Tag: 100-200

Isoxazolone Based Inhibitors of p38 MAP Kinases was written by Laufer, Stefan A.;Margutti, Simona. And the article was included in Journal of Medicinal Chemistry in 2008.Category: esters-buliding-blocks This article mentions the following:

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Category: esters-buliding-blocks).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic asymmetric allylic alkylation in water with a recyclable amphiphilic resin-supported P,N-chelating palladium complex was written by Uozumi, Yasuhiro;Shibatomi, Kazutaka. And the article was included in Journal of the American Chemical Society in 2001.Related Products of 20637-09-6 This article mentions the following:

The PS-PEG resin-bound [(diphenylphosphino)phenyl]pyrroloimidazolones I and II (R = H, HO; Q = polystyrene resin) were prepared and formed palladium complexes with [PdCl(η³-C₃H₅)]₂. These immobilized complexes were catalysts for the asym. allylic alkylation of both cyclic and acyclic α,β-unsaturated carbonates in water with enantioselectivities up to 98% ee. Thus, reaction of the cyclohexenyl carbonate III with di-Me malonate in H₂O containing Li₂CO₃ and the complex I-[PdCl(η³-C₃H₅)]₂ gave (S)-cyclohexenylmalonate IV in 78% yield and 89% enantiomeric excess. In the experiment, the researchers used many compounds, for example, Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6Related Products of 20637-09-6).

Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 20637-09-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simultaneous chemical and sensory analysis of domestic cat urine and feces with headspace solid-phase microextraction and GC-MS-olfactometry was written by Banik, Chumki;Koziel, Jacek A.;Li, James Z.. And the article was included in Separations in 2021.HPLC of Formula: 868-57-5 This article mentions the following:

The association between humans and cats (Felis catus) is well known. This domestic animal is also known for its malodorous urine and feces. The complexity of the odorous urine and feces impacts human life by triggering the human sensory organ in a neg. way. The objective of this research was to identify the volatile organic chems. (VOCs) and associated odors in cat urine and feces using gas chromatog.-mass spectrometry and simultaneous sensory anal. of fresh and aged samples. The solid-phase microextraction (SPME) technique was used to preconc. the VOCs emitted from urine or feces samples. Twenty-one compounds were identified as emitted from fresh urine, whereas 64 compounds were emitted from fresh feces. A contrasting temporal impact was observed in the emission of VOCs for urine and feces. On aging, the emission increased to 34 detected chems. for stale urine, whereas only 12 chems. were detected in stale feces. Not all compounds were malodorous; some compounds had a pleasant hedonic smell to the human nose. Although trimethylamine, low-mol.-weight organic acids, and ketones were contributors to the odor to some extent, phenolic compounds and aromatic heterocyclic organic N compounds generated the most intense odors and substantially contributed to the overall malodor, as observed by this study. This work might be useful to formulate cat urine and feces odor remediation approaches to reduce odor impacts. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5HPLC of Formula: 868-57-5).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 868-57-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via an Unexpected α-Addition of α,β-Unsaturated γ-Butyrolactams to Coumarin Derivatives was written by Yang, Shu-Mei;Madhusudhan Reddy, Ganapuram;Liu, Meng-Hsien;Wang, Tzu-Ping;Yu, Jhen-Kuei;Lin, Wenwei. And the article was included in Journal of Organic Chemistry in 2017.Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A novel, base-catalyzed and highly diastereoselective direct Michael addition-isomerization sequence is presented for the efficient synthesis of Rauhut-Currier-type adducts. An unexpected α-addition of γ-butyrolactam onto the 3-acyl coumarin derivatives was observed rather than the γ-addition, which is more common. The adducts could further undergo hydrolysis/decarboxylation to generate the products which are equivalent to those obtained by α-addition of γ-butyrolactam onto the corresponding chalcones. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Microwave-assisted palladium-catalyzed isonitrile insertion in 2-bromophenylureas for efficient synthesis of 4-substituted imino 4H-benzo[d][1,3]oxazin-2-amines was written by Pandey, Garima;Batra, Sanjay. And the article was included in RSC Advances in 2015.Recommanded Product: 16413-26-6 This article mentions the following:

A general route to the synthesis of 4-substituted imino 4H-benzo[d][1,3]oxazin-2-amines via palladium-catalyzed isonitrile insertion in 2-bromophenylureas succeeded by a C-O cross-coupling of the intermediate imidoylpalladium species under microwave irradiation was reported. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A Pan Photoaffinity Probe for Detecting Active Forms of Matrix Metalloproteinases was written by Nury, Catherine;Czarny, Bertrand;Cassar-Lajeunesse, Evelyne;Georgiadis, Dimitris;Bregant, Sarah;Dive, Vincent. And the article was included in ChemBioChem in 2013.Formula: C10H14O4 This article mentions the following:

A photoaffinity probe based on the scaffold of a potent broad-spectrum phosphinic peptide inhibitor of matrix metalloproteinases (MMPs) has been developed. A photolabile diazirine group for covalent modification of MMP active forms was incorporated at the P₁‘ position, and a tritium radioactive label for the sensitive detection of MMP covalent adducts by radioimaging was attached. The probe was characterized on seven catalytic domains of human MMPs (MMP-2, -3, -8, -9, -12, -13 and -14) and was found to display nanomolar affinities toward this set of MMPs, covalently modifying them with crosslinking yields varying from 12 to 58 %, thus leading to highly sensitive detection of these MMPs. In a complex proteome complemented with four recombinant MMPs (MMP-2, -9, -12 and -13), this probe enabled their simultaneous detection with a threshold of few femtomoles and low background labeling. Those properties should make this new pan-activity-based MMP probe a valuable tool for the detection of MMP active forms from biol. fluids or tissue extracts In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Formula: C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Artemisia magellanica. Chemical composition of the essential oil from an unexplored endemic species of Patagonia was written by Gonzalez, Silvia B.;Gastaldi, Bruno;Catalan, Cesar;Di Leo Lira, Paola;Retta, Daiana;van Baren, Catalina M.;Bandoni, Arnaldo L.. And the article was included in Chemistry & Biodiversity in 2019.Electric Literature of C6H12O2 This article mentions the following:

The essential oil composition of the aerial parts of Artemisia magellanica Sch. Bip. (Asteraceae), native to Patagonia, was analyzed by GC-FID-MS. This is the first report on the essential oil composition of A. magellanica. A total of 113 components were identified accounting for 95.6-95.7% of the oil. The essential oil was characterized by a high percentage of γ-costol (21.0-43.5%), selina-4,11-diene, (Z)-β-ocimene, (E)-β-farnesene, (Z)-en-yn-dicycloether and 23 different esters (28.7%). In turn, Artemisia biennis, a species native to North America, which is considered by some authors to be conspecific with A. magellanica, yielded an essential oil that was rich in (Z)-β-ocimene (34.7%), (E)-β-farnesene (40.0%) and the acetylenes (Z)- and (E)-en-yn-dicycloethers (11.0%). Thus, as A. biennis lacks the three main components present in A. magellanica, namely γ-costol, 2-methylbutyl 2-methylbutyrate and selina-4,11-diene, these compounds could be considered as potential chem. markers for A. magellanica since they are absent or only found as minor constituents in other members of the genus. The data presented herein is also useful for genus taxonomy. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Electric Literature of C6H12O2).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C6H12O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Direct Fluoro-aminosulfenylation of Active Methylenes by Dialkylaminosulfur Trifluorides under Catalyst-Free Conditions was written by Saidalimu, Ibrayim;Guo, Ming;Tokunaga, Etsuko;Shibata, Norio. And the article was included in Asian Journal of Organic Chemistry in 2016.Recommanded Product: 13669-10-8 This article mentions the following:

The direct fluoro-aminosulfenylation of active methylene compounds, e.g., 2-(2,3-dihydro-1H-inden-1-ylidene)malononitrile by diethylaminosulfur trifluoride and its derivatives F₃SR (R = dimethylamino, diethylamino, bis(2-methoxyethyl)amino, morpholino) has been disclosed. A variety of α-fluorinated α-sulfenamides with a tetrasubstituted carbon center, e.g., I were synthesized from active methylene compounds under mild reaction conditions. This direct fluoro-aminosulfenylation reaction occurs very smoothly under metal-free and base-free conditions. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists was written by Kamenecka, Theodore M.;Bonnefous, Celine;Govek, Steven;Vernier, Jean-Michel;Hutchinson, John;Chung, Janice;Reyes-Manalo, Grace;Anderson, Jeffery J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 14667-47-1 This article mentions the following:

Modulation of the metabotropic glutamate subtype 5 (mGluR5) receptor may be useful in the treatment of a variety of central nervous system disorders. Here, the discovery, synthesis, and biol. evaluation of dipyridyl amines as small mol. mGluR5 antagonists, is reported. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Reference of 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Understanding the aroma diversity of Dancong tea (Camellia sinensis) from the floral and honey odors: Relationship between volatile compounds and sensory characteristics by chemometrics was written by Chen, Wei;Hu, Die;Miao, Aiqing;Qiu, Guangjun;Qiao, Xiaoyan;Xia, Hongling;Ma, Chengying. And the article was included in Food Control in 2022.Quality Control of 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

Dancong is a Chinese oolong tea famous for its aroma diversity. However, this diversity in characteristic is challenging to be clarified in either sensory or chem. aspects. In this study, the aromas from Dancong teas were characterized based on the typical odors of “floral” and “honey”. The volatile compounds underlying the odors were investigated through chemometrics. Seventy Dancong teas of various categories were collected to approx. the diversity in aroma. According to the sensory evaluation, the floral or honey odor was detected in every sample. For volatile characterization, 57 compounds were identified by gas chromatog.-mass spectrometry (GC-MS) coupled with headspace-solid phase microextraction (HS-SPME) across samples. The difference in floral and honey odors was related to volatile variation among the teas, as both the odor-based classification and the volatile-based unsupervised learning analyses yielded consistent sample clustering patterns. Nine volatiles were identified as putative markers for the odor difference, where indole, (E)-nerolidol, 2-phenylacetonitrile, and γ-caprolactone accounted for the floral odor predominance, while hexyl 2-methylbutanoate, (Z)-3-hexenyl pentanoate, (Z)-linalool oxide (pyranoid), (E)-linalool oxide (furanoid), and (Z)-linalool oxide (furanoid) contributed to the honey odor perception. These results point to a volatile-endorsed categorization framework based on the floral and honey odors that can assist in Dancong aroma quality control. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Quality Control of 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics