Tag: 100-200

On April 5, 2021, Zhao, Huaibo; Leonori, Daniele published an article.Reference of Methyl N-Methylanthranilate The title of the article was Minimization of Back-Electron Transfer Enables the Elusive sp3 C-H Functionalization of Secondary Anilines. And the article contained the following:

Anilines are some of the most used class of substrates for application in photoinduced electron transfer. N,N-Dialkyl-derivatives enable radical generation α to the N-atom by oxidation followed by deprotonation. This approach is however elusive to monosubstituted anilines owing to fast back-electron transfer (BET). Here we demonstrate that BET can be minimised by using photoredox catalysis in the presence of an exogenous alkylamine. This approach synergistically aids aniline SET oxidation and then accelerates the following deprotonation. In this way, the generation of α-anilinoalkyl radicals is now possible and these species can be used in a general sense to achieve divergent sp3 C-H functionalization. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Reference of Methyl N-Methylanthranilate

The Article related to arylamine arylpyrrolidinone aminobenzonitrile chemoselective photochem preparation, iridium cobalt photoredox catalyst dealkylation addition arylation base mediated, inhibition back electron transfer photochem dealkylation addition alkylarylamine, c−h functionalization, anilines, electron transfer, late-stage modification, photoredox catalysis and other aspects.Reference of Methyl N-Methylanthranilate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2015,Neubert, Timothy D.; Schmidt, Yvonne; Conroy, Erica; Stamos, Dean published 《Radical Mediated C-H Functionalization of 3,6-Dichloropyridazine: Efficient Access to Novel Tetrahydropyridopyridazines》.Organic Letters published the findings.Category: esters-buliding-blocks The information in the text is summarized as follows:

A radical mediated C-H functionalization of 3,6-dichloropyridazine using primary alcs., t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step can then be employed to efficiently access diversely substituted tetrahydropyridopyridazines, e.g., I (X-rays single crystal structure shown), with multiple functional handles. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Category: esters-buliding-blocks)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Zheng, Jianwei; Lin, Haiqiang; Wang, Ya-nan; Zheng, Xinlei; Duan, Xinping; Yuan, Youzhu published 《Efficient low-temperature selective hydrogenation of esters on bimetallic Au-Ag/SBA-15 catalyst》.Journal of Catalysis published the findings.Product Details of 6149-41-3 The information in the text is summarized as follows:

Gold (Au)-silver (Ag) bimetallic catalyst supported on ordered mesoporous silica SBA-15 exhibits unprecedentedly high activity and superior stability for the selective hydrogenation of di-Me oxalate to Me glycolate at a low temperature of 418 K. By contrast, monometallic Au/SBA-15 and Ag/SBA-15 catalysts are almost inactive under identical conditions. A combined tuning of particle dispersion and its surface electronic structure is shown as a consequence of the changes in the size and valence band structure of Au and Ag, which leads to significantly enhanced synergy. Considerably reduced apparent activation energies indicate that special active sites with the ability to activate substrate mols. more efficiently are generated in Au-Ag alloy nanoparticles. The Au-Ag bimetallic catalyst also displays excellent activity for the selective hydrogenation of some other unsaturated or saturated esters and acetic acid. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-hydroxypropanoate(cas: 6149-41-3Product Details of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2007,Lotesta, Stephen D.; Hou, Yongquan; Williams, Lawrence J. published 《A Spirodiepoxide-Based Strategy to the A-B Ring System of Pectenotoxin 4》.Organic Letters published the findings.Quality Control of Methyl 3-hydroxypropanoate The information in the text is summarized as follows:

A synthesis of a pectenotoxin 4 C1-C15 segment is reported. Suitable C1-C7 I and C8-C15 II segments were prepared, coupled, converted to product III and the C3-hydroxy variant, and then cyclized. Key findings include the stereoselective conversion of the allene to the corresponding spirodiepoxide, oxidative cleavage of the p-methoxybenzyl ether, and cyclization of the spirodiepoxide to spiroketal IV. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3Quality Control of Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Carbonylation in liquid sulfur dioxide. IV. Carbonylation in the antimony pentachloride-liquid sulfur dioxide system. Carboxylic acid ester synthesis from alkyl chlorosulfite and dialkyl sulfite》 were Nojima, Masatomo; Shiba, Fumiaki; Tokura, Niichiro. And the article was published in Chemistry Letters in 1972. Synthetic Route of C9H16O2 The author mentioned the following in the article:

The carbonylation of BuBr, BuOSOCl, Me(CH2)3OS(O)(CH2)3Me, and PrOSOCl in SbCl5-SO2(1)-EtOH at -70° gave 5% EtCHMeCO2Et (I), 66% I, 75% BuCO2Et, and 65% PrCO2Et, resp. Similar treatment of cyclohexyl chloride, cyclohexyl chlorosulfite, and dicyclohexyl sulfite gave 8% Et cyclohexanecarboxylate (II) and 23% Et 1-methylcyclopentane carboxylate (III); 19% II and 37% III; and 53% II and 3% III; resp. The experimental process involved the reaction of Ethyl 1-methylcyclopentanecarboxylate(cas: 6553-72-6Synthetic Route of C9H16O2)

Ethyl 1-methylcyclopentanecarboxylate(cas: 6553-72-6) is a member of cyclopentanes. Although cyclopentane itself doesn’t have a single highly favoured conformation, a substituent on the cyclopentane ring can upset the balance of strains thereby favouring either the envelope or the half-chair.Synthetic Route of C9H16O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 30414-53-0On May 31, 2022, Giannopoulos, Vasileios; Katsoulakis, Nikolaos; Smonou, Ioulia published an article in Synthesis. The article was 《Dichlorination of β-Keto Esters and 1,3-Diketones Mediated by Oxone/Aluminum Trichloride Mixture in Aqueous Medium》. The article mentions the following:

A new method for the α,α-dichlorination of β-keto esters using oxone/aluminum trichloride mixture in aqueous medium had been developed. This useful process had also been applied successfully for the dichlorination of 1,3-diketones. The dichlorinated compds of formula I [R1 = CH3, C2H5, vinyl, etc.; R2 = CH3, C2H5, t-Bu]. had been produced in one step, high yields, and short reaction times. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0HPLC of Formula: 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.HPLC of Formula: 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Diastereoselective and enantioselective microbial reduction of cyclic α-alkyl β-keto esters》 was published in Tetrahedron Letters in 1986. These research results belong to Buisson, Didier; Azerad, Robert. Safety of Cis-methyl 2-hydroxycyclohexanecarboxylate The article mentions the following:

The reduction of racemic cyclopenta- and cyclohexanone 2-carboxyesters by various yeast and mold strains produced different amounts of isomeric β-hydroxyesters with predominant (1S) stereochem. With several strains, only one optically pure cis or trans stereoisomer was obtained in high yield, indicating a diastereoselective and enantioselective reduction In the part of experimental materials, we found many familiar compounds, such as Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8Safety of Cis-methyl 2-hydroxycyclohexanecarboxylate)

Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Safety of Cis-methyl 2-hydroxycyclohexanecarboxylate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A Discrete 3d-4f Metallacage as an Efficient Catalytic Nanoreactor for a Three-Component Aza-Darzens Reaction》 was written by Zhou, Shengbin; Zhang, Zhichao; Bai, Dongjie; Li, Jingzhe; Cui, Xiang; Xu, Zhichuan J.; Tang, Yu; Tang, Xiaoliang; Liu, Weisheng. Recommanded Product: 4755-77-5This research focused onzinc europium metallacage preparation nanoreactor Darzens reaction catalysis; crystal structure europium zinc metallacage quadruple helicate. The article conveys some information:

The exploration and development of coordination nanocages can provide an approach to control chem. reactions beyond the bounds of the flask, which has aroused great interest due to their significant applications in the field of mol. recognition, supramol. catalysis, and mol. self-assembly. Herein, the authors employ a semirigid and nonsym. bridging ligand (H5L) with rich metal-chelating sites to construct an unusual and discrete 3d-4f metallacage, [Zn2Er4(H2L)4(NO3)Cl2(H2O)]·NO3·xCH3OH·yH2O (Zn2Er4). The 3d-4f Zn2Er4 cage possesses a quadruple-stranded structure, and all of the ligands wrap around an open spherical cavity within the core. The self-assembly of the unique cage not only ensures the structural stability of the Zn2Er4 cage as a nanoreactor in solution but also makes the bimetallic lanthanide cluster units active sites that are exposed in the medium-sized cavity. It is important to note that the Zn2Er4 cage as a homogeneous catalyst was successfully applied to catalyze three-component aza-Darzens reactions of formaldehyde, anilines, and α-diazo esters without another additive under mild conditions, displaying better catalytic activity, higher specificity, short reaction time, and low catalyst loadings. A possible mechanism for this three-component aza-Darzens reaction catalyzed by the Zn2Er4 cage is proposed. These exptl. results demonstrated the great potential of the discrete 3d-4f metallacage as a host nanoreactor for the development of supramol. or mol. catalysis. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 403-33-8In 2020 ,《Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions》 was published in Science China: Chemistry. The article was written by Chen, Hang; Chen, Dong-Huang; Huang, Pei-Qiang. The article contains the following contents:

Reported that by employing Ni(COD)2/2,2′-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcs. can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50°C/80°C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, N-acylindoles, and to other (functionalized) primary and secondary alcs. In all cases, only 1.5 equivalent of alc. were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asym. methodologies. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2021 ,《Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications》 appeared in Tetrahedron Letters. The author of the article were Zhou, Jing-xuan; Zhu, Dong-yu; Chen, Jie; Zhang, Xue-jing; Yan, Ming; Chan, Albert S. C.. The article conveys some information:

A series of chiral polysulfonate cyclohexyldiamine-Ni(II) catalysts were prepared via sulfur (VI) fluoride exchange click-reactions. The catalysts exhibited good catalytic activity and enantioselectivity in the Michael addition of malonates to nitroalkenes. The excellent recyclability of the catalysts was demonstrated via the reuse of the privileged catalyst for ten times. The results provided a new strategy for the immobilization of chiral homogeneous catalysts. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Category: esters-buliding-blocks)

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics