Tag: 100-200

《Facile amidation of esters with aromatic amines promoted by lanthanide tris (amide) complexes》 was written by Li, Zhao; Guo, Chenjun; Chen, Jue; Yao, Yingming; Luo, Yunjie. Name: Methyl 4-fluorobenzoate And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

The development of catalysts capable of catalyzing amidation of esters with amines to construct amides under mild conditions is of great importance. Compared to aliphatic amines, the direct catalytic amidation of esters with less nucleophilic aromatic amines was rather difficult. Employing simple lanthanide tris (amide) complexes Ln[N (SiMe3)2]3(μ-Cl)Li (THF)3 as the catalysts, it was found a broad range of aromatic amines and esters were efficiently converted into various amides in good yields under mild conditions. A plausible mechanism for this transformation was exptl. supported as starting from an amide exchange reaction between the lanthanide tris (amide) complex and the substrate amine. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Characterization of the key aroma compounds in Longjing tea using stir bar sorptive extraction (SBSE) combined with gas chromatography-mass spectrometry (GC-MS), gas chromatography-olfactometry (GC-O), odor activity value (OAV), and aroma recombination》 was published in Food Research International in 2020. These research results belong to Wang, Meng-Qi; Ma, Wan-Jun; Shi, Jiang; Zhu, Yin; Lin, Zhi; Lv, Hai-Peng. Safety of Methyl Salicylate The article mentions the following:

Longjing tea is the most famous premium green tea, and is regarded as the national tea in China, with its attractive aroma contributing as a prime factor for its general acceptability; however, its key aroma compounds are essentially unknown. In the present study, volatile compounds from Longjing tea were extracted and examined using stir bar sorptive extraction (SBSE) combined with gas chromatog.-mass spectrometry (GC-MS). Data obtained from the present study revealed that 151 volatile compounds from 16 different chem. classes were identified by GC-MS anal. Enols (8096 μg/kg), alkanes (6744 μg/kg), aldehydes (6442 μg/kg), and esters (6161 μg/kg) were the four major chem. classes and accounted for 54% of the total content of volatile compounds Geraniol (6736 μg/kg) was the most abundant volatile compound in Longjing tea, followed by hexanal (1876 μg/kg) and β-ionone (1837 μg/kg). Moreover, 14 volatile compounds were distinguished as the key aroma compounds of Longjing tea based on gas chromatog.-olfactometry (GC-O) anal., odor activity value (OAV) calculations, and a preliminary aroma recombination experiment, including 2-Me butyraldehyde, DMSO, heptanal, benzaldehyde, 1-octen-3-ol, (E, E)-2,4-heptadienal, benzeneacetaldehyde, linalool oxide I, (E, E)-3,5-octadien-2-one, linalool, nonanal, Me salicylate, geraniol, and β-ionone. This is the first comprehensive report describing the aroma characterizations and the key aroma compounds in Longjing tea using SBSE/GC-MS. The findings from this study contribute to the scientific elucidation of the chem. basis for the aromatic qualities of Longjing tea. In the experimental materials used by the author, we found Methyl Salicylate(cas: 119-36-8Safety of Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Safety of Methyl Salicylate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Pendant Functionalized Polyester Nanofibers with Dual Cargo Release》 were Nun, Nicholas; Xu, Ying; Joy, Abraham. And the article was published in ACS Applied Bio Materials in 2019. Application In Synthesis of N-tert-Butoxycarbonylhydroxylamine The author mentioned the following in the article:

Common polymeric biomaterials lack the ability to control the release of multiple bioactive compounds due to their inherent lack of functionality. These materials often require addnl. components or complicated fabrication techniques to achieve the sep. release profiles desired for wound healing and tissue engineering applications. This prevents many biomaterials from being translated to the clinic, because the complexity of the wound environment necessitates temporal control of multiple additives for effective healing. Electrospun nanofibers comprised of a functional polymer would allow for sep. release profiles of multiple bioactive compounds through covalent conjugation or tuning noncovalent interactions. In this work, two fluorescent dyes as model drugs were released from functional polyester electrospun mats. Two mats were fabricated: one in which both dyes were blended into the electrospinning solution and one in which one dye was blended and the other was covalently conjugated to the polymer. Average fiber diameters were determined using SEM, while fluorescence microscopy showed the presence of both dyes in the fibers. Dye release was tracked using UV-vis spectroscopy by comparing measured values to standard curves. Finally, degradation of the mats was tracked using gel permeation chromatog. With this functional polyester platform, distinct release profiles were achieved for two model drugs. Not only does the release of two model drugs show potential for the future use of this polymer platform in the applications of wound healing and tissue engineering but also the ability to incorporate several distinct conjugation chemistries is of great benefit. In the experiment, the researchers used many compounds, for example, N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Application In Synthesis of N-tert-Butoxycarbonylhydroxylamine)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of N-tert-Butoxycarbonylhydroxylamine

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Identification and quantification of key odorants in the world’s four most famous black teas》 were Kang, Suyoung; Yan, Han; Zhu, Yin; Liu, Xu; Lv, Hai-Peng; Zhang, Yue; Dai, Wei-Dong; Guo, Li; Tan, Jun-Feng; Peng, Qun-Hua; Lin, Zhi. And the article was published in Food Research International in 2019. Related Products of 119-36-8 The author mentioned the following in the article:

Keemun, Assam, Darjeeling and Ceylon black teas are honored as the world’s four most famous black teas, and their excellent aroma qualities are well received by people around the world. In this study, aroma components in these four types of teas were analyzed by comprehensive two-dimensional gas chromatog. time-of-flight mass spectrometry (GC × GC-TOFMS) and gas chromatog.-olfactometry (GC-O) technologies. A total of 42 aroma-active compounds were ultimately identified, especially benzeneacetaldehyde, geraniol, (Z)-3-hexen-1-yl hexanoate, trans-β-ionone, cis-linalool oxide (pyranoid), hotrienol, and Me salicylate presented the strongest aroma strengths with pleasant scents in all tested teas. The quantification results indicated that 19 compounds including (Z)-3-hexenol, 1-octen-3-ol, linalool, phenylethyl alc., hexanal, benzeneacetaldehyde, limonene, heptanoic acid, (Z)-3-hexen-1-ol, acetate, benzyl alc., trans-linalool oxide (furanoid), hotrienol, 1-octen-3-one, 2-nonanone, (E)-2-octenal, nonanal, β-myrcene, 2-pentylfuran, and methylpyrazine were identified as the key compounds with odor activity values (OAVs) higher than 1.0 in the world’s four most famous black teas. Notably, the comparison of GC-O and OAV calculation results showed that Me salicylate (Ceylon), (E)-2-octenal (Assam), benzeneacetaldehyde (Keemun) and linalool and trans-linalool oxide (furanoid) (Darjeeling) might be the most definitive odorants in the corresponding tea categories. In the part of experimental materials, we found many familiar compounds, such as Methyl Salicylate(cas: 119-36-8Related Products of 119-36-8)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Related Products of 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Inorganic Chemistry included an article by Kalinke, Lucas H. G.; Cangussu, Danielle; Mon, Marta; Bruno, Rosaria; Tiburcio, Estefania; Lloret, Francesc; Armentano, Donatella; Pardo, Emilio; Ferrando-Soria, Jesus. Recommanded Product: 4755-77-5. The article was titled 《Metal-Organic Frameworks as Playgrounds for Reticulate Single-Molecule Magnets》. The information in the text is summarized as follows:

Achieving fine control on the structure of metal-organic frameworks (MOFs) is mandatory to obtain target phys. properties. Herein, the authors present how the combination of a metalloligand approach and a postsynthetic method is a suitable and highly useful synthetic strategy to success on this extremely difficult task. First, a novel oxamato-based tetranuclear Co(III) compound with a tetrahedron-shaped geometry was used, for the 1st time, as the metalloligand toward Ca(II) metal ions to lead to a diamagnetic CaII-CoIII three-dimensional (3D) MOF {Ca6(H2O)24[CoIII4(tpatox)4]}·44H2O (1), tpatox6- = N,N’,N”-tris(4-phenyl)aminetris(oxamate). In a 2nd stage single-crystal-to-single-crystal manner, the Ca(II) ions are replaced by Tb(III), Dy(III), Ho(III), and Er(III) to yield isostructural LnIII-CoIII [Ln = Tb 2, Dy 3, Ho 4, and Er 5] 3-dimensional MOFs. Direct-current magnetic properties for 2-5 show typical performances for the ground-state terms of the lanthanoid cations [7F6 (TbIII), 6H15/2 (DyIII), 5I8 (HoIII), and 4I15/2 (ErIII)]. Anal. of the χMT data indicates that the ground state is the lowest MJ value, i.e., MJ = 0 (2 and 4) and ±1/2 (3 and 5). Kramers’ ions (3 and 5) exhibit field-induced emergent frequency-dependent alternating-current magnetic susceptibility signals, which is indicative of the presence of slow magnetic relaxation typical of single-mol. magnets. The authors report the combined use of the metalloligand design strategy and postsynthetic methodologies to build up a family of isostructural metal-organic frameworks as playgrounds toward the controlled spatial organization of single-mol. magnets. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Journal of Medicinal Chemistry included an article by Yang, Wei; Li, Yingjun; Ai, Yong; Obianom, Obinna N.; Guo, Dong; Yang, Hong; Sakamuru, Srilatha; Xia, Menghang; Shu, Yan; Xue, Fengtian. SDS of cas: 4949-44-4. The article was titled 《Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation》. The information in the text is summarized as follows:

Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an addnl. anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxopentanoate(cas: 4949-44-4SDS of cas: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.SDS of cas: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Journal of Flow Chemistry included an article by Szabo, Balazs; Tamas, Balint; Faigl, Ferenc; Eles, Janos; Greiner, Istvan. HPLC of Formula: 36016-38-3. The article was titled 《Diastereoselective synthesis of cis-N-Boc-4-aminocyclohexanol with reductive ring opening method using continuous flow》. The information in the text is summarized as follows:

A novel continuous flow process for hydrogenation of tert-Bu 2-oxa-3azabicyclo[2.2.2]oct-5-ene-3-carboxylate to the corresponding cis-4-aminocyclohexanols I (R = Me, NMe2, benzyloxy, 9H-fluoren-9-ylmethyloxy) has been reported using H-Cube Pro. A > 99% selectivity towards the desired product was obtained using Raney nickel catalyst cartridge. Under carefully selected hydrogenation parameters, the reduction could stop at the also valuable tert-Bu 2-oxa-3-azabicyclo[2.2.2]octane-3-carboxylate intermediate with a selectivity of >99%. The tert-Bu 2-oxa-3azabicyclo[2.2.2]oct-5-ene-3-carboxylate producing nitroso hetero-Diels-Alder cycloaddition was also accomplished in a flow system using an Omnifit column packed with MnO2. The two flow reactions were successfully merged in a system, thus the product was obtained in a multistep flow synthesis without any isolation or purification steps. Compared with the previously reported batch processes, the present multistep procedure facilitates an efficient cis selective preparation of numerous synthetically valuable 4-aminocyclohexanol derivatives In addition to this study using N-tert-Butoxycarbonylhydroxylamine, there are many other studies that have used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3HPLC of Formula: 36016-38-3) was used in this study.

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.HPLC of Formula: 36016-38-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2012,Vypolzov, A. V.; Dar’in, D. V.; Lobanov, P. S. published 《Synthesis of cinnoline 1-oxides by the reaction of ortho-fluoronitrobenzenes with enediamines》.Russian Chemical Bulletin published the findings.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:

Reaction of α-carbonylacetamidines existing in the enediamine tautomeric form with the substituted ortho-fluoronitrobenzene afforded products of the replacement of the fluorine by the α-C atom of amidine. The latter underwent cyclization into cinnoline 1-oxides on treatment with sodium hydride. In the experiment, the researchers used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Liu, Yu-Bing; Wang, Yi-Ning; Lu, Hai-Meng; Liang, Shuang; Xu, Bo-Lian; Fan, Yi-Ning published 《Immobilization of Carbonylcobalt Catalyst by Poly(4-vinylpyridine) (P4VP) through N→Co Coordination Bonds: The Promotional Effect of Pyridine and the Reusability of Polymer Catalyst》.Chemistry – An Asian Journal published the findings.HPLC of Formula: 6149-41-3 The information in the text is summarized as follows:

A carbonylcobalt catalyst, immobilized by poly(4-vinylpyridine) (P4VP) through N→Co coordination bonds, has been prepared by solvothermal method. It has been revealed that the pyridine fragments in the polymer catalyst act not only as promoters to improve the catalytic performance of the carbonylcobalt catalyst for alkoxycarbonylation of ethylene oxide to Me 3-hydroxypropanoate but also as stabilizers to enhance the reusability of the polymer catalyst. Furthermore, the polymer catalyst could be easily separated by filtration and reused with only a slight loss of catalytic efficiency. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-hydroxypropanoate(cas: 6149-41-3HPLC of Formula: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2011,Dang, Qun; Liu, Yan; Cashion, Daniel K.; Kasibhatla, Srinivas Rao; Jiang, Tao; Taplin, Frank; Jacintho, Jason D.; Li, Haiqing; Sun, Zhili; Fan, Yi; DaRe, Jay; Tian, Feng; Li, Wenyu; Gibson, Tony; Lemus, Robert; van Poelje, Paul D.; Potter, Scott C.; Erion, Mark D. published 《Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase》.Journal of Medicinal Chemistry published the findings.Category: esters-buliding-blocks The information in the text is summarized as follows:

Oral delivery of previously disclosed purine and benzimidazole fructose-1,6-bisphosphatase (FBPase) inhibitors via prodrugs failed, which was likely due to their high mol. weight (>600). Therefore, a smaller scaffold was desired, and a series of phosphonic acid-containing thiazoles, which exhibited high potency against human liver FBPase (IC50 of 10-30 nM) and high selectivity relative to other 5′-adenosinemonophosphate (AMP)-binding enzymes, were discovered using a structure-guided drug design approach. The initial lead compound I produced profound glucose lowering in rodent models of type 2 diabetes mellitus (T2DM) after parenteral administration. Various phosphonate prodrugs were explored without success, until a novel phosphonic diamide prodrug approach was implemented, which delivered compound I with good oral bioavailability (OBAV) (22-47%). Extensive lead optimization of both the thiazole FBPase inhibitors and their prodrugs culminated in the discovery of compound II (MB06322) as the first oral FBPase inhibitor advancing to human clin. trials as a potential treatment for T2DM.Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Category: esters-buliding-blocks) was used in this study.

Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics