanism of water on diol oxidation in methanol is generally valid, the solvent effect on the aerobic catalytic oxidation of 1,3-propanediol and its two methyl-substituted homologues, 2-methyl-1,3-propanediol and 2,2-dimethyl-1,3-propanediol, over a Au/TiO2 catalyst has been studied here using conventional catalytic reaction monitoring in combination with pulsed-field gradient NMR (PFG-NMR) diffusion and NMR relaxation time measurements. Diol conversion is significantly lower when water is present in the initial diol/methanol mixture A reactivity trend within the group of diols was also observed Combined NMR diffusion and relaxation time measurements suggest that mol. diffusion and, in particular, the relative strength of diol adsorption, are important factors in determining the conversion. These results highlight NMR diffusion and relaxation techniques as novel, non-invasive characterization tools for catalytic materials, which complement conventional reaction data.Methyl 3-hydroxypropanoate(cas: 6149-41-3Formula: C4H8O3) was used in this study.

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2010,Morinaka, Brandon I.; Pawlik, Joseph R.; Molinski, Tadeusz F. published 《Amaranzoles B-F, Imidazole-2-carboxy Steroids from the Marine Sponge Phorbas amaranthus. C24-N- and C24-O-Analogues from a Divergent Oxidative Biosynthesis》.Journal of Organic Chemistry published the findings.Electric Literature of C4H7NO2S The information in the text is summarized as follows:

Five new steroidal imidazoles, amaranzoles B-F (I-V), were isolated from extracts of the marine sponge Phorbas amaranthus along with the known amaranzole A. The C24-N-(4-p-hydroxyphenyl)imidazol-5-yl constitution found in amaranzoles A, C, and D is replaced by a C24-O-(4-p-hydroxyphenyl)imidazole-2-carboxylate motif in amaranzoles B, E, and F. The structures were elucidated by interpretation of spectroscopic data. The C24 side chain configuration was assigned by synthesis of a model ester followed by chiroptical comparisons of its CD spectrum with that of an amaranzole B derivative In the experiment, the researchers used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Electric Literature of C4H7NO2S)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C4H7NO2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics