Tag: 100-200

Recommanded Product: Methyl 3-hydroxypropanoateIn 2006 ,《Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy》 was published in Chemistry – A European Journal. The article was written by Hirata, Yuuki; Nakamura, Seiichi; Watanabe, Nobuhide; Kataoka, Osamu; Kurosaki, Takahiro; Anada, Masahiro; Kitagaki, Shinji; Shiro, Motoo; Hashimoto, Shunichi. The article contains the following contents:

A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids A and C is described. The carbonyl ylide precursor was synthesized starting from di-tert-Bu D-tartrate via an eleven-step sequence involving the regioselective reduction of the mono-MPM (MPM = 4-methoxybenzyl) ether with LiBH4 and the diastereoselective addition of sodium tert-Bu diazoacetate to α-keto ester. The reaction of α-diazo ester with 3-butyn-2-one in the presence of a catalytic amount of [Rh2(OAc)4] gave the desired cycloadduct as a single diastereomer. The dihydroxylation of enone followed by sequential transformations permitted the construction of the fully functionalized 2,8-dioxabicyclo[3.2.1]octane core. Alkene serves as a common precursor to zaragozic acids A (1) and C (2), since the elongation of the C1 alkyl side chain can be attained by olefin cross-metathesis, especially under the influence of Blechert’s catalyst. In the experiment, the researchers used Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate

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Reference of Methyl SalicylateIn 2019 ,《Signaling mechanisms underlying systemic acquired resistance to microbial pathogens》 appeared in Plant Science (Shannon, Ireland). The author of the article were Shine, M. B.; Xiao, Xueqiong; Kachroo, Pradeep; Kachroo, Aardra. The article conveys some information:

A review. Plants respond to biotic stress by inducing a variety of responses, which not only protect against the immediate diseases but also provide immunity from future infections. One example is systemic acquired resistance (SAR), which provides long-lasting and broad-spectrum protection at the whole plant level. The induction of SAR prepares the plant for a more robust response to subsequent infections from related and unrelated pathogens. SAR involves the rapid generation of signals at the primary site of infection, which are transported to the systemic parts of the plant presumably via the phloem. SAR signal generation and perception requires an intact cuticle, a waxy layer covering all aerial parts of the plant. A chem. diverse set of SAR inducers has already been identified, including hormones (salicylic acid, Me salicylate), primary/secondary metabolites (nitric oxide, reactive oxygen species, glycerol-3-phosphate, azelaic acid, pipecolic acid, dihyroabetinal), fatty acid/lipid derivatives (18 carbon unsaturated fatty acids, galactolipids), and proteins (DIR1-Defective in Induced Resistance 1, AZI1-Azelaic acid Induced 1). Some of these are demonstrably mobile and the phloem loading routes for three of these SAR inducers is known. Here we discuss the recent findings related to synthesis, transport, and the relationship between these various SAR inducers.Methyl Salicylate(cas: 119-36-8Reference of Methyl Salicylate) was used in this study.

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Reference of Methyl Salicylate

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Application of 403-33-8In 2021 ,《Optimization of a Series of RIPK2 PROTACs》 appeared in Journal of Medicinal Chemistry. The author of the article were Miah, Afjal H.; Smith, Ian E. D.; Rackham, Mark; Mares, Alina; Thawani, Aditya R.; Nagilla, Rakesh; Haile, Pamela A.; Votta, Bartholomew J.; Gordon, Laurie J.; Watt, Gillian; Denyer, Jane; Fisher, Don T.; Dace, Phoebe; Giffen, Paul; Goncalves, Andrea; Churcher, Ian; Scott-Stevens, Paul; Harling, John D.. The article conveys some information:

Receptor-interacting serine/threonine protein kinase 2 (RIPK2) is an important kinase of the innate immune system. Herein, we describe the optimization of a series of RIPK2 PROTACs which recruit members of the inhibitor of apoptosis (IAP) family of E3 ligases. Our PROTAC optimization strategy focused on reducing the lipophilicity of the early lead which resulted in the identification of analogs with improved solubility and increased human and rat microsomal stability. We identified a range of IAP binders that were successfully incorporated into potent RIPK2 PROTACs with attractive pharmacokinetic profiles. Compound 20 possessed the best overall profile with good solubility, potent degradation of RIPK2, and associated inhibition of TNFα release. A proof-of-concept study utilizing a slow release matrix demonstrated the feasibility of a long-acting parenteral formulation with >1 mo duration. This represents an attractive alternative dosing paradigm to oral delivery, especially for chronic diseases where compliance can be challenging. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8

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《Thioether Ligand-Enabled Cationic Palladium(II)-Catalyzed Electrophilic C-H Arylation of α,β-Unsaturated Oxime Ethers》 was written by Yamada, Takahiro; Hashimoto, Yoshimitsu; Tanaka, Kosaku III; Morita, Nobuyoshi; Tamura, Osamu. Recommanded Product: 2495-35-4 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

The use of the cationic palladium(II) catalyst realized electrophilic C-H arylation of α,β-unsaturated O-SEM oximes with arylboronic acids. This Pd-catalyzed electrophilic C-H arylation is facilitated by employing alkyl aryl thioether ligands, and optimization of the ligand structure greatly improves the yield. The resulting α,β-unsaturated oximes would provide access to multisubstituted heterocyclic compounds The experimental part of the paper was very detailed, including the reaction process of Benzyl acrylate(cas: 2495-35-4Recommanded Product: 2495-35-4)

Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Recommanded Product: 2495-35-4

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity》 was published in ACS Infectious Diseases in 2020. These research results belong to Villemagne, Baptiste; Machelart, Arnaud; Tran, Ngoc Chau; Flipo, Marion; Moune, Martin; Leroux, Florence; Piveteau, Catherine; Wohlkonig, Alexandre; Wintjens, Rene; Li, Xue; Gref, Ruxandra; Brodin, Priscille; Deprez, Benoit; Baulard, Alain R.; Willand, Nicolas. Application of 16982-21-1 The article mentions the following:

Killing more than one million people each year, tuberculosis remains the leading cause of death from a single infectious agent. The growing threat of multidrug-resistant strains of Mycobacterium tuberculosis stresses the need for alternative therapies. EthR, a mycobacterial transcriptional regulator, is involved in the control of the bioactivation of the second-line drug ethionamide. We have previously reported the discovery of in vitro nanomolar boosters of ethionamide through fragment-based approaches. In this study, we have further explored the structure-activity and structure-property relationships in this chem. family. By combining structure-based drug design and in vitro evaluation of the compounds, we identified a new oxadiazole compound as the first fragment-based ethionamide booster which proved to be active in vivo, in an acute model of tuberculosis infection. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Application of 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 16982-21-1

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Ester – Wikipedia,
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《Synthesis and Antimicrobial Activity of Burkholderia-Related 4-Hydroxy-3-methyl-2-alkenylquinolines (HMAQs) and Their N-Oxide Counterparts》 was published in Journal of Natural Products in 2020. These research results belong to Piochon, Marianne; Coulon, Pauline M. L.; Caulet, Armand; Groleau, Marie-Christine; Deziel, Eric; Gauthier, Charles. Recommanded Product: Ethyl 3-oxopentanoate The article mentions the following:

The synthesis of a series of six 4-hydroxy-3-methyl-2-alkenylquinolines (HMAQs)/4-hydroxy-3-methyl-2-alkenylquinoline N-oxides (HMAQNOs) featuring a trans-Δ2 double bond at the C2-alkyl chain was reported. The quinolone scaffold was obtained via the Conrad-Limpach approach, while the (E)-2-alkenyl chain was inserted through Suzuki-Miyaura cross-coupling under microwave radiation without noticeable isomerization according to the optimized conditions. Subsequent oxidation of enolate-protected HMAQs cleanly led to the formation of HMAQNOs following cleavage of the Et carbonate group. Synthetic HMAQs/HMAQNOs were evaluated in vitro for their antimicrobial activity against different Gram-neg. and Gram-pos. bacteria as well as against molds and yeasts. The biol. results support and extend the potential of HMAQs/HMAQNOs as antimicrobials, especially against Gram-pos. bacteria. The involvement of HMAQs in the autoregulation of the Hmq system in Burkholderia ambifaria was confirmed. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 3-oxopentanoate

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Ester – Wikipedia,
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《Copper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights》 was published in Molecular Catalysis in 2020. These research results belong to Rajmani Singh, Rahul Kumar; Karsili, Tolga N. V.; Srivastava, Radhey. Product Details of 609-14-3 The article mentions the following:

Authors report a novel and efficient Cu-catalyzed direct asym. amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives, without the need for any post-reaction manipulation. This method reveals an effective strategy for the synthesis of enantioenriched α-C-H aminated derivatives which is hitherto challenging. The choice of the robust chiral indabox ligand was ascertained to be very crucial for the desired enantioselectivity in the contemporary transformation. The reaction mechanism is fully supported by ab initio electronic structure calculations The reaction is facile, efficient and performs well at room temperature with an enantiomeric excess (ee) up to 93%. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 609-14-3

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Synthesis of a chiral rod-like metal-organic framework from a preformed amino acid-based hexanuclear wheel》 were Grancha, T.; Ferrando-Soria, J.; Armentano, D.; Pardo, E.. And the article was published in Journal of Coordination Chemistry in 2019. SDS of cas: 4755-77-5 The author mentioned the following in the article:

The authors report the two-step synthesis of a chiral rod-like metal-organic framework (MOF). The chem. approach consists on the use of a previously prepared oxamato-based homochiral hexanuclear wheel, the ligand being a derivative of the natural amino acid L-alanine, (Me4N)6{CuII6[(S)-alama]6}·10H2O (1) [where (S)-alama = (S)-N-(Et oxoacetate)alanine]. The anionic hexacopper(II) wheels, stabilized by the presence of templating tetramethylammonium countercations, disassemble in the presence of cationic square-planar [Ni(cyclam)]2+ complexes to yield, after a supramol. reorganization process that involves axial coordination of the [Ni(cyclam)]2+ cations through the free carbonyl groups of the copper(II) moieties, a neutral chiral rod-like, three-dimensional (3D) MOF [Ni(cyclam)][Cu(S)-alama]2·16H2O (2). The resulting MOF constitutes one of the few examples where such a high-nuclearity metal complex was used as precursor for the construction of rod-like MOFs. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5SDS of cas: 4755-77-5) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 4755-77-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Varying the spatial arrangement of synthetic herbivore-induced plant volatiles and companion plants to improve conservation biological control》 were Jaworski, Coline C.; Xiao, Da; Xu, Qingxuan; Ramirez-Romero, Ricardo; Guo, Xiaojun; Wang, Su; Desneux, Nicolas. And the article was published in Journal of Applied Ecology in 2019. Product Details of 119-36-8 The author mentioned the following in the article:

Conservation biol. control aims to control pests by promoting wild populations of natural enemies. One challenge is to attract and retain efficient natural enemies in crop fields, which often are a suboptimal environment. Towards this goal, the attract-and-reward strategy relies on combining attractive synthetically produced herbivore-induced plant volatiles (HIPVs) with companion plants (non-crop plants which provide alternative resources to the targeted natural enemies). Although severely overlooked, the spatial arrangement of HIPV dispensers and rewards inside crop fields may strongly influence the foraging behavior and persistence of natural enemies and thus the success of this pest management strategy. We tested the impact of two contrasting spatial arrangements of HIPV dispensers and rewards, alternatively inside and around a block of target apple trees, on the efficacy of the biol. control of Aphis citricola populations by the common predatory ladybird Propylea japonica in apple orchards in northern China. We used synthetic Me salicylate (MeSA) as an attractant and the companion plant Calendula officinalis as a reward. To better understand how the spatial arrangement of MeSA dispensers and companion plants affected the attraction and foraging behavior of adult ladybirds, we conducted indoor experiments in a flight mill, an olfactometer and a wind-tunnel. Blocks of target trees treated with MeSA dispensers inside and companion plants around provided the most efficient pest control in orchards, compared with the opposite spatial arrangement. The synthetic MeSA dispenser and the companion plant synergistically attracted ladybirds in the olfactometer and enhanced their flight activity in the flight mill. In the wind-tunnel, MeSA served as a spatial cue for ladybirds to find nearby prey, while companion plants were sought in the absence of prey. Synthesis and applications. This study aims to further improve aphid control in apple orchards through a careful spatial arrangement of herbivore-induced plant volatiles dispensers (HIPVs) and rewards (companion plants) in optimized attract-and-reward strategies. Without such assessment, these strategies may be hazardous even with well-identified targeted natural enemies. Associated lab experiments highlight that interactions between HIPVs and companion plants influence ladybird foraging pattern, and that their spatial arrangement can modulate the ability of such key predators to find their prey. After reading the article, we found that the author used Methyl Salicylate(cas: 119-36-8Product Details of 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Product Details of 119-36-8

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Ester – Wikipedia,
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In 2019,Advanced Synthesis & Catalysis included an article by Zhang, Xiaoke; Pan, Yang; Liang, Peng; Ma, Xiaofeng; Jiao, Wei; Shao, Huawu. Electric Literature of C5H11NO3. The article was titled 《An Effective Method for the Synthesis of 1,3-Dihydro-2H-indazoles via N-N Bond Formation》. The information in the text is summarized as follows:

The [4+1] cycloaddition reaction of bifunctional amino reagents was achieved with in-situ formed aza-ortho-quinone methides. Specifically, N-(tosyloxy)carbamates were used as an N1 synthon and bifunctional amino reagents for this transformation, which provided a metal-free, catalyst-free and oxidant-free strategy to form nitrogen-nitrogen bonds. The experimental process involved the reaction of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Electric Literature of C5H11NO3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Electric Literature of C5H11NO3

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics