Tag: 100-200

In 2022,Perez-Aparicio, Alicia; Ammagarahalli, Byrappa; Gemeno, Cesar published an article in Scientific Reports. The title of the article was 《A closer look at sex pheromone autodetection in the Oriental fruit moth》.Application In Synthesis of Methyl Salicylate The author mentioned the following in the article:

Female moths emit sex pheromone to attracts males, and although they are not attracted to their own sex pheromone, they appear to detect it as it affects their behavior. In order to elucidate the mechanism of pheromone “”autodetection”” we compared responses of olfactory receptor neurons (ORNs) of male and female Grapholita molesta, a species with reported pheromone autodetection. Two concentrations of the major (Z8-12:Ac) and minor (E8-12:Ac) sex pheromone components, a plant-volatile blend containing Me salicylate, terpinyl acetate and (E)-β-farnesene, and the male-produced hair-pencil (i.e., courtship) pheromone (Et trans-cinnamate) were tested in 45 male and 305 female ORNs. Hierarchical cluster anal. showed radically different peripheral olfactory systems between sexes that could be linked to their specific roles. In males 63% of the ORNs were tuned specifically to the major or minor female sex pheromone components, and 4% to the plant volatile blend, while the remaining 33% showed unspecific responses to the stimulus panel. In females 3% of the ORNs were specifically tuned to the male hair-pencil pheromone, 6% to the plant volatile blend, 91% were unspecific, and no ORN was tuned their own sex pheromone components. The lack of sex pheromone-specific ORNs in females suggests that they are not able to discriminate pheromone blends, and thus pheromone autodetection is unlikely in this species. We discuss our results in the context of the methodol. limitations inherent to odor stimulation studies. The experimental part of the paper was very detailed, including the reaction process of Methyl Salicylate(cas: 119-36-8Application In Synthesis of Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Application In Synthesis of Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Liu, Zhixin; Liu, Xinyu; Yang, Shengkuan; Miao, Xiaohe; Li, Dehai; Wang, De published an article in Journal of Organic Chemistry. The title of the article was 《Titanium-Mediated aza-Nazarov Annulation for the Synthesis of N-Fused Tricycles: A General Method to Access Lamellarin Analogues》.Synthetic Route of C5H11NO2 The author mentioned the following in the article:

Fused heterocycles with nitrogen incorporation are of particular bioactive use and high importance in many research fields, especially isoquinoline-based [6/6/5] tricycles. Here, authors report a unique strategy to access multifunctional N-fused tricycles from α,β-unsaturated isoquinoline ketone and sulfonamide under mild reaction conditions. The methodol. features wide substrate tolerance, and a set of N-fused heteroarenes including quinoline, phthalazine, quinazoline, quinoxaline, and benzothiazole cores are furnished efficiently. Moreover, the protocol is easy to scale up to synthesize lamellarin analogs, and the amide group of the product is also easy to transfer to other functional groups. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Synthetic Route of C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Xu, Wengang; Zhang, Yangyang; Wu, Yongdi; Wang, Jian; Lu, Xuelian; Zhou, Yirong; Zhang, Fang-Lin published an article in Journal of Organic Chemistry. The title of the article was 《Direct Assembly of Diverse Unsymmetrical Tertiary 9-Fluorenols via Transient Directing Group-Enabled Palladium-Catalyzed Dual C-H Bond Activation of α-Ketoesters》.Formula: C4H5ClO3 The author mentioned the following in the article:

An expeditious construction of an unsym. tertiary 9-fluorenol skeleton, e.g., I was accomplished starting from readily available α-keto esters and aryl iodides. An inexpensive, com. available, substituted aniline was utilized as a potent monodentate transient directing group (TDG) to assist palladium-catalyzed direct ortho-C-H arylation and tandem dual C-H activation of α-ketoesters to form two carbon-carbon bonds. To demonstrate practical applications, the reaction was enlarged to the gram scale, and subsequent one-step derivatization allowed facile access to structurally diversified useful derivatives A series of control experiments was carried out to shed light on the possible catalytic mechanism. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Ma, Yu-Hong; He, Xiao-Yu; Wang, Long; Yang, Qing-Qing published an article in Journal of Organic Chemistry. The title of the article was 《PPh3-Triggered Tandem Synthesis of 2,3-Disubstituted Benzofuran Derivatives from o-Quinone Methides with Acyl Chlorides》.COA of Formula: C4H5ClO3 The author mentioned the following in the article:

A PPh3-triggered tandem strategy for the efficient synthesis of valuable 2,3-disubstituted benzofuran derivatives in generally good to high yields from aryl or alkyl acyl chlorides and o-quinone methides has been developed. This method features mild reaction conditions, simple operation, and a broad substrate scope.Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.COA of Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chang, Wenxu; Li, Zongyang; Yuan, Chenhui; Liu, Xinying; Feng, Jiyao; Pang, Sen; Duan, Liusheng; Zhang, Zhenhua published an article in 2022. The article was titled 《Synthesis of Highly Substituted 2-Aminopyridines from Vinyl Azides, Isonitriles, and Ketones》, and you may find the article in Chemistry – An Asian Journal.Application of 4949-44-4 The information in the text is summarized as follows:

Authors developed a facile, efficient method for synthesizing highly substituted 2-aminopyridines I (R1 = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R2 = t-Bu, c-hexyl, Bn, etc.; R3 = Me, i-Pr, 4-O2NC6H4, etc.; R4 = CN, COMe, COOEt, etc.) from unstable vinyl carbodiimides generated in situ in a one-pot transformation. A series of novel highly substituted 3-functionalized 2-aminopyridines were produced in good yields. Reaction mechanism studies, which included control experiments and d.-functional theory (DFT) calculations, demonstrated that Rh and potassium carbonate played key roles in the cyclization step. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Application of 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Yao; Zhao, Shuang; Hu, Lei published an article in 2022. The article was titled 《Identification of potent α-amylase inhibitors via dynamic combinatorial chemistry》, and you may find the article in Bioorganic & Medicinal Chemistry.Recommanded Product: 16982-21-1 The information in the text is summarized as follows:

In this study, we report for the first time the discovery of potent α-amylase inhibitors using principle of dynamic combinatorial chem. The best compound identified exhibited not only high inhibitory efficiency but also low cytotoxicity. The binding mode and possible mechanism are determined in the subsequent kinetic and mol. docking studies. In the experimental materials used by the author, we found Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Recommanded Product: 16982-21-1)

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Recommanded Product: 16982-21-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hou, Xi-Qiang; Lin, Ye; Du, Da-Ming published an article in 2021. The article was titled 《Organocatalytic domino annulation of in-situ generated tert-butyl 2-hydroxybenzylidenecarbamates with 2-isothiocyanato-1-indanones for synthesis of bridged and fused ring heterocycles》, and you may find the article in Organic Chemistry Frontiers.Quality Control of tert-Butyl carbamate The information in the text is summarized as follows:

A one-pot efficient asym. domino annulation of 2-isothiocyanato-1-indanones with tert-Bu 2-hydroxybenzylidene carbamates in-situ generated from 2-hydroxyaryl-substituted α-amido sulfones was developed. This reaction firstly provided a powerful tool for the enantioselective construction of functionalized bridged fused ring hererocycles bearing three adjacent stereogenic centers in high yields with excellent diastereo- and enantioselectivities (up to 91% yield, >20 : 1 dr and 99% ee). In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Chun; Zhang, Chao; Tang, Jie; Ye, Shengqing; Ma, Mingliang; Wu, Jie published an article in 2021. The article was titled 《Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO·(SO2)2 and Alkyl Halides》, and you may find the article in Advanced Synthesis & Catalysis.Recommanded Product: Methyl 4-fluorobenzoate The information in the text is summarized as follows:

A route to γ-keto sulfones RC(O)(CH2)2SO2R1 [R = 4-FC6H4, Bn, 2-naphthyl, etc.; R1 = Me, Bn, 4-BrC6H4CH2, etc.] through a metal-free reaction of cyclopropanols, DABCO·(SO2)2 and alkyl halides was described. This reaction occurs under mild conditions in the absence of any catalysts, additives, or oxidants. Various functional groups including as ester, amino, methoxy, bromo, trifluoromethyl, nitro and carbonyl were tolerated well in this transformation and the corresponding γ-keto sulfones were afforded in 35% to 95% yields. The proposed mechanism implies that this reaction proceeded through γ-keto sulfinate intermediate generated in situ, which further undergoes nucleophilic substitution with alkyl halides leading to γ-keto sulfones. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Aipeng; Wang, Ting; Tian, Qing; Yang, Xiaohong; Yin, Dongming; Qin, Yong; Zhang, Lianbing published their research in Chemistry – A European Journal in 2021. The article was titled 《Single-Point Mutant Inverts the Stereoselectivity of a Carbonyl Reductase toward β-Ketoesters with Enhanced Activity》.Category: esters-buliding-blocks The article contains the following contents:

Enzyme stereoselectivity control is still a major challenge. To gain insight into the mol. basis of enzyme stereo-recognition and expand the source of antiPrelog carbonyl reductase toward β-ketoesters, rational enzyme design aiming at stereoselectivity inversion was performed. The designed variant Q139G switched the enzyme stereoselectivity toward β-ketoesters from Prelog to antiPrelog, providing corresponding alcs. in high enantiomeric purity (89.1-99.1% ee). More importantly, the well-known trade-off between stereoselectivity and activity was not found. Q139G exhibited higher catalytic activity than the wild-type enzyme, the enhancement of the catalytic efficiency (kcat/Km) varied from 1.1- to 27.1-fold. Interestingly, the mutant Q139G did not lead to reversed stereoselectivity toward aromatic ketones. Anal. of enzyme-substrate complexes showed that the structural flexibility of β-ketoesters and a newly formed cave together facilitated the formation of the antiPrelog-preferred conformation. In contrast, the relatively large and rigid structure of the aromatic ketones prevents them from forming the antiPrelog-preferred conformation. In the experiment, the researchers used Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondrashov, Mikhail; Svensson, Samuel P. S.; Stroem, Peter; Westermark, Andreas; Jacobson-Ingemyr, Hanna; Takano, Akihiro; Tari, Lenke; Toth, Miklos; Cai, Minying; Hruby, Victor J.; Schou, Magnus published their research in Bioconjugate Chemistry in 2021. The article was titled 《Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma》.HPLC of Formula: 403-33-8 The article contains the following contents:

A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomog. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8HPLC of Formula: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.HPLC of Formula: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics