Tag: 100-200

On September 30, 2019, Chhanda, Sadia Afrin; Itsuno, Shinichi published an article.Product Details of 10472-24-9 The title of the article was Design and synthesis of chiral hyperbranched polymers containing cinchona squaramide moieties and their catalytic activity in the asymmetric Michael addition reaction. And the article contained the following:

Chiral hyperbranched polymers (HBP) containing cinchona alkaloids were synthesized using a Mizoroki-Heck (MH) coupling polymerization reaction between a cinchona squaramide dimer and tri- or tetra-substituted aromatic iodides. This was a new type of polymeric chiral organocatalyst. We found that the as-obtained chiral HBPs show excellent catalytic activity in the asym. Michael reaction. Almost perfect enantioselectivity (>99% ee) was achieved in the reaction of β-ketoester and trans-β-nitrostyrene. The three-dimensional network structure of the chiral HBPs is structurally robust and can be reused for further reaction without any loss in their catalytic activity. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Product Details of 10472-24-9

The Article related to cinchona squaramide iodoarene copolymer preparation recyclability, keto ester nitro vinylarene chiral polymer organocatalyst michael addition, alkyl aryl nitroalkyl oxo cyclopentanecarboxylate diastereoselective enantioselective preparation and other aspects.Product Details of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2022, Tofalo, Rosanna; Perpetuini, Giorgia; Rossetti, Alessio Pio; Gaggiotti, Sara; Piva, Andrea; Olivastri, Lino; Cichelli, Angelo; Compagnone, Dario; Arfelli, Giuseppe published an article.Computed Properties of 123-25-1 The title of the article was Impact of Saccharomyces cerevisiae and non-Saccharomyces yeasts to improve traditional sparkling wines production. And the article contained the following:

In this study the effect of a co-inoculum of S. cerevisiae (F6789) with Torulaspora delbrueckii (TB1) or Starmerella bacillaris (SB48) on the oenol. and aroma characteristics of sparkling wines obtained with the Champenoise method was investigated. The autolytic outcome and the sensory profile of sparkling wines were also evaluated. The secondary fermentations were completed by all mixed and single starter cultures with the only exception of those guided by Starm.bacillaris. Sparkling wines produced with S. cerevisiae F6789+Starm.bacillaris SB48 showed the highest amounts of glycerol (6.51 g/L). The best autolytic potential was observed in sparkling wines produced with +Starm.bacillaris (81.98 mg leucin/L) and S. cerevisiae+T. delbrueckii (79.03 mg leucin/L). The lowest value was observed for sparkling wines obtained with S. cerevisiae F6789 (53.96 mg leucin/L). Sparkling wines showed different aroma and sensory profiles. Esters were mainly present in sparkling wines obtained with S. cerevisiae F6789 (88.09 mg/L) followed by those obtained with S. cerevisiae+T. delbrueckii (87.20 mg/L), S. cerevisiae +Starm.bacillaris (81.93 mg/L). The content of esters decreased over time, and that might be related to the adsorption on lees and chem. hydrolysis. The highest concentrations of higher alcs. were found in sparkling wines produced with S. cerevisiae+T. delbrueckii (27.50 mg/L). Sparkling wines obtained with S. cerevisiae +Starm.bacillaris were well differentiated from the others due to their high score for the descriptor for spicy, bread crust, freshness and floral. Tailored strains with different autolytic potential might represent an interesting strategy to improve traditional sparkling wine production and favor their differentiation. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Computed Properties of 123-25-1

The Article related to saccharomyces cerevisiae torulaspora delbrueckii sparkling wine production hydrolysis, aroma compounds, champenoise method, saccharomyces cerevisiae, sparkling wines, starmerella bacillaris, torulaspora delbrueckii, non-saccharomyces yeasts and other aspects.Computed Properties of 123-25-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2022, Ma, Longhua; Meng, Qingran; Chen, Feng; Gao, Wenjie published an article.Recommanded Product: 123-25-1 The title of the article was SAFE and SBSE combined with GC-MS and GC-O for characterization of flavor compounds in Zhizhonghe Wujiapi medicinal liquor. And the article contained the following:

Volatile compounds in Chinese Zhizhonghe Wujiapi (WJP) medicinal liquor were extracted by solvent-assisted flavor evaporation extraction (SAFE) and stir bar sorptive extraction (SBSE), resp., and identified by gas chromatog.-mass spectrometry. Results showed that a total of 123 volatile compounds (i.e., 108 by SAFE, 50 by SBSE, and 34 by both) including esters, alcs., acids, aldehydes, ketones, heterocycles, terpenes and terpenoids, alkenes, phenols, and other compounds were identified, and 67 of them were confirmed as aroma-active compounds by the application of the aroma extract dilution anal. coupled with gas chromatog.-olfactometry. After making a simulated reconstitute by mixing 41 characterized aroma-active compounds (odor activity values ≥1) based on their concentrations, the aroma profile of the reconstitute showed good similarity to that of the original WJP liquor. Omission test further corroborated 34 key aroma-active compounds in the WJP liquor. The study of WJP liquor is expected to provide some insights into the characterization of special volatile components in traditional Chinese medicine liquors for the purpose of quality improvement and aroma optimization. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Recommanded Product: 123-25-1

The Article related to zhizhonghe wujiapi medicinal liquor flavor compound gcms safe sbse, wujiapi liquor, aromas, gas chromatography-mass spectrometry, gas chromatography-olfactometry, solvent-assisted flavor evaporation extraction, stir bar sorptive extraction and other aspects.Recommanded Product: 123-25-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 6, 2013, Steeneck, Christoph; Kinzel, Olaf; Gege, Christian; Kleymann, Gerald; Hoffmann, Thomas published a patent.HPLC of Formula: 93476-46-1 The title of the patent was Preparation of pyrrolocarboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases. And the patent contained the following:

The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolocarboxamide compounds I [R1 = H, alkyl, cycloalkyl, etc.; R2 = H, alkyl, haloalkyl, hydroxyalkyl; or NR1R2 = (un)substituted 3-8 membered ring containing carbon atoms and optionally containing 1-2 heteroatoms selected from O, S and N; R3 = (un)substituted pyridinone, 6-10 membered mono- or bicyclic aryl, 5-10 membered mono- or bicyclic heteroaryl containing 1-4 heteroatoms selected from N, O or S, etc.; R4 = SO2(CR8R8)yR7, SO2NR12R7, (CR8R8)xR10 or cycloalkyl, which is spirocyclic fused with cycloalkyl; R5 = H, alkyl, haloalkyl, etc.; R6 = H, alkyl, haloalkyl, halo; R7 = (un)substituted cycloalkyl, heterocycloalkyl; R8 = H, F, alkyl, haloalkyl, OH; R10 = (un)substituted cycloalkyl; R12 = H, alkyl, haloalkyl; x = 1-2; y = 0-2; with the proviso] and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof. Over six hundred compounds I were prepared E.g., a multi-step synthesis of II, starting from 1-cyclohexylethanol, was described. Exemplified compounds I were tested in RORγ GaI4 reporter gene assay (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).HPLC of Formula: 93476-46-1

The Article related to pyrrolocarboxamide preparation orphan nuclear receptor rar related gamma modulator, retinoid related orphan receptor gamma modulator pyrrolocarboxamide preparation antiinflammatory, autoimmune disease treatment pyrrolocarboxamide preparation ror gamma modulator and other aspects.HPLC of Formula: 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2022, Wu, Fan-lin; Hu, Yong-hao; Ji, Peng; Li, Chen-chen; He, Jian published an article.SDS of cas: 3976-69-0 The title of the article was Metabonomics study on the hepatoprotective effect mechanism of polysaccharides from different processed products of Angelica sinensis on layer chickens based on UPLC-Q/TOF-MS/MS, multivariate statistical analysis and conjoint analysis. And the article contained the following:

Chicken colibacillosis is one of the most severe diseases in the poultry industry. Ceftiofur sodium (CS) is often used to treat it in clin. practice and lipopolysaccharide (LPS) accumulates in the chicken ′s body. Previous exptl. studies found that CS combined with LPS could induce liver injury in layer chickens, and polysaccharides from charred Angelica sinensis(CASP) had a better hepatoprotective effect than polysaccharides from unprocessed Angelica sinensis(UASP). However, the intervention mechanism was unclear. Thus, UPLC-Q/TOF-MS/MS-based metabonomics and transcriptomics were used in this study to clarify the hepatoprotective effect mechanism of CASP and UASP in layer chickens. Transcriptomics and ELISA were used for biol. verification of some critical mutual metabolic pathways screened with metabonomics. The comprehensive anal. results showed that in a layer chicken liver injury model built with LPS and CS, 12 critical metabolic pathways were disturbed, involving 10 important differential metabolites. The hepatoprotective effect mechanism of CASP is related to the arachidonic acid metabolism and mTOR signaling pathways, involving nine important differential metabolites. In contrast, the hepatoprotective effect mechanism of UASP is related to the arachidonic acid metabolism pathway, involving six important differential metabolites. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).SDS of cas: 3976-69-0

The Article related to angelica sinensis polysaccharide hepatoprotective metabonomic multivariate statistical analysis, lps, layer chickens, liver injury, metabonomics, polysaccharides from charred angelica sinensis(casp), polysaccharides from unprocessed angelica sinensis(uasp) and other aspects.SDS of cas: 3976-69-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 15, 2016, Lavecchia, Martin J.; Puig de la Bellacasa, Raimon; Borrell, Jose I.; Cavasotto, Claudio N. published an article.Formula: C9H8F2O2 The title of the article was Investigating molecular dynamics-guided lead optimization of EGFR inhibitors. And the article contained the following:

The epidermal growth factor receptor (EGFR) is part of an extended family of proteins that together control aspects of cell growth and development, and thus a validated target for drug discovery. The authors explore the suitability of a mol. dynamics-based end-point binding free energy protocol to estimate the relative affinities of a virtual combinatorial library designed around the EGFR model inhibitor 6{1} as a tool to guide chem. synthesis toward the most promising compounds To investigate the validity of this approach, selected analogs including some with better and worse predicted affinities relative to 6{1} were synthesized, and their biol. activity determined To understand the binding determinants of the different analogs, hydrogen bonding and van der Waals contributions, and water mol. bridging in the EGFR-analog complexes were analyzed. The exptl. validation was in good qual. agreement with the authors’ theor. calculations, while also a 6-dibromophenyl-substituted compound with enhanced inhibitory effect on EGFR compared to the reference ligand was obtained. The experimental process involved the reaction of Methyl 2-(2,6-difluorophenyl)acetate(cas: 872046-08-7).Formula: C9H8F2O2

The Article related to pyridopyrimidine egfr inhibitor preparation mol dynamics structure activity binding, egfr, hit-to-lead optimization, ligand binding free energy calculation, mm/gbsa, molecular docking, molecular dynamics, pyrido[2,3-d]pyrimidine, small-molecule inhibitor and other aspects.Formula: C9H8F2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 30, 2019, Lambert, William D.; Fang, Yinzhi; Mahapatra, Subham; Huang, Zhen; am Ende, Christopher W.; Fox, Joseph M. published an article.Formula: C10H14O3 The title of the article was Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids. And the article contained the following:

Described is a general method for the installation of a minimal 6-methyltetrazin-3-yl group via the 1st example of a Ag-mediated Liebeskind-Srogl cross-coupling. The attachment of bioorthogonal tetrazines on complex mols. typically relies on linkers that can neg. impact the physiochem. properties of conjugates. Cross-coupling with arylboronic acids and a new reagent, 3-((p-biphenyl-4-ylmethyl)thio)-6-methyltetrazine (b-Tz), proceeds under mild, PdCl2(dppf)-catalyzed conditions to introduce minimal, linker-free tetrazine functionality. Safety considerations guided the authors’ design of b-Tz which can be prepared on decagram scale without handling hydrazine and without forming volatile, high-N tetrazine byproducts. Replacing conventional Cu(I) salts used in Liebeskind-Srogl cross-coupling with a Ag2O mediator resulted in higher yields across a broad library of aryl and heteroaryl boronic acids and provides improved access to a fluorogenic tetrazine-BODIPY conjugate. A covalent probe for MAGL incorporating 6-methyltetrazinyl functionality was synthesized in high yield and labeled endogenous MAGL in live cells. This new Ag-mediated cross-coupling method using b-Tz is anticipated to find addnl. applications for directly introducing the tetrazine subunit to complex substrates. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Formula: C10H14O3

The Article related to silver palladium catalyzed liebeskind srogl coupling tetrazine arylboronic acid, biphenylylmethylthiomethyltetrazine reagent preparation cross coupling arylboronic acid, safety palladium catalyzed liebeskind srogl coupling tetrazine arylboronic acid and other aspects.Formula: C10H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 16, 2021, Liu, Xigong; Zhao, Changyin; Zhu, Rongxiu; Liu, Lei published an article.Product Details of 10472-24-9 The title of the article was Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition. And the article contained the following:

The asym. construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. A solution involving diastereo- and enantioselective oxidative 1,6-conjugate addn was disclosed. The practical asym. cross-dehydrogenative coupling of 2,2-diarylacetonitriles and diverse α-substituted cyclic 1,3-dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach was further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β-ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo- and enantioselectivity. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Product Details of 10472-24-9

The Article related to diarylacetonitrile keto ester copper catalyst enantioselective oxidative conjugate addition, diaryl cyanomethyl alkanone carboxylate preparation, 1,6-conjugate addition, asymmetric catalysis, cross-dehydrogenative coupling, synthetic methods, vicinal quaternary stereocenters and other aspects.Product Details of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 16, 2021, Liu, Xigong; Zhao, Changyin; Zhu, Rongxiu; Liu, Lei published an article.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition. And the article contained the following:

The asym. construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. A solution involving diastereo- and enantioselective oxidative 1,6-conjugate addn was disclosed. The practical asym. cross-dehydrogenative coupling of 2,2-diarylacetonitriles and diverse α-substituted cyclic 1,3-dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach was further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β-ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo- and enantioselectivity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

The Article related to diarylacetonitrile keto ester copper catalyst enantioselective oxidative conjugate addition, diaryl cyanomethyl alkanone carboxylate preparation, 1,6-conjugate addition, asymmetric catalysis, cross-dehydrogenative coupling, synthetic methods, vicinal quaternary stereocenters and other aspects.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 18, 2017, Abe, Takumi; Suzuki, Takuro; Anada, Masahiro; Matsunaga, Shigeki; Yamada, Koji published an article.Recommanded Product: Methyl N-Methylanthranilate The title of the article was 2-Hydroxyindoline-3-triethylammonium Bromide: A Reagent for Formal C3-Electrophilic Reactions of Indoles. And the article contained the following:

A novel indole-2,3-epoxide equivalent, trans-2-hydroxyindoline-3-triethylammonium bromide (I), was found to be a convenient reagent for formal C3-electrophilic reactions of indoles with various nucleophiles. By taking advantage of the nucleophilic character of the oxygen of the 2-hydroxyindoline, the interrupted retro-Claisen and interrupted Feist-Benary reactions with 1,3-dicarbonyl compounds were efficiently achieved. The process was successfully applied to the synthesis of cryptolepine. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: Methyl N-Methylanthranilate

The Article related to hydroxyindole triethylammonium bromide nucleophilic amination substitution indole, cryptolepine preparation, interrupted retro claisen hydroxyindole triethylammonium bromide dicarbonyl compound, feist benary interrupted hydroxyindole triethylammonium bromide cyclic diketone and other aspects.Recommanded Product: Methyl N-Methylanthranilate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics