Tag: 100-200

On July 23, 2009, Kurimoto, Ayumu; Katoda, Wataru; Hashimoto, Kazuki; Takahashi, Kazuhiko published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of adenine compound. And the patent contained the following:

The title compounds I [A1 = (CH2)m; A2 = (CH2)n; R1 = alkyl; R2, R3 = H, alkyl; or NR2R3 = pyrrolidine, morpholine, thiomorpholine, etc.; R4 = alkyl; m, n = integer from 2 to 5] are prepared by debenzylation of II [p = 1 or 2; R = H, halo, alkyl, etc.; A1, A2, R1 – R3, m, n = as defined above], followed by reaction with alkyl (3-formylphenyl)acetate in the presence of a boron-containing reducing agent. I are useful as pharmaceuticals (no data). Thus, debenzylation of 6-(benzylamino)-2-butoxy-9-(3-[(3-morpholin-4-ylpropyl)amino]propyl)-7,9-dihydro-8H-purin-8-one, followed by reaction with Me (3-formylphenyl)acetate in the presence of sodium triacetoxyborohydride, gave Me (3-([[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl)phenyl)acetate. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Category: esters-buliding-blocks

The Article related to benzylaminobutoxymorpholinylpropylaminopropyldihydropurinone debenzylation, aminobutoxyoxodihydropurinylpropylmorpholinylpropylaminomethylphenylacetate preparation, aminobutoxymorpholinylpropylaminopropyldihydropurinone reaction formylphenylacetate sodium triacetoxyborohydride and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2021, Meninno, Sara; Villano, Rosaria; Lattanzi, Alessandra published an article.Name: Methyl 2-cyclopentanonecarboxylate The title of the article was Magnesium Monoperphthalate (MMPP): a Convenient Oxidant for the Direct Rubottom Oxidation of Malonates, β-Keto Esters, and Amides. And the article contained the following:

A mild and convenient protocol for the α-hydroxylation of α-substituted malonates, β-ketoesters, and β-ketoamides is disclosed. Cheap and stable magnesium monoperphthalate (MMPP) was effective for a first direct α-hydroxylation protocol of the Rubottom oxidation, providing tartronic esters, cyclic α-hydroxy β-ketoesters and amides in good to high yields, when working at room temperature and in ethanol as the solvent. The protocol has been successfully scaled up to gram quantity. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Name: Methyl 2-cyclopentanonecarboxylate

The Article related to malonate magnesium monoperphthalate regioselective rubottom hydroxylation, ketoester magnesium monoperphthalate regioselective rubottom hydroxylation, ketoamide magnesium monoperphthalate regioselective rubottom hydroxylation, hydroxy malonate ketoester ketoamide preparation and other aspects.Name: Methyl 2-cyclopentanonecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Senol, Ilbilge Merve; Celik, Ilhami; Avan, Ilker published an article in 2019, the title of the article was One-pot synthesis of quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones utilizing N-(2-aminobenzoyl)benzotriazoles.Recommanded Product: 707-07-3 And the article contains the following content:

A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3H)-ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3H)-ones, and 2,3-dihydroquinazolin-4(1H)-ones were obtained at yields of 46% to 95% by a one-pot reaction of N-(2-aminobenzoyl)benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: 707-07-3

The Article related to aminobenzoyl benzotriazole orthoester ammonium acetate one pot reaction, quinazolinone preparation green chem, aldehyde aminobenzoyl benzotriazole ammonium acetate one pot reaction, primary amine aminobenzoyl benzotriazole aldehyde one pot reaction, dihydroquinazolinone preparation green chem and other aspects.Recommanded Product: 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2020, Fan, Shanshan; Tang, Ke; Xu, Yan; Chen, Shuang published an article.Application In Synthesis of Diethyl succinate The title of the article was Characterization of the potent odorants in Tibetan Qingke Jiu by sensory analysis, aroma extract dilution analysis, quantitative analysis and odor activity values. And the article contained the following:

Tibetan Qingke Jiu is the most important alc. beverage in the daily life of Tibetan people due to its unique flavor and rich nutrients. In this study, the aromatic characteristics of Qingke Jiu were studied by sensory anal., aroma extract dilution anal. (AEDA), quant. anal., and odor activity values (OAVs). Sensory evaluation demonstrated that Qingke Jiu had fruity, cooked potato, honey, sour, sweet, and caramel-like aroma. A total of 66 aroma compounds were identified by AEDA and gas chromatog.-mass spectrometry, with flavor dilution (FD) factors ranging from 4 to 2048. Among them, methional, acetic acid, Et butanoate, phenylacetaldehyde and U+03B2-phenylethanol appeared with the highest FD factors. The concentration of these aroma-active compounds was further quantitated by combination of four different quant. measurements, and 17 odorants had concentrations higher than their odor thresholds. Based on the OAVs, phenylacetaldehyde, U+03B2-phenylethanol, Et phenylacetate, sotolon, furaneol, methional, methionol, U+03B3-nonalactone, Et 2-methylbutanoate, U+03B2-damascenone, Et 3-methylbutanoate, Et acetate, Et butanoate, and acetic acid could be potentially important to the overall aroma profile of Qingke Jiu. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Application In Synthesis of Diethyl succinate

The Article related to tibetan qingke jiu sensory odorants, aeda, acetic acid, aroma active compounds, ethyl 2-methylbutanoate, ethyl 3-methylbutanoate, furaneol, methional, oavs, phenylacetaldehyde, quantitative analysis, sensory analysis, sotolon, tibetan qingke jiu, β-damascenone, β-phenylethanol, γ-nonalactone and other aspects.Application In Synthesis of Diethyl succinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Miura, Tomoya; Fujimoto, Yoshikazu; Funakoshi, Yuuta; Murakami, Masahiro published an article in 2015, the title of the article was A Reaction of Triazoles with Thioesters to Produce β-Sulfanyl Enamides by Insertion of an Enamine Moiety into the Sulfur-Carbonyl Bond.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

N-Sulfonyl-1,2,3-triazoles I (R1 = n-Pr, 1-cyclohexenyl, Ph, 4-MeC6H4, 3-thienyl, etc., R2 = 4-MeC6H4; R1 = Ph, R2 = Me, n-Bu, 2-MeC6H4, etc.) react with thioesters R3C(O)SR4 [R3 = Me, R4 = Et, n-Bu, Ph, 4-MeOC6H4, etc.; R3 = t-BuO, R4 = Ph; R3R4 = (CH2)3, CHClCH2CH2, PhCH2CHCH2, etc.] in the presence of a rhodium(II) catalyst to produce β-sulfanyl enamides II in a stereoselective manner. The reaction proceeds through generation of an α-imino rhodium carbene complex, nucleophilic addition of the sulfur atom of a thioester onto the carbenoid carbon atom, and subsequent intramol. migration of the acyl group from the sulfur atom to the imino nitrogen atom. The method is successfully applied to a ring-expansion reaction of thiolactones, thus leading to the formation of sulfur-containing lactams. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to triazole sulfonyl stereoselective nucleophilic addition rearrangement thioester rhodium, amide sulfonyl thiovinyl stereoselective preparation, lactam thia sulfonyl preparation, thiolactone ring expansion sulfonyl triazole rhodium catalyst, carbenoids, copper, heterocycles, rhodium, sulfur and other aspects.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 15, 2020, Hussain, Javeena; Chhabria, Dimple; Kirubakaran, Sivapriya published an article.Product Details of 707-07-3 The title of the article was Design, synthesis and biological evaluation of new Myo-inositol derivatives as potential RAS inhibitors. And the article contained the following:

Ras is a small family of GTPases that control numerous cellular functions like cell proliferation, growth, survival, gene expression, and is closely engaged in cancer pathogenesis. The ras-targeted methodol. entails a holy grail in oncol. Nevertheless, there are no specific mols. reported targeting the same, although it is a known oncogene for more than three decades. In this study, we have designed and synthesized new phosphate derivatives of Myo-inositol to inhibit the oncogenic KRAS pathway in breast cancer cells, which has been validated by cellular and theor. studies. The synthesized compound I (C2-O-phosphate derivative of myo-inositol 1,3,5-orthobenzoate) inhibited the downstream signaling pathway of oncogenic KRAS, RAF/MEK/ERK. Furthermore, we also found that this compound induced necrosis/apoptosis and causes cell cycle arrest. This class of mols. may work as a potential inhibitor of breast cancer caused by a mutation in KRAS and its downstream proteins. Though the efficacy of the mols. is in the micromolar scale, they have not been explored previously for RAS inhibition. Impressive preliminary results are presented in this article which could be further explored for its detailed biol. studies to get better candidates as RAS inhibitors. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Product Details of 707-07-3

The Article related to gene expression inositol benzoate synthesis mol docking kras, ras inhibition gtpase cell proliferation crystal structure human, antitumor inositol cyclitol preparation breast cancer necrosis apoptosis kras, antiproliferative activity, breast cancer, kras, molecular docking, myo-inositol and other aspects.Product Details of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Yan-Li; Qin, Zhou-Zhou; Wang, Yu-Xia; Zhao, Peng-Fei; Li, Hong-Feng; Du, Zhi-Hong; Da, Chao-Shan published an article in 2021, the title of the article was Highly enantioselective one-pot sequential synthesis of valerolactones and pyrazolones bearing all-carbon quaternary stereocentres.COA of Formula: C6H8O3 And the article contains the following content:

Highly enantiopure and bioactive δ-valerolactones I (R = Me, Ph, 1-naphthyl, 2-chlorophenyl, etc.; R1 = Ph, 1-naphthyl, 2-methylphenyl, etc.; n = 0, 1), and pyrazolones II, bearing α-all-carbon quaternary stereocentres, were successfully and sequentially prepared via a one-pot procedure starting from readily available, inexpensive materials, catalyzed by a new chiral squaramide III under mild reaction conditions. An organocatalytic Michael reaction afforded the valerolactones I, while a one-pot Michael-hydrazinolysis-imidization cascade yielded the pyrazolones II. This procedure is economically efficient and environmentally benign. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).COA of Formula: C6H8O3

The Article related to acyl alkyl valerolactone preparation enantioselective, vinyl ketone acyl valerolactone conjugate michael addition squaramide catalyst, dialkyl aryl pyrazolone preparation enantioselective green chem, vinylketone valerolactone michael hydrazinolysis imidization tandem one pot squaramide and other aspects.COA of Formula: C6H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 5, 2021, Hayrapetyan, Davit; Stepanova, Valeriya published an article.Formula: C6H8O3 The title of the article was Facile Synthesis of Spirocyclic Lactams via [3+2] and [3+3] Aza-Annulation Reactions. And the article contained the following:

Spirocyclic pyrrolidones and piperidones such as I and II were synthesized starting from readily available α-ketolactones and α-ketolactams employing [3+2]- and [3+3]-aza-annulation reactions. Tandem reactions of enamino lactams and lactones with maleic and itaconic anhydride yielded alkylidenespirolactams in good yields; further reduction of the exocyclic C=C double bond of the enamino moiety proceeded with excellent diastereoselectivity. Overall, one C-C and two C-N bonds, as well as three new stereocenters were created in a diastereoselective manner resulting in a fast upbuild of mol. complexity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Formula: C6H8O3

The Article related to pyrrolidinone piperidinone spirolactam diastereoselective preparation, tandem michael addition cyclization maleic itaconic anhydride aminoalkylidene lactam, stereoselective cyclization maleic itaconic anhydride aminoalkylidene lactam, reduction stereoselective alkylidene spirolactam and other aspects.Formula: C6H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 27, 2013, Markovic, Martin; Duranova, Marianna; Koos, Peter; Szolcsanyi, Peter; Gracza, Tibor published an article.Category: esters-buliding-blocks The title of the article was Synthesis of bis-tetrahydrofuran subunit of (-)-neopallavicinin. And the article contained the following:

The stereospecific Pd/Cu-catalyzed oxycarbonylation of syn/anti-hex-5-ene-2,4-diols I and II was used as a key step in the synthesis of bicyclic lactones III and IV. Eventually, the major intermediate III was transformed to the bis-tetrahydrofuran subunit of naturally occurring diterpenoid (-)-neopallavicinin (V). The target compound VI was thus prepared in 7.5% overall yield over eight steps starting from com. available Me (R)-3-hydroxybutanoate. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Category: esters-buliding-blocks

The Article related to neopallavicinin diterpenoid bistetrahydrofuran subunit preparation, hexenediol palladium copper catalyzed oxycarbonylation, lactone bicyclic bistetrahydrofuran preparation ethylidenation, chiral hydroxybutanoate silylation vinylation, siloxybutanoate chiral preparation vinylation and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sable, Ganesh A.; Lee, Kang Ju; Lim, Hyun-Suk published an article in 2019, the title of the article was Solid-phase synthesis and circular dichroism study of β-AB-peptoids.Electric Literature of 3976-69-0 And the article contains the following content:

The development of peptidomimetic foldamers that can form well-defined folded structures is highly desirable yet challenging. We previously reported on α-ABpeptoids, oligomers of N-alkylated β2-homoalanines and found that due to the presence of chiral Me groups at α-positions, α-ABpeptoids were shown to adopt folding conformations. Here, we report β-ABpeptoids having chiral Me group at β-positions rather than α-positions as a different class of peptoids with backbone chirality. We developed a facile solid-phase synthetic route that enables the synthesis of β-ABpeptoid oligomers ranging from 2-mer to 8-mer in excellent yields. These oligomers were shown to adopt ordered folding conformations based on CD (CD) and NMR studies. Overall, these results suggest that β-ABpeptoids represent a novel class of peptidomimetic foldamers that will find a wide range of applications in biomedical and material sciences. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Electric Literature of 3976-69-0

The Article related to peptoid beta solid phase synthesis peptidomimetic foldamer cd nmr, chirality peptidomimetic conformation solvent effect, alkyl homoalanine synthesis hydroxybutanate azidation reduction arylation protection, foldamers, peptidomimetics, peptoids, solid-phase synthesis, β-abpeptoids and other aspects.Electric Literature of 3976-69-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics