Tag: 100-200

Gu, Yuanyun; Zhang, Zhen; Wang, Yan-En; Dai, Ziteng; Yuan, Yaqi; Xiong, Dan; Li, Jie; Walsh, Patrick J.; Mao, Jianyou published an article in 2022. The article was titled 《Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+ System》, and you may find the article in Journal of Organic Chemistry.Electric Literature of C8H7FO2 The information in the text is summarized as follows:

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple Me benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alc. products. This finding greatly increases the practicality and impact of this chem. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Electric Literature of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Electric Literature of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naikwadi, Dhanaji R.; Singh, Amravati S.; Biradar, Ankush V. published an article in 2021. The article was titled 《Bronsted acidic cellulose-PO3H: An efficient catalyst for the chemoselective synthesis of fructones and trans-esterification via condensation of acetoacetic esters with alcohols and diols》, and you may find the article in Molecular Catalysis.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate The information in the text is summarized as follows:

Cellulose is the most abundant organic source and has expedient a great deal of interest as renewable and emerged as sustainable feedstock. The functionalization of cellulose as designed catalytic system intriguing furnished to the production of fine chems. Herein, we synthesized an environmental friendly solid acid catalyst by functionalizing cellulose with phosphoric acid (PO3H). The successful functionalization of cellulose with PO3H was confirmed by 31P NMR, ICP-OES, FE-SEM, and XPS anal. ICP-OES revealed the presence of phosphorus content of ~1.0 weight % on the catalyst’s surface while elemental mapping by FESEM and XPS shows a uniform distribution of phosphorus over the material. The synthesized solid acid catalyst was utilized for condensation of diols with acetoacetic esters in solvent-free conditions to synthesize fine chems. The present approach not only circumvented the one-step protection and other products but more fascinatingly provided trans-esterification of acetoacetic esters with diols and n-alcs. The catalyst was successfully used for chemoselective protection on Et acetoacetate with 1,2 diols to essential fructone mol. with ~100% conversion and 99% selectivity. The results suggested that the catalyst has the advantage over com. solid acid heterogeneous and homogeneous catalysts. In the experimental materials used by the author, we found Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anchan, Kavitha; Puttappa, Nagaswarupa H.; Poongavanam, Baburajan; Sarkar, Sujit Kumar published an article in 2021. The article was titled 《Microwave assisted rapid synthesis of phenoxazines and benzopyridoxazines》, and you may find the article in Synthetic Communications.Safety of Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:

A facile protocol for the synthesis of phenoxazines and benzopyridoxazines by Smiles rearrangement have been demonstrated in short reaction time under microwave irradiation The control experiments suggest that a reaction proceeds through Smiles rearrangement followed SNAr ring closure by in situ cascade process. In present work, both the electron donating and electron withdrawing groups were tolerant and provided a corresponding phenoxazine/benzopyridoxazine in good to moderate yields. After reading the article, we found that the author used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Safety of Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Safety of Methyl 4-fluoro-3-nitrobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Petrovicova, Tatiana; Gyuranova, Dominika; Plz, Michal; Myrtollari, Kamela; Smonou, Ioulia; Rebros, Martin published an article in 2021. The article was titled 《Application of robust ketoreductase from Hansenula polymorpha for the reduction of carbonyl compounds》, and you may find the article in Molecular Catalysis.Product Details of 609-14-3 The information in the text is summarized as follows:

Enzyme-catalyzed asym. reduction of ketones is an attractive tool for the production of chiral building blocks or precursors for the synthesis of bioactive compounds Expression of robust ketoreductase (KRED) from Hansenula polymorpha was upscaled and applied for the asym. reduction of 31 prochiral carbonyl compounds (aliphatic and aromatic ketones, diketones and β-keto esters) to the corresponding optically pure hydroxy compounds Biotransformations were performed with the purified recombinant KRED together with NADP+ recycling glucose dehydrogenase (GDH, Bacillus megaterium), both overexpressed in Escherichia coli BL21(DE3). Maximum activity of KRED for biotransformation of ethyl-2-methylacetoacetate achieved by the high cell d. cultivation was 2499.7 ± 234 U g-1DCW and 8.47 ± 0.40 U·mg-1E, resp. The KRED from Hansenula polymorpha is a very versatile enzyme with broad substrate specificity and high activity towards carbonyl substrates with various structural features. Among the 36 carbonyl substrates screened in this study, the KRED showed activity with 31, with high enantioselectivity in most cases. With several ketones, the Hansenula polymorpha KRED catalyzed preferentially the formation of the (R)-secondary alcs., which is highly valued. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yang; Ruan, Hanying; Li, Ying; Sun, Guoliang; Liu, Xiao; He, Wenhui; Mao, Fengfeng; He, Miaomiao; Yan, Liwei; Zhong, Guocai; Yan, Huan; Li, Wenhui; Zhang, Zhiyuan published an article in 2021. The article was titled 《Potent and Specific Inhibition of NTCP-Mediated HBV/HDV Infection and Substrate Transporting by a Novel, Oral-Available Cyclosporine A Analogue》, and you may find the article in Journal of Medicinal Chemistry.Synthetic Route of C4H8O3 The information in the text is summarized as follows:

Analogs of the natural product cyclosporine A (CsA) were developed and assessed as antivirals against infection of hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). An analog termed 27A exhibits potent inhibition of HBV/HDV infection by specifically blocking viral engagement to its cellular receptor NTCP, while it lacks immunosuppressive activity found in natural CsA. I.p. injection or oral intake of 27A protects HDV-susceptible mouse model from HDV infection. 27A serves as a promising lead for the development of novel anti-HDV/HBV agents. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Synthetic Route of C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manzoor, Muhammad Aamir; Manzoor, Muhammad Mudassar; Li, Guohui; Abdullah, Muhammad; Han, Wang; Han, Wenlong; Shakoor, Awais; Riaz, Muhammad Waheed; Rehman, Shamsur; Cai, Yongping published an article in 2021. The article was titled 《Genome-wide identification and characterization of bZIP transcription factors and their expression profile under abiotic stresses in Chinese pear (Pyrus bretschneideri)》, and you may find the article in BMC Plant Biology.HPLC of Formula: 119-36-8 The information in the text is summarized as follows:

In plants, basic leucine zipper transcription factors (TFs) play important roles in multiple biol. processes such as anthesis, fruit growth & development and stress responses. However, systematic investigation and characterization of bZIP-TFs remain unclear in Chinese white pear. Chinese white pear is a fruit crop that has important nutritional and medicinal values. In this study, 62 bZIP genes were comprehensively identified from Chinese Pear, and 54 genes were distributed among 17 chromosomes. Frequent whole-genome duplication (WGD) and dispersed duplication (DSD) were the major driving forces underlying the bZIP gene family in Chinese white pear. bZIP-TFs are classified into 13 subfamilies according to the phylogenetic tree. Subsequently, purifying selection plays an important role in the evolution process of PbbZIPs. Synteny anal. of bZIP genes revealed that 196 orthologous gene pairs were identified between Pyrus bretschneideri, Fragaria vesca, Prunus mume, and Prunus persica. Moreover, cis-elements that respond to various stresses and hormones were found on the promoter regions of PbbZIP, which were induced by stimuli. Gene structure (intron/exon) and different compositions of motifs revealed that functional divergence among subfamilies. Expression pattern of PbbZIP genes differential expressed under hormonal treatment abscisic acid, salicylic acid, and Me jasmonate in pear fruits by real-time qRT-PCR. Collectively, a systematic anal. of gene structure, motif composition, subcellular localization, synteny anal., and calculation of synonymous (Ks) and non-synonymous (Ka) was performed in Chinese white pear. Sixty-two bZIP-TFs in Chinese pear were identified, and their expression profiles were comprehensively analyzed under ABA, SA, and MeJa hormones, which respond to multiple abiotic stresses and fruit growth and development. PbbZIP gene occurred through Whole-genome duplication and dispersed duplication events. These results provide a basic framework for further elucidating the biol. function characterizations under multiple developmental stages and abiotic stress responses. In the experimental materials used by the author, we found Methyl Salicylate(cas: 119-36-8HPLC of Formula: 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.HPLC of Formula: 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Xiaofang; Zhou, Lei; Li, Fangshao; Xiao, Jing published an article in 2021. The article was titled 《PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation》, and you may find the article in Journal of Chemical Research.Product Details of 403-33-8 The information in the text is summarized as follows:

A PCl3-mediated conversion of tert-Bu esters into esters R1C(O)OR2 [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R2 = Me, Et, i-Pr, etc.] and amides R1C(O)NR2R3 [R1 = Ph, n-Bu, CH2Bn, etc.; R2 = Ph, n-Bu, Bn, etc.; R3 = H, Me, Ph] in one-pot under air was developed. This novel protocol highlighted by the synthesis of skeletons of bioactive mols. and gram-scale reactions. Mechanistic studies revealed that this transformation involved the formation of an acid chloride in situ, which was followed by reactions with alcs. or amines to afford the desired products. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Product Details of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chattopadhyay, Samir; Ghatak, Arnab; Ro, Youngju; Guillot, Regis; Halime, Zakaria; Aukauloo, Ally; Dey, Abhishek published their research in Inorganic Chemistry in 2021. The article was titled 《Ligand Radical Mediated Water Oxidation by a Family of Copper o-Phenylene Bis-oxamidate Complexes》.Application of 4755-77-5 The article contains the following contents:

Understanding the reactivity landscape for the activation of water until the formation of the O-O bond and O2 release in mol. chem. is a decisive step in guiding the elaboration of cost-effective catalysts for the oxygen-evolving reaction (OER). Copper(II) complexes have recently caught the attention of chemists as catalysts for the 4e-/4H+ water oxidation process. While a copper(IV) intermediate has been proposed as the reactive intermediate species, no spectroscopic signature has been reported so far. Copper(III) ligand radical species have also been formulated and supported by theor. studies. We found, herein, that the reactivity sequence for the water oxidation with a family of Copper(II) o-phenylene bis-oxamidate complexes is a function of the substitution pattern on the periphery of the aromatic ring. In-situ EPR, FTIR, and rR spectroelectrochem. studies helped to sequence the elementary electrochem. and chem. events leading toward the O2 formation selectively at the copper center. EPR and FTIR spectroelectrochem. suggests that ligand-centered oxidations are preferred over metal-centered oxidations rR spectroelectrochem. study revealed the accumulation of a bis-imine bound copper(II) superoxide species, as the reactive intermediate, under catalytic turnover, which provides the evidence for the O-O bond formation during OER. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Application of 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sang, Dayong; Yue, Huaxin; Fu, Yang; Tian, Juan published their research in Journal of Organic Chemistry in 2021. The article was titled 《Cleavage of Carboxylic Esters by Aluminum and Iodine》.Recommanded Product: 403-33-8 The article contains the following contents:

A one-pot procedure for deprotecting carboxylic esters such as ArC(O)OR [Ar = Ph, 2-HOC6H4, 4-BrC6H4, etc.; R = Me, Bn, iPr, t-But] using aluminum and iodine under nonhydrolytic conditions was described. Cleavage of lactones afforded the corresponding ω-iodoalkylcarboxylic acids ICH2(CH2)nC(O)OH [n = 2, 4, 12]. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enabled the selective cleavage of alkyl carboxylic esters in the presence of aryl esters. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Recommanded Product: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O-Methyl S-Aryl Thiocarbonates》 was written by Cao, Ya-Fang; Li, Ling-Jun; Liu, Min; Xu, Hui; Dai, Hui-Xiong. SDS of cas: 403-33-8 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Here, we report O-Me S-aryl thiocarbonates as a versatile esterification reagent for palladium-catalyzed methoxycarbonylation of arylboronic acid in the presence of copper(I) thiophene-2-carboxylate (CuTC). The reaction condition is mild, and a variety of substituents including sensitive -Cl, -Br, and free -NH2 could be tolerated. Further applications in the late-stage esterification of some pharmaceutical drugs demonstrate the broad utility of this method. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics