Tag: 100-200

Wang, Minlong; Du, Ying; Ling, Chen; Yang, Zhaokai; Jiang, Biaobiao; Duan, Hongxia; An, Jie; Li, Xinghai; Yang, Xinling published their research in Pest Management Science in 2021. The article was titled 《Design, synthesis and antifungal/anti-oomycete activity of pyrazolyl oxime ethers as novel potential succinate dehydrogenase inhibitors》.Electric Literature of C5H11NO3 The article contains the following contents:

Succinate dehydrogenase inhibitors (SDHIs) play an increasingly important role in controlling plant diseases. However, the similar structures of SDHIs result in rapid development of cross-resistance development and a clear bottleneck of poor activity against oomycetes, therefore the need to seek new SDHI fungicides with novel structures is urgent. Innovative pyrazolyl oxime ethers were designed by replacing amide with oxime ether based on the succinate dehydrogenase (SDH) structure, and 19 pairs of Z- and E-isomers were efficiently prepared for the discovery of SDHI compounds with a novel bridge. Their biol. activities against four fungi and two oomycetes were evaluated, and substantial differences were observed between the Z- and E- isomers of the title compounds Furthermore, most of these compounds exhibited remarkable activities against Rhizoctonia solani with EC50 values of less than 10 mg L-1 in vitro, and bioassay in vivo further confirmed that E-I-6 exhibited good protective efficacy (76.12%) at 200 mg L-1. In addition, Z-I-12 provided better activity against the oomycetes Pythium aphanidermatum and Phytophthora capsici (EC50 = 1.56 and 0.93 mg L-1) than those of boscalid. Moreover, E-I-12 exhibited excellent SDH inhibition (IC50 = 0.21 mg L-1) thanks to its good binding ability to the SDH by hydrogen-bonding interactions, π-cation interaction and hydrophobic interactions. Novel pyrazolyl oxime ethers have the potential as SDHI compounds for future development, and the strategy of replacing an amide bond with oxime ether may offer an alternative option in SDHI fungicide discovery. After reading the article, we found that the author used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Electric Literature of C5H11NO3)

N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Electric Literature of C5H11NO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Fangcao; Gong, Mingliang; Xie, Hongzhen; Luo, Yunjie published their research in New Journal of Chemistry in 2021. The article was titled 《La(CH2C6H4NMe2-o)3-catalyzed reduction of esters to alcohols with pinacolborane》.Product Details of 403-33-8 The article contains the following contents:

La(CH2C6H4NMe2-o)3, a simple and facilely accessible lanthanide complex, can serve as a highly efficient catalyst for the reduction of esters e.g., Me 4-(trifluoromethyl)benzoate with pinacolborane (HBpin), selectively affording alcs. e.g., [4-(trifluoromethyl)phenyl]methanol in good yields under mild conditions. This protocol exhibits good tolerance for many functional groups such as C=C double bond, nitro, halogen, furyl, and thienyl groups. A lanthanum hydride species like [La]-H.HBpin is proposed to play a crucial role in promoting the interaction of esters with HBpin. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Product Details of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Thermoresponsive starch hydrogel stabilized Pd nanoparticles: Soft catalyst for the preparation of (±)-α-methylbiphenylalanine in water aiming at bioorthogonal chemistries》 was written by dos Santos, Raquel V.; Vitoi, Vitor Hugo M.; Costa, Marcio V.; da Silva, Lorenna C. L. L. F.; Archanjo, Braulio S.; Achete, Carlos A.; Silva, Raphael S. F.; Aguiar, Lucia C. S.; Malta, Luiz Fernando B.; Senra, Jaqueline D.. Category: esters-buliding-blocks And the article was included in Catalysis Letters in 2021. The article conveys some information:

The corn-starch was able to reduce Pd(II) species under relatively low concentration (5.0 wt/vol) leading to the formation of a thermoresponsive palladium nanoparticles-containing hydrogel with D = 16.1 nm ± 6.4 nm. It was successfully applied to the Suzuki-Miyaura reaction step in neat water involved in the synthesis of (±)-N-acetyl-α-methyl-4-biphenylalanine Et ester, a direct precursor of an unnatural quaternary biarylalanine. In the experiment, the researchers used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Category: esters-buliding-blocks)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Total Synthesis of (±)-Liphagal via Organic-Redox-Driven Palladium-Catalyzed Hydroxybenzofuran Formation》 was written by Tao, Eriko; Inoue, Masaki; Jeong, Taejoo; Kim, In Su; Yoshimitsu, Takehiko. COA of Formula: C8H14O4 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A synthetic route to liphagal, a natural PI3Kα inhibitor isolated from Aka coralliphaga, was established. The present route features an organic redox process where an alkynylquinone undergoes reductive cyclization in the presence of a hydroquinone derivative such as hydroxyquinol (1,2,4-benzenetriol) and catalytic PdCl2 to provide a substituted benzofuran suitable for accessing the natural product. The benzofuran formation takes place via the redox transformation between the alkynylquinone and the electron-rich hydroquinones followed by the concomitant Pd(II)-catalyzed oxycyclization of the resultant alkynylhydroquinone. The experimental part of the paper was very detailed, including the reaction process of Diethyl 2-methylmalonate(cas: 609-08-5COA of Formula: C8H14O4)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.COA of Formula: C8H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Identification of key odorants responsible for cooked corn-like aroma of green teas made by tea cultivar Zhonghuang 1》 was published in Food Research International in 2020. These research results belong to Liao, Xueli; Yan, Jingna; Wang, Bei; Meng, Qing; Zhang, Longyun; Tong, Huarong. Reference of Methyl Salicylate The article mentions the following:

Fangping green tea (FPGT) produced by Zhonghuang 1 (C. sinensis var. sinensis cv. Zhonghuang 1), a new tea variety, has a classical cooked corn-like aroma, which is completely different from the green tea aroma. In order to illustrate the aroma characteristics of the green tea, the volatiles of FPGT was analyzed with gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O). The results showed that odor activity value (OAV) of di-Me sulfide (DMS) was 1195.21 and the odor intensity about DMS was 6.2 in FPGT. Aroma recombination experiment also confirmed the important contribution of DMS to cooked corn-like aroma. Aroma character impact (ACI) values of DMS in tea processed by Zhonghuang 1 and Fudingdabai were 72.01% and 37.86%, resp. This indicated that the high proportion of DMS was the dominant character of green tea with cooked corn-like aroma. In addition, the S-methylmethionine (SMM) content in fresh leaves of Zhonghuang 1 (0.21 mg/g) was significantly higher than that of Fudingdabai (0.16 mg/g), which was an important reason for high DMS content. In the experimental materials used by the author, we found Methyl Salicylate(cas: 119-36-8Reference of Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Reference of Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《A luminescent inorganic-organic hybrid, [Cd(C16H10N2O8S)(H2O)], for the selective and recyclable detection of chromates and dichromates in aqueous solution》 were Kundu, Tanaya; Manna, Krishna; Jana, Ajay K.; Natarajan, Srinivasan. And the article was published in New Journal of Chemistry in 2019. Recommanded Product: 4755-77-5 The author mentioned the following in the article:

A new inorganic-organic hybrid compound [Cd(H2L)(H2O)], 1, {where, H2L2- = 4,4′-sulfonylbis(phenylene)bis(oxamate)} was prepared under solvothermal conditions. The compound has a three-dimensional structure. The compound exhibits strong luminescence behavior, and was used for the detection of chromate and dichromate anions in aqueous media at low concentrations The compound exhibited high selectivity and recyclability for the detection of low concentrations (ppm levels) of chromate and dichromate ions. Compound 1 also is an effective catalyst for the Knoevenagel condensation involving aromatic aldehyde and malononitrile under green solvent-free conditions with high yield and recyclability. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kang, Qing-Qing; Meng, Ya-Nan; Zhang, Jun-Hao; Li, Long; Ge, Guo-Ping; Zheng, Hongxing; Liu, Hongxin; Wei, Wen-Ting published their research in New Journal of Chemistry in 2021. The article was titled 《Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds: Facile access to 2,3-dihydrofurans》.Quality Control of Diethyl 2-methylmalonate The article contains the following contents:

Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds through C-C and C-O bond formations has been described for the first time. A broad substrate scope and ease of scale-up are the attractive features of this synthetic method, which provides a series of potentially bioactive 2,3-dihydrofurans. The reaction pathway is proposed to involve a radical addition of the in situ-formed α-carbonyl radical to the C=C bond of olefinic 1,3-dicarbonyls followed by intramol. 5-endo-trig cyclization. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Quality Control of Diethyl 2-methylmalonate)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Quality Control of Diethyl 2-methylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Shichao; Hou, Bo; Wang, Jianbo published their research in Journal of Organic Chemistry in 2021. The article was titled 《Palladium-Catalyzed Oxidative Coupling of the Allenic C-H Bond with α-Diazo Esters: Synthesis of [3]Dendralenes》.Formula: C7H12O3 The article contains the following contents:

A palladium-catalyzed highly regio- and stereoselective C-H oxidative coupling of allenes such as I with α-diazo esters such as benzyl 2-diazopropanoate is developed. The reaction pathway involves allylic palladium carbene as the key intermediate, which is followed by a carbene migratory insertion process. The reaction proceeds efficiently under mild conditions without external base, providing substituted [3]dendralenes such as II bearing various functional groups. After reading the article, we found that the author used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Formula: C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nasseri, Mohammad Ali; Rezazadeh, Zinat; Kazemnejadi, Milad; Allahresani, Ali published their research in Catalysis Letters in 2021. The article was titled 《Cu-Mn Bimetallic Complex Immobilized on Magnetic NPs as an Efficient Catalyst for Domino One-Pot Preparation of Benzimidazole and Biginelli Reactions from Alcohols》.Computed Properties of C7H12O3 The article contains the following contents:

An efficient magnetically recyclable bimetallic catalyst by anchoring copper and manganese complexes on the Fe3O4 NPs was prepared and named as Fe3O4@Cu-Mn. It was founded as a powerful catalyst for the domino one-pot oxidative benzimidazole and Biginelli reactions from benzyl alcs. as a green protocol in the presence of air, under solvent-free and mild conditions. Fe3O4@Cu-Mn NPs were well characterized by FT-IR, XRD, FE-SEM, TEM, VSM, TGA, EDX, DLS, and ICP analyses. The optimum range of parameters such as time, temperature, amount of catalyst, and solvent were investigated for the domino one-pot benzimidazole and Biginelli reactions to find the optimum reaction conditions. The catalyst was compatible with a variety of benzyl alcs., which provides favorable products with good to high yields for all of derivatives Hot filtration and Hg poisoning tests from the nanocatalyst revealed the stability, low metal leaching and heterogeneous nature of the catalyst. To prove the synergistic and cooperative effect of the catalytic system, the various homologs of the catalyst were prepared and then applied to a model reaction sep. Finally, the catalyst could be filtered from the reaction mixture simply, and reused for five consecutive cycles with a min. loss in catalytic activity and performance. Graphic Abstract: A new magnetically recyclable Cu/Mn bimetallic catalyst has been developed for domino one-pot oxidation-condensation of benzimidazole and Biginelli reactions from alcs. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Computed Properties of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Computed Properties of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reihani, Neda; Kiyani, Hamzeh published their research in Current Organic Chemistry in 2021. The article was titled 《Three-component Synthesis of 4-Arylidene-3-alkylisoxazol-5(4H)-ones in the Presence of Potassium 2,5-dioxoimidazolidin-1-ide》.Category: esters-buliding-blocks The article contains the following contents:

An efficient synthesis of 4-arylidene-3-alkylisoxazole-5(4H)-ones I (R = Me, Et, propyl; Ar = 4-dimethylaminophenyl, 2-thienyl, 3-indolyl, etc.) has been implemented via the three-component cyclocondensation of aryl(heteroaryl)aldehydes ArCHO with hydroxylamine hydrochloride and β-ketoesters RC(O)CH2C(O)OCH2CH3. The potassium 2,5-dioxoimidazolidin-1-ide II has been introduced as the new organocatalyst to facilitate this heterocyclization. In the current process, three starting materials, including substituted benzaldehydes/heterocyclic aromatic aldehydes ArCHO, hydroxylamine hydrochloride, and Et acetoacetate/propyl acetoacetate/butyryl acetoacetate have been successfully used to synthesize the number of substituted isoxazole- 5(4H)-ones I in good to high yields in ethylene glycol as a green reaction medium at 80°C. The low catalyst loading is also a main advantage over some reported catalysts. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics