Tag: 100-200

Joly, Nicolas; Bettoni, Leo; Gaillard, Sylvain; Poater, Albert; Renaud, Jean-Luc published their research in Journal of Organic Chemistry in 2021. The article was titled 《Phosphine-Free Ruthenium Complex-Catalyzed Synthesis of Mono- or Dialkylated Aryl Hydrazides via the Borrowing Hydrogen Strategy》.Quality Control of Methyl 4-fluorobenzoate The article contains the following contents:

A diaminocyclopentadienone ruthenium tricarbonyl complex-catalyzed synthesis of mono- or dialkylated aryl hydrazides from N-unsubstituted aryl hydrazides and various substituted primary and secondary alcs. as alkylating reagents using the borrowing hydrogen strategy has been developed. Deuterium labeling experiments confirmed that the alcs. are the hydride source in this cascade process. D. functional theory (DFT) calculations unveiled the origin and the threshold between the mono- and dialkylation. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Catalytic asymmetric addition of an amine N-H bond across internal alkenes》 was written by Xi, Yumeng; Ma, Senjie; Hartwig, John F.. HPLC of Formula: 609-08-5 And the article was included in Nature (London, United Kingdom) in 2020. The article conveys some information:

Hydroamination of alkenes, the addition of the N-H bond of an amine across an alkene, is a fundamental, yet challenging, organic transformation that creates an alkylamine from two abundant chem. feedstocks, alkenes and amines, with full atom economy. The reaction is particularly important because amines, especially chiral amines, are prevalent substructures in a wide range of natural products and drugs. Although extensive efforts have been dedicated to developing catalysts for hydroamination, the vast majority of alkenes that undergo intermol. hydroamination have been limited to conjugated, strained, or terminal alkenes; only a few examples occur by the direct addition of the N-H bond of amines across unactivated internal alkenes, including photocatalytic hydroamination, and no asym. intermol. additions to such alkenes are known. In fact, current examples of direct, enantioselective intermol. hydroamination of any type of unactivated alkene lacking a directing group occur with only moderate enantioselectivity. Here we report a cationic iridium system that catalyzes intermol. hydroamination of a range of unactivated, internal alkenes, including those in both acyclic and cyclic alkenes, to afford chiral amines with high enantioselectivity. The catalyst contains a phosphine ligand bearing trimethylsilyl-substituted aryl groups and a triflimide counteranion, and the reaction design includes 2-amino-6-methylpyridine as the amine to enhance the rates of multiple steps within the catalytic cycle while serving as an ammonia surrogate. These design principles point the way to the addition of N-H bonds of other reagents, as well as O-H and C-H bonds, across unactivated internal alkenes to streamline the synthesis of functional mols. from basic feedstocks. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5HPLC of Formula: 609-08-5)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.HPLC of Formula: 609-08-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of protected α-amino acids via decarboxylation amination from malonate derivatives》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Fu, Hui; Li, Peihe; Wang, Zheng; Li, Xiaoying; Dai, Qipu; Hu, Changwen. Related Products of 36016-38-3 The article mentions the following:

A general and efficient strategy for the synthesis of protected α-amino acids is reported. The method uses malonate derivatives as the starting materials and Cs2CO3 as a base at 60 degrees, giving α-amino acid derivatives in moderate yields by releasing CO2. This methodol. shows broad substrate scope (primary and secondary acids), excellent functional group tolerance and high efficiency to give the desired products under mild reaction conditions. It also allows the construction of β and γ-amino acids and other unnatural products. After reading the article, we found that the author used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Related Products of 36016-38-3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Related Products of 36016-38-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Biosensors & Bioelectronics included an article by Khadka, Roshan; Aydemir, Nihan; Carraher, Colm; Hamiaux, Cyril; Colbert, Damon; Cheema, Jamal; Malmstrom, Jenny; Kralicek, Andrew; Travas-Sejdic, Jadranka. Related Products of 119-36-8. The article was titled 《An ultrasensitive electrochemical impedance-based biosensor using insect odorant receptors to detect odorants》. The information in the text is summarized as follows:

Herein, we present that insect odorant receptors reconstituted into the lipid bilayers of liposomes can be successfully immobilized onto a gold surface and selectively and sensitively detect odorant mols. The odorant receptors (OrXs) Or10a, Or22a, and Or71a from the common fruit fly, Drosophila melanogaster, were recombinantly expressed, purified and integrated into nano-liposomes (100-200 nm). These liposomes were covalently attached to the self-assembled monolayers (SAMs) of a 6-mercaptohexanoic acid (MHA)-modified gold surface. X-ray Photo Electron Spectroscopy (XPS) and Quartz Crystal Microbalance with Dissipation (QCM-D) measurements confirmed the successful modification of the gold surface and immobilization of liposomes. Atomic Force Microscopy (AFM) revealed that the liposomes were covalently attached to the surface without any disruption of vesicles. The liposomes tethered to the gold sensor surface were then treated with a range of known ligands of various concentrations We demonstrated by Electrochem. Impedance Spectroscopy (EIS) that an OrX/liposome EIS sensor can sensitively and selectively detect its known ligand to femtomolar concentrations by detecting a change in elec. signal upon binding. Our study is the first step towards using purified insect odorant receptors alone in biosensors to enable the development of novel ultrasensitive volatile sensors for medical diagnostic, air quality, food safety and border security applications. After reading the article, we found that the author used Methyl Salicylate(cas: 119-36-8Related Products of 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Related Products of 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,ACS Chemical Neuroscience included an article by Pallesen, Jakob; Moellerud, Stine; Frydenvang, Karla; Pickering, Darryl S.; Bornholdt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm; Johansen, Tommy N.. Electric Literature of C4H5ClO3. The article was titled 《N1-substituted quinoxaline-2,3-diones as kainate receptor antagonists: x-ray crystallography, structure-affinity relationships, and in vitro pharmacology》. The information in the text is summarized as follows:

Among the ionotropic glutamate receptors, the physiol. role of kainate receptors is less well understood. Although ligands with selectivity toward the kainate receptor subtype GluK1 are available, tool compounds with selectivity at the remaining kainate receptor subtypes are sparse. Here, we have synthesized a series of quinoxaline-2,3-diones with substitutions in the N1-, 6-, and 7-position to investigate the structure-activity relationship (SAR) at GluK1-3 and GluK5. Pharmacol. characterization at native and recombinant kainate and AMPA receptors revealed that I had a GluK3-binding affinity (Ki) of 0.142 μM and 8-fold preference for GluK3 over GluK1. Despite lower binding affinity of II at GluK3 (Ki = 2.91 μM), its preference for GluK3 over GluK1 and GluK2 was >30-fold. I was crystallized with the GluK1 ligand-binding domain to understand the SAR. The X-ray structure showed that I stabilized the protein in an open conformation, consistent with an antagonist binding mode. In the experimental materials used by the author, we found Ethyl oxalyl monochloride(cas: 4755-77-5Electric Literature of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Electric Literature of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2018,Lee, Yun-Ta; Chiu, Feng-Yu; Barve, Indrajeet J.; Sun, Chung-Ming published 《Microwave-assisted synthesis of benzimidazole-linked indoline and indole hybrids from C-2 linked (o-aminobenzyl)benzimidazoles》.Advanced Synthesis & Catalysis published the findings.Application of 329-59-9 The information in the text is summarized as follows:

An efficient and novel synthesis of benzimidazole-linked indoline hybrids I [R1 = H, (CH2)3CH3, (CH2)2Ph, etc.; R2 = Me, Ph, 4-HOC6H4, 4-MeOC6H4, 4-O2NC6H4, 1,3-benzodioxol-5-yl; R3 = H, Me, Ph; R2R3 = (CH2)4; R4 = H, 7-Me, 5-CF3, 5-C(O)OMe] via an unconventional Pictet-Spengler-type condensation of C-2 linked (o-aminobenzyl)benzimidazoles with aldehydes and ketones under microwave irradiation was explored. Addnl., benzimidazole-linked indoline hybrids were further converted into the corresponding benzimidazole-linked indole hybrids II [R5 = CH2CH(CH3)2, (CH2)3CH3; R6 = Ph, 4-MeOC6H4, 4-O2NC6H4] by oxidation utilizing DDQ as oxidizing agent and the desired products were obtained in excellent yields. The key condensation step consisted acid-catalyzed imine generation followed by intramol. C-C bond formation through unique reactivity of the benzimidazole moiety. The scope of this method was further extended to synthesize tetracyclic pyrroloindole benzimidazole-carboxylates through 2-carboxaldehydes.Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Application of 329-59-9) was used in this study.

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Application of 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2014,Xiao, Jingbo; Free, R. Benjamin; Barnaeva, Elena; Conroy, Jennie L.; Doyle, Trevor; Miller, Brittney; Bryant-Genevier, Marthe; Taylor, Mercedes K.; Hu, Xin; Dulcey, Andres E.; Southall, Noel; Ferrer, Marc; Titus, Steve; Zheng, Wei; Sibley, David R.; Marugan, Juan J. published 《Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists》.Journal of Medicinal Chemistry published the findings.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:

The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for neuropsychiatric and endocrine disorders. However, clin. approved drugs targeting D2 DAR display poor selectivity between the D2 and other receptors, especially the D3 DAR. This lack of selectivity may lead to undesirable side effects. Described are chem. and pharmacol. characterizations of a novel D2 DAR antagonist series with excellent D2 vs. D1, D3, D4, and D5 receptor selectivity. The final probe, 10-Methyl-11-oxo-N-(2-(thiophen-2-yl)ethyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5-(S)-oxide, was obtained through a quant. high-throughput screening campaign, followed by medicinal chem. optimization, to yield a selective mol. with good in vitro phys. properties, metabolic stability, and in vivo pharmacokinetics. The optimized mol. may be a useful in vivo probe for studying D2 DAR signal modulation and could also serve as a lead compound for the development of D2 DAR-selective drug-like mols. for the treatment of multiple neuropsychiatric and endocrine disorders. After reading the article, we found that the author used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weis, Erik; Johansson, Magnus J.; Martin-Matute, Belen published their research in Chemistry – A European Journal on December 23 ,2021. The article was titled 《Late-Stage Amination of Drug-Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium-Catalyzed C-H Activation》.Formula: C9H8O4 The article contains the following contents:

The method presented herein enables the amination of a wide array of benzoic acids RC(O)OH (R = 2-fluorophenyl, naphthalen-1-yl, thiophen-2-yl, 2H-1,3-benzodioxol-4-yl, etc.) with high selectivity. The robustness of the system is manifested by the large number of functional groups tolerated, which allowed the amination of a diverse array of marketed drugs and drug-like mols. Furthermore, the introduction of a synthetic handle enabled expeditious access to targeted drug-delivery conjugates, e.g., I, PROTACs II, and probes for chem. biol. This rapid access to valuable analogs, combined with operational simplicity and applicability to high-throughput experimentation has the potential to aid and considerably accelerate drug discovery. The experimental process involved the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Formula: C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Formula: C9H8O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Favorskii reactions of α-halo-α,β-unsaturated monocyclic ketones》 were Khawd, Ibrahim E.; Iskander, George M.. And the article was published in Revue Roumaine de Chimie in 1980. Electric Literature of C8H14O3 The author mentioned the following in the article:

I (R = Br, Cl) undergoes the Favorskii reaction in MeONa-MeOH to give II (R = OH, OMe), and III, formed via the intermediacy of IV which is itself the eventual product of V itself formed in the initial double bond isomerization of I. VI under these conditions gives VII and VIII gives IX in methanolic acid. The experimental process involved the reaction of Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8Electric Literature of C8H14O3)

Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Electric Literature of C8H14O3 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2021,Organic Chemistry Frontiers included an article by Liu, Chengwei; Szostak, Michal. Recommanded Product: 1877-71-0. The article was titled 《Decarbonylative sulfide synthesis from carboxylic acids and thioesters via cross-over C-S activation and acyl capture》. The information in the text is summarized as follows:

A method for the synthesis of sulfides from carboxylic acids via thioester C-S activation and acyl capture has been developed, wherein thioesters serve as dual electrophilic activators of carboxylic acids and S-nucleophiles through the merger of decarbonylative palladium catalysis and sulfur coupling. This new concept employs readily available carboxylic acids as coupling partners to directly intercept sulfur reagents via redox-neutral thioester-enabled cross-over thioetherification. The scope of this platform is demonstrated in the highly selective decarbonylative thioetherification of a variety of carboxylic acids and thioesters, including late-stage derivatization of pharmaceuticals and natural products. This method operates under mild, external base-free, and operationally practical conditions, providing a powerful new framework to unlock aryl electrophiles from carboxylic acids and increase the reactivity by employing common building blocks in organic synthesis.3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Recommanded Product: 1877-71-0) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Recommanded Product: 1877-71-0 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics