Tag: 100-200

Gao, Wen-Chao; Liu, Jianrong; Jiang, Xuefeng published an article in 2021, the title of the article was Phthalimide-based-SSCF3 reagent for enantioselective dithiotrifluoromethylation.Application In Synthesis of Methyl 2-cyclopentanonecarboxylate And the article contains the following content:

An electrophilic phthalimide-based-SSCF3 reagent was designed and prepared for straightforward SSCF3 incorporation of diverse β-keto esters in natural products, pharmaceuticals and biol. mols. The asym. dithiotrifluoromethylation was achieved with a good to excellent enantioselectivity, catalyzed by a cinchona-alkaloid-based catalyst (DHQD)2PHAL via an ammonium-hydrogen-bonded induction mode. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Application In Synthesis of Methyl 2-cyclopentanonecarboxylate

The Article related to indanone carboxylate dithiotrifluoromethyl phthalimide cinchona catalyst enantioselective dithiotrifluoromethylation, dithiotrifluoromethyl phthalimide indanone carboxylate dmap catalyst dithiotrifluoromethylation, trifluoromethyldisulfanyl indanone carboxylate preparation and other aspects.Application In Synthesis of Methyl 2-cyclopentanonecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 5, 2021, Liang, Ren-Xiao; Zhong, Chao; Liu, Zhi-Hong; Yang, Miao; Tang, Heng-Wei; Chen, Jian-Fei; Yang, Yun-Fang; Jia, Yi-Xia published an article.Product Details of 517-23-7 The title of the article was Enantioselective Arylation of Tetrasubstituted Enamines: Access to Enantioenriched Indolenine and 1H-Indole Derivatives. And the article contained the following:

Palladium-catalyzed intramol. enantioselective β-arylation of tetrasubstituted endocyclic and exocyclic enamines was developed. A range of optically active medium-ring fused indolenines or 3,3′-spiroindolenines were achieved in enantiomeric ratios up to 98:2 with Cs2CO3 or K3PO4 as the base in the presence of chiral PHOX ligands. The use of Ag3PO4 as a base led to enantioenriched 1H-indoles in good enantiomeric ratios (up to 89:11) with (S)-DIFLUORPHOS as a chiral ligand, which proceeded via a possible domino enamine-isomerization/β-arylation sequence. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Product Details of 517-23-7

The Article related to haloarylamino cycloalkenyl ester palladium catalyst enantioselective regioselective heteroarylation, cycloalkylpyrroloarene preparation, bromophenylaminomethylidene oxolanone palladium catalyst enantioselective regioselective heteroarylation, spirofuranindolone preparation and other aspects.Product Details of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 6, 2020, Abronina, Polina I.; Zinin, Alexander I.; Chizhov, Alexander O.; Kononov, Leonid O. published an article.Quality Control of (Trimethoxymethyl)benzene The title of the article was Unusual Outcome of Glycosylation: Hydrogen-Bond Mediated Control of Stereoselectivity by N-Trifluoroacetyl Group?. And the article contained the following:

During the synthesis of protected tetrasaccharide fragment of the repeating unit of polysaccharide of Azospirillum brasilense sp7 we found that glycosylation with a mixture of protected N-trifluoroacetyl (TFA)-protected glucosamine N-phenyltrifluoroacetimidate and the corresponding 2-trifluoromethyl-oxazoline led to 1,2-cis-linked glycoside along with the expected 1,2-trans-linked isomer. This fact looks quite unusual bearing in mind that both N-TFA-containing glycosyl donor and 2-trifluoromethyl-oxazoline are usually expected to favor the formation of 1,2-trans-glycosides. Formation of 1,2-cis-glycoside was explained by hydrogen-bond mediated complexation of hydrogen atom of NHTFA at C-2 of oxacarbenium ion derived from glycosyl donor and oxygen atom of hydroxy group of the incoming nucleophile. Conversely, glycosylation with N-phthaloyl protected glycosyl donors resulted in exclusive formation of 1,2-trans-isomer presumably due to a significant steric effect and the absence of addnl. hydrogen-bonding sites of N-phthaloyl group. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Quality Control of (Trimethoxymethyl)benzene

The Article related to synthon polysaccharide aminoglycoside stereoselective glycosylation catalyst, polysaccharide repeating unit azospirillum brasilense glycosylation glucosamine fluoromethyloxazoline, steric effect stereoselective glycosylation catalyst hydrogen bond phthaloyl aminoglycoside and other aspects.Quality Control of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koroji, Samira; Mohammadi, Ali A.; Mehrshad, Mohammad published an article in 2018, the title of the article was An Efficient One-Pot Three-Component Synthesis of Some New 3-(Benzo[d]thiazol-2-yl)-2-alkyl-4(3H)-quinazolinones Using Silica Sulfuric Acid as a Heterogeneous Catalyst.Application of 707-07-3 And the article contains the following content:

Silica sulfuric acid catalyzed one-pot synthesis of some new 3-(benzo[d]thiazol-2-yl)-2-alkyl or 3-(2-benzimidazolyl)-2-alkyl quinazolin-4(3H)-one by condensation of a three component of anthranilic acid, 2-aminobenzothiazole or 2-aminobenzimidazole, and orthoesters under microwave irradiation The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Application of 707-07-3

The Article related to benzothiazolylalkylquinazolinone preparation condensation anthranilic acid aminobenzothiazole aminobenzimidazole orthoester, benzothiazolylquinazolinone benzimidazolylquinazolinone alkyl preparation cyclocondensation anthranilic acid aminobenzothiazole aminobenzimidazole and other aspects.Application of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kirby, Gordon W.; Nazeer, Muhammad published an article in 1988, the title of the article was Asymmetric induction in the Diels-Alder reactions of α-hydroxyacylnitroso compounds.Recommanded Product: Methyl 2-hydroxy-3,3-dimethylbutanoate And the article contains the following content:

Transient, chiral α-hydroxyacylnitroso compounds, RCH(OR1)CONO (R = Ph, R1 = OH, OMe; R = CMe3, cyclohexyl, R1 = OH), form intramol. hydrogen bonds, react stereoselectively with cyclopentadiene and cyclohexa-1,3-diene to yield the cycloadducts I and II. The cycloadduct of cyclohexadiene and the nitroso derivative of (S)-mandelic acid has been converted into the known (-)-oxazine derivative III. The experimental process involved the reaction of Methyl 2-hydroxy-3,3-dimethylbutanoate(cas: 121129-31-5).Recommanded Product: Methyl 2-hydroxy-3,3-dimethylbutanoate

The Article related to hydroxyacylnitroso compound desls alder stereoselectivity, cyclopentadiene diels alder hydroxyacylnitroso compound stereochem, cyclohexadiene diels alder hydroxyacylnitroso compound stereochem, asym induction diels alder hydroxyacylnitroso compound, oxazine derivative and other aspects.Recommanded Product: Methyl 2-hydroxy-3,3-dimethylbutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 25, 2020, Zhu, Lin; Wang, Xinlei; Song, Xuebo; Zheng, Fuping; Li, Hehe; Chen, Feng; Zhang, Yuhang; Zhang, Fuyan published an article.Synthetic Route of 123-25-1 The title of the article was Evolution of the key odorants and aroma profiles in traditional Laowuzeng baijiu during its one-year ageing. And the article contained the following:

Changes of key odorants and aroma profiles of Chinese Laowuzeng baijiu during its one-year ageing were determined by HS-SPME-AEDA and direct injection-AEDA (DI-AEDA). Et hexanoate, (E,E)-2,4-decadienal, and 2-phenylethyl acetate showed the highest FD value (486) in all ageing stages. With regards to aroma profiles, fruity, floral, acidic, sweet/honey and cheesy aromas were enhanced during storage, while pickled vegetable, grain and alc. notes weakened during the ageing. Quantitation and OAVs showed that most of the aroma compounds (OAVs > 1), including Et esters, aldehydes, and acids, increased their contents within the same period, whereas nonanal, 2-phenylethyl acetate, Et benzoate, 4-ethylguaiacol, propanol and 3-methyl-1-butanol decreased in content after the storage of 365 days. Simulated aged samples, in which fresh samples were spiked with 18 compounds, were examined by triangle tests, which indicated that the “fruity” compounds were crucial for maintaining the special aroma profile of an aged sample. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Synthetic Route of 123-25-1

The Article related to baijiu odorant aroma profile, 3-methyl-1-butyl acetate, aeda, ageing, aromas, chinese liquor, dimethyl trisulfide, ethyl 3-methylbutanoate, ethyl acetate, ethyl butanoate, ethyl hexanoate, ethyl octanoate, ethyl pentanoate, gc–ms/o, hexanal, laobaigan baijiu, nonanal and other aspects.Synthetic Route of 123-25-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 28, 2019, Fan, Lian-Feng; Wang, Tian-Ci; Wang, Pu-Sheng; Gong, Liu-Zhu published an article.SDS of cas: 10472-24-9 The title of the article was Palladium-Catalyzed Asymmetric Allylic C-H Alkylation of 1,4-Dienes with Cyclic β-Keto Esters. And the article contained the following:

In the presence of chiral phosphoramidite ligand, a palladium-catalyzed asym. allylic C-H alkylation of 1,4-dienes with cyclic β-keto esters has been established to afford chiral α,α-disubstituted β-keto esters I (3, R1 = H, Me, F, OMe, Cl, OCH2CH:CH2, OCH2CCMe; R2 = Me, Et, iPr, tBu, PhCH2; R = alkyl, cycloalkyl, Ph, carboxy, carboxamide) in good to excellent yields, with high levels of regioselectivity, E/Z selectivity, and enantioselectivity. 1,4-Dienes bearing a wide scope of functional groups, such as ketone, chloride, ester, and amide as well, have been nicely tolerated. In addition, preliminary application of this method enables a concise formal synthesis of (-)-tanikolide. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).SDS of cas: 10472-24-9

The Article related to asym allylic alkylation keto ester indanone diene palladium catalyst, phosphoramidite palladium chiral allylation catalyst preparation allyl dienyl ketoester, oxo indanecarboxylate cyclopentanecarboxylate asym allylic alkylation palladium phosphoramidite catalyst and other aspects.SDS of cas: 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 8, 2010, Coumar, Mohane Selvaraj; Chu, Chang-Ying; Lin, Cheng-Wei; Shiao, Hui-Yi; Ho, Yun-Lung; Reddy, Randheer; Lin, Wen-Hsing; Chen, Chun-Hwa; Peng, Yi-Hui; Leou, Jiun-Shyang; Lien, Tzu-Wen; Huang, Chin-Ting; Fang, Ming-Yu; Wu, Szu-Huei; Wu, Jian-Sung; Chittimalla, Santhosh Kumar; Song, Jen-Shin; Hsu, John T.-A.; Wu, Su-Ying; Liao, Chun-Chen; Chao, Yu-Sheng; Hsieh, Hsing-Pang published an article.COA of Formula: C4H8ClNOS The title of the article was Fast-Forwarding Hit to Lead: Aurora and Epidermal Growth Factor Receptor Kinase Inhibitor Lead Identification. And the article contained the following:

Furanopyrimidines such as I [R = (S)-HOCH2CHPh; R1 = 3-(H2C:CCONH)C6H4] are prepared as Aurora A kinase and epidermal growth factor receptor (EGFR) inhibitors by preparation of a combinatorial library of approx. 350 furanopyridines and optimization of the inhibitors found from the library. The initial hit compound I (R = HOCH2CH2; R1 = Ph) was modified to better fit the back pocket to produce the potent Aurora A kinase inhibitor I (R = 4-PhNHCONHC6H4; R1 = Ph) with submicromolar antiproliferative activity in the HCT-116 human colon cancer cell line. On the basis of docking studies with EGFR hit I [R = (S)-HOCH2CHPh; R1 = Ph], introduction of an acrylamide Michael acceptor group led to I [R = (S)-HOCH2CHPh; R1 = 3-(H2C:CCONH)C6H4], which inhibited both the wild and mutant EGFR kinases and also showed antiproliferative activity in the gefitinib-resistant HCC827 human lung cancer cells. The X-ray cocrystal structures of I (R = HOCH2CH2, 4-PhNHCONHC6H4; R1 = Ph) bound to Aurora A kinase and the crystal structure of I [R = (S)-HOCH2CHPh; R1 = 3-(H2C:CCONH)C6H4] bound to EGFR confirmed their hypothesized binding modes. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).COA of Formula: C4H8ClNOS

The Article related to furanopyrimidine combinatorial library preparation aurora egfr kinase inhibitor, structure furanopyrimidine activity aurora egfr kinase inhibitor, optimization furanopyrimidine aurora egfr kinase inhibitor activity, mol crystal structure furanopyrimidine bound aurora egfr kinase and other aspects.COA of Formula: C4H8ClNOS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 9, 2014, Falkowski, Joseph M.; Sawano, Takahiro; Zhang, Teng; Tsun, Galen; Chen, Yuan; Lockard, Jenny V.; Lin, Wenbin published an article.Electric Literature of 3976-69-0 The title of the article was Privileged Phosphine-Based Metal-Organic Frameworks for Broad-Scope Asymmetric Catalysis. And the article contained the following:

A robust and porous Zr metal-organic framework (MOF) based on a BINAP-derived dicarboxylate linker, BINAP-MOF, was synthesized and post-synthetically metalated with Ru and Rh complexes to afford highly enantioselective catalysts for important organic transformations. The Rh-functionalized MOF is not only highly enantioselective (up to >99% ee) but also 3 times as active as the homogeneous control. XAFS studies revealed that the Ru-functionalized MOF contains Ru-BINAP precatalysts with the same coordination environment as the homogeneous Ru complex. The post-synthetically metalated BINAP-MOFs provide a versatile family of single-site solid catalysts for catalyzing a broad scope of asym. organic transformations, including addition of aryl and alkyl groups to α,β-unsaturated ketones and hydrogenation of substituted alkene and carbonyl compounds The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Electric Literature of 3976-69-0

The Article related to preparation ruthenium rhodium zirconium carboxyphenylethynyl binap hydroxo oxo framework, hydrogenation enantioselective catalyst ruthenium rhodium zirconium binap derivative framework, alkylation enantioselective catalyst ruthenium rhodium zirconium binap derivative framework and other aspects.Electric Literature of 3976-69-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 29, 2007, Hashimoto, Kazuki; Nakamura, Tomoaki; Nakamura, Kei; Kurimoto, Ayumu; Isobe, Yoshiaki published a patent.Quality Control of Methyl 2-(3-formylphenyl)acetate The title of the patent was Preparation of novel adenine compounds having immunomodulating activity. And the patent contained the following:

Novel N-benzyl- and 9-(3-pyridyl)-7,8-dihydro-8-oxoadenine derivatives represented by the formula (I) [A1, A2 = each (un)substituted aromatic carbocycle or aromatic heterocycle; L4 = independently a single bond or linear or branched alkylene; X = O, S, SO, SO2, NH, or alkyl-N; L1, L2, L3 = single bond, alkylene, alkenylene, or alkynylene wherein any methylene group is optionally replaced with O, S, SO, SO2, CO, or each N-(un)substituted alkyl-(un)substituted NHCO, CONH, NHSO2, SO2NH, NHCO2, O2CNH, NHCONH, NHC(:NH)NH, or C(:NH)NH; R1 = halo, each (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heteroaryl; R2 = H or (un)substituted alkyl; R3 = each (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, saturated heterocyclyl, aryl, or heteroaryl; any methylene, methine, or imino group in L2 or L3 is bonded to R3 on the N atom adjacent to L2 an dL3 to form 4- to 7-membered N-containing heterocyclic ring] or pharmaceutically acceptable salts thereof were prepared The compounds have activity of activating Toll-like receptor (TLR7) and useful as immunomodulators for treating and/or preventing allergies, viral diseases, and cancers, in particular asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis, allergic conjunctivitis, atopic dermatitis, hepatitis B, hepatitis C, human immunodeficiency virus (HIV), human papillomavirus (HPV), bacterial infection, or dermatitis (no data). Thus, mesylation of 2-butoxy-9-[6-(4-hydroxybutoxy)pyridin-3-yl]-8-methoxyadenine by methanesulfonyl chloride in the presence of 4-dimethylaminopyridine and Et3N in THF at room temperature for 30 min followed by condensation with 2-(aminomethyl)phenylacetic acid Me ester in the presence of NaI and K2CO3 in DMF at 60° for 48 h gave 2-butoxy-8-methoxy-9-[6-[4-(3-methoxycarbonylmethylbenzyl)aminobutoxy]pyridin-3-ylmethyl]adenine which was stirred with a mixture of concentrated H2SO4 and MeOH and neutralized with 28% aqueous NH3 solution to give 2-butoxy-7,8-dihydro-9-(6-[4-(3-methoxycarbonylmethylbenzyl)aminobutoxy]pyridin-3-ylmethyl)-8-oxoadenine. II activated human TLR-7 in HEK293 cells with EC50 of 9.1 nM in a human TLR-7 reporter assay. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Quality Control of Methyl 2-(3-formylphenyl)acetate

The Article related to dihydrooxoadenine preparation immunomodulator, pyridinylmethyldihydrooxoadenine benzyldihydrooxoadenine preparation immunomodulator, toll like receptor tlr7 activator dihydrooxoadenine preparation, allergy viral disease cancer treatment prevention dihydrooxoadenine preparation and other aspects.Quality Control of Methyl 2-(3-formylphenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics