Tag: 100-200

Application In Synthesis of Methyl 4-fluorobenzoateIn 2021 ,《Practical and rapid construction of 2-pyridyl ketone library in continuous flow》 appeared in Journal of Flow Chemistry. The author of the article were Sun, Maolin; Li, Jianchang; Liang, Chaoming; Shan, Chao; Shen, Xinyuan; Cheng, Ruihua; Ma, Yueyue; Ye, Jinxing. The article conveys some information:

Herein, a practical method for the rapid synthesis of 2-pyridyl ketone ArC(O)R [Ar = 2-pyridyl; R = Me, Ph, Bn, etc.] library in continuous flow was reported, in which the 2-lithiopyridine formed by Br/Li exchange reacts with com. available esters to obtain 2-pyridyl ketones ArC(O)R in a good yield at short reaction time. This protocol functions broadly on a variety of esters and had been applied to the synthesis of TGF-β type 1 receptor inhibitor LY580276 intermediate ArC(O)R [Ar = 6-methyl-2-pyridyl; R = (4-fluorophenyl)methyl] in an environmentally friendly method. It was rapid, reliable, and cost-efficient to afford diverse kinds of 2-pyridyl ketones ArC(O)R in the compound library. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Application In Synthesis of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application In Synthesis of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 609-14-3In 2021 ,《Umbelliferyloxymethyl phosphonate compounds-weakly binding zinc ionophores with neuroprotective properties》 appeared in Dalton Transactions. The author of the article were Guesne, Sebastien; Connole, Laura; Kim, Stephanie; Motevalli, Majid; Robson, Lesley; Michael-Titus, Adina T.; Sullivan, Alice. The article conveys some information:

Umbelliferone is a member of the coumarin family of compounds which are known for diverse pharmacol. activity including in targets relevant to Alzheimers disease, AD. The toxicity associated with some forms of the amyloid protein, Aβ, and the role of Zn2+ (and other biometals) dyshomeostasis in this, are of great interest in AD and make metal ionophore capability desirable in so called multi target drug ligands MTDLs. A new series of umbelliferyloxymethyl phosphonic acid diethylester compounds (umbelliferyloxymethyl phosphonates) bearing a phosphonate at the 7-position (compounds 1, 3-6), hydrolysis products 2, 2a and 2b from 1 and analogs 7 and 8 of 1 with 7-O to 7-S and 1-O to 1-NH substitutions, are reported. Single crystal x-ray structures of compounds 1, 2 and 2a were determined In terms of neuroprotective properties, the compounds 1, 2, 3, 4, 5 and 6 at 1μM concentration, inhibited the toxicity of Aβ1-42 (Aβ42) in both toxic Amyloid Derived Diffusible Ligand (ADDL) and fibrillar (fibril) forms towards rat hippocampal cells. Compound 7 displayed cytotoxicity and 8 failed to inhibit Aβ42 toxicity. Concerning compound-metal ionophore activity (assessed using chem. experiments), despite weak binding to Zn2+ determined from 31P NMR titration of 1 and 2 by ZnCl2, compounds 1, 3, 4, 5 and 6 demonstrated ionophore assisted partition of Zn2+ from water to octanol at micromolar concentrations with efficacy on a par with or better than the chelator MTDL clioquinol (5-chloro-7-iodo-8-hydroxyquinoline). Partition was assessed using furnace Atomic Absorption Spectroscopy (AAS). In further experiments interaction of compound 1 with Zn2+ or it’s pathways was inferred by (i) delayed fluorescence response with added Zn2+ in cells treated with FluoZin-3 and (ii) by suppression of Zn2+ promoted aggregation of Aβ42. The results came from multiple reactions, including the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Krakowian, Daniel; Gadarowska, Dominika; Daniel-Wojcik, Anna; Mrzyk, Inga published an article in Toxicology In Vitro. The title of the article was 《Cytotoxicity assay to assess eye irritation – A comparison with other methods and possible strategies for use》.Synthetic Route of C7H12O3 The author mentioned the following in the article:

Many in vitro methods can be used to classify eye irritation or damage caused by exposure to a substance. In this study, a recently described method called the Cytotoxicity Assay to Assess Eye Irritation (CEI) was compared with other selected in vitro methods adopted in the OECD guidelines. Furthermore, the influence of combining more than one in vitro method was investigated. Basic performance indexes were considered and a risk assessment based on the number of correct and incorrect results (overestimated or underestimated) was performed. The CEI results were similar to those of other in vitro tests, however, the CEI can also directly classify substances irritating to the eyes. When the CEI preceded an eye irritation test based reconstructed human corneal-like epithelium, there were fewer underestimates compared with other method combinations. This combination can better protect human health and provides results comparable to those obtained in animal tests. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Zhang, Qi; Shi, Mingying; Mi, Xueling; Luo, Sanzhong published an article in Organic Chemistry Frontiers. The title of the article was 《Catalytic asymmetric oxidative sulfenylation of β-ketocarbonyls using a chiral primary amine》.HPLC of Formula: 609-14-3 The author mentioned the following in the article:

Enantioselective oxidative construction of a C(sp3)-S bond has been achieved using a chiral primary amine catalyst in the presence of tert-Bu hydroperoxide and a catalytic amount of tetrabutylammonium iodide. The distinctive feature of the current reaction is coupling with nucleophilic sulfur reactants under oxidative conditions. This protocol provides facile access to chiral thioethers bearing S-containing quaternary stereocenters with good chemo- and enantiocontrol. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3HPLC of Formula: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.HPLC of Formula: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Ni, Congjian; Yu, Hailong; Liu, Ling; Yan, Ben; Zhang, Bingyi; Ma, Xiaoli; Zhang, Xiuhui; Yang, Zhi published an article in New Journal of Chemistry. The title of the article was 《An efficient catalytic method for the borohydride reaction of esters using diethylzinc as precatalyst》.Synthetic Route of C8H7FO2 The author mentioned the following in the article:

A cheap and easily available ZnEt2 is an effective precatalyst, which can be used for the hydroboration reaction of various organic carbonates and esters with HBpin. The preliminary hydroboration reaction mechanism has been investigated via the corresponding DFT calculation In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Synthetic Route of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Synthetic Route of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nifant’ev, Ilya E.; Shlyakhtin, Andrey V.; Bagrov, Vladimir V.; Tavtorkin, Alexander N.; Ilyin, Sergey O.; Gavrilov, Dmitry E.; Ivchenko, Pavel V. published an article in 2021. The article was titled 《Cyclic ethylene phosphates with (CH2)nCOOR and CH2CONMe2 substituents: synthesis and mechanistic insights of diverse reactivity in aryloxy-Mg complex-catalyzed (co)polymerization》, and you may find the article in Polymer Chemistry.Product Details of 6149-41-3 The information in the text is summarized as follows:

A novel pathway is proposed for the formation of branched poly(ethylene phosphate)s during the coordination ring-opening polymerization (ROP) of ethylene phosphates catalyzed by a 2,6-di-tert-butyl-4-methylphenoxy (BHT) magnesium complex, [(BHT)Mg(μ-OBn)(THF)]2 (Mg1). Electron-donating fragments in the substituents at the P atom of the ethylene phosphates and the stability of chelate Mg complexes were hypothesized to drive the formation of ethylene phosphate macromonomers. This hypothesis was validated through a comparative exptl. and theor. study of the ROP reactivity of the ethylene phosphates with -O(CH2)nCOOMe (n = 1-3, 5), -CH2COOtBu, -OCHMeCOOMe, and -OCH2CONMe2 substituents (1-7). In good agreement with the results of theor. modeling, glycolate- and lactate-substituted ethylene phosphates 1, 5, and 6 formed highly branched polymers, and the participation of the BHT-Mg glycolate intermediate in ROP was confirmed by the presence of -P(O)(OCH2COOMe)2 fragments in the homopolymer of 1. Notably, the reaction of amide-substituted 7 with Mg1 quant. afforded benzyl ethylene phosphate without subsequent ROP. The copolymerization of 1 with Et ethylene phosphonate furnished branched polymers, the architectures of which were determined by spectral and rheol. studies. Consequently, new -OCH2COX substituted cyclic phosphates can be used as efficient branching (X = OR) or chain termination (X = NR2) agents. In the experiment, the researchers used Methyl 3-hydroxypropanoate(cas: 6149-41-3Product Details of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdelkawy, Mahmoud A.; Davin, Christopher; Aly, El-Saied A.; El-Badawi, Mahmoud A.; Itsuno, Shinichi published their research in ChemistrySelect in 2021. The article was titled 《Chiral Polyureas Derived Cinchona Alkaloids: Highly Efficient Bifunctional Organocatalysts for the Asymmetric Michael Addition Reaction》.Synthetic Route of C7H12O3 The article contains the following contents:

Repetitive Mizoroki-Heck (MH) coupling polymerization was used to create novel chiral polyureas with cinchona alkaloids in the main chain. Apart from two-component polycondensation of cinchona urea dimers with diiodobenzene via MH reaction conditions, some chiral polyureas were easily polymerized under self polycondensation to yield the chiral polymers. The asym. Michael addition reaction was successfully carried out using chiral polymers derived cinchona urea. Interestingly, phenolic-based chiral polymers served as heterogeneous catalysts for the enantioselective Michael reaction, with high catalytic activity and excellent enantioselectivities (up to 99% ee). These polymeric catalysts were also stable, and they could be recycled and reused. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Binyu; Wen, Xiaolu; Chen, Hongbing; Hu, Lin published their research in Organic Chemistry Frontiers in 2021. The article was titled 《N-Nosyl-O-bromoethyl hydroxylamine acts as a multifunctional formaldehyde, formaldimine, and 1,2-oxazetidine surrogate for C-C and C-O bond-forming reactions》.Synthetic Route of C7H12O3 The article contains the following contents:

N-Nosyl-O-bromoethyl hydroxylamine, a bench stable solid, could function as a novel formaldehyde, formaldimine and 1,2-oxazetidine surrogate under DBU basic conditions were described. By merely using this simple reagent, a broad range of synthetically useful β-aminomethyl ketones I [R1 = Me, Ph, 2-furyl, etc.; R2 = Me, Et, allyl, Bn; R1R2 = (CH2)3, (CH2)4, (CH2)5, etc.; R3 = Ac, CO2Me, CO2Et, SO2Ph] and α-hydroxymethyl ketones II [R4 = Me, Et, allyl, Bn; Q = (CH2)n, n = 1,2], as well as chiral α-alkoxyl indanone carboxylates III [R5 = H, 4-MeO, 5-F, etc.; X = OCH2CH2] and α-aminomethyl indanone carboxylates III [X = CH2] could be divergently obtained via chemo- and stereoselective aldol, Mannich or umpolung C-O bond-forming reactions. The challenging catalytic asym. Mannich reaction of formaldimine equivalent was also realized with moderate enantioselectivities. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Evaluation of semiochemical based push-pull strategy for population suppression of ambrosia beetle vectors of laurel wilt disease in avocado》 was written by Rivera, Monique J.; Martini, Xavier; Conover, Derrick; Mafra-Neto, Agenor; Carrillo, Daniel; Stelinski, Lukasz L.. Name: Methyl Salicylate And the article was included in Scientific Reports in 2020. The article conveys some information:

Ambrosia beetles (Coleoptera: Curculionidae: Scolytinae and Platypodinae) bore into tree xylem to complete their life cycle, feeding on symbiotic fungi. Ambrosia beetles are a threat to avocado where they have been found to vector a symbiotic fungus, Raffaelea lauricola, the causal agent of the laurel wilt disease. We assessed the repellency of Me salicylate and verbenone to two putative laurel wilt vectors in avocado, Xyleborus volvulus (Fabricius) and Xyleborus bispinatus (Eichhoff), under laboratory conditions. Then, we tested the same two chems. released from SPLAT flowable matrix with and without low-dose ethanol dispensers for manipulation of ambrosia beetle populations occurring in com. avocado. The potential active space of repellents was assessed by quantifying beetle catch on traps placed ‘close’ (∼5-10 cm) and ‘far’ (∼1-1.5 m) away from repellent dispensers. Ambrosia beetles collected on traps associated with all in-field treatments were identified to species to assess beetle diversity and community variation. Xyleborus volvulus was not repelled by Me salicylate (MeSA) or verbenone in laboratory assays, while X. bispinatus was repelled by MeSA but not verbenone. Ambrosia beetle trap catches were reduced in the field more when plots were treated with verbenone dispensers (SPLAT) co-deployed with low-dose ethanol dispensers than when treated with verbenone alone. Beetle diversity was highest on traps deployed with low-dose ethanol lures. The repellent treatments and ethanol lures significantly altered the species composition of beetles captured in experiment plots. Our results indicate that verbenone co-deployed with ethanol lures holds potential for manipulating ambrosia beetle vectors via push-pull management in avocado. This tactic could discourage immigration and/or population establishment of ambrosia beetles in com. avocado and function as an addnl. tool for management programs of laurel wilt. The experimental process involved the reaction of Methyl Salicylate(cas: 119-36-8Name: Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Name: Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Guo, Peng; Yuan, Guo-Cai; Xu, Liu-Hui; Ye, Ke-Yin published an article in Organic Chemistry Frontiers. The title of the article was 《Cobalt-catalyzed modular assembly toward multi-functionalized furan derivatives》.Recommanded Product: Ethyl 3-oxopentanoate The author mentioned the following in the article:

A cobalt-catalyzed modular [3+2] assembling of unsaturated hydrocarbons and β-dicarbonyls was reported. This protocol featured mild reaction conditions and a broad substrate scope, providing facile entries toward diverse multi-functionalized dihydrofurans such as I [R = H, Me, Ph, etc.; R1 = Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Me, Et; R3 = OMe, OEt, Ot-Bu; R4 = H, Ph; R2R3 = (CH2)3] and furans II [Ar = ph, 1-naphthyl, 2-thienyl, etc.; R5 = H, Me, CO2Et, TMS; R6 = OMe, OEt; R7 = Me; R6R7 = (CH2)2, (CH2)3, (CH2)4, CH2CH(Me)CH2, CH2C(Me2)CH2]. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics