Tag: 100-200

Kumar, Krishna; Singh, Bhuvnesh; Hore, Soumyadip; Singh, Ravi P. published their research in New Journal of Chemistry in 2021. The article was titled 《Catalytic enantioselective synthesis of chiral 4-hydroxy 4′-substituted pyrazolones by the vinylogous aldol reaction of pyrazole-4,5-diones with 3-alkylidene-2-oxindoles》.Related Products of 4949-44-4 The article contains the following contents:

A bifunctional quinine-derived benzamide catalyzed direct enantioselective vinylogous aldol reaction between 3-alkylidene-2-oxindoles and pyrazole-4,5-diones was developed. This challenging protocol was achieved via the H-bonding dual activation mode of the catalyst. Highly functional rich pyrazolone moieties had an oxindole core was obtained with an excellent E/Z (>19 : 1), and high yields along with moderate enantioselectivity. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-oxopentanoate(cas: 4949-44-4Related Products of 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Related Products of 4949-44-4

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Ester – an overview | ScienceDirect Topics

《Regioselective Intramolecular Allene Amidation Enabled by an EDA Complex》 was written by Liu, Lu; Ward, Robert M.; Schomaker, Jennifer M.. Name: N-tert-Butoxycarbonylhydroxylamine And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

A direct and regioselective addition of amidyl radicals to allenes to furnish highly modifiable heterocycle scaffolds such as I that can serve as scaffolds for drugs and natural products was developed. Various substitution patterns were well-tolerated and diverse electrophiles could be used to trap the intermediate vinyl radicals. Ongoing investigations are targeted toward methods that deliver products where all three allene carbons were functionalized, as well as exptl. and computational studies of other radical additions to allenes to achieve complexity-forming cascade reactions. The experimental part of the paper was very detailed, including the reaction process of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Name: N-tert-Butoxycarbonylhydroxylamine)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Name: N-tert-Butoxycarbonylhydroxylamine

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Characterization of the key aroma compounds and microorganisms during the manufacturing process of Fu brick tea》 was written by Li, Qin; Li, Yongdi; Luo, Yu; Xiao, Lizheng; Wang, Kunbo; Huang, Jianan; Liu, Zhonghua. Category: esters-buliding-blocks And the article was included in LWT–Food Science and Technology in 2020. The article conveys some information:

Aroma is one of the most important criteria of tea quality, but the dynamic changes of aroma profile during the manufacturing process, and the chem. basis of characteristic aroma in Fu brick tea remain largely unknown. In this study, a total of 72 volatiles were identified and quantified, only the esters content increased sharply during the process. Sensory quant. description anal. revealed that the ‘green’ attribute was dominated in the early processing stage, and the ‘fungal flower’, ‘flower’, ‘mint’ and ‘woody’ attributes became the major contributors to the aroma character in the later processing stages. Indicated by partial least-squares anal., the linalool, acetophenone, and Me salicylate were identified as key volatiles contributors to the ‘fungal flower’, ‘flower’, and ‘mint’ attributes, the cedrol contributed to ‘woody’ attribute, and twelve alcs. and aldehydes were related to ‘green’ attribute. Besides, bidirectional orthogonal partial least squares anal. revealed that six fungal genera Aspergillus, Candida, Debaryomyces, Penicillium, Unclassified_k_Fungi, Unclassified_o_Saccharomycetales were identified as core functional microorganisms link to the metabolism of volatiles. Taken together, these findings provide new insights into Fu brick tea aroma profile variation and increase our understanding of the formation mechanism of the characteristic aroma during the manufacturing process. The experimental process involved the reaction of Methyl Salicylate(cas: 119-36-8Category: esters-buliding-blocks)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Copper-Catalyzed C-H Fluorination/Functionalization Sequence Enabling Benzylic C-H Cross Coupling with Diverse Nucleophiles》 was published in Organic Letters in 2020. These research results belong to Vasilopoulos, Aristidis; Golden, Dung L.; Buss, Joshua A.; Stahl, Shannon S.. Category: esters-buliding-blocks The article mentions the following:

Alkylbenzenes underwent regioselective fluorination with N-fluorobenzenesulfonimide in the presence of CuOAc and bathophenanthroline mediated by methylboronic acid and lithium carbonate in chlorobenzene to yield secondary and tertiary benzylic fluorides. The benzylic fluorides generated in these reactions were reactive electrophiles in the presence of the hydrogen-bond donor hexafluoroisopropanol or the Lewis acid BF3·Et2O, yielding benzylic ethers, alcs., protected amines, and diarylalkanes directly from the alkylarenes. The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5Category: esters-buliding-blocks)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: esters-buliding-blocks

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Femtosecond real-time probing of the excited-state intramolecular proton transfer reaction in methyl salicylate》 were Ling, Fengzi; Liu, Dejun; Li, Shuai; Li, Wei; Zhang, Bing; Wang, Pengfei. And the article was published in Journal of Chemical Physics in 2019. Related Products of 119-36-8 The author mentioned the following in the article:

The excited-state intramol. proton transfer (ESIPT) process and subsequent electronic relaxation dynamics in Me salicylate have been investigated using femtosecond time-resolved ion yield spectroscopy combined with time-resolved photoelectron imaging. Excitation with a tunable pump pulse populates the keto tautomer in the first excited electronic state S1(ππ*). As a hydrogen atom transfers from the phenolic group to the carbonyl group within 100 fs, the mol. geometry changes gradually, leading to a variation in the electronic photoionization channel. By virtue of the accidental resonance with some intermediate Rydberg states, the time-dependent photoelectron spectra provide a direct mapping of the ESIPT reaction from the initially populated keto tautomer to the proton-transferred enol tautomer. Subsequently, the population around the enol configuration undergoes intramol. vibrational redistribution on a subpicosecond time scale, followed by internal conversion to the ground state with a wavelength-dependent lifetime in the picosecond range. Furthermore, the excitation energies of several Rydberg states in Me salicylate are determined exptl. (c) 2019 American Institute of Physics. The experimental part of the paper was very detailed, including the reaction process of Methyl Salicylate(cas: 119-36-8Related Products of 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Related Products of 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic Chemistry Frontiers included an article by Shen, Guoli; Khan, Ruhima; Lv, Haiping; Yang, Yong; Zhang, Xia; Zhan, Yong; Zhou, Yongyun; Fan, Baomin. Application of 4248-19-5. The article was titled 《Palladium/silver co-catalyzed syn-stereoselective asymmetric ring-opening reactions of azabenzonorbornadienes with amides》. The information in the text is summarized as follows:

The first syn-stereoselective generation of 1,2-diamino dihydronaphthalene derivatives by asym. ring-opening reaction of azabenzonorbornadienes was reported. Electron-deficient amides was successfully employed as nucleophiles in the aromatic ring-opening reaction of azabenzonorbornadienes. The reaction was co-catalyzed by Pd(OAc)2 and AgBF4 with (R)-BINAP as the chiral ligand. The asym. ring-opening (ARO) products were obtained in good to high yields (up to 96%) with excellent enantioselectivities (up to 98%). In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Application of 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Kardile, Rahul Dadabhau; Liu, Rai-Shung. Recommanded Product: 4248-19-5. The article was titled 《Two Distinct Ag(I)- and Au(I)-Catalyzed Olefinations between α-Diazo Esters and N-Boc-Derived Imines》. The information in the text is summarized as follows:

In the presence of (C6F5)3PAuCl and AgNTf2 in CH2Cl2, aldimines such as (E)-PhCH:NBoc underwent regioselective and diastereoselective olefination with diazoacetates such as Et diazoacetate to yield α-aryl enamino esters such as (Z)-EtO2CCPh:CHNHBoc. Reaction of aldimines such as (E)-PhCH:NBoc with diazoacetates such as Et diazoacetate in the presence of AgOTf in toluene yielded β-aryl enamino esters such as (Z)-EtO2CCH:C(NHBoc)Ph as the major products. Reactions of a deuterated imine and diazoester and of potential aziridine and aminodiazoester intermediates were used to understand the mechanism of the reactions. The olefinations likely involve initial addition of diazo esters to metal/imine complexes followed either by Roskamp reactions to form the α-aryl-β-aminoacrylates or by the formation of silver carbenes to yield β-aryl-β-aminoacrylates. In addition to this study using tert-Butyl carbamate, there are many other studies that have used tert-Butyl carbamate(cas: 4248-19-5Recommanded Product: 4248-19-5) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2017,Ma, Jing; Wang, Qingpeng; Huang, Zhonglv; Yang, Xiande; Nie, Quandeng; Hao, Wenpei; Wang, Peng George; Wang, Xin published 《Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery》.Journal of Medicinal Chemistry published the findings.Computed Properties of C4H8O3 The information in the text is summarized as follows:

Glycosylated platinum(IV) complexes were synthesized as substrates for GLUTs and OCTs for the first time, and the cytotoxicity, and detailed mechanism were determined in vitro and in vivo. Galactoside Pt(IV), glucoside Pt(IV) and mannoside Pt(IV) were highly cytotoxic and showed specific cancer-targeting properties in vitro and in vivo. Glycosylated platinum(IV) complexes 5, 6, 7 and 8 (IC50 0.24 μM-3.97 μM) had better antitumor activity of nearly 166-fold higher than the pos. controls cisplatin, oxaliplatin and satraplatin. The presence of a hexadecanoic chain allowed binding with human serum albumin (HSA) for drug delivery, which not only enhanced the stability of the inert platinum(IV) prodrugs but also decreased their reduction by reductants present in human whole blood. Their preferential accumulation in cancer cells compared to noncancerous cells (293T and 3T3 cells) suggested that they were potentially safe for clin. therapeutic use. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Computed Properties of C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2017,Paunovic, Amalia I.; Drowley, Lauren; Nordqvist, Anneli; Ericson, Elke; Mouchet, Elizabeth; Jonebring, Anna; Groenberg, Gunnar; Kvist, Alexander J.; Engkvist, Ola; Brown, Martin R.; Gedda, Karin; Goumans, Marie-Jose; Wang, Qing-Dong; Plowright, Alleyn T. published 《Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts》.ACS Chemical Biology published the findings.Related Products of 329-59-9 The information in the text is summarized as follows:

Activation and proliferation of resident cardiac progenitor cells has therapeutic potential to repair the heart after injury. However, research has been impeded by lack of well-defined and characterized cell sources and difficulties in translation to screening platforms. Here the authors describe the development, validation, and use of a 384 well phenotypic assay in primary human epicardium-derived cells (EPDCs) to identify compounds that induce proliferation while maintaining the progenitor phenotype. Using this assay, the authors have screened 7400 structurally diverse compounds where >90% are biol. annotated and known to modulate a broad range of biol. targets. From the primary screen, the authors identified and validated hits and expanded upon the lead mols. of interest. A counter screen was developed in human primary cardiac fibroblasts to filter out compounds with a general proliferative effect, after which the activity of selected mols. was confirmed across multiple EPDC donors. To further examine the mechanism of action of compounds with annotated targets, the authors performed knockdown experiments to understand whether a single known target was responsible for the proliferative effect, confirming results with protein expression and activity assays. Here the authors were able to show that the annotated targets of compounds of interest were not responsible for the proliferative effect, which highlights potential differences in cell types and signaling pathways and possible polypharmacol. These studies demonstrate the feasibility of using relevant human primary cells in a phenotypic screen to identify compounds as novel biol. tools and starting points for drug discovery projects and the authors disclose the first small mols. to proliferate human primary EPDCs. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Related Products of 329-59-9)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Related Products of 329-59-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Maiti, Barnali; Chanda, Kaushik; Selvaraju, Manikandan; Tseng, Chih-Chung; Sun, Chung-Ming published 《Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-a]-pyridine Under Microwave Irradiation》.ACS Combinatorial Science published the findings.Reference of Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:

A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodol. facilitates the rapid generation of intricate mol. frameworks in three-dimensional fashion leading to benzimidazole-imidazo[1,2-a]pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biol. interesting compounds The present synthetic sequence permits the introduction of three points of structural diversity to expand chem. space with high purity and excellent yields. In addition to this study using Methyl 4-fluoro-3-nitrobenzoate, there are many other studies that have used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Reference of Methyl 4-fluoro-3-nitrobenzoate) was used in this study.

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Reference of Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics